PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22751104-5	2012	We successfully treated the Slc6a8-/y mice with the creatine analog cyclocreatine.	Creatine	52-60	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	28-34	
22751104-6	2012	Brain cyclocreatine and cyclocreatine phosphate were detected after 9 weeks of cyclocreatine treatment in Slc6a8-/y mice, in contrast to the same mice treated with creatine or placebo.	Creatine	11-19	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	106-112	
34050321-1	2021	PURPOSE: Creatine transporter deficiency (CTD) is a rare X-linked disorder of creatine transport caused by pathogenic variants in SLC6A8 (Xq28).	Creatine	9-17	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	130-136	
18652074-4	2007	CRT is essential for normal brain function as mutations in the CRT gene (SLC6A8) result in X-linked mental retardation, associated with the almost complete lack of creatine in the brain, severe speech and language delay, epilepsy, and autistic behaviour.	Creatine	164-172	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	73-79	
11919171-7	2002	Expression of the creatine transport protein (CreaT) that is responsible for creatine uptake in myocytes was preserved in G4N cardiac tissue.	Creatine	18-26	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	46-51	
34050321-1	2021	PURPOSE: Creatine transporter deficiency (CTD) is a rare X-linked disorder of creatine transport caused by pathogenic variants in SLC6A8 (Xq28).	Creatine	78-86	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	130-136	
32182846-5	2020	While Ivd and Kcnip3 showed regulation by hArg supplementation, Bcas1 and Slc6a8 were creatine dependent.	Creatine	86-94	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	74-80	
33990217-17	2021	CONCLUSIONS: Our study indicates that SLC6A8-mediated creatine accumulation plays an important role in promoting TNBC progression, and may provide a potential therapeutic strategy option for treatment of SLC6A8 high expressed TNBC.	Creatine	54-62	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	38-44	
33990217-17	2021	CONCLUSIONS: Our study indicates that SLC6A8-mediated creatine accumulation plays an important role in promoting TNBC progression, and may provide a potential therapeutic strategy option for treatment of SLC6A8 high expressed TNBC.	Creatine	54-62	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	204-210	
33452333-6	2021	Different mouse models of CTD were generated by doing long deletions in the Slc6a8 gene showing reduced brain creatine and cognitive deficiencies or impaired motor function.	Creatine	110-118	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	76-82	
31628186-2	2019	When studying nutrient usage of tumor-infiltrating immune cells in mice, we detected a sharp increase of the expression of a CrT (Slc6a8) gene, which encodes a surface transporter controlling the uptake of creatine into a cell.	Creatine	206-214	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	130-136	
29384270-0	2018	Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8.	Creatine	36-44	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	118-124	
29384270-3	2018	Slc6a8-/y mice lacked whole body Cr and exhibited cognitive deficits.	Creatine	33-35	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	0-6	
29384270-11	2018	The results show that the loss of cerebral Cr is responsible for the learning and memory deficits seen in ubiquitous Slc6a8-/y mice.	Creatine	43-45	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	117-123	
25206338-0	2014	Creatine transporter (SLC6A8) knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle.	Creatine	87-95	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	22-28	
31542396-0	2020	Creatine transporter knockout mice (Slc6a8) show increases in serotonin-related proteins and are resilient to learned helplessness.	Creatine	0-8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	36-42	
23715727-1	2013	Creatine is important for energy metabolism, yet excitable cells such as cardiomyocytes do not synthesize creatine and rely on uptake via a specific membrane creatine transporter (CrT; SLC6A8).	Creatine	0-8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	Mus musculus	185-191