PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18343996-1 2008 Guanidinoacetate methyltransferase (GAMT) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation of guanidinoacetate (GAA) and depletion of creatine. Creatine 187-195 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 19017728-2 2009 Creatine synthesis requires three amino acids, methionine, glycine, and arginine, and two enzymes, l-arginine:glycine amidinotransferase (AGAT), which produces guanidinoacetate acid (GAA), and guanidinoacetate methyltransferase (GAMT), which methylates GAA to produce creatine. Creatine 0-8 guanidinoacetate N-methyltransferase Rattus norvegicus 193-227 19017728-2 2009 Creatine synthesis requires three amino acids, methionine, glycine, and arginine, and two enzymes, l-arginine:glycine amidinotransferase (AGAT), which produces guanidinoacetate acid (GAA), and guanidinoacetate methyltransferase (GAMT), which methylates GAA to produce creatine. Creatine 0-8 guanidinoacetate N-methyltransferase Rattus norvegicus 229-233 18343996-1 2008 Guanidinoacetate methyltransferase (GAMT) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation of guanidinoacetate (GAA) and depletion of creatine. Creatine 187-195 guanidinoacetate N-methyltransferase Rattus norvegicus 36-40 18437545-1 2008 Guanidinoacetate methyltransferase deficiency (GAMT-deficiency) is an inborn error of metabolism biochemically characterized by accumulation of guanidinoacetate (GAA) and depletion of creatine; the pathogenesis of brain dysfunction in this disorder is not yet established. Creatine 184-192 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 18256932-1 2008 Guanidinoacetate methyltransferase (GAMT) deficiency is a disorder of creatine metabolism characterized by low plasma creatine concentrations in combination with elevated guanidinoacetate (GAA) concentrations. Creatine 70-78 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 18256932-1 2008 Guanidinoacetate methyltransferase (GAMT) deficiency is a disorder of creatine metabolism characterized by low plasma creatine concentrations in combination with elevated guanidinoacetate (GAA) concentrations. Creatine 70-78 guanidinoacetate N-methyltransferase Rattus norvegicus 36-40 18256932-1 2008 Guanidinoacetate methyltransferase (GAMT) deficiency is a disorder of creatine metabolism characterized by low plasma creatine concentrations in combination with elevated guanidinoacetate (GAA) concentrations. Creatine 118-126 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 18256932-1 2008 Guanidinoacetate methyltransferase (GAMT) deficiency is a disorder of creatine metabolism characterized by low plasma creatine concentrations in combination with elevated guanidinoacetate (GAA) concentrations. Creatine 118-126 guanidinoacetate N-methyltransferase Rattus norvegicus 36-40 18380667-3 2008 The aim of the present work was thus to analyse how the genes of arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), allowing creatine synthesis, as well as of the creatine transporter SLC6A8, allowing creatine uptake into cells, are regulated in rat brain cells under NH4+ exposure. Creatine 164-172 guanidinoacetate N-methyltransferase Rattus norvegicus 112-146 18380667-3 2008 The aim of the present work was thus to analyse how the genes of arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), allowing creatine synthesis, as well as of the creatine transporter SLC6A8, allowing creatine uptake into cells, are regulated in rat brain cells under NH4+ exposure. Creatine 164-172 guanidinoacetate N-methyltransferase Rattus norvegicus 148-152 18380667-3 2008 The aim of the present work was thus to analyse how the genes of arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), allowing creatine synthesis, as well as of the creatine transporter SLC6A8, allowing creatine uptake into cells, are regulated in rat brain cells under NH4+ exposure. Creatine 202-210 guanidinoacetate N-methyltransferase Rattus norvegicus 148-152 17273928-3 2007 Guanidinoacetate methyltransferase (GAMT) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation of guanidinoacetate (GAA) and depletion of creatine. Creatine 187-195 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 17928413-3 2007 This is a two-step process in which l-arginine:glycine amidinotransferase (AGAT) catalyzes the conversion of glycine and arginine to ornithine and guanidinoacetate (GAA); guanidinoacetate methyltransferase (GAMT) then catalyzes the S-adenosylmethionine-dependent methylation of GAA to creatine. Creatine 285-293 guanidinoacetate N-methyltransferase Rattus norvegicus 171-205 17928413-3 2007 This is a two-step process in which l-arginine:glycine amidinotransferase (AGAT) catalyzes the conversion of glycine and arginine to ornithine and guanidinoacetate (GAA); guanidinoacetate methyltransferase (GAMT) then catalyzes the S-adenosylmethionine-dependent methylation of GAA to creatine. Creatine 285-293 guanidinoacetate N-methyltransferase Rattus norvegicus 207-211 17273928-3 2007 Guanidinoacetate methyltransferase (GAMT) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation of guanidinoacetate (GAA) and depletion of creatine. Creatine 187-195 guanidinoacetate N-methyltransferase Rattus norvegicus 36-40 17407807-1 2007 Guanidinoacetate methyltransferase (GAMT) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation of guanidinoacetate (GAA) and depletion of creatine. Creatine 187-195 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 17407807-1 2007 Guanidinoacetate methyltransferase (GAMT) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation of guanidinoacetate (GAA) and depletion of creatine. Creatine 187-195 guanidinoacetate N-methyltransferase Rattus norvegicus 36-40 15918910-0 2005 Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1. Creatine 0-8 guanidinoacetate N-methyltransferase Rattus norvegicus 94-98 16773469-1 2006 Guanidinoacetate methyltransferase deficiency (GAMT deficiency) is an inherited neurometabolic disorder clinically characterized by epilepsy and mental retardation and biochemically by accumulation of guanidinoacetate (GAA) and depletion of creatine. Creatine 241-249 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 15892122-3 2005 We also characterized the localization of the creatine synthetic enzyme, S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase (GAMT) in the retina. Creatine 46-54 guanidinoacetate N-methyltransferase Rattus norvegicus 73-133 15892122-3 2005 We also characterized the localization of the creatine synthetic enzyme, S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase (GAMT) in the retina. Creatine 46-54 guanidinoacetate N-methyltransferase Rattus norvegicus 135-139 15918910-7 2005 CONCLUSION: Our results suggest that de novo synthesis of Cr by AGAT and GAMT, as well as cellular Cr uptake by CT1, are essential during embryonic development. Creatine 58-60 guanidinoacetate N-methyltransferase Rattus norvegicus 73-77 15918910-1 2005 BACKGROUND: Creatine (Cr) is synthesized by a two-step mechanism involving arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), and is taken up by cells through a specific Cr transporter, CT1. Creatine 12-20 guanidinoacetate N-methyltransferase Rattus norvegicus 122-156 15918910-1 2005 BACKGROUND: Creatine (Cr) is synthesized by a two-step mechanism involving arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), and is taken up by cells through a specific Cr transporter, CT1. Creatine 12-20 guanidinoacetate N-methyltransferase Rattus norvegicus 158-162 15918910-1 2005 BACKGROUND: Creatine (Cr) is synthesized by a two-step mechanism involving arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), and is taken up by cells through a specific Cr transporter, CT1. Creatine 12-14 guanidinoacetate N-methyltransferase Rattus norvegicus 122-156 15918910-1 2005 BACKGROUND: Creatine (Cr) is synthesized by a two-step mechanism involving arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), and is taken up by cells through a specific Cr transporter, CT1. Creatine 12-14 guanidinoacetate N-methyltransferase Rattus norvegicus 158-162 15533043-1 2004 Guanidinoacetate methyltransferase (GAMT) is the enzyme that catalyzes the last step of creatine biosynthesis. Creatine 88-96 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 15533043-1 2004 Guanidinoacetate methyltransferase (GAMT) is the enzyme that catalyzes the last step of creatine biosynthesis. Creatine 88-96 guanidinoacetate N-methyltransferase Rattus norvegicus 36-40 12079381-1 2002 Guanidinoacetate methyltransferase (GAMT) is the enzyme that catalyzes the last step of creatine biosynthesis. Creatine 88-96 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 12925789-1 2003 Guanidinoacetate methyltransferase (GAMT) is the enzyme that catalyzes the last step of creatine biosynthesis. Creatine 88-96 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 12925789-1 2003 Guanidinoacetate methyltransferase (GAMT) is the enzyme that catalyzes the last step of creatine biosynthesis. Creatine 88-96 guanidinoacetate N-methyltransferase Rattus norvegicus 36-40 12079381-1 2002 Guanidinoacetate methyltransferase (GAMT) is the enzyme that catalyzes the last step of creatine biosynthesis. Creatine 88-96 guanidinoacetate N-methyltransferase Rattus norvegicus 36-40 10531498-1 1999 Guanidinoacetate methyltransferase is the enzyme which catalyzes the last step of creatine biosynthesis. Creatine 82-90 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 11165387-1 2001 Creatine is synthesized from arginine by L-arginine:glycine amidinotransferase (AGAT) and S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase (GAMT) and can be taken up by cells by creatine transporters (CRT). Creatine 0-8 guanidinoacetate N-methyltransferase Rattus norvegicus 90-150 11165387-1 2001 Creatine is synthesized from arginine by L-arginine:glycine amidinotransferase (AGAT) and S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase (GAMT) and can be taken up by cells by creatine transporters (CRT). Creatine 0-8 guanidinoacetate N-methyltransferase Rattus norvegicus 152-156 11165387-2 2001 While creatine is mainly synthesized by the liver and the kidney, most of other tissues, including the brain, also express AGAT and GAMT. Creatine 6-14 guanidinoacetate N-methyltransferase Rattus norvegicus 132-136 34936099-2 2022 Cr is taken from the diet or endogenously synthetized by the enzymes AGAT and GAMT, and specifically taken up by the transporter SLC6A8. Creatine 0-2 guanidinoacetate N-methyltransferase Rattus norvegicus 78-82 3970526-1 1985 Guanidinoacetate methyltransferase, the enzyme catalyzing the last step in creatine biosynthesis, has previously been considered to be restricted to a few tissues, but it has been found to occur in the cultured cells H4Az C2 rat hepatoma, N4TG1 mouse neuroblastoma, and IMR-90 human fetal lung fibroblast, as well as in skeletal and cardiac muscle of the rat. Creatine 75-83 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 28710553-2 2017 Guanidinoacetate methyltransferase methylates GAA on its non-guanidine N atom to produce creatine. Creatine 89-97 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 33452333-2 2021 Creatine is taken from the diet or endogenously synthetized by the enzymes AGAT and GAMT, and specifically taken up by the transporter SLC6A8. Creatine 0-8 guanidinoacetate N-methyltransferase Rattus norvegicus 84-88 24256608-0 2014 Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate methyltransferase activity. Creatine 42-50 guanidinoacetate N-methyltransferase Rattus norvegicus 76-110 27581622-3 2016 Guanidinoacetate methyltransferase (GAMT) is an important enzyme that catalyzes the final reaction in the creatine biosynthetic process. Creatine 106-114 guanidinoacetate N-methyltransferase Rattus norvegicus 0-34 27581622-3 2016 Guanidinoacetate methyltransferase (GAMT) is an important enzyme that catalyzes the final reaction in the creatine biosynthetic process. Creatine 106-114 guanidinoacetate N-methyltransferase Rattus norvegicus 36-40 27581622-4 2016 The liver is a major site for creatine synthesis which places a substantial methylation burden on this organ as GAMT-mediated reactions consume as much as 40% of all the SAM-derived methyl groups. Creatine 30-38 guanidinoacetate N-methyltransferase Rattus norvegicus 112-116 24842317-2 2014 One such reaction, catalyzed by guanidinoacetate methyltransferase (GAMT), is a major consumer of methyl groups and utilizes as much as 40% of the SAM-derived groups to convert guanidinoacetate (GAA) to creatine. Creatine 203-211 guanidinoacetate N-methyltransferase Rattus norvegicus 32-66 24842317-2 2014 One such reaction, catalyzed by guanidinoacetate methyltransferase (GAMT), is a major consumer of methyl groups and utilizes as much as 40% of the SAM-derived groups to convert guanidinoacetate (GAA) to creatine. Creatine 203-211 guanidinoacetate N-methyltransferase Rattus norvegicus 68-72 24256608-2 2014 One such methyltransferase is guanidinoacetate methyltransferase (GAMT) that catalyzes the last step of creatine synthesis. Creatine 104-112 guanidinoacetate N-methyltransferase Rattus norvegicus 30-64 24256608-2 2014 One such methyltransferase is guanidinoacetate methyltransferase (GAMT) that catalyzes the last step of creatine synthesis. Creatine 104-112 guanidinoacetate N-methyltransferase Rattus norvegicus 66-70 24256608-8 2014 Further, in vitro experiments with cell-free system and hepatic cells revealed it is indeed elevated SAH and lower SAM:SAH ratio that directly impairs GAMT activity and significantly reduces creatine synthesis. Creatine 191-199 guanidinoacetate N-methyltransferase Rattus norvegicus 151-155 24256608-9 2014 EtOH intake also slightly decreases the hepatocellular uptake of the creatine precursor, guanidinoacetate (GAA), and the GAMT enzyme expression that could additionally contribute to reduced liver creatine synthesis. Creatine 196-204 guanidinoacetate N-methyltransferase Rattus norvegicus 121-125 24103317-3 2014 Creatine can be obtained from the diet or synthesised from endogenous amino acids via the enzymes arginine:glycine amidinotransferase (AGAT) and guanidinoacetate N-methyltransferase (GAMT). Creatine 0-8 guanidinoacetate N-methyltransferase Rattus norvegicus 145-181 24103317-3 2014 Creatine can be obtained from the diet or synthesised from endogenous amino acids via the enzymes arginine:glycine amidinotransferase (AGAT) and guanidinoacetate N-methyltransferase (GAMT). Creatine 0-8 guanidinoacetate N-methyltransferase Rattus norvegicus 183-187 24103317-7 2014 We found significant AGAT activity and somewhat lower GAMT activity in the pancreas and that pancreatic acini had measurable activities of both AGAT and GAMT and the capacity to synthesise GAA and creatine from amino acids. Creatine 197-205 guanidinoacetate N-methyltransferase Rattus norvegicus 153-157 19879361-1 2010 AGAT and GAMT, the two enzymes of the creatine synthesis pathway, are well expressed within CNS, suggesting autonomous brain creatine synthesis. Creatine 38-46 guanidinoacetate N-methyltransferase Rattus norvegicus 9-13 19879361-1 2010 AGAT and GAMT, the two enzymes of the creatine synthesis pathway, are well expressed within CNS, suggesting autonomous brain creatine synthesis. Creatine 125-133 guanidinoacetate N-methyltransferase Rattus norvegicus 9-13 19879361-4 2010 We finely analyzed the cell-to-cell co-expression of AGAT, GAMT and SLC6A8 in various regions of rat CNS, and showed that in most structures, cells co-expressing AGAT+GAMT (equipped for autonomous creatine synthesis) were in low proportions (<20%). Creatine 197-205 guanidinoacetate N-methyltransferase Rattus norvegicus 167-171 19879361-7 2010 This suggests that in most brain regions, guanidinoacetate is transported from AGAT- to GAMT-expressing cells through SLC6A8 to allow creatine synthesis, thereby explaining creatine deficiency in SLC6A8-deficient CNS. Creatine 134-142 guanidinoacetate N-methyltransferase Rattus norvegicus 88-92