PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21059661-1 2011 In vivo, KCNQ1 alpha-subunits associate with the beta-subunit KCNE1 to generate the slowly activating cardiac potassium current (I(Ks)). Potassium 110-119 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 62-67 21059661-1 2011 In vivo, KCNQ1 alpha-subunits associate with the beta-subunit KCNE1 to generate the slowly activating cardiac potassium current (I(Ks)). Potassium 131-133 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 62-67 19348785-6 2009 G314S, co-expressed with WT KCNQ1 and KCNE1, suppressed I(ks) currents in a dominant-negative manner, which is consistent with long QT syndrome in the members of the Chinese family carrying G314S KCNQ1 mutation. Potassium 58-60 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 38-43 20399767-15 2010 These results indicate that Rg(3)-induced activation of I(Ks) requires co-assembly of KCNQ1 and KCNE1 subunits and achieves this through interaction with residues K318 and V319 of KCNQ1 subunit. Potassium 58-60 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 96-101 19913547-4 2010 Mutant subunits with this arginine substitution generated no or barely detectable currents in a homotetrameric condition, but did generate I(Ks)-like currents in association with hKCNE1. Potassium 141-143 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 179-185 20139709-5 2010 In this study we used a novel approach to demonstrate that purified recombinant human KCNE1 protein (prKCNE1) modulates KCNQ1 channels heterologously expressed in Xenopus oocytes resulting in generation of I(Ks). Potassium 208-210 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 86-91 20185111-2 2010 Genetic variants in the KCNE1 gene, encoding for the beta-subunit (minK) of a slowly activated cardiac potassium channel (I(ks)), may impair myocardial repolarization. Potassium 124-126 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 24-29 22073228-11 2011 CONCLUSIONS: The results of our study indicate that N-terminal arginines in positions 32, 33, 36 of KCNE1 are important for reconstitution of I(Ks). Potassium 144-146 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 100-105 21915266-1 2011 Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac I(Ks) current with mutations causing short and long QT cardiac arrhythmias. Potassium 104-106 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 68-73 20399767-11 2010 The increase of KCNE1/KCNQ1 ratio converted I(Ks) inhibition to I(Ks) activations. Potassium 46-48 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 16-21 20399767-11 2010 The increase of KCNE1/KCNQ1 ratio converted I(Ks) inhibition to I(Ks) activations. Potassium 66-68 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 16-21 20399767-12 2010 One to ten ratio of KCNE1 and KCNQ1 subunit is required for Rg(3) activation of I(Ks). Potassium 82-84 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 20-25 19907016-1 2010 KCNE1 associates with the pore-forming alpha-subunit KCNQ1 to generate the slow (I(Ks)) current in cardiac myocytes. Potassium 83-85 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 0-5 19907016-3 2010 We previously investigated a mutation in KCNE1, T58P/L59P, which causes severe attenuation of I(Ks). Potassium 96-98 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 41-46 19521339-2 2009 In heart, assembly of Kv7.1 pore-forming subunits with KCNE1 beta subunits generates the repolarizing K(+) current I(KS). Potassium 117-119 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 55-60 18757482-1 2008 Stable coexpression of human (h)KCNQ1 and hKCNE1 in human embryonic kidney (HEK)-293 cells reconstitutes a nativelike slowly activating delayed rectifier K+ current (HEK-I(Ks)), allowing beta-adrenergic modulation of the current by stimulation of endogenous receptors in the host cell line. Potassium 172-174 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 42-48 19590188-10 2009 All three mutations reduced KCNQ1/KCNE1 channel currents in a dominant-negative manner when the mutants were coexpressed with wt subunits suggesting reduced I(Ks) as the molecular basis of LQT1. Potassium 159-161 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 34-39 18441444-2 2008 The syndrome is caused by homozygous or compound heterozygous mutations in genes KCNQ1 and KCNE1, which are responsible for encoding the delayed rectifier repolarizing current, I(Ks). Potassium 179-181 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 91-96 17443681-1 2007 In cardiac cells, KCNQ1 assembles with KCNE1 and forms a channel complex constituting the slow delayed rectifier current I(Ks). Potassium 123-125 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 39-44 17986649-7 2008 Effects on hK(v)11.1, hK(v)4.3, and hK(v)7.1/hKCNE1 potassium currents and calcium current were not involved. Potassium 52-61 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 45-51 18266681-1 2008 INTRODUCTION: Slowly activating delayed-rectifier potassium currents in the heart are produced by a complex protein with alpha and beta subunits composed of the potassium voltage-gated channel KQT-like subfamily, member 1 (KCNQ1) and the potassium voltage-gated channel Isk-related family, member 1 (KCNE1), respectively. Potassium 50-59 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 238-298 18266681-1 2008 INTRODUCTION: Slowly activating delayed-rectifier potassium currents in the heart are produced by a complex protein with alpha and beta subunits composed of the potassium voltage-gated channel KQT-like subfamily, member 1 (KCNQ1) and the potassium voltage-gated channel Isk-related family, member 1 (KCNE1), respectively. Potassium 50-59 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 300-305 18279388-2 2008 Heterologous expression studies have demonstrated diverse functional effects of KCNE subunits on several K(V) channels, including KCNQ1 (K(V)7.1) that, together with KCNE1, generates the slow-delayed rectifier current (I(Ks)) important for cardiac repolarization. Potassium 221-223 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 166-171 17939752-0 2007 Application of PatchXpress planar patch clamp technology to the screening of new drug candidates for cardiac KCNQ1/KCNE1 (I Ks) activity. Potassium 124-126 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 115-120 15528278-2 2004 I(Ks), the slow heart potassium current, is carried by the I(Ks) potassium channel, a substrate for PKA phosphorylation in response to sympathetic nerve stimulation, is a macromolecular complex that includes the KCNQ1 alpha subunit, the KCNE1 regulatory subunit, and the AKAP Yotiao. Potassium 2-4 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 237-242 17384445-8 2007 Prolongation of the APD and decrease in I(Ks) with increasing the amount of KCNE1 concentration were well predicted in a computer simulation. Potassium 42-44 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 76-81 16909339-1 2006 The present study was designed to characterize pharmacological, biophysical and electrophysiological properties of the recombinant human cardiac I (Ks) (KCNQ1/KCNE1) channels at physiological temperature. Potassium 148-150 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 159-164 16909339-4 2006 The typical I (Ks) was slowly activated upon depolarization voltages in HEK 293 cells stably expressing human cardiac KCNQ1 and KCNE1 genes, and the current was inhibited by I (Ks) blockers HMR 1556 and chromanol 293B, with 50% inhibitory concentrations (IC(50)s) of 83.8 nM: and 9.2 muM: , respectively. Potassium 15-17 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 128-133 16480714-5 2006 A concentration-dependent effect of estradiol on the KCNQ1/KCNE1-mediated potassium current was observed. Potassium 74-83 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 59-64 16109388-9 2005 Coexpression of wtKCNQ1+KCNE1 subunits induced the typical slowly activating and voltage-dependent delayed rectifier K(+) current, I(Ks). Potassium 133-135 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 24-29 15698834-3 2005 KCNE1 associates with KCNQ1 in vitro to generate a potassium current closely resembling the slowly activating delayed rectifier (I(Ks)). Potassium 51-60 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 0-5 15698834-3 2005 KCNE1 associates with KCNQ1 in vitro to generate a potassium current closely resembling the slowly activating delayed rectifier (I(Ks)). Potassium 131-133 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 0-5 15698834-10 2005 Even in the presence of additional KCNE1, KCNE4 and KCNE5 exert dominant effects on I(Ks). Potassium 86-88 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 35-40 15528278-2 2004 I(Ks), the slow heart potassium current, is carried by the I(Ks) potassium channel, a substrate for PKA phosphorylation in response to sympathetic nerve stimulation, is a macromolecular complex that includes the KCNQ1 alpha subunit, the KCNE1 regulatory subunit, and the AKAP Yotiao. Potassium 22-31 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 237-242 9929573-1 1999 Functional and pharmacological data point to the involvement of KCNQ1/IsK potassium channels in the basolateral potassium conductance of secretory epithelia. Potassium 74-83 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 70-73 12710526-7 2003 Coexpressing KCNE1 with equal amount of cDNAs encoding wild type and mutant KCNQ1 results in an 11-fold reduction in the amplitude of potassium currents. Potassium 134-143 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 13-18 12047800-2 2002 This investigation was undertaken to determine which of the two structural units reconstituting the I(Ks) channel, KCNQ1 (KvLQT1) and KCNE1 (minK/IsK), plays a key role in the cell swelling-induced I(Ks) enhancement and to dissect a possible involvement of tyrosine phosphorylation therein. Potassium 102-104 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 134-139 10428953-8 1999 Owing to allosteric interactions, stilbene and fenamate compounds can rescue the dominant-negative suppression of I(KS) produced by IsK mutations and thus, may have important therapeutic relevance for LQT syndrome. Potassium 116-118 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 132-135 11438691-7 2001 These results, which show that KCNE1 and I(Ks) are involved in K(+) homeostasis, might have important implications for patients with I(Ks)-related long QT syndrome, because hypokalemia is a well known risk factor for the occurrence of torsades de pointes ventricular arrhythmia. Potassium 135-137 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 31-36 9654228-1 1998 INTRODUCTION: Inherited long QT syndrome (LQTS) recently has been associated with mutations in genes coding for potassium (KVLQT1, KCNE1, and HERG) or sodium (SCN5A) ion channels involved in regulating either sodium inward or potassium outward currents of heart cells, resulting in prolongation of the repolarization period. Potassium 112-121 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 131-136 9654228-1 1998 INTRODUCTION: Inherited long QT syndrome (LQTS) recently has been associated with mutations in genes coding for potassium (KVLQT1, KCNE1, and HERG) or sodium (SCN5A) ion channels involved in regulating either sodium inward or potassium outward currents of heart cells, resulting in prolongation of the repolarization period. Potassium 226-235 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 131-136 32270035-1 2020 The potassium channel Kv7.1 associates with the KCNE1 regulatory subunit to trigger cardiac I Ks currents. Potassium 94-96 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 48-53 33373586-2 2021 The pore-forming alpha-subunit KCNQ1, which belongs to the voltage-gated ion channel superfamily, associates to its beta-auxiliary subunit KCNE1 to generate the slow cardiac potassium IKs current, whose dysfunction leads to cardiac arrhythmia. Potassium 174-183 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 139-144 9302275-4 1997 Co-expression of KvLQT1 with the IsK protein elicits slowly activating potassium currents resembling the cardiac Iks current. Potassium 71-80 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 33-36 32270035-4 2020 Kv7.1 and KCNE1 mutations, responsible for long QT syndromes, impair association and traffic, thereby altering I Ks currents. Potassium 113-115 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 10-15 31236320-3 2019 For example, the KCNQ1-KCNE1 channel produces a slowly-activating potassium current, while KCNE3 makes KCNQ1 a voltage-independent, constitutively open channel. Potassium 66-75 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 23-28 31834838-1 2020 The cardiac potassium IKs current is carried by a channel complex formed from a-subunits encoded by KCNQ1 and b-subunits encoded by KCNE1. Potassium 12-21 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 132-137 31785237-1 2020 The slow voltage-gated potassium channel (IKs) is composed of the KCNQ1 and KCNE1 subunits and is one of the major repolarizing currents in the heart. Potassium 23-32 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 76-81 31461851-1 2019 The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium current, IKs, that responds to sympathetic stimulation and is critical for human cardiac repolarization. Potassium 79-88 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 23-28 28976808-1 2017 In the heart, co-assembly of Kv7.1 with KCNE1 produces the slow IKS potassium current, which repolarizes the cardiac action potential and mutations in human Kv7.1 and KCNE1 genes cause cardiac arrhythmias. Potassium 68-77 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 40-45 30918124-2 2019 The underlying channels are formed from tetramers of KCNQ1 along with one to four KCNE1 accessory subunits, but how these components together gate the I Ks complex to open the pore is controversial. Potassium 153-155 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 82-87 28976808-1 2017 In the heart, co-assembly of Kv7.1 with KCNE1 produces the slow IKS potassium current, which repolarizes the cardiac action potential and mutations in human Kv7.1 and KCNE1 genes cause cardiac arrhythmias. Potassium 68-77 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 167-172 24314077-2 2013 Design of I(KS)-targeting anti-arrhythmic drugs requires detailed three-dimensional structures of the KCNQ1/KCNE1 complex, a task made possible by Kv channel crystal structures (templates for KCNQ1 homology-modeling) and KCNE1 NMR structures. Potassium 12-14 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 108-113 27902841-8 2017 In cardiac myocytes, there are several Ca2+ -sensitive potassium (K+ ) currents such as the slowly activating delayed rectifier current (IKs ) and the small conductance Ca2+ -activated potassium (SK) current (ISK ). Potassium 55-64 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 209-212 25037568-9 2014 In the KCNE1 distal C-terminus, the LQT mutation P127T suppressed yotiao-dependent cAMP-mediated upregulation of the I(KS) current, which was caused by reduced KCNQ1 phosphorylation at S27. Potassium 119-121 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 7-12 24721657-1 2014 Co-assembly of KCNQ1 with KCNE1 generates the IKS potassium current that is vital for the proper repolarization of the cardiac action potential. Potassium 50-59 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 26-31 28233402-1 2017 KCNE1 is known to modulate the voltage-gated potassium channel alpha subunit KCNQ1 to generate slowly activating potassium currents. Potassium 45-54 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 0-5 28193246-4 2017 The same KvLQT1/KCNE1 channel complex is expressed in the inner ear and essential for luminal potassium secretion into the endolymphatic space. Potassium 94-103 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 16-21 24947509-2 2014 Assembled with the beta-subunit KCNE1, Kv7.1 conducts the slowly activating potassium current IKs, which is one of the major currents underlying repolarization of the cardiac action potential. Potassium 76-85 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 32-37 22908235-1 2012 The co-assembly of KCNQ1 with KCNE1 produces I(KS), a K(+) current, crucial for the repolarization of the cardiac action potential. Potassium 47-49 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 30-35 23424208-9 2013 Our data indicated that the mechanism by which probucol inhibits I(Ks) was not mediated by the inhibition of cholesterol synthesis but depended on an interaction with the KCNQ1/KCNE1 complex. Potassium 67-69 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 177-182 23000022-8 2012 Co-expression of G325R and WT KCNQ1 with KCNE1 shifted the voltage-dependence of I(Ks) activation by 12.0mV, indicating co-assembly of mutant and WT subunits. Potassium 83-85 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 41-46 22100668-7 2012 The SNP KCNE1 D85N (rs1805128), known to modulate an important potassium current in the heart, predicted diLQTS with an odds ratio of 9.0 (95% confidence interval, 3.5-22.9). Potassium 63-72 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 8-13 22421958-4 2012 Here we review our previous study of biophysical properties of I(ks) in human embryonic stem cell-derived cardiomyocytes (hESC-CMs) showed that I(ks) in hESC-CMs is a coassembly channel with a stoichiometry other than 1:1, which could be further modulated by additional KCNE1. Potassium 65-67 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 270-275 21084310-2 2011 The assembly of KCNQ1 with KCNE1 generates the delayed rectifier current I(Ks) in the heart. Potassium 75-77 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 27-32 21241800-6 2011 In addition, expression of S277L and wild type KCNQ1 with KCNE1 resulted in a shift of the voltage-dependence of activation by -8.7mV compared to wild type I(Ks), indicating co-assembly of mutant and wild type subunits. Potassium 158-160 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 58-63 22109556-4 2011 Using computational modeling, we show that intrinsic potassium currents (I(A) and I(SK)) in projection neurons may combine with extrinsic inhibition from local interneurons to implement a dual latency code for both pheromone identity and intensity. Potassium 53-62 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 82-87 21895724-1 2011 BACKGROUND: The hereditary long QT syndrome is characterized by prolonged ventricular repolarization that can be caused by mutations to the KCNQ1 gene, which encodes the alpha subunits of the cardiac potassium channel complex that carries the I(Ks) current (the beta subunits are encoded by KCNE1). Potassium 245-247 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 291-296