PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35319066-4	2022	First, we have demonstrated that menadione and plumbagin inhibit the nucleolar NAD+-dependent deacetylase Sirtuin 7 in vitro.	Vitamin K 3	33-42	sirtuin 7	Homo sapiens	79-115	
35319066-5	2022	As assessed by their inhibitions of rDNA transcription, pre-rRNA processing and formation of etoposide-induced 53BP1 foci, menadione and plumbagin inhibit also Sirtuin 7 catalytic activity in vivo.	Vitamin K 3	123-132	sirtuin 7	Homo sapiens	160-169	
35319066-6	2022	Second, we have established that in experimental conditions in which the sulfhydryl arylation by menadione or plumbagin is prevented by the thiol reducing agent N-acetyl-L-cysteine, the inhibition of Sirtuin 7 catalytic activity is also prevented.	Vitamin K 3	97-106	sirtuin 7	Homo sapiens	200-209