PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27875297-0 2016 Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival. Floxuridine 119-130 uracil DNA glycosylase Homo sapiens 63-85 27875297-0 2016 Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival. Floxuridine 119-130 uracil DNA glycosylase Homo sapiens 87-91 27875297-1 2016 Uracil N-glycosylase 2 (UNG2), the nuclear isoform of UNG, catalyzes the removal of uracil or 5-fluorouracil lesions that accumulate in DNA following treatment with the anticancer agents 5-fluorouracil and 5-fluorodeoxyuridine (floxuridine), a 5-fluorouracil metabolite. Floxuridine 206-226 uracil DNA glycosylase Homo sapiens 0-22 27875297-1 2016 Uracil N-glycosylase 2 (UNG2), the nuclear isoform of UNG, catalyzes the removal of uracil or 5-fluorouracil lesions that accumulate in DNA following treatment with the anticancer agents 5-fluorouracil and 5-fluorodeoxyuridine (floxuridine), a 5-fluorouracil metabolite. Floxuridine 206-226 uracil DNA glycosylase Homo sapiens 24-28 27875297-1 2016 Uracil N-glycosylase 2 (UNG2), the nuclear isoform of UNG, catalyzes the removal of uracil or 5-fluorouracil lesions that accumulate in DNA following treatment with the anticancer agents 5-fluorouracil and 5-fluorodeoxyuridine (floxuridine), a 5-fluorouracil metabolite. Floxuridine 206-226 uracil DNA glycosylase Homo sapiens 24-27 27875297-1 2016 Uracil N-glycosylase 2 (UNG2), the nuclear isoform of UNG, catalyzes the removal of uracil or 5-fluorouracil lesions that accumulate in DNA following treatment with the anticancer agents 5-fluorouracil and 5-fluorodeoxyuridine (floxuridine), a 5-fluorouracil metabolite. Floxuridine 228-239 uracil DNA glycosylase Homo sapiens 0-22 27875297-1 2016 Uracil N-glycosylase 2 (UNG2), the nuclear isoform of UNG, catalyzes the removal of uracil or 5-fluorouracil lesions that accumulate in DNA following treatment with the anticancer agents 5-fluorouracil and 5-fluorodeoxyuridine (floxuridine), a 5-fluorouracil metabolite. Floxuridine 228-239 uracil DNA glycosylase Homo sapiens 24-28 27875297-1 2016 Uracil N-glycosylase 2 (UNG2), the nuclear isoform of UNG, catalyzes the removal of uracil or 5-fluorouracil lesions that accumulate in DNA following treatment with the anticancer agents 5-fluorouracil and 5-fluorodeoxyuridine (floxuridine), a 5-fluorouracil metabolite. Floxuridine 228-239 uracil DNA glycosylase Homo sapiens 24-27 27875297-7 2016 Using an UNG2-deficient ovarian cancer cell line that is hypersensitive to floxuridine, we show that GSK-3 phosphorylation facilitates UNG2-dependent repair of floxuridine-induced DNA lesions and promotes tumor cell survival following exposure to this agent. Floxuridine 75-86 uracil DNA glycosylase Homo sapiens 9-13 27875297-7 2016 Using an UNG2-deficient ovarian cancer cell line that is hypersensitive to floxuridine, we show that GSK-3 phosphorylation facilitates UNG2-dependent repair of floxuridine-induced DNA lesions and promotes tumor cell survival following exposure to this agent. Floxuridine 160-171 uracil DNA glycosylase Homo sapiens 9-13 27517750-0 2016 Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage. Floxuridine 64-84 uracil DNA glycosylase Homo sapiens 14-36 27517750-10 2016 Together, these data provide novel mechanistic insights into the roles of UDG in DNA replication, damage repair, and cell death in response to 5-FdU and suggest that UDG is a target for improving the anticancer effect of this agent. Floxuridine 144-148 uracil DNA glycosylase Homo sapiens 74-77 27517750-10 2016 Together, these data provide novel mechanistic insights into the roles of UDG in DNA replication, damage repair, and cell death in response to 5-FdU and suggest that UDG is a target for improving the anticancer effect of this agent. Floxuridine 144-148 uracil DNA glycosylase Homo sapiens 166-169 16951200-0 2006 Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase. Floxuridine 0-18 uracil DNA glycosylase Homo sapiens 88-110 33675849-2 2021 UDG depletion sensitizes cells to high APOBEC3B deaminase and to pemetrexed (PEM) and floxuridine (5-FdU), which are toxic to tumor cells through incorporation of uracil and 5-FU into DNA. Floxuridine 86-97 uracil DNA glycosylase Homo sapiens 0-3 33795350-0 2021 Inhibition of hUNG2 Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-fluorodeoxyuridine (FdU) and Raltitrexed (RTX) but not Fluorouracil (FU). Floxuridine 78-98 uracil DNA glycosylase Homo sapiens 14-19 33795350-0 2021 Inhibition of hUNG2 Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-fluorodeoxyuridine (FdU) and Raltitrexed (RTX) but not Fluorouracil (FU). Floxuridine 100-103 uracil DNA glycosylase Homo sapiens 14-19 33795350-1 2021 Previous shRNA knockdown studies have established that depletion of human uracil DNA glycosylase 2 (hUNG2) sensitizes some cell lines to 5-fluorodeoxyuridine (FdU). Floxuridine 137-157 uracil DNA glycosylase Homo sapiens 100-105 33795350-1 2021 Previous shRNA knockdown studies have established that depletion of human uracil DNA glycosylase 2 (hUNG2) sensitizes some cell lines to 5-fluorodeoxyuridine (FdU). Floxuridine 159-162 uracil DNA glycosylase Homo sapiens 100-105 33795350-11 2021 Here we show that its deoxynucleoside form, 5-fluorodeoxyuridine (FdU), operates by a distinct DNA incorporation mechanism that is strongly potentiated by inhibition of the DNA repair enzyme uracil DNA glycosylase (hUNG). Floxuridine 44-64 uracil DNA glycosylase Homo sapiens 191-213 33795350-11 2021 Here we show that its deoxynucleoside form, 5-fluorodeoxyuridine (FdU), operates by a distinct DNA incorporation mechanism that is strongly potentiated by inhibition of the DNA repair enzyme uracil DNA glycosylase (hUNG). Floxuridine 44-64 uracil DNA glycosylase Homo sapiens 215-219 33795350-11 2021 Here we show that its deoxynucleoside form, 5-fluorodeoxyuridine (FdU), operates by a distinct DNA incorporation mechanism that is strongly potentiated by inhibition of the DNA repair enzyme uracil DNA glycosylase (hUNG). Floxuridine 66-69 uracil DNA glycosylase Homo sapiens 191-213 33795350-11 2021 Here we show that its deoxynucleoside form, 5-fluorodeoxyuridine (FdU), operates by a distinct DNA incorporation mechanism that is strongly potentiated by inhibition of the DNA repair enzyme uracil DNA glycosylase (hUNG). Floxuridine 66-69 uracil DNA glycosylase Homo sapiens 215-219