PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20301298-1 1993 The mild end of the spectrum includes the phenotypes of asymptomatic increase in serum concentration of creatine phosphokinase (CK) and muscle cramps with myoglobinuria. Creatine 104-112 cytidine/uridine monophosphate kinase 1 Homo sapiens 128-130 19112826-4 2008 In this model the CK isoforms together with easily diffusible compounds like creatine and phosphocreatine, maintain a cellular energy buffer and intracellular energy transport system, where the "high-energy" phosphate is transferred between site of ATP synthesis and site of ATP utilization. Creatine 77-85 cytidine/uridine monophosphate kinase 1 Homo sapiens 18-20 34396457-1 2021 Creatine kinase (CK) catalyzes the formation of phosphocreatine from adenosine triphosphate (ATP) and creatine. Creatine 102-110 cytidine/uridine monophosphate kinase 1 Homo sapiens 0-20 34472118-10 2021 Pooled data showed that creatine significantly reduced creatine kinase (CK) concentration overall (WMD = -30.94; 95% CI: -53.19, -8.69; p = .006) and at three follow-up times (48, 72, and 96 hr) in comparison with placebo. Creatine 24-32 cytidine/uridine monophosphate kinase 1 Homo sapiens 55-70 34472118-10 2021 Pooled data showed that creatine significantly reduced creatine kinase (CK) concentration overall (WMD = -30.94; 95% CI: -53.19, -8.69; p = .006) and at three follow-up times (48, 72, and 96 hr) in comparison with placebo. Creatine 24-32 cytidine/uridine monophosphate kinase 1 Homo sapiens 72-74 34472118-15 2021 In the current meta-analysis, the positive effects of creatine could cause a decrease in CK concentration overall. Creatine 54-62 cytidine/uridine monophosphate kinase 1 Homo sapiens 89-91 34371517-3 2022 However, it is unknown if creatine, a substrate of CK, is associated with the development of hypertension. Creatine 26-34 cytidine/uridine monophosphate kinase 1 Homo sapiens 51-53 33923719-1 2021 Early reports from Asia suggested that increased serum levels of the muscular enzyme creatine-(phospho)-kinase (CK/CPK) could be associated with a more severe prognosis in COVID-19. Creatine 85-93 cytidine/uridine monophosphate kinase 1 Homo sapiens 112-114 33918657-4 2021 Once within cells, creatine kinase (CK) catalyzes the reversible transphosphorylation reaction between [Mg2+:ATP4-]2- and Cr to produce phosphocreatine (PCr) and [Mg2+:ADP3-]-. Creatine 122-124 cytidine/uridine monophosphate kinase 1 Homo sapiens 19-34 33918657-14 2021 Thus, we suggest the CK/PCr system acts as a dynamic biosensor based on chemo-mechanical energy transduction, which might explain why dysregulation in Cr metabolism contributes to a wide range of diseases besides the mitigating effect that Cr supplementation may have in some of these disease states. Creatine 25-27 cytidine/uridine monophosphate kinase 1 Homo sapiens 21-23 33918657-14 2021 Thus, we suggest the CK/PCr system acts as a dynamic biosensor based on chemo-mechanical energy transduction, which might explain why dysregulation in Cr metabolism contributes to a wide range of diseases besides the mitigating effect that Cr supplementation may have in some of these disease states. Creatine 151-153 cytidine/uridine monophosphate kinase 1 Homo sapiens 21-23 33918657-4 2021 Once within cells, creatine kinase (CK) catalyzes the reversible transphosphorylation reaction between [Mg2+:ATP4-]2- and Cr to produce phosphocreatine (PCr) and [Mg2+:ADP3-]-. Creatine 122-124 cytidine/uridine monophosphate kinase 1 Homo sapiens 36-38 33479817-1 2021 Kinetic reactions of the transphosphorylation with creatine kinase (CK) were individually investigated between creatine (Cr) and creatine phosphate (CrP) by pressure-assisted capillary electrophoresis/dynamic frontal analysis (pCE/DFA). Creatine 51-59 cytidine/uridine monophosphate kinase 1 Homo sapiens 68-70 33479817-1 2021 Kinetic reactions of the transphosphorylation with creatine kinase (CK) were individually investigated between creatine (Cr) and creatine phosphate (CrP) by pressure-assisted capillary electrophoresis/dynamic frontal analysis (pCE/DFA). Creatine 121-123 cytidine/uridine monophosphate kinase 1 Homo sapiens 51-66 33479817-1 2021 Kinetic reactions of the transphosphorylation with creatine kinase (CK) were individually investigated between creatine (Cr) and creatine phosphate (CrP) by pressure-assisted capillary electrophoresis/dynamic frontal analysis (pCE/DFA). Creatine 121-123 cytidine/uridine monophosphate kinase 1 Homo sapiens 68-70 31872611-10 2019 Creatine phosphate kinase( CK) was significantly higher than that of Qizu Xueyu group( P<0. Creatine 0-8 cytidine/uridine monophosphate kinase 1 Homo sapiens 27-29 32954822-1 2020 During recent years, creatine kinase (CK) and its substrates phosphocreatine and creatine emerged as important players in uncoupling protein 1-independent, ATP-dependent non-shivering thermogenesis in beige/brown adipocytes. Creatine 21-29 cytidine/uridine monophosphate kinase 1 Homo sapiens 38-40 32883247-1 2020 BACKGROUND: Creatine (Cr), an amino acid derivative, is one of the most important sources of energy acting as both a spatial and temporal energy buffer through its phosphorylated analogue phosphocreatine (PCr) and creatine kinase (CK). Creatine 12-20 cytidine/uridine monophosphate kinase 1 Homo sapiens 214-229 32883247-1 2020 BACKGROUND: Creatine (Cr), an amino acid derivative, is one of the most important sources of energy acting as both a spatial and temporal energy buffer through its phosphorylated analogue phosphocreatine (PCr) and creatine kinase (CK). Creatine 12-20 cytidine/uridine monophosphate kinase 1 Homo sapiens 2-4 32883247-1 2020 BACKGROUND: Creatine (Cr), an amino acid derivative, is one of the most important sources of energy acting as both a spatial and temporal energy buffer through its phosphorylated analogue phosphocreatine (PCr) and creatine kinase (CK). Creatine 12-14 cytidine/uridine monophosphate kinase 1 Homo sapiens 214-229 32883247-1 2020 BACKGROUND: Creatine (Cr), an amino acid derivative, is one of the most important sources of energy acting as both a spatial and temporal energy buffer through its phosphorylated analogue phosphocreatine (PCr) and creatine kinase (CK). Creatine 12-14 cytidine/uridine monophosphate kinase 1 Homo sapiens 2-4 29945780-3 2018 OBJECTIVE: We tested the hypothesis in this pilot study that creatine (Cr) monohydrate supplementation would reduce the CK response to eccentric exercise in patients using statins to determine if Cr supplementation could be a strategy to mitigate statin-associated muscle symptoms in physically active individuals. Creatine 61-69 cytidine/uridine monophosphate kinase 1 Homo sapiens 120-122 29945780-3 2018 OBJECTIVE: We tested the hypothesis in this pilot study that creatine (Cr) monohydrate supplementation would reduce the CK response to eccentric exercise in patients using statins to determine if Cr supplementation could be a strategy to mitigate statin-associated muscle symptoms in physically active individuals. Creatine 71-73 cytidine/uridine monophosphate kinase 1 Homo sapiens 120-122