PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34157864-9 2021 The protective effects of daidzein and equol required estrogen receptor-beta. Equol 39-44 estrogen receptor 1 (alpha) Mus musculus 54-76 10942316-3 2000 Genistein and equol, administered by gavage for 4 consecutive days [post-natal day (PND) 17-20, 100 mg/kg body weight], was found to significantly increase uterine weights and the overall uterine concentration of estrogen receptor alpha (ERalpha). Equol 14-19 estrogen receptor 1 (alpha) Mus musculus 213-236 10942316-3 2000 Genistein and equol, administered by gavage for 4 consecutive days [post-natal day (PND) 17-20, 100 mg/kg body weight], was found to significantly increase uterine weights and the overall uterine concentration of estrogen receptor alpha (ERalpha). Equol 14-19 estrogen receptor 1 (alpha) Mus musculus 238-245 34157864-12 2021 CONCLUSIONS: Our study establishes that both dietary daidzein and its metabolite, equol, protect against aneurysm formation in ovariectomized female mice through the activation of estrogen receptor-beta and subsequent suppression of inflammation. Equol 82-87 estrogen receptor 1 (alpha) Mus musculus 180-202 33462142-10 2021 Lastly, the ERbeta-selective agonist S-equol was evaluated for its efficacy to boost immune checkpoint blockade (ICB)-based anticancer immunotherapy.Disabling the ERbeta-specific phosphotyrosine switch in tumor-bearing hosts exacerbates tumor growth. Equol 37-44 estrogen receptor 1 (alpha) Mus musculus 12-18 33462142-10 2021 Lastly, the ERbeta-selective agonist S-equol was evaluated for its efficacy to boost immune checkpoint blockade (ICB)-based anticancer immunotherapy.Disabling the ERbeta-specific phosphotyrosine switch in tumor-bearing hosts exacerbates tumor growth. Equol 37-44 estrogen receptor 1 (alpha) Mus musculus 163-169 33462142-13 2021 S-equol facilitates TCR activation that stimulates the ERbeta phosphotyrosine switch and boosts anti-PD-1 (Programmed cell death protein 1) ICB immunotherapy.Our mouse genetic study clearly demonstrates a role of the ERbeta phosphotyrosine switch in regulating ERbeta-dependent antitumor immunity in CD8+ T cells. Equol 0-7 estrogen receptor 1 (alpha) Mus musculus 55-61 33462142-13 2021 S-equol facilitates TCR activation that stimulates the ERbeta phosphotyrosine switch and boosts anti-PD-1 (Programmed cell death protein 1) ICB immunotherapy.Our mouse genetic study clearly demonstrates a role of the ERbeta phosphotyrosine switch in regulating ERbeta-dependent antitumor immunity in CD8+ T cells. Equol 0-7 estrogen receptor 1 (alpha) Mus musculus 217-223 33462142-13 2021 S-equol facilitates TCR activation that stimulates the ERbeta phosphotyrosine switch and boosts anti-PD-1 (Programmed cell death protein 1) ICB immunotherapy.Our mouse genetic study clearly demonstrates a role of the ERbeta phosphotyrosine switch in regulating ERbeta-dependent antitumor immunity in CD8+ T cells. Equol 0-7 estrogen receptor 1 (alpha) Mus musculus 217-223 33462142-14 2021 Our findings support the development of ERbeta agonists including S-equol in combination with ICB immunotherapy for cancer treatment. Equol 66-73 estrogen receptor 1 (alpha) Mus musculus 40-46