PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21699843-0	2011	Protein kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis.	Potassium	33-35	potassium voltage-gated channel subfamily E member 1	Cricetulus griseus	58-63	
21699843-1	2011	BACKGROUND: The slow-activating cardiac repolarization K(+) current (I(Ks)), generated by the KCNQ1-KCNE1 potassium channel complex, is controlled via sympathetic and parasympathetic regulation in vivo.	Potassium	71-73	potassium voltage-gated channel subfamily E member 1	Cricetulus griseus	100-105	
21699843-3	2011	Protein kinase C (PKC), which is activated by alpha1 adrenergic receptor stimulation, is known to downregulate I(Ks) via phosphorylation of KCNE1 serine 102, but the underlying mechanism has remained enigmatic.	Potassium	113-115	potassium voltage-gated channel subfamily E member 1	Cricetulus griseus	140-145	
21699843-10	2011	KCNE1-S102A abolished the effect of PMA on I(Ks) currents and endocytosis.	Potassium	45-47	potassium voltage-gated channel subfamily E member 1	Cricetulus griseus	0-5	
21224508-3	2010	Here the action potential (AP) voltage clamp technique was used to elucidate the effect of S140G KCNQ1 on the profile of recombinant I(Ks) during atrial and ventricular APs applied to KCNQ1+KCNE1 expressing CHO cells, at 37 C. Under conventional voltage clamp the S140G KCNQ1 mutation shifted voltage-dependent activation by  -62 mV, with a marked instantaneous current component evident on membrane depolarisation.	Potassium	135-137	potassium voltage-gated channel subfamily E member 1	Cricetulus griseus	190-195	
15731462-2	2005	Genetic mutations in the alpha- (KCNQ1) and beta- (KCNE1) subunits of I(Ks) underlie Long QT Syndrome type 1 and 5 (LQT-1 and LQT-5), respectively, and predispose carriers to the development of polymorphic ventricular arrhythmias and sudden cardiac death.	Potassium	72-74	potassium voltage-gated channel subfamily E member 1	Cricetulus griseus	51-56	
12482884-10	2002	The slowing of I(KS) deactivation produced by low pH(o) was absent in the KCNE1 mutant Delta39-43, suggesting that the residues lying at the N-terminal boundary of the transmembrane segment are involved in this process.	Potassium	17-19	potassium voltage-gated channel subfamily E member 1	Cricetulus griseus	74-79	
11134230-1	2001	I(Ks), a slowly activating delayed rectifier K(+) current through channels formed by the assembly of two subunits KCNQ1 (KvLQT1) and KCNE1 (minK), contributes to the control of the cardiac action potential duration.	Potassium	2-4	potassium voltage-gated channel subfamily E member 1	Cricetulus griseus	133-138