PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34103445-0	2021	STRESS-AFFECTED AKT/MTOR PATHWAY UPREGULATED BY LONG-TERM CREATINE INTRAPERITONEAL ADMINISTRATION.	Creatine	58-66	mechanistic target of rapamycin kinase	Homo sapiens	20-24	
16466692-4	2006	In Xenopus oocytes expressing SLC6A8 but not in water injected oocytes, creatine-induced a current which was significantly enhanced by coexpression of mTOR.	Creatine	72-80	mechanistic target of rapamycin kinase	Homo sapiens	151-155	
34103445-6	2021	Since the central regulatory substance in energy metabolism is the signalling molecule mTOR, we studied its quantitative changes under long-term disruption of circadian rhythm and exogenous creatine administration.	Creatine	190-198	mechanistic target of rapamycin kinase	Homo sapiens	87-91	
34103445-7	2021	The results revealed that Creatine"s exogenous supplementation increases phosphorylated mTOR and its activator - Akt.	Creatine	26-34	mechanistic target of rapamycin kinase	Homo sapiens	88-92	
34103445-8	2021	Consequently, it can be assumed that Creatine performs its positive role in hippocampal cells" energy metabolism via its modulatory effects on the PI3K/Akt/mTOR signalling pathway.	Creatine	37-45	mechanistic target of rapamycin kinase	Homo sapiens	156-160	
26120775-1	2015	Previous studies have demonstrated that AMP-activated protein kinase (AMPK) controls autophagy through the mammalian target of rapamycin (mTOR) and Unc-51 like kinase 1 (ULK1/Atg1) signaling, which augments the quality of cellular housekeeping, and that beta-guanidinopropionic acid (beta-GPA), a creatine analog, leads to a chronic activation of AMPK.	Creatine	297-305	mechanistic target of rapamycin kinase	Homo sapiens	107-136	
35417269-10	2022	The present result indicates that at normal state, Cr stimulated protein synthesis via the mTOR/P70S6K pathway.	Creatine	51-53	mechanistic target of rapamycin kinase	Homo sapiens	91-95	
28595527-6	2017	Other reports indicated that creatine directly affects muscle protein synthesis via modulations of components in the mammalian target of rapamycin (mTOR) pathway.	Creatine	29-37	mechanistic target of rapamycin kinase	Homo sapiens	117-146	
28595527-6	2017	Other reports indicated that creatine directly affects muscle protein synthesis via modulations of components in the mammalian target of rapamycin (mTOR) pathway.	Creatine	29-37	mechanistic target of rapamycin kinase	Homo sapiens	148-152	
26120775-1	2015	Previous studies have demonstrated that AMP-activated protein kinase (AMPK) controls autophagy through the mammalian target of rapamycin (mTOR) and Unc-51 like kinase 1 (ULK1/Atg1) signaling, which augments the quality of cellular housekeeping, and that beta-guanidinopropionic acid (beta-GPA), a creatine analog, leads to a chronic activation of AMPK.	Creatine	297-305	mechanistic target of rapamycin kinase	Homo sapiens	138-142