PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7772050-9	1995	The possible physiological significance of the lower Kd(Cr) value of dimeric versus octameric Mib-CK, as well as the apparent negative cooperativity of ATP binding at higher [Cr], are discussed within the context of a possible functional role for dimeric Mib-CK in vivo.	Creatine	56-58	creatine kinase, mitochondrial 2	Gallus gallus	94-100	
7920251-4	1994	Trp-223 is responsible for a strong (18-21%) fluorescence quenching effect occurring upon formation of a transition state-analogue complex (TSAC;Mib-CK.creatine.MgADP.NO3-), and Trp-223 is probably required for the conformational change leading to the TSAC-induced octamer dissociation of Mib-CK.	Creatine	152-160	creatine kinase, mitochondrial 2	Gallus gallus	145-151	
7920251-4	1994	Trp-223 is responsible for a strong (18-21%) fluorescence quenching effect occurring upon formation of a transition state-analogue complex (TSAC;Mib-CK.creatine.MgADP.NO3-), and Trp-223 is probably required for the conformational change leading to the TSAC-induced octamer dissociation of Mib-CK.	Creatine	152-160	creatine kinase, mitochondrial 2	Gallus gallus	289-295	
8399219-6	1993	However, upon addition of MgADP plus creatine and nitrate to induce a transition-state analogue complex of the enzyme, native Mib-CK dissociated much more readily into dimers than proteinase K-digested Mib-CK.	Creatine	37-45	creatine kinase, mitochondrial 2	Gallus gallus	126-132	
8399219-7	1993	Furthermore, proteinase K cleavage of Mib-CK resulted in 2-11-fold decreases in the Vmax values, as well as in 6-23-fold increases in the Km values for phosphocreatine, creatine, and MgATP, whereas the Kd values for both MgATP and creatine were unaffected.	Creatine	159-167	creatine kinase, mitochondrial 2	Gallus gallus	38-44	
8399219-7	1993	Furthermore, proteinase K cleavage of Mib-CK resulted in 2-11-fold decreases in the Vmax values, as well as in 6-23-fold increases in the Km values for phosphocreatine, creatine, and MgATP, whereas the Kd values for both MgATP and creatine were unaffected.	Creatine	169-177	creatine kinase, mitochondrial 2	Gallus gallus	38-44