PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33861365-5 2021 For patients with hyperkalemia during surgery, the odds ratios [ORs] of failure to decrease potassium (K+) after insulin treatment were higher in patients with eGFR < 30 mL/min/1.73 m2 (adjusted OR 3.24; 95% confidence interval 1.38-7.64; P = 0.007) than in patients with eGFR >= 60 mL/min/1.73 m2. Potassium 92-101 insulin Homo sapiens 113-120 33499915-0 2021 A nutrient pattern characterized by vitamin A, C, B6, potassium, and fructose is associated with reduced risk of insulin-related disorders: A prospective study among participants of Tehran lipid and glucose study. Potassium 54-63 insulin Homo sapiens 113-120 33741353-0 2021 A standardized glucose-insulin-potassium infusion protocol in surgical patients: use of real clinical data from a clinical data warehouse. Potassium 31-40 insulin Homo sapiens 23-30 33741353-1 2021 AIMS: We evaluated the clinical usefulness of a new unified glucose-insulin-potassium (GIK) regimen in a general surgical department. Potassium 76-85 insulin Homo sapiens 68-75 33460257-1 2021 AIMS/INTRODUCTION: Excessive dietary salt or low potassium intakes are strongly correlated with insulin resistance (IR) and type 2 diabetes mellitus. Potassium 49-58 insulin Homo sapiens 96-103 33499915-13 2021 CONCLUSIONS: Present study showed that high adherence to a nutrient pattern rich in vitamin A, vitamin C, pyridoxine, potassium, and fructose is inversely associated with 3-years changes in insulin, HOMA-IR, and directly associated with HOMA-S. Potassium 118-127 insulin Homo sapiens 190-197 33419247-3 2020 There is substantial evidence that c-peptide counteracts the detrimental changes caused by hyperglycemia at the cellular level, such as decreased activation of endothelial nitric oxide synthase and sodium potassium ATPase, and increase in formation of pro-inflammatory molecules mediated by nuclear factor kappa-light-chain-enhancer of activated B cells: cytokines, chemokines, cell adhesion molecules, vascular endothelial growth factor, and transforming growth factor beta. Potassium 205-214 insulin Homo sapiens 35-44 32861249-2 2020 Insulin sensitivity and metabolic acidosis are associated with muscle wasting and may be improved with potassium intake. Potassium 103-112 insulin Homo sapiens 0-7 32847923-2 2020 In the emergency room (ER), interventions aim to protect patients from the immediate dangers of elevated serum potassium by redistributing potassium ions from the bloodstream into the cells via intravenous insulin or nebulised beta2-agonists. Potassium 111-120 insulin Homo sapiens 206-213 33040821-16 2020 Low-dose insulin combined with electrolyte supplementation is effective in the treatment of DKA in children, which can effectively control blood sugar, sodium, potassium level, and inflammatory factor concentration. Potassium 160-169 insulin Homo sapiens 9-16 32742012-13 2020 Similar decreases in serum potassium were noted following IV regular insulin administration. Potassium 27-36 insulin Homo sapiens 69-76 32027066-2 2020 These genes encode the subunits of the beta-cell ATP sensitive potassium channel, a key component of the glucose-stimulated insulin secretion pathway. Potassium 63-72 insulin Homo sapiens 124-131 30189765-9 2020 CONCLUSIONS: Conventional dose insulin may be more effective than reduced dose regular insulin at baseline serum potassium levels >6 mmol/L in the treatment of hyperkalemia. Potassium 113-122 insulin Homo sapiens 31-38 30189765-9 2020 CONCLUSIONS: Conventional dose insulin may be more effective than reduced dose regular insulin at baseline serum potassium levels >6 mmol/L in the treatment of hyperkalemia. Potassium 113-122 insulin Homo sapiens 87-94 30189765-10 2020 Frequent monitoring of serum potassium and glucose after administration of insulin is necessary to confirm adequate response and avoidance of hypoglycemia. Potassium 29-38 insulin Homo sapiens 75-82 31053371-5 2019 After treatment with an injection of calcium gluconate, insulin with glucose, bicarbonate, and an enema with polystyrene sulfonate, the patient"s serum potassium level normalized and the bradyarrhythmia converted to a normal sinus rhythm. Potassium 152-161 insulin Homo sapiens 56-63 32426734-9 2020 Conclusions: Patients treated for hyperkalemia with insulin doses less than 10 units had reduced frequency of hypoglycemia; however, potassium reduction post treatment was more modest in these patients. Potassium 133-142 insulin Homo sapiens 52-59 30446179-8 2019 Alterations in metabolic pathways associated with the sensitivity of sodium, potassium, magnesium and calcium may lead to obesity, hypertension, and insulin resistance. Potassium 77-86 insulin Homo sapiens 149-156 32179729-1 2020 BACKGROUND Insulin lowers not only blood glucose levels but also serum potassium levels by driving potassium into the cells. Potassium 71-80 insulin Homo sapiens 11-18 32179729-1 2020 BACKGROUND Insulin lowers not only blood glucose levels but also serum potassium levels by driving potassium into the cells. Potassium 99-108 insulin Homo sapiens 11-18 31700971-5 2019 The potassium level has dropped gradually to a normal level with continuous insulin infusion and dextrose for almost 12 hours that waved the need of the dialysis. Potassium 4-13 insulin Homo sapiens 76-83 30323912-0 2018 An association of urinary sodium-potassium ratio with insulin resistance among Korean adults. Potassium 33-42 insulin Homo sapiens 54-61 31001573-4 2019 Given insulin to these patients immediately can lead to further decrease in extracellular potassium level and lead to cardiac dysrhythmias and death. Potassium 90-99 insulin Homo sapiens 6-13 29861377-2 2019 The goals of this study were to describe the frequency of hypoglycemia following the use of insulin to shift potassium intracellularly and to examine the association of key variables with this complication. Potassium 109-118 insulin Homo sapiens 92-99 29553285-6 2018 These data suggest weight-based insulin dosing is equally effective for lowering serum potassium and may lower risk of severe hypoglycemia. Potassium 87-96 insulin Homo sapiens 32-39 30054673-10 2018 Glucose-stimulated first-phase insulin secretion and potassium-stimulated insulin secretion decreased by 53% and 59%, respectively, in perfused pancreases of 10-week-old Wfs1-/- mice compared with wild-type (WT) mice. Potassium 53-62 insulin Homo sapiens 74-81 30106427-7 2018 The meta-analysis revealed that the animals given C-peptide had lower glomerular volumes and lower urine potassium levels than the groups not given C-peptide. Potassium 105-114 insulin Homo sapiens 50-59 30106427-9 2018 However, the meta-analysis showed that the animals given C-peptide had lower glomerular volumes and lower urine potassium levels. Potassium 112-121 insulin Homo sapiens 57-66 30323912-1 2018 BACKGROUND/OBJECTIVES: This study was conducted to investigate the effects of sodium-potassium ratio on insulin resistance and sensitivity in Korean adults. Potassium 85-94 insulin Homo sapiens 104-111 30323912-5 2018 The generalized linear model was applied to determine the association between urinary sodium-potassium ratio and insulin resistance. Potassium 93-102 insulin Homo sapiens 113-120 30323912-8 2018 CONCLUSION: The present study suggests that high sodium-potassium ratio is related to high insulin resistance and low insulin sensitivity. Potassium 56-65 insulin Homo sapiens 91-98 30323912-8 2018 CONCLUSION: The present study suggests that high sodium-potassium ratio is related to high insulin resistance and low insulin sensitivity. Potassium 56-65 insulin Homo sapiens 118-125 30323912-9 2018 Decreasing sodium intake and increasing potassium intake are important for maintaining insulin sensitivity. Potassium 40-49 insulin Homo sapiens 87-94 32026957-4 2018 A potassium concentration after recovery from VT was 6.4 mEq/L, which was normalized by the administration of calcium gluconate, furosemide, and insulin with glucose. Potassium 2-11 insulin Homo sapiens 145-152 29661658-0 2018 Is Transcellular Potassium Shifting With Insulin, Albuterol, or Sodium Bicarbonate in Emergency Department Patients With Hyperkalemia Associated With Recurrent Hyperkalemia After Dialysis? Potassium 17-26 insulin Homo sapiens 41-48 29671960-2 2018 Insulin is known to favor potassium entry into cells. Potassium 26-35 insulin Homo sapiens 0-7 28993757-11 2017 Thus, we speculated this insulin-induced sharp drop in serum potassium levels as potentiating the patient"s already existing advanced diabetic neuropathy, thereby leading to muscle cramping. Potassium 61-70 insulin Homo sapiens 25-32 29359681-0 2018 Involvement of NLRP3 inflammasome in the impacts of sodium and potassium on insulin resistance in normotensive Asians. Potassium 63-72 insulin Homo sapiens 76-83 28748724-7 2017 Insulin administration is associated with a reduction in serum potassium, magnesium and phosphorus concentration, along with reduced renal magnesium excretion. Potassium 63-72 insulin Homo sapiens 0-7 28976587-11 2017 CONCLUSION: In patients with renal insufficiency and hyperkalemia, 5 units of insulin reduced serum potassium to the same extent as 10 units of insulin but with a lower rate of hypoglycemia. Potassium 100-109 insulin Homo sapiens 78-85 28993757-13 2017 This tilted our diagnosis toward the insulin-induced acute drop in serum potassium levels as the most likely etiology underlying the patient"s cramps. Potassium 73-82 insulin Homo sapiens 37-44 27756725-4 2016 Insulin and beta-adrenergic tone play critical roles in maintaining the internal distribution of potassium under normal conditions. Potassium 97-106 insulin Homo sapiens 0-7 28924484-6 2017 After starting insulin and rapid hemodialysis, the serum potassium level was normalized. Potassium 57-66 insulin Homo sapiens 15-22 27939864-2 2017 Serum potassium should be investigated in patients developing chronic or frequent vomiting or diarrhea, marked polyuria, muscle weakness, or unexpected cardiac arrhythmias, as well as in those undergoing therapy with insulin, diuretics, or total parenteral nutrition. Potassium 6-15 insulin Homo sapiens 217-224 27599629-6 2016 In patients with DKA and a relatively low plasma potassium level, insulin administration may cause hypokalemia and cardiac arrhythmias. Potassium 49-58 insulin Homo sapiens 66-73 28926857-0 2017 The Amelioration of Insulin Resistance in Salt Loading Subjects by Potassium Supplementation is Associated with a Reduction in Plasma IL-17A Levels. Potassium 67-76 insulin Homo sapiens 20-27 28926857-7 2017 Results Participants exhibited increased plasma insulin level, as well as progressed HOMA-IR, during a high-salt diet intervention, which potassium supplementation reversed. Potassium 138-147 insulin Homo sapiens 48-55 26634368-4 2016 Furthermore, accumulating epidemiological evidence from, especially, the last decade relates low dietary potassium intake or serum potassium levels to an increased risk for insulin resistance or diabetes. Potassium 105-114 insulin Homo sapiens 173-180 26843409-2 2016 The impact of sodium, potassium, choline, guanidinium, and 1-ethyl-3-methylimidazolium chloride on the fibrillation kinetics of insulin in an acid-denaturing solvent environment is studied by fluorescence spectroscopy using thioflavin T as a fibril-specific stain. Potassium 22-31 insulin Homo sapiens 128-135 26634368-4 2016 Furthermore, accumulating epidemiological evidence from, especially, the last decade relates low dietary potassium intake or serum potassium levels to an increased risk for insulin resistance or diabetes. Potassium 131-140 insulin Homo sapiens 173-180 25430801-3 2016 Insulin therapy was delayed for 9 h to allow replenishment of potassium to safe serum levels. Potassium 62-71 insulin Homo sapiens 0-7 25778467-0 2015 Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial. Potassium 49-58 insulin Homo sapiens 41-48 24895271-2 2015 METHODS: Among participants of the Cardiovascular Health Study, a community-based cohort of older American adults, we examined a) cross-sectional associations between potassium and measures of insulin sensitivity and secretion estimated from oral glucose tolerance tests and b) longitudinal associations of serum and dietary potassium with diabetes risk. Potassium 167-176 insulin Homo sapiens 193-200 25966806-0 2015 A relationship between serum potassium concentration and insulin resistance in patients with type 2 diabetes mellitus. Potassium 29-38 insulin Homo sapiens 57-64 25966806-2 2015 However, the relationship between serum potassium concentration and insulin resistance is poorly defined. Potassium 40-49 insulin Homo sapiens 68-75 25966806-3 2015 This study aimed to investigate the association between serum potassium concentration and insulin resistance in these patients. Potassium 62-71 insulin Homo sapiens 90-97 25966806-6 2015 The association between serum potassium concentration and insulin resistance was analyzed using linear regression methods. Potassium 30-39 insulin Homo sapiens 58-65 25966806-10 2015 When the patients were compared based on insulin resistance, serum potassium concentration was higher in the patients with insulin resistance compared with the patients without (4.25 +- 0.48 vs. 4.09 +- 0.44 mEq/l, p = 0.015). Potassium 67-76 insulin Homo sapiens 41-48 25966806-10 2015 When the patients were compared based on insulin resistance, serum potassium concentration was higher in the patients with insulin resistance compared with the patients without (4.25 +- 0.48 vs. 4.09 +- 0.44 mEq/l, p = 0.015). Potassium 67-76 insulin Homo sapiens 123-130 25966806-14 2015 CONCLUSIONS: Serum potassium concentration is likely to be increased in the patients with poorly controlled type 2 DM with insulin resistance than in those without insulin resistance. Potassium 19-28 insulin Homo sapiens 123-130 25966806-14 2015 CONCLUSIONS: Serum potassium concentration is likely to be increased in the patients with poorly controlled type 2 DM with insulin resistance than in those without insulin resistance. Potassium 19-28 insulin Homo sapiens 164-171 26036654-11 2015 For a rapid drop in potassium by shifting the potassium to the intracellular space, administration of glucose with insulin and high-dose inhalative administration of betamimetics can be used. Potassium 20-29 insulin Homo sapiens 115-122 24895271-4 2015 In multivariate models, baseline serum and dietary potassium were both associated with lower insulin sensitivity and greater insulin secretion. Potassium 51-60 insulin Homo sapiens 93-100 24666922-10 2014 Serum potassium levels decreased similarly after insulin injection during both hypoglycaemia and euglycaemia. Potassium 6-15 insulin Homo sapiens 49-56 25827151-4 2015 The pathophysiological mechanism comprises an increase in insulin levels, resulting in shifts of phosphate, potassium and magnesium into the intracellular environment, as well as fluid retention and relative deficiency of vitamin B1. Potassium 108-117 insulin Homo sapiens 58-65 26021685-7 2014 RESULTS: After administration of 10 gram glucose and 10 units regular insulin bolus intravenously, a drastic and significant decreased of serum potassium from 5.73 +- 0.44 to 4.48 +- 0.06 mEq/L was noted. Potassium 144-153 insulin Homo sapiens 70-77 26021685-9 2014 CONCLUSIONS: An intravenous bolus of 10 units regular insulin with 10 gram glucose was able to decrease the serum -potassium level effectively and additionally increase serum glucose in LDLT patients. Potassium 115-124 insulin Homo sapiens 54-61 25092935-8 2014 Our most notable findings included the following: (1) monitoring of serum potassium concentrations identified unanticipated hypokalemia episodes, not recognized before standard work implementation, and earlier addition of potassium to fluids resulted in a notable reduction in hypokalemia; (2) improvements in insulin infusion management were associated with reduced duration of ICU stay; and (3) with overall improved DKA management and education, cerebral edema occurrence and bicarbonate use were reduced. Potassium 74-83 insulin Homo sapiens 310-317 25092935-8 2014 Our most notable findings included the following: (1) monitoring of serum potassium concentrations identified unanticipated hypokalemia episodes, not recognized before standard work implementation, and earlier addition of potassium to fluids resulted in a notable reduction in hypokalemia; (2) improvements in insulin infusion management were associated with reduced duration of ICU stay; and (3) with overall improved DKA management and education, cerebral edema occurrence and bicarbonate use were reduced. Potassium 222-231 insulin Homo sapiens 310-317 23405890-8 2014 With the reduction in serum potassium level, participants have larger waist circumference (WC) and more severe insulin resistance. Potassium 28-37 insulin Homo sapiens 111-118 24671621-9 2014 Our findings suggest that hair mineral concentrations, such as calcium, magnesium, zinc, sodium, and potassium concentrations, may play a role in the development of insulin resistance. Potassium 101-110 insulin Homo sapiens 165-172 23405890-10 2014 In logistic regression analysis, compared with subjects in the highest quartile of serum potassium level, the adjusted odds ratios (ORs) in the lowest quartile was 1 33 [95% confidence interval (CI), 1 11-1 60] for NAFLD, 1 81 (95% CI, 1 49-2 19) for insulin resistance and 1 58 (95% CI, 1 30-1 93) for central obesity. Potassium 89-98 insulin Homo sapiens 251-258 23405890-11 2014 In subgroup analysis after multiple adjustments, significant relation between serum potassium level and prevalent NAFLD was detected in women, younger subjects, those with insulin resistance and those with central obesity, respectively. Potassium 84-93 insulin Homo sapiens 172-179 22747613-2 2012 In this secondary analysis, the authors tested whether this enhanced insulin response to valsartan/hydrochlorothiazide was influenced by serum potassium levels, which were reduced to a lesser extent, when compared with amlodipine/hydrochlorothiazide. Potassium 143-152 insulin Homo sapiens 69-76 23849528-10 2013 Regular insulin therapy may be more effective than infrequent large bolus therapy for potassium homeostasis. Potassium 86-95 insulin Homo sapiens 8-15 23220438-1 2012 We report a unique case of diabetic ketoacidosis in which a relatively low potassium level on admission was associated with consequent life-threatening and refractory arrhythmia secondary to inappropriate use of intravenous insulin and bicarbonate therapy. Potassium 75-84 insulin Homo sapiens 224-231 21922321-8 2012 Arginine-stimulated (p = 0.02) insulin secretion was reduced in vivo, which was further reflected by a reduction of glucose- and potassium-stimulated insulin secretion (p = 0.002 and p = 0.04, respectively) in human islets in vitro. Potassium 129-138 insulin Homo sapiens 150-157 22650221-4 2012 Although there is a theoretical basis for the use of glucose-insulin-potassium infusion during AMI, lack of outcome efficacy (and inability to reach glycemic targets) in recent randomized trials has resulted in little enthusiasm for this strategy. Potassium 69-78 insulin Homo sapiens 61-68 21316179-2 2012 Because insulin therapy decreases serum potassium levels, which creates potential to precipitate a fatal cardiac arrhythmia in a patient with hypokalemia, the American Diabetes Association (ADA) recommends obtaining a serum potassium level before giving insulin. Potassium 40-49 insulin Homo sapiens 8-15 21316179-2 2012 Because insulin therapy decreases serum potassium levels, which creates potential to precipitate a fatal cardiac arrhythmia in a patient with hypokalemia, the American Diabetes Association (ADA) recommends obtaining a serum potassium level before giving insulin. Potassium 224-233 insulin Homo sapiens 8-15 21946656-1 2012 OBJECTIVES: Insulin administration lowers plasma potassium concentration by augmenting intracellular uptake of potassium. Potassium 49-58 insulin Homo sapiens 12-19 21946656-1 2012 OBJECTIVES: Insulin administration lowers plasma potassium concentration by augmenting intracellular uptake of potassium. Potassium 111-120 insulin Homo sapiens 12-19 21946656-3 2012 Some studies suggest that insulin has an antikaliuretic effect although plasma potassium levels were poorly controlled. Potassium 79-88 insulin Homo sapiens 26-33 21946656-5 2012 We examined the relation between administered insulin and renal potassium excretion in critically ill patients under computer-assisted glucose and potassium regulation. Potassium 64-73 insulin Homo sapiens 46-53 21946656-17 2012 After multivariate analysis correcting for relevant variables (including diuretics, pH, potassium levels and renal sodium excretion), insulin administration was independently and positively associated with renal potassium excretion. Potassium 88-97 insulin Homo sapiens 134-141 21946656-17 2012 After multivariate analysis correcting for relevant variables (including diuretics, pH, potassium levels and renal sodium excretion), insulin administration was independently and positively associated with renal potassium excretion. Potassium 212-221 insulin Homo sapiens 134-141 21946656-20 2012 CONCLUSION: Insulin administration is associated with an increase in the renal potassium excretion in critically ill patients. Potassium 79-88 insulin Homo sapiens 12-19 21030184-5 2012 Treatment with norepinephrine, sodium bicarbonate, and insulin improved both the hemodynamic situation and the serum potassium with subsequent regaining pacemaker actions even before additional hemodialysis normalized the potassium level. Potassium 117-126 insulin Homo sapiens 55-62 21030184-5 2012 Treatment with norepinephrine, sodium bicarbonate, and insulin improved both the hemodynamic situation and the serum potassium with subsequent regaining pacemaker actions even before additional hemodialysis normalized the potassium level. Potassium 222-231 insulin Homo sapiens 55-62 21075579-11 2011 Once an urgent situation has been handled with intravenous push of a 10% calcium salt, short-term measures should be started with agents that cause a transcellular shift of potassium, namely, insulin with glucose, beta2-agonist, and NaHCO(3). Potassium 173-182 insulin Homo sapiens 192-199 22009997-15 2011 CONCLUSIONS: An intravenous infusion including a dextrose:insulin ratio of 3.3:1, compared with a higher ratio, results in less hyperglycemia and appears to be as effective in decreasing potassium concentrations in newborns. Potassium 187-196 insulin Homo sapiens 58-65 21470398-7 2011 High extracellular potassium and 10 mM tolbutamide abrogated the inhibition of insulin secretion by GA. Glyceraldehyde, dihydroxyacetone, methylpyruvate, GLP-1, and forskolin, an activator of adenylate cyclase, did not abrogate the inhibition. Potassium 19-28 insulin Homo sapiens 79-86 23346606-3 2011 Intensive insulin therapy is defined as an intravenous infusion of insulin and glucose with or without potassium. Potassium 103-112 insulin Homo sapiens 10-17 21700825-0 2011 A critically swift response: insulin-stimulated potassium and glucose transport in skeletal muscle. Potassium 48-57 insulin Homo sapiens 29-36 21734082-1 2011 BACKGROUND AND OBJECTIVES: Insulin has several physiologic actions that include stimulation of cellular glucose and potassium uptake. Potassium 116-125 insulin Homo sapiens 27-34 21734082-12 2011 Conclusions Insulin-stimulated intracellular uptake of glucose and potassium are independent of each other. Potassium 67-76 insulin Homo sapiens 12-19 20827508-0 2011 Abnormalities of serum potassium concentration in dialysis-associated hyperglycemia and their correction with insulin: review of published reports. Potassium 23-32 insulin Homo sapiens 110-117 21453644-10 2011 CONCLUSIONS: The m.3243A>G mutation not only underlies a dysfunction of the insulin-producing beta cell of the pancreas but also results in a reduction in adenosine triphosphate production of the strial marginal cells of the inner ear, thus diminishing the energy (in the form of potassium ion gradient) needed for the outer hair cells of the organ of Corti to amplify the soundwaves, particularly at high frequencies. Potassium 283-292 insulin Homo sapiens 79-86 21461038-4 2011 Furthermore, systematic glucose-insulin-potassium infusion (GIK) has been studied to improve outcome after AMI. Potassium 40-49 insulin Homo sapiens 32-39 21051417-4 2011 Moreover, insulin is the key component of glucose-insulin-potassium cocktail and exerts significant cardiovascular protective effect via a phosphatidylinositol 3"-kinase-protein kinase B-endothelial nitric oxide synthase (PI3K-Akt-eNOS)-dependent signalling mechanism in addition to its metabolic modulation, which renders it a potent organ protector in multiple clinical applications. Potassium 58-67 insulin Homo sapiens 10-17 20853142-0 2010 Abnormalities of serum potassium concentration in dialysis-associated hyperglycemia and their correction with insulin: a unique clinical/physiologic exercise in internal potassium balance. Potassium 23-32 insulin Homo sapiens 110-117 20853142-0 2010 Abnormalities of serum potassium concentration in dialysis-associated hyperglycemia and their correction with insulin: a unique clinical/physiologic exercise in internal potassium balance. Potassium 170-179 insulin Homo sapiens 110-117 20853142-4 2010 Calculations of transcellular potassium shifts based on the combined effects of insulin-the increase in the electrical potential differences (hyperpolarization) of the cell membranes and the correction of the hyperglycemic intracellular dehydration through decrease in serum glucose concentration-produced quantitative predictions of the decrease in serum K(+) similar to the reported changes in serum K(+) during treatment of DH with insulin. Potassium 30-39 insulin Homo sapiens 80-87 20853142-4 2010 Calculations of transcellular potassium shifts based on the combined effects of insulin-the increase in the electrical potential differences (hyperpolarization) of the cell membranes and the correction of the hyperglycemic intracellular dehydration through decrease in serum glucose concentration-produced quantitative predictions of the decrease in serum K(+) similar to the reported changes in serum K(+) during treatment of DH with insulin. Potassium 30-39 insulin Homo sapiens 435-442 20853142-5 2010 The lessons from analyzing serum K(+) changes during treatment of DH with insulin are applicable to other conditions where internal potassium balance is called upon to protect serum K(+), such as the postprandial state. Potassium 132-141 insulin Homo sapiens 74-81 20369755-9 2010 Some authors still recommend glucose-potassium-insulin infusions for all patients with type 1 diabetes. Potassium 37-46 insulin Homo sapiens 47-54 19485915-4 2010 Also, potassium supplement suppressed salt-induced insulin resistance. Potassium 6-15 insulin Homo sapiens 51-58 19362017-8 2010 The divided insulin regimen was associated with significantly lower mean potassium levels within 2 hours before reperfusion of the graft compared with the conventional group (p < 0.005). Potassium 73-82 insulin Homo sapiens 12-19 19362017-10 2010 CONCLUSIONS: The divided insulin dose regimen that specifically targets the risk factors for prereperfusion hyperkalemia is associated with significantly lower prereperfusion potassium and pre- and postreperfusion glucose levels and provides a useful alternative to the conventional large-bolus method in management of intraoperative hyperkalemia during liver transplantation. Potassium 175-184 insulin Homo sapiens 25-32 19485915-9 2010 Thus, it is possible that dietary potassium protects against salt-induced cardiovascular damage by the reduction of ROS generation and by central sympatholytic action and amelioration of insulin resistance induced through its antioxidant effect. Potassium 34-43 insulin Homo sapiens 187-194 20144338-1 2009 BACKGROUND: Adrenaline release and excess insulin during hypoglycemia stimulate the uptake of potassium from the bloodstream, causing low plasma potassium (hypokalemia). Potassium 94-103 insulin Homo sapiens 42-49 19792989-9 2009 Significant elevations were noted in fasting serum glucose (mean +/- SD 3.42 +/- 10.38 mg/dl, p<0.0001) and plasma insulin (2.35 +/- 9.47 microU/ml, p<0.0001) levels, and a significant reduction in serum potassium level (0.30 +/- 0.44 mEq/L, p<0.0001) was noted. Potassium 210-219 insulin Homo sapiens 118-125 20144338-1 2009 BACKGROUND: Adrenaline release and excess insulin during hypoglycemia stimulate the uptake of potassium from the bloodstream, causing low plasma potassium (hypokalemia). Potassium 145-154 insulin Homo sapiens 42-49 20144338-5 2009 An insulin-induced uptake of potassium was modeled using a negative exponential function, and an adrenaline-induced uptake of potassium was modeled as a linear function. Potassium 29-38 insulin Homo sapiens 3-10 18752977-6 2009 Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp and body composition by computed tomography (CT) scans and from total body potassium, K(40). Potassium 150-159 insulin Homo sapiens 0-7 19281748-9 2009 When thiopental infusion was suddenly stopped, the potassium level increased to 8.9 mmol/l, which required quick administration of calcium gluconate and infusion of glucose solution mixed with regular insulin. Potassium 51-60 insulin Homo sapiens 201-208 19069684-2 2008 Massive shift of potassium into cells is caused by elevated levels of insulin and catecholamines in the blood. Potassium 17-26 insulin Homo sapiens 70-77 17436794-2 2007 Blood potassium concentration is primarily under the control of cellular transfer, driven either by the acid basic equilibrium, the action of catecholamines and insulin, and secondarily by the kidney. Potassium 6-15 insulin Homo sapiens 161-168 18837770-3 2008 Initial treatment with insulin drip resulted in a decrease in serum potassium to 5.3 mmol/L, but no significant change in mental status or other laboratory parameters. Potassium 68-77 insulin Homo sapiens 23-30 19343122-0 2008 Effects of intermittent and long-term glucose-insulin-potassium infusion in patients with systolic heart failure. Potassium 54-63 insulin Homo sapiens 46-53 17968975-0 2008 Insulin effect on serum potassium and auto-inhibition of insulin secretion is intact in a patient with leprechaunism despite severe impairment of substrates metabolism. Potassium 24-33 insulin Homo sapiens 0-7 17897250-4 2007 Intravenous insulin and nebulized albuterol lower serum potassium acutely, by shifting it into the cells. Potassium 56-65 insulin Homo sapiens 12-19 18064068-1 2007 The ATP-sensitive potassium (K(ATP)) channels which extensively distribute in diverse tissues (e.g. vascular smooth muscle, cardiac cells, and pancreas) are well-established for characteristics like vasodilatation, myocardial protection against ischemia, and insulin secretion. Potassium 18-27 insulin Homo sapiens 259-266 16831872-4 2006 We found that overexpression of mir-9 in insulin-secreting cells causes a reduction in exocytosis elicited by glucose or potassium. Potassium 121-130 insulin Homo sapiens 41-48 17469342-8 2006 The glucose-insulin-potassium solution provides the glucose needed by the myocardium in reperfusion conditions and protects the cellular membrane"s integrity as well as pumps and ionic channels, it allows maintaining the action potential probably because ATP-depended channels block and prevent potassium loss, it reduces the cytosol calcium overload and prevent cardiac arrhythmias, preserves the sodium ATPasa pump avoiding the rise in cytosolic sodium; glucose prevents the production of free oxygen radicals. Potassium 20-29 insulin Homo sapiens 12-19 16943722-2 2006 Several further trials and meta-analyses investigating the role of insulin treatment, either aimed at tight control of blood glucose concentration or as part of a regimen including glucose and potassium, have been reported recently and are the subject of this review. Potassium 193-202 insulin Homo sapiens 67-74 16943722-5 2006 The use of glucose-insulin-potassium regimens does not improve outcomes in patients with acute myocardial infarction who have undergone reperfusion therapy, but may be beneficial during cardiac surgery. Potassium 27-36 insulin Homo sapiens 19-26 17245074-4 2007 More recent experimental and clinical studies have added data about the exact tubular sites of this insulin action, its relation with the respective insulin action on potassium handling, its possible role in the development of salt sensitivity in essential hypertension, as well as the involvement of oxidant stress in these associations. Potassium 167-176 insulin Homo sapiens 100-107 17245074-4 2007 More recent experimental and clinical studies have added data about the exact tubular sites of this insulin action, its relation with the respective insulin action on potassium handling, its possible role in the development of salt sensitivity in essential hypertension, as well as the involvement of oxidant stress in these associations. Potassium 167-176 insulin Homo sapiens 149-156 17459601-1 2007 It is proposed that insulin has a cardinal role in the regulation of serum potassium levels in man, which may be of greater importance than the effect of insulin on glucose metabolism. Potassium 75-84 insulin Homo sapiens 20-27 17459601-3 2007 Insulin also promotes the transport of potassium ions from the extracellular space to the intracellular space and it is suggested that there are occasions where this action may take place at the expense of glucose regulation. Potassium 39-48 insulin Homo sapiens 0-7 17125532-6 2006 A high intake of calcium, magnesium and potassium, together with a low sodium intake, is associated with protection against bone demineralisation, arterial hypertension, insulin resistance, and overall cardiovascular risk. Potassium 40-49 insulin Homo sapiens 170-177 16905514-4 2006 In 2 prospective studies using glucose-insulin-potassium infusion, glucose levels did not reach target, and the results of both trials were negative with regard to the primary endpoint, mortality. Potassium 47-56 insulin Homo sapiens 39-46 16191494-12 2005 Intravenously administered insulin should be withheld until the serum potassium concentration is (3)3.3 mEq/L. Potassium 70-79 insulin Homo sapiens 27-34 25696601-0 2006 Glucose and potassium derangements by glucose-insulin-potassium infusion in acute myocardial infarction. Potassium 12-21 insulin Homo sapiens 46-53 25696601-0 2006 Glucose and potassium derangements by glucose-insulin-potassium infusion in acute myocardial infarction. Potassium 54-63 insulin Homo sapiens 46-53 25696601-1 2006 BACKGROUND: High-dose glucose-insulin-potassium infusion (GIK) has been suggested to be beneficial in acute myocardial infarction (MI). Potassium 38-47 insulin Homo sapiens 30-37 16445274-7 2006 Serum potassium levels can be lowered acutely by using intravenous insulin and glucose, nebulized beta2 agonists, or both. Potassium 6-15 insulin Homo sapiens 67-74 16399292-1 2006 OBJECTIVE: We sought to assess the role of glucose-insulin-potassium in providing myocardial protection in nondiabetic patients undergoing coronary artery surgery with cardiopulmonary bypass. Potassium 59-68 insulin Homo sapiens 51-58 16399292-8 2006 RESULTS: The glucose-insulin-potassium group experienced higher cardiac indices (P < .001) throughout infusion and reduced vascular resistance (P < .001). Potassium 29-38 insulin Homo sapiens 21-28 16399292-9 2006 The incidence of low cardiac output episodes was 15.9% (22/138) in the glucose-insulin-potassium group and 27.5% (39/142) in the placebo group (P = .021). Potassium 87-96 insulin Homo sapiens 79-86 16399292-10 2006 Inotropes were required in 18.8% (26/138) of the glucose-insulin-potassium group and 40.8% (58/142) of the placebo group (P < .001). Potassium 65-74 insulin Homo sapiens 57-64 16399292-11 2006 Fewer patients in the glucose-insulin-potassium group (12.3% [16/133]) versus those in the placebo group (23.4% [32/137]) had significant myocardial injury (P = .017). Potassium 38-47 insulin Homo sapiens 30-37 16383643-3 2005 These two are coupled to interact with each other in the combined model, and two basic assumptions are made on the basis of biological observations: The conductance gK(ATP) for the ATP-dependent potassium current is a decreasing function of the glucose concentration whereas the insulin secretion rate is given by a function of the intracellular calcium concentration. Potassium 195-204 insulin Homo sapiens 279-286 16183425-2 2005 Exogenous insulin stimulates this disposal by enhancing potassium uptake into cells in hemodialysis (HD) patients and healthy subjects. Potassium 56-65 insulin Homo sapiens 10-17 16183425-8 2005 In HD patients, the decrease in serum potassium levels was dependent on the increase in serum insulin levels and was more prominent when 150 g of glucose was administered. Potassium 38-47 insulin Homo sapiens 94-101 16183425-9 2005 In HD patients, the decrease in serum potassium levels correlated negatively (r = -0.45; P < 0.001) with the increase in serum insulin levels, and maximal decrease in serum potassium levels correlated negatively (r = -0.54; P < 0.001) with maximal increase in serum insulin levels. Potassium 38-47 insulin Homo sapiens 130-137 16183425-9 2005 In HD patients, the decrease in serum potassium levels correlated negatively (r = -0.45; P < 0.001) with the increase in serum insulin levels, and maximal decrease in serum potassium levels correlated negatively (r = -0.54; P < 0.001) with maximal increase in serum insulin levels. Potassium 38-47 insulin Homo sapiens 272-279 16183425-10 2005 CONCLUSION: Endogenous production of physiological concentrations of insulin in response to exogenous glucose administration decreases serum potassium levels only in HD patients, independently of plasma aldosterone and epinephrine levels. Potassium 141-150 insulin Homo sapiens 69-76 16641887-5 2006 This may have relevance to the use of glucose-insulin-potassium regimen in these clinical conditions, sepsis, and cancer. Potassium 54-63 insulin Homo sapiens 46-53 16427537-3 2005 Changing insulin therapy can also have profound effects on potassium homeostasis in certain patients. Potassium 59-68 insulin Homo sapiens 9-16 16427537-4 2005 This case demonstrates that changes in insulin therapy warrant not only close monitoring of blood glucose, but also of serum potassium. Potassium 125-134 insulin Homo sapiens 39-46 15818545-0 2005 Serum potassium and acid-base parameters in severe dialysis-associated hyperglycemia treated with insulin therapy. Potassium 6-15 insulin Homo sapiens 98-105 15883206-13 2005 These nongenomic functional effects of insulin may be of clinical relevance, eg, during insulin-glucose-potassium infusions. Potassium 104-113 insulin Homo sapiens 39-46 15883206-13 2005 These nongenomic functional effects of insulin may be of clinical relevance, eg, during insulin-glucose-potassium infusions. Potassium 104-113 insulin Homo sapiens 88-95 15811898-2 2005 DATA SOURCES: Evidence of efficacy for high-dose insulin therapy with supplemental dextrose and potassium was sought by performing a search of MEDLINE and Toxline between 1966 and July 2004 using combinations of the terms calcium-channel blocker, overdose, poisoning, antidote, and insulin. Potassium 96-105 insulin Homo sapiens 49-56 15811898-6 2005 DATA SYNTHESIS: Animal models of CCB overdose demonstrate that high-dose insulin with supplemental dextrose and potassium was a more effective therapy than calcium, glucagon, or catecholamines. Potassium 112-121 insulin Homo sapiens 73-80 25696497-8 2005 In order to further stimulate potassium transport into the cell, insulin was administered. Potassium 30-39 insulin Homo sapiens 65-72 15153570-9 2004 The finding of a hyperinsulinemic response in acute metabolic acidosis suggests that an insulin response counterregulates any acidemia-induced cellular potassium efflux, resulting in stable plasma potassium concentrations. Potassium 152-161 insulin Homo sapiens 22-29 15285036-1 2004 AIM: To investigate the effectiveness of insulin on decreasing serum potassium concentration during anhepatic stage of orthotopic liver transplantation. Potassium 69-78 insulin Homo sapiens 41-48 15285036-7 2004 CONCLUSION: In patients undergoing orthotopic liver transplantation, the administration of insulin rapidly decreases serum potassium concentration even in the absence of the liver, suggesting an important contribution by extrahepatic tissues in insulin-stimulated uptake of potassium. Potassium 123-132 insulin Homo sapiens 91-98 15285036-7 2004 CONCLUSION: In patients undergoing orthotopic liver transplantation, the administration of insulin rapidly decreases serum potassium concentration even in the absence of the liver, suggesting an important contribution by extrahepatic tissues in insulin-stimulated uptake of potassium. Potassium 123-132 insulin Homo sapiens 245-252 15285036-7 2004 CONCLUSION: In patients undergoing orthotopic liver transplantation, the administration of insulin rapidly decreases serum potassium concentration even in the absence of the liver, suggesting an important contribution by extrahepatic tissues in insulin-stimulated uptake of potassium. Potassium 274-283 insulin Homo sapiens 91-98 15285036-7 2004 CONCLUSION: In patients undergoing orthotopic liver transplantation, the administration of insulin rapidly decreases serum potassium concentration even in the absence of the liver, suggesting an important contribution by extrahepatic tissues in insulin-stimulated uptake of potassium. Potassium 274-283 insulin Homo sapiens 245-252 16276080-6 2005 Glucose-potassium-insulin infusion or adjusted insulin infusions each have their proponents: both are effective but both carry a small risk of hypoglycaemia. Potassium 8-17 insulin Homo sapiens 18-25 15671919-7 2004 Preserving cellular potassium and magnesium pools by blocking the aldosterone effects could also improve both cellular insulin action and insulin secretion. Potassium 20-29 insulin Homo sapiens 119-126 15153570-9 2004 The finding of a hyperinsulinemic response in acute metabolic acidosis suggests that an insulin response counterregulates any acidemia-induced cellular potassium efflux, resulting in stable plasma potassium concentrations. Potassium 197-206 insulin Homo sapiens 22-29 12463620-5 2002 Glucose-insulin-potassium protocol consisted of a fixed dose of insulin (100 microU/kg/hour IV) and a variable glucose/potassium infusion rate. Potassium 16-25 insulin Homo sapiens 8-15 17021526-0 2004 New perspectives for an old cure: a glucose-insulin-potassium revival in cardiac surgery? Potassium 52-61 insulin Homo sapiens 44-51 12566104-1 2003 The renaissance of glucose-insulin-potassium infusion (GIK) as a treatment of acute myocardial infarction both in diabetic and nondiabetic subjects has raised new interests to clarify the effects and mechanisms of insulin on myocardium. Potassium 35-44 insulin Homo sapiens 27-34 12553944-4 2003 In contrast to its sodium retaining properties in normal, obese and diabetic subjects, insulin-glucose-potassium therapy may induce a sodium diuresis in catabolic patients with salt and water overload and in patients with congestive heart failure in whom haemodynamic improvement has also been observed. Potassium 103-112 insulin Homo sapiens 87-94 15783125-5 2004 Although renal and intestinal adaptation are important in maintaining overall potassium balance during CKD, movement of potassium into the cells is extremely important in the body"s acute defense against hyperkalemia, and occurs daily during postprandial potassium overload, through shift of this cation into hepatic cells mediated by insulin and thus avoiding post-prandial hyperkalemia. Potassium 120-129 insulin Homo sapiens 335-342 15783125-5 2004 Although renal and intestinal adaptation are important in maintaining overall potassium balance during CKD, movement of potassium into the cells is extremely important in the body"s acute defense against hyperkalemia, and occurs daily during postprandial potassium overload, through shift of this cation into hepatic cells mediated by insulin and thus avoiding post-prandial hyperkalemia. Potassium 120-129 insulin Homo sapiens 335-342 15783126-6 2004 In peritoneal dialysis patients, despite lower potassium removal (about 30-40 mmol/day), hypokalemia is the most frequent electrolyte alteration, probably due to movement of potassium into the cells mediated by insulin, secondary to glucose absorption from the dialysis solution. Potassium 174-183 insulin Homo sapiens 211-218 12499920-7 2003 Moreover, although the insulin response to high glucose and potassium loading was maintained, the magnitude of the responses to both stimuli was attenuated in the late period of culture. Potassium 60-69 insulin Homo sapiens 23-30 10408765-9 1999 These findings suggest that hyperinsulinemia and insulin-induced transmembrane shift of extracellular potassium and phosphate may have been involved in the abnormalities of serum electrolytes and development of hypokalemic periodic paralysis in the present patient. Potassium 102-111 insulin Homo sapiens 33-40 12058435-7 2002 We especially should pay attention to hypokalemia because of hyperventilation, absorption of potassium with insulin and transudation of potassium from the intestine. Potassium 93-102 insulin Homo sapiens 108-115 11793017-2 2001 We hypothesized that insulin response to glucose-insulin-potassium infusion might lead to vasodilation in ischemia/reperfusion (I/R). Potassium 57-66 insulin Homo sapiens 21-28 11793017-2 2001 We hypothesized that insulin response to glucose-insulin-potassium infusion might lead to vasodilation in ischemia/reperfusion (I/R). Potassium 57-66 insulin Homo sapiens 49-56 11793017-11 2001 Adhering leukocytes to venules decreased by 56 and 86 % while platelets adhering to microvessels was reduced by 52 and 72 % at reperfusion in glucose-insulin-potassium groups with and without dipyridamole, respectively. Potassium 158-167 insulin Homo sapiens 150-157 11435055-0 2001 Comparison of a continuous glucose-insulin-potassium infusion versus intermittent bolus application of insulin on perioperative glucose control and hormone status in insulin-treated type 2 diabetics. Potassium 43-52 insulin Homo sapiens 35-42 11377135-2 2001 Therefore, the glucose-insulin-potassium regimen might be beneficial in acute myocardial infarction and useful in the management of patients with septicemia, septic shock, and other inflammatory diseases in which tumor necrosis factor-alpha and macrophage migration-inhibitory factor have important roles. Potassium 31-40 insulin Homo sapiens 23-30 11211109-8 2000 Potassium balance measured by microdialysis shifted from a net release to a net uptake in response to insulin, with no difference between SCI and H. In conclusion, the mechanism by which insulin mediates an increase in skeletal muscle blood flow is not due to a CNS recruitment of sympathetic vasodilatory nervous activity. Potassium 0-9 insulin Homo sapiens 102-109 11211109-8 2000 Potassium balance measured by microdialysis shifted from a net release to a net uptake in response to insulin, with no difference between SCI and H. In conclusion, the mechanism by which insulin mediates an increase in skeletal muscle blood flow is not due to a CNS recruitment of sympathetic vasodilatory nervous activity. Potassium 0-9 insulin Homo sapiens 187-194 11092145-2 2000 Various conventional therapies including intravenous sodium bicarbonate, insulin with glucose and several beta-2 agonists are commonly employed as transient measures to enhance shift of potassium from the extracellular to the intracellular compartment. Potassium 186-195 insulin Homo sapiens 73-80 10767668-5 2000 Minerals such as magnesium, calcium, potassium, zinc, chromium, and vanadium appear to have associations with insulin resistance or its management. Potassium 37-46 insulin Homo sapiens 110-117 12398773-5 2002 Adequate attention should be given to maintaining euglycemia (plasma glucose <or= 110 mg/dl) in order to reduce infarct size and improve cardiac function while using a glucose-insulin-potassium cocktail. Potassium 187-196 insulin Homo sapiens 179-186 12165944-4 2002 During both protocols an insulin-related inhibition of muscle protein degradation occurred; however peritoneal dialysis caused a 20% decrease in forearm phenylalanine rate of disposal (an index of muscle protein synthesis), which correlated with the decline of arterial BCAA and potassium, which were removed via the peritoneal fluid. Potassium 279-288 insulin Homo sapiens 25-32 11872361-3 2002 Decrease of serum potassium during insulin sensitivity test and intraplatelet free Ca2+ concentration is positively and negatively correlated with insulin sensitivity, respectively. Potassium 18-27 insulin Homo sapiens 35-42 11872361-3 2002 Decrease of serum potassium during insulin sensitivity test and intraplatelet free Ca2+ concentration is positively and negatively correlated with insulin sensitivity, respectively. Potassium 18-27 insulin Homo sapiens 147-154 11910982-9 2001 Glucose--insulin--potassium infusion in acute myocardial infarction leads to a significant reduction in the mortality relative risk in diabetic patients (ECLA and DIGAMI studies). Potassium 18-27 insulin Homo sapiens 9-16 11868861-7 2001 Whereas, intravenous infusion of insulin-dextrose decreased plasma potassium from 6.59 +/- 0.31 mEq/L to 5.76 +/- 0.32 mEq/L (p < 0.001 Vs basal) and 5.84 +/- 0.21 mEq/L (p < 0.001 Vs basal). Potassium 67-76 insulin Homo sapiens 33-40 11777323-0 2001 Insulin and mineralocorticoids influence on extrarenal potassium metabolism in chronic hemodialysis patients. Potassium 55-64 insulin Homo sapiens 0-7 11461170-0 2001 Can glucose-insulin-potassium regimen suppress inflammatory bowel disease? Potassium 20-29 insulin Homo sapiens 12-19 11410112-0 2001 Effects of high-dose glucose-insulin-potassium on myocardial metabolism after coronary surgery in patients with Type II diabetes. Potassium 37-46 insulin Homo sapiens 29-36 11224662-1 2001 In target organs, insulin switches substrate utilization from free fatty acids to glucose, a change that: (i) is oxygen-efficient; (ii) repletes glycogen stores; (iii) removes potentially toxic fatty acids; and (iv) restores intracellular potassium. Potassium 239-248 insulin Homo sapiens 18-25 11204289-4 2001 The changes in serum potassium and magnesium were both inversely related to the insulin-mediated glucose uptake (r= -0.62, P< 0.0001; r= -0.31, P< 0.05, respectively). Potassium 21-30 insulin Homo sapiens 80-87 10656225-7 1999 It had been known since 1923 that insulin lowered serum potassium, but this was not of great interest because the symptoms of hypokalaemia were not known. Potassium 56-65 insulin Homo sapiens 34-41 9828151-9 1998 Insulin/ IGF-1 translocates Mg2+ from the extracellular space to intracellular space and these effects are affected by external sodium and potassium. Potassium 139-148 insulin Homo sapiens 0-7 10482044-3 1999 We investigated whether supplementation of potassium during euglycaemic glucose clamps influences insulin sensitivity. Potassium 43-52 insulin Homo sapiens 98-105 10482044-10 1999 In conclusion, this study shows that potassium supply during hyperinsulinaemic euglycaemic glucose clamps in healthy subjects does not influence the insulin sensitivity index. Potassium 37-46 insulin Homo sapiens 66-73 9322807-7 1997 Preincubation with metformin also induced an attenuating (vasodilating-like) action of insulin on arterial tissue rings contracted by potassium. Potassium 134-143 insulin Homo sapiens 87-94 9828151-7 1998 In the medium containing choline instead of sodium or the medium without potassium, an elevation of [Mg2+]i with addition of insulin/IGF-1 was moderately suppressed. Potassium 73-82 insulin Homo sapiens 125-132 9727207-9 1998 The plasma potassium concentration was maintained by means of insulin receptors on erythrocytes. Potassium 11-20 insulin Homo sapiens 62-69 9459288-8 1998 Insulin is the most reliable agent for promoting transcellular shift of potassium. Potassium 72-81 insulin Homo sapiens 0-7 9497875-14 1997 IGF-I and insulin under conditions of adequate substrate supply have acute effects on IGFBP-1 and potassium physiology, but have little effect on IGFBP-3, ALS or catecholamines. Potassium 98-107 insulin Homo sapiens 10-17 9322807-8 1997 Conversely, glyburide induced an accentuating action of insulin on potassium-mediated contractions. Potassium 67-76 insulin Homo sapiens 56-63 9040630-3 1997 In 15 patients, glucose-insulin-potassium solution (30% dextrose in water; K+, 80 mEq/L: regular insulin, 50 units) was given intravenously at 1 ml/kg per hour after induction of anesthesia and administration continued for 12 hours after aortic unclamping. Potassium 32-41 insulin Homo sapiens 24-31 9240458-1 1997 In the rat adipocyte, insulin increases potassium uptake by a preferential activation of the alpha2 isoform of the Na,K-ATPase. Potassium 40-49 insulin Homo sapiens 22-29 9186877-6 1997 Plasma insulin rose to a level known to induce cellular potassium uptake (39.2 +/- 7.7 mU/ml) after 60 minutes of drug therapy and remained at this level for four hours. Potassium 56-65 insulin Homo sapiens 7-14 9164118-1 1997 Thallium-201 chloride (201Tl) kinetics, may be affected by serum insulin levels like potassium kinetics. Potassium 85-94 insulin Homo sapiens 65-72 9081107-2 1997 (2) Does the addition of insulin (glucose-insulin-potassium solution) provide additional effects to those of an amino acid infusion? Potassium 50-59 insulin Homo sapiens 25-32 8889439-6 1996 Furthermore, insulin infusion increased forearm lactate release and potassium uptake. Potassium 68-77 insulin Homo sapiens 13-20 9346691-0 1996 Glucose and potassium metabolic responses to insulin during liver transplantation. Potassium 12-21 insulin Homo sapiens 45-52 9346691-1 1996 Insulin regulates glucose and potassium metabolism by acting differently upon peripheral tissues (e.g., skeletal muscle) and the splanchnic bed, including the liver. Potassium 30-39 insulin Homo sapiens 0-7 9346691-5 1996 The present study evaluated the role of the liver in maximal insulin responsiveness of whole-body glucose and potassium metabolism, using a hyperinsulinemic clamp technique, to identify the mechanism(s) underlying post-reperfusion hyperglycemia and intraoperative hyperkalemia. Potassium 110-119 insulin Homo sapiens 61-68 9346691-10 1996 Insulin-stimulated exogenous glucose and potassium uptakes were determined in protocol 2 before skin incision and during the dissection, anhepatic, and neohepatic stages. Potassium 41-50 insulin Homo sapiens 0-7 9346691-19 1996 Insulin-stimulated potassium uptake, in mEq . Potassium 19-28 insulin Homo sapiens 0-7 9346691-25 1996 The liver, even with end-stage disease, accounts for approximately 70% of insulin-stimulated potassium uptake. Potassium 93-102 insulin Homo sapiens 74-81 8840939-2 1996 Whereas insulin and albuterol are effective in lowering plasma potassium acutely, bicarbonate by itself is not. Potassium 63-72 insulin Homo sapiens 8-15 8840939-3 1996 Bicarbonate administration may, however, potentiate the effects of insulin and albuterol on plasma potassium. Potassium 99-108 insulin Homo sapiens 67-74 8840939-7 1996 Intravenous insulin decreased plasma potassium by a similar degree when given in conjunction with bicarbonate or saline (-0.81 +/- 0.05 mmol/L v -0.85 +/- 0.06 mmol/L at 60 minutes; P = 0.65). Potassium 37-46 insulin Homo sapiens 12-19 8815525-5 1996 Insulin therapy is associated with precocious sodium and potassium replacement, and with gradual rehydration coupled to intensive monitoring. Potassium 57-66 insulin Homo sapiens 0-7 8674891-4 1996 SSPG correlated with the percentage decrease of branched chain amino acids, free fatty acids, and serum potassium during the insulin sensitivity test. Potassium 104-113 insulin Homo sapiens 125-132 1637215-2 1992 The hemodynamic parameters measured before and after administration of the solution, after cardiopulmonary bypass, after administration of protamine, and 3 hours after leaving the operating room showed the beneficial effect of the glucose-insulin-potassium infusion on cardiac index (+23.6% after protamine infusion) and left (+16.3% 3 hours postoperatively) and right (+47.3% after cardiopulmonary bypass) ventricular workload index with a decrease in systemic vascular resistance. Potassium 247-256 insulin Homo sapiens 239-246 8589279-4 1995 Moreover, the beta-adrenergic agonist albuterol has been shown to be a useful adjunct to insulin for acutely lowering plasma potassium. Potassium 125-134 insulin Homo sapiens 89-96 7881352-11 1994 The potassium elevation was treated successfully with hyperventilation, calcium chloride, sodium bicarbonate, glucose, and insulin. Potassium 4-13 insulin Homo sapiens 123-130 8039040-17 1994 The reduction of potassium was significantly correlated with the elevation of insulin (i.v. Potassium 17-26 insulin Homo sapiens 78-85 7692419-6 1993 The sequence of changes suggests that the decrease of potassium and magnesium after ventricular tachycardia was due to a shift of the electrolytes into cells, related to the insulin-mediated movement of glucose from the blood into cells. Potassium 54-63 insulin Homo sapiens 174-181 8433561-4 1993 We tested the hypothesis that the infusion of physiologic doses of insulin prevents fasting hyperkalemia in hemodialysis patients, both by a direct stimulation of extrarenal potassium disposal, as well as by augmenting the potassium-lowering effect of epinephrine. Potassium 174-183 insulin Homo sapiens 67-74 8433561-4 1993 We tested the hypothesis that the infusion of physiologic doses of insulin prevents fasting hyperkalemia in hemodialysis patients, both by a direct stimulation of extrarenal potassium disposal, as well as by augmenting the potassium-lowering effect of epinephrine. Potassium 223-232 insulin Homo sapiens 67-74 8852501-5 1996 Intravenous infusion of insulin and glucose (5 mU/kg/min for 60 min) significantly lowered plasma potassium from 6.3 +/- 0.1 to 5.7 +/- 0.1 mEq/l (p < 0.01). Potassium 98-107 insulin Homo sapiens 24-31 8852501-6 1996 The combined infusion of bicarbonate and insulin with glucose showed the greatest decline in plasma potassium, from 6.2 +/- 0.2 to 5.2 +/- 0.1 mEq/l (p < 0.01). Potassium 100-109 insulin Homo sapiens 41-48 8520522-5 1995 Interestingly, the reduction in serum potassium levels during the ITT was also lower in the patients than in the controls (0.6 +/- 0.06 mEq/l vs 1.06 +/- 0.07 mEq/l, P < 0.05), suggesting that the insulin resistance observed in psoriasis is not only related to glucose metabolism, but also to another important action of insulin, namely extrarenal potassium homeostasis. Potassium 38-47 insulin Homo sapiens 200-207 8520522-5 1995 Interestingly, the reduction in serum potassium levels during the ITT was also lower in the patients than in the controls (0.6 +/- 0.06 mEq/l vs 1.06 +/- 0.07 mEq/l, P < 0.05), suggesting that the insulin resistance observed in psoriasis is not only related to glucose metabolism, but also to another important action of insulin, namely extrarenal potassium homeostasis. Potassium 38-47 insulin Homo sapiens 324-331 7919903-1 1994 OBJECTIVE: The goal of this study was to examine the metabolic and hemodynamic effects of a glucose-insulin-potassium infusion in elective coronary surgery, when blood cardioplegia was used for cardiac protection. Potassium 108-117 insulin Homo sapiens 100-107 8206564-8 1994 After treatment, intracellular potassium and magnesium were both associated with higher serum insulin (P < .001 for each), and serum potassium was associated with higher and serum magnesium with lower serum glucose (P < .01 for each). Potassium 31-40 insulin Homo sapiens 94-101 8141164-3 1994 In essential hypertensive subjects, intracellular potassium is decreased and intracellular sodium increased, which is consistent with insulin resistance. Potassium 50-59 insulin Homo sapiens 134-141 8086322-4 1994 Interest has been expressed on the influence of diuretic induced hypokalemia (and intracellular potassium deficiency) in inducing insulin resistance. Potassium 96-105 insulin Homo sapiens 130-137 8285977-3 1994 Increased serum glucose and insulin may also contribute to the intracellular shift of potassium after sympathomimetic use. Potassium 86-95 insulin Homo sapiens 28-35 7700069-6 1994 The effects of angiotensin-converting enzyme inhibition on insulin sensitivity and glucose tolerance are reviewed in the context of the glucose-potassium cycle. Potassium 144-153 insulin Homo sapiens 59-66 8403806-11 1993 In addition, whereas the glycaemic profile was superimposable, the response of the plasma insulin concentration was significantly greater with than without maintenance of the plasma potassium concentration (total area 79 +/- 14 versus 63 +/- 8 nmol l-1 3 h, P < 0.04). Potassium 182-191 insulin Homo sapiens 90-97 8403806-13 1993 We conclude that (a) insulin causes antinatriuresis, antikaliuresis and hypokalaemia under physiological conditions; (b) in hyperinsulinaemic (insulin-resistant) patients with essential hypertension, the antinatriuretic action of insulin is quantitatively preserved; and (c) clamping plasma potassium levels prevents insulin-induced antikaliuresis but not antinatriuresis, and potentiates the insulin secretory response to glucose. Potassium 291-300 insulin Homo sapiens 21-28 8498392-2 1993 Insulin is known to stimulate this disposal by enhancing potassium uptake into the cells. Potassium 57-66 insulin Homo sapiens 0-7 8498392-3 1993 Since dietary potassium is generally ingested in combination with carbohydrates, the predictable stimulation of endogenous insulin release may blunt the expected increase in plasma potassium. Potassium 14-23 insulin Homo sapiens 123-130 8498392-3 1993 Since dietary potassium is generally ingested in combination with carbohydrates, the predictable stimulation of endogenous insulin release may blunt the expected increase in plasma potassium. Potassium 181-190 insulin Homo sapiens 123-130 8498392-8 1993 On a separate study day, the subjects underwent the identical protocol, with the addition of 50 g of oral glucose to the potassium load to stimulate endogenous insulin release. Potassium 121-130 insulin Homo sapiens 160-167 8498392-16 1993 CONCLUSIONS: Exogenous glucose, by stimulating endogenous secretion of insulin, enhances extrarenal disposal of a potassium load. Potassium 114-123 insulin Homo sapiens 71-78 8488854-12 1993 In the responders, fasting potassium levels at baseline were directly related to the decrease in BP (p < 0.01) and to the improvement of glucose-induced insulin response (p < 0.04) achieved after treatment. Potassium 27-36 insulin Homo sapiens 156-163 8488854-13 1993 Thus, the therapeutic effect of ACE inhibition is in part related to fractional potassium excretion, which, in turn, affects glucose tolerance through the influence of potassium levels on glucose-induced insulin release. Potassium 80-89 insulin Homo sapiens 204-211 8488854-13 1993 Thus, the therapeutic effect of ACE inhibition is in part related to fractional potassium excretion, which, in turn, affects glucose tolerance through the influence of potassium levels on glucose-induced insulin release. Potassium 168-177 insulin Homo sapiens 204-211 8466068-0 1993 Insulin decreases the serum potassium concentration during the anhepatic stage of liver transplantation. Potassium 28-37 insulin Homo sapiens 0-7 8466068-2 1993 The effectiveness of insulin in decreasing serum potassium concentration during the anhepatic stage of orthotopic liver transplantation was investigated. Potassium 49-58 insulin Homo sapiens 21-28 8466068-9 1993 CONCLUSIONS: In patients undergoing orthotopic liver transplantation, the administration of insulin rapidly decreases serum potassium concentration, even in the absence of the liver, suggesting an important contribution by extrahepatic tissues in the insulin-stimulated uptake of potassium. Potassium 124-133 insulin Homo sapiens 92-99 8466068-9 1993 CONCLUSIONS: In patients undergoing orthotopic liver transplantation, the administration of insulin rapidly decreases serum potassium concentration, even in the absence of the liver, suggesting an important contribution by extrahepatic tissues in the insulin-stimulated uptake of potassium. Potassium 124-133 insulin Homo sapiens 251-258 8466068-9 1993 CONCLUSIONS: In patients undergoing orthotopic liver transplantation, the administration of insulin rapidly decreases serum potassium concentration, even in the absence of the liver, suggesting an important contribution by extrahepatic tissues in the insulin-stimulated uptake of potassium. Potassium 280-289 insulin Homo sapiens 92-99 8466068-9 1993 CONCLUSIONS: In patients undergoing orthotopic liver transplantation, the administration of insulin rapidly decreases serum potassium concentration, even in the absence of the liver, suggesting an important contribution by extrahepatic tissues in the insulin-stimulated uptake of potassium. Potassium 280-289 insulin Homo sapiens 251-258 8381931-4 1993 Insulin infusion reduced both the absolute and fractional urinary excretion rates of sodium (P < 0.001) and potassium (P < 0.001); these effects of insulin were not altered after converting enzyme inhibition. Potassium 111-120 insulin Homo sapiens 0-7 8381931-4 1993 Insulin infusion reduced both the absolute and fractional urinary excretion rates of sodium (P < 0.001) and potassium (P < 0.001); these effects of insulin were not altered after converting enzyme inhibition. Potassium 111-120 insulin Homo sapiens 154-161 1637215-6 1992 The data reflect the beneficial effect associated with the action of glucose-insulin-potassium on myocardial protection during heart operations and were confirmed by the hemodynamic results. Potassium 85-94 insulin Homo sapiens 77-84 1637215-5 1992 Laboratory tests showed that postoperative hypoglycemia was more common in the glucose-insulin-potassium group but had no detrimental effects; it no longer occurs since we began administering the glucose infusion at 15 g/h over 8 hours. Potassium 95-104 insulin Homo sapiens 87-94 1284139-8 1992 Other actions of insulin, such as the transport of ions, (e.g., sodium and potassium), synthesis of insulin-like growth factor-binding proteins, translocation of transporter proteins, and regulation of enzyme activities, are much more difficult to quantify. Potassium 75-84 insulin Homo sapiens 17-24 1619503-0 1992 Potassium as a link between insulin and the renin-angiotensin-aldosterone system. Potassium 0-9 insulin Homo sapiens 28-35 1619503-2 1992 EFFECTS ON INSULIN: Insulin is a potent stimulus for hypokalaemia, sparing body potassium from urinary excretion by transporting it into cells. Potassium 80-89 insulin Homo sapiens 11-18 1619503-2 1992 EFFECTS ON INSULIN: Insulin is a potent stimulus for hypokalaemia, sparing body potassium from urinary excretion by transporting it into cells. Potassium 80-89 insulin Homo sapiens 20-27 1619503-3 1992 Potassium also appears to play a key role in the antinatriuretic effect of insulin. Potassium 0-9 insulin Homo sapiens 75-82 1619503-5 1992 In turn, the renin-angiotensin-aldosterone system affects glucose tolerance by modulating plasma potassium levels, which act as a stimulus for glucose-induced insulin release. Potassium 97-106 insulin Homo sapiens 159-166 1619503-11 1992 Through the potential effects on blood pressure control, plasma levels of potassium represent a link between insulin and blood pressure in humans. Potassium 74-83 insulin Homo sapiens 109-116 1793613-0 1991 Impaired insulin mediated potassium uptake in adolescents with IDDM. Potassium 26-35 insulin Homo sapiens 9-16 1477029-6 1992 This finding suggests that osmotic mechanisms with various degree of well known abnormal insulin secretion and resistance to insulin action in target tissues in NIDDM patients may account for these heterogeneous responses in serum potassium changes after glucose load, and normal aldosterone levels may not be sufficient to prevent glucose induced increases in serum potassium in NIDDM patients. Potassium 231-240 insulin Homo sapiens 89-96 1793613-3 1991 Insulin-mediated decrease in serum potassium (K+) and in blood urea nitrogen (BUN) concentration was evaluated in 20 adolescents with IDDM and 10 matched controls during a 3-h hyperinsulinemic (1.7 mU/kg/min)-euglycemic clamp study. Potassium 35-44 insulin Homo sapiens 0-7 1928061-5 1991 Insulin is well positioned to play an important role in the regulation of plasma potassium concentration in patients with impaired renal function. Potassium 81-90 insulin Homo sapiens 0-7 1928061-7 1991 Furthermore, stimulation of endogenous insulin by oral glucose results in a greater intracellular translocation of potassium in uremic rats than in controls. Potassium 115-124 insulin Homo sapiens 39-46 1680616-0 1991 Effects of adrenergic blockade on serum potassium changes in response to acute insulin-induced hypoglycemia in nondiabetic humans. Potassium 40-49 insulin Homo sapiens 79-86 1874934-0 1991 Insulin effects on glucose and potassium metabolism in vivo: evidence for selective insulin resistance in humans. Potassium 31-40 insulin Homo sapiens 0-7 1874934-1 1991 UNLABELLED: The effects of insulin on in vivo glucose use and potassium uptake in healthy humans are well documented. Potassium 62-71 insulin Homo sapiens 27-34 1874934-9 1991 These results indicate that: 1) patients with AN are resistant to insulin action on glucose use, 2) AN patients have a normal response to insulin on potassium uptake, 3) HK is a patient with normal response to insulin on glucose use, and 4) this patient is resistant to insulin action on potassium uptake. Potassium 149-158 insulin Homo sapiens 138-145 1874934-9 1991 These results indicate that: 1) patients with AN are resistant to insulin action on glucose use, 2) AN patients have a normal response to insulin on potassium uptake, 3) HK is a patient with normal response to insulin on glucose use, and 4) this patient is resistant to insulin action on potassium uptake. Potassium 149-158 insulin Homo sapiens 138-145 1874934-9 1991 These results indicate that: 1) patients with AN are resistant to insulin action on glucose use, 2) AN patients have a normal response to insulin on potassium uptake, 3) HK is a patient with normal response to insulin on glucose use, and 4) this patient is resistant to insulin action on potassium uptake. Potassium 149-158 insulin Homo sapiens 138-145 1874934-10 1991 IN CONCLUSION: 1) we have demonstrated the independence of insulin action on glucose and potassium uptake in vivo, 2) we documented the existence of selective insulin resistance in the above patients, 3) we speculate, that in patients with a normal response to insulin on one parameter of its actions, and subnormal response on another parameter, a postreceptor defect rather than a receptor abnormality must exist. Potassium 89-98 insulin Homo sapiens 59-66 1680616-1 1991 OBJECTIVE: To determine the possible role of adrenergic mechanisms in mediating the fall in serum potassium concentration after intravenous injection of insulin. Potassium 98-107 insulin Homo sapiens 153-160 1823389-4 1991 The rise in urinary potassium excretion following furosemide administration was significantly lower in the presence of high insulin concentrations. Potassium 20-29 insulin Homo sapiens 124-131 1870424-5 1991 At any given insulin level, the obese individuals excreted significantly more calcium, phosphate, and potassium per minute than lean controls. Potassium 102-111 insulin Homo sapiens 13-20 1826998-6 1991 In contrast, plasma insulin response was negatively correlated with erythrocyte potassium concentration (r = 0.40, P less than 0.05). Potassium 80-89 insulin Homo sapiens 20-27 1991649-9 1991 Insulin had no effect on oxygen consumption, carbon dioxide production, and respiratory quotient in either study group, whereas it stimulated free fatty acids, glycerol, and potassium uptake to the same extent in the hypertensive and normotensive groups. Potassium 174-183 insulin Homo sapiens 0-7 1988777-0 1991 Sodium retention by insulin may depend on decreased plasma potassium. Potassium 59-68 insulin Homo sapiens 20-27 1988777-5 1991 Without potassium infusion, insulin caused a marked decrease in plasma potassium (-0.75 mmol/L), and decreased urinary sodium and potassium excretions by, approximately 38% and 65%, respectively. Potassium 71-80 insulin Homo sapiens 28-35 1988777-5 1991 Without potassium infusion, insulin caused a marked decrease in plasma potassium (-0.75 mmol/L), and decreased urinary sodium and potassium excretions by, approximately 38% and 65%, respectively. Potassium 71-80 insulin Homo sapiens 28-35 1823389-5 1991 Although we observed a slight decrease in plasma potassium levels during the equilibration phase of the clamp required before the administration of furosemide, a significantly lower increase in potassium fractional excretion indicated a direct tubular effect of insulin. Potassium 194-203 insulin Homo sapiens 262-269 1684641-3 1991 Suppression of insulin by somatostatin may have contributed to the hyperkalemia by impairing cellular potassium uptake. Potassium 102-111 insulin Homo sapiens 15-22 2266671-2 1990 There was a similar decrease in plasma potassium following either insulin with glucose (0.65 +/- 0.09 mmol/liter) or albuterol (0.66 +/- 0.12 mmol/liter), and a substantially greater fall with the combined regimen (1.21 +/- 0.19 mmol/liter, P less than 0.02 vs. either drug alone). Potassium 39-48 insulin Homo sapiens 66-73 2266671-10 1990 These observations suggest that albuterol and insulin with glucose are equally efficacious in lowering plasma potassium in uremic patients, and that the hypokalemic effects of the two drugs is additive. Potassium 110-119 insulin Homo sapiens 46-53 34167889-2 2022 One treatment approach includes intravenous (IV) insulin to shift potassium intracellularly. Potassium 66-75 insulin Homo sapiens 49-56 2141843-4 1990 Transmembrane potassium distribution is influenced largely by acid-base equilibrium and hormones including insulin and catecholamines. Potassium 14-23 insulin Homo sapiens 107-114 2283639-2 1990 Major findings include a positive correlation between glucose/insulin ratio and serum potassium (P = 0.0014) and a weaker negative correlation between fasting insulin and serum potassium (P = 0.004). Potassium 86-95 insulin Homo sapiens 62-69 2181872-2 1990 Insulin, epinephrine, and aldosterone all play major roles in maintaining the normal distribution of potassium between the intracellular and extracellular environment. Potassium 101-110 insulin Homo sapiens 0-7 2155002-8 1990 Alternatively, insulin might alter sodium/potassium distribution thus causing increased vascular peripheral resistance. Potassium 42-51 insulin Homo sapiens 15-22 2336813-5 1990 The trend of rising potassium levels must be foreseen in case of a poor compensation even in case of insulin treatment of diabetes. Potassium 20-29 insulin Homo sapiens 101-108 2248802-6 1990 The potassium content of the serum of the diabetics was significantly decreased by insulin administration. Potassium 4-13 insulin Homo sapiens 83-90 34873512-7 2021 As her ketonemia resolved, she was initiated on subcutaneous insulin with a small but acceptable decrease in potassium. Potassium 109-118 insulin Homo sapiens 61-68 34686554-11 2021 By multivariable regression, on average, liver cirrhosis was associated with a reduced potassium lowering effect of 0.42 mmol/L (95% CI 0.22 to 0.63 mmol/L, p<0.001) from insulin-glucose treatment, after adjusting for age, serum creatinine, cancer, pretreatment potassium level, beta-blocker use and cotreatments (sodium polystyrene sulfonate, salbutamol, sodium bicarbonate). Potassium 87-96 insulin Homo sapiens 171-178 34686554-11 2021 By multivariable regression, on average, liver cirrhosis was associated with a reduced potassium lowering effect of 0.42 mmol/L (95% CI 0.22 to 0.63 mmol/L, p<0.001) from insulin-glucose treatment, after adjusting for age, serum creatinine, cancer, pretreatment potassium level, beta-blocker use and cotreatments (sodium polystyrene sulfonate, salbutamol, sodium bicarbonate). Potassium 262-271 insulin Homo sapiens 171-178 34597356-5 2022 Using intravenous (IV) insulin to shift potassium intracellularly may cause hypoglycemia, requiring additional treatment or longer hospitalization. Potassium 40-49 insulin Homo sapiens 23-30 34597356-14 2022 CONCLUSION: Administration of reduced-dose IV insulin for treatment of hyperkalemia was significantly less effective in lowering serum potassium levels and did not decrease prevalence of hypoglycemia. Potassium 135-144 insulin Homo sapiens 46-53 34348722-12 2021 OGTT showed that her glucose metabolism and insulin resistance much improved after potassium and magnesium supplemental therapy. Potassium 83-92 insulin Homo sapiens 44-51 34334139-5 2021 These actions of sodium, potassium and magnesium and other minerals, trace elements and vitamins are likely to be secondary to their action on pro-inflammatory cytokines IL-6, TNF-alpha and IL-17 and metabolism of essential fatty acids that may account for their involvement in the pathobiology of insulin resistance, T2DM, HTN and autoimmune diseases. Potassium 25-34 insulin Homo sapiens 298-305 34167889-10 2022 However, lower insulin doses provide a similar potassium-lowering effect and cause a meaningful decrease in hypoglycaemic episodes. Potassium 47-56 insulin Homo sapiens 15-22 35194770-4 2022 Glucose- and potassium-stimulated insulin secretion assays were performed to assess beta-cell function. Potassium 13-22 insulin Homo sapiens 34-41 35578361-7 2022 The usage of infusion of glucose-insulin-potassium in rice tablet poisoning has been suggested, after its positive beneficial cardiac inotropic effects in patients with beta-blocker and calcium channel blocker poisoning. Potassium 41-50 insulin Homo sapiens 33-40 35578361-9 2022 In contrast to our previous experiences, in which nearly all patients with critical aluminum phosphide poisoning died, this patient was saved with glucose-insulin-potassium. Potassium 163-172 insulin Homo sapiens 155-162 35494963-2 2022 As the correction of acidosis and insulin drive potassium intracellularly, measured serum potassium levels decrease and require repletion. Potassium 48-57 insulin Homo sapiens 34-41 35494963-2 2022 As the correction of acidosis and insulin drive potassium intracellularly, measured serum potassium levels decrease and require repletion. Potassium 90-99 insulin Homo sapiens 34-41 35058093-4 2022 OBJECTIVE: Describe the incidence of hypoglycemia and relative change in serum potassium when using 5 vs. 10 units of insulin for hyperkalemia in patients with moderate renal dysfunction. Potassium 79-88 insulin Homo sapiens 118-125 35058093-20 2022 insulin lowered serum potassium significantly more than 5 units of i.v. Potassium 22-31 insulin Homo sapiens 0-7 35386772-10 2022 When TG levels spiked again, the patient was put on an insulin infusion with heparin, glucose, and potassium to rapidly reduce TG level. Potassium 99-108 insulin Homo sapiens 55-62 2665998-10 1989 The serum immunoreactive insulin (IRI) was elevated from the basal level to 289 microU/l, showing the prominent peak response at 30 min after the load, and both the serum potassium and the grasping power decreased significantly, although the blood glucose fluctuated within the normal level. Potassium 171-180 insulin Homo sapiens 25-32 2677612-3 1989 Compared with bed-rested controls, the septic patients showed an insulin-induced plasma clearance of potassium, which was 183% higher (P less than .001), and a concomitant glucose clearance, which was 52% lower (P less than .001). Potassium 101-110 insulin Homo sapiens 65-72 2677612-8 1989 It is concluded that septic and postburn insulin resistance differ in that peripheral glucose uptake in sepsis, but not nonseptic burn injury, is refractory to pharmacologic insulin stimulation, whereas in both states insulin effectively stimulates potassium uptake. Potassium 249-258 insulin Homo sapiens 41-48 2668254-6 1989 Insulin action on glucose uptake and tyrosine release of the thighs at mean plasma insulin concentrations of 67 (clamp step I) and 447 microU/ml (clamp step II) was decreased by immobilization, whereas immobilization did not affect insulin action on thigh exchange of free fatty acids, glycerol, O2, or potassium. Potassium 303-312 insulin Homo sapiens 0-7 2496078-4 1989 Furthermore, prior contractions directed glucose uptake toward glycogen synthesis and increased insulin effects on thigh O2 consumption and at some insulin concentrations on potassium exchange. Potassium 174-183 insulin Homo sapiens 148-155 3052050-8 1988 On the other hand, insulin in glucose, 5 mU/kg/minute intravenously, effectively lowered plasma potassium levels from 5.62 to 4.70 mmol/liter, and hemodialysis induced the most rapid decline from 5.63 to 4.29 mmol/liter. Potassium 96-105 insulin Homo sapiens 19-26 2682302-6 1989 Basal insulin levels were higher in the CRF patients and increased with the oral potassium and carbohydrate load in both controls and patients. Potassium 81-90 insulin Homo sapiens 6-13 2849310-1 1988 Insulin promotes potassium uptake into skeletal muscle by stimulating the activity of the Na+-K+ pump. Potassium 17-26 insulin Homo sapiens 0-7 2849310-7 1988 Under these conditions of fixed flow (7.0 +/- 0.8 ml.min-1.100 ml-1), ouabain still abolished the stimulatory effect of insulin on potassium uptake but had only a small (and statistically insignificant) effect on forearm glucose extraction (from 20 +/- 2 to 16 +/- 2%, P = N>). Potassium 131-140 insulin Homo sapiens 120-127 3057941-0 1988 Hyperkalemic cardiac arrest after cardiac surgery following high-dose glucose-insulin-potassium infusion for inotropic support. Potassium 86-95 insulin Homo sapiens 78-85 3073091-4 1988 These data suggest that potassium metabolism plays a critical role in the mechanisms of insulin sensitivity. Potassium 24-33 insulin Homo sapiens 88-95 2694763-5 1989 The most important hormones involved in the regulation of internal potassium balance are the catecholamines, insulin and aldosterone. Potassium 67-76 insulin Homo sapiens 109-116 2563217-2 1989 We considered that terbutaline-induced hypokalemia may be due to the insulin-induced shift of potassium (K+) from the extracellular to the intracellular space. Potassium 94-103 insulin Homo sapiens 69-76 2695195-0 1989 Peripheral muscle glucose and potassium transport in a family with acanthosis nigricans and insulin resistance. Potassium 30-39 insulin Homo sapiens 92-99 2695195-1 1989 This study was designed to determine the forearm exchange of glucose and potassium in four members of a family exhibiting acanthosis nigricans and insulin resistance. Potassium 73-82 insulin Homo sapiens 147-154 2695195-4 1989 In the latter patient, the dissociation observed between glucose and potassium transport suggests several manners of differential impairment of insulin action and/or steps distal to the insulin receptor as being responsible for insulin resistance. Potassium 69-78 insulin Homo sapiens 144-151 3068066-3 1988 Incubation of neurointermediate lobes in Locke"s solution containing 3.3 mumol/l insulin resulted in an inhibition of oxytocin release under resting conditions as well as in a decrease of both vasopressin and oxytocin release during depolarization due to excess potassium. Potassium 262-271 insulin Homo sapiens 81-88 3046411-2 1988 In a prospective randomised study in 20 insulin-dependent diabetics who had minor surgery under general anaesthesia we compared the metabolic responses to intravenous glucose-insulin-potassium infusion with those who had conventional subcutaneous insulin administration. Potassium 183-192 insulin Homo sapiens 175-182 3447811-3 1987 One group received 20 mmol/l potassium chloride in the dextrose infusate, calculated to replace the extracellular potassium deficit due to the action of insulin on potassium flux. Potassium 29-38 insulin Homo sapiens 153-160 3277011-1 1988 The ability of insulin to promote extrarenal potassium uptake and to stimulate glucose uptake was examined in eight obese and ten normal weight control subjects. Potassium 45-54 insulin Homo sapiens 15-22 3277011-3 1988 Insulin-mediated potassium, as well as glucose uptake, was diminished during the lowest dose insulin clamp study (100 microU/mL) but could be normalized at pharmacologic plasma insulin concentrations. Potassium 17-26 insulin Homo sapiens 0-7 3277011-3 1988 Insulin-mediated potassium, as well as glucose uptake, was diminished during the lowest dose insulin clamp study (100 microU/mL) but could be normalized at pharmacologic plasma insulin concentrations. Potassium 17-26 insulin Homo sapiens 93-100 3277011-4 1988 These results indicate that obese subjects are resistant to the ability of insulin to stimulate potassium uptake by extrarenal tissues. Potassium 96-105 insulin Homo sapiens 75-82 3277011-5 1988 Impaired potassium uptake at physiologic plasma insulin levels, with normalization at supraphysiologic insulin concentrations, is most consistent with a decrease in the number of insulin receptors on insulin target tissues. Potassium 9-18 insulin Homo sapiens 48-55 3277011-5 1988 Impaired potassium uptake at physiologic plasma insulin levels, with normalization at supraphysiologic insulin concentrations, is most consistent with a decrease in the number of insulin receptors on insulin target tissues. Potassium 9-18 insulin Homo sapiens 103-110 3277011-5 1988 Impaired potassium uptake at physiologic plasma insulin levels, with normalization at supraphysiologic insulin concentrations, is most consistent with a decrease in the number of insulin receptors on insulin target tissues. Potassium 9-18 insulin Homo sapiens 103-110 3277011-5 1988 Impaired potassium uptake at physiologic plasma insulin levels, with normalization at supraphysiologic insulin concentrations, is most consistent with a decrease in the number of insulin receptors on insulin target tissues. Potassium 9-18 insulin Homo sapiens 103-110 3075149-3 1988 Insulin without affecting the filtration rate of creatinine and the urine flow rate resulted in significant increases in urinary calcium (3.56 +/- 0.80 vs. 7.48 +/- 0.80 mumol/min/1.73 m2) and magnesium (2.44 +/- 0.41 vs. 4.29 +/- 0.5 mumol/min/1.73 m2) and a fall in potassium excretion (53.25 +/- 13.17 vs. 23.71 +/- 4.21 mumol/min/1.73 m2). Potassium 268-277 insulin Homo sapiens 0-7 3287913-1 1988 To elucidate a potential role for insulin-mediated extra-renal potassium disposal in the clinical syndrome of hypokalemic periodic paralysis, an obese affected man was studied using the euglycemic insulin clamp, which, in normal and obese subjects, produces predictable, insulin dose-dependent declines in plasma potassium levels. Potassium 63-72 insulin Homo sapiens 34-41 3287913-2 1988 During a 20 mU/m2/minute euglycemic clamp (insulin level, 88 microU/ml) procedure, while the patient with hypokalemic periodic paralysis demonstrated severe resistance to insulin-mediated glucose uptake (glucose uptake 50 percent of that of normal control subjects, n = 17), his plasma potassium declined to a degree similar to that seen in normal subjects. Potassium 286-295 insulin Homo sapiens 171-178 3287913-3 1988 During a subsequent higher dose, 200 mU/m2/minute insulin infusion (insulin level, 914 microU/ml), plasma potassium declined to 2.5 meq/liter, a value significantly below that seen in normal (n = 19) (3.3 +/- 0.1 meq/liter) and obese (n = 6) (3.2 +/- 0.1 meq/liter) subjects. Potassium 106-115 insulin Homo sapiens 68-75 3287913-8 1988 Enhanced sensitivity of potassium uptake systems to activation by insulin (and other factors) may be a central feature of this syndrome. Potassium 24-33 insulin Homo sapiens 66-73 3277570-3 1988 Liver and muscles represent the major buffering system, partially mediated by insulin, in the distribution of potassium between intracellular and extracellular fluids. Potassium 110-119 insulin Homo sapiens 78-85 2455613-1 1988 The effects of insulin on sodium and potassium metabolism have been well known for many years; clinical observation and laboratory experience showed different results about the insulin effect on the sodium-potassium pump. Potassium 37-46 insulin Homo sapiens 15-22 3447811-4 1987 Despite this, serum potassium fell equally in both groups in response to each level of insulin infusion. Potassium 20-29 insulin Homo sapiens 87-94 3514489-7 1986 It was concluded that the interplay of various factors, CAP, upright posture and impaired renal functions resulting in suppression of aldosterone and insulin played a role in the paradoxical glucose-induced serum potassium elevation. Potassium 213-222 insulin Homo sapiens 150-157 3299096-9 1987 We conclude that this insulin resistance involves glucose but not lipid or potassium metabolism, is located in peripheral tissues but not the liver, is limited to nonoxidative pathways of intracellular glucose disposal, and is directly correlated with the severity of hypertension. Potassium 75-84 insulin Homo sapiens 22-29 3294899-3 1987 At the lowest insulin level, the Michaelis constants (Ks:s) for glucose disposal in whole body (8.7 +/- 1.1 mM) and across forearm (7.4 +/- 1.4) mM) were compatible with a Ks determined in vitro for the transport system. Potassium 54-56 insulin Homo sapiens 14-21 3294899-4 1987 At higher insulin levels, the apparent Ks increased significantly in whole body (16.2-37.7 mM) and across forearm (20.7-31.2 mM). Potassium 39-41 insulin Homo sapiens 10-17 3294899-5 1987 We interpret the apparent increase of Ks by insulin to reflect a shift in the rate-limiting step from glucose transport to some step beyond transport. Potassium 38-40 insulin Homo sapiens 44-51 3516300-4 1986 Glucose insulin potassium infusion (GIK) resulted in lower plasma nonesterified fatty acid, and blood 3-hydroxybutyrate and glycerol concentrations, with markedly higher serum insulin levels compared to patients managed with a "no insulin" regimen. Potassium 16-25 insulin Homo sapiens 8-15 3516300-4 1986 Glucose insulin potassium infusion (GIK) resulted in lower plasma nonesterified fatty acid, and blood 3-hydroxybutyrate and glycerol concentrations, with markedly higher serum insulin levels compared to patients managed with a "no insulin" regimen. Potassium 16-25 insulin Homo sapiens 176-183 3673912-5 1987 These results with a hypertonic glucose infusion are similar to those reported after infusion of glucose-insulin-potassium without the potential for harmful adverse effects from infusions of insulin or potassium. Potassium 113-122 insulin Homo sapiens 105-112 3296457-3 1987 Treatment with parenteral insulin alone resulted in a decrease of the serum glucose value from 41 +/- 14 (standard deviation) to 11 +/- 5 mmol per liter (P <.001) and of serum potassium level from 5.2 +/- 1.2 to 4.0 +/- 0.6 mmol per liter (P <.001). Potassium 179-188 insulin Homo sapiens 26-33 3028812-5 1987 The increased plasma levels of insulin, but also of catecholamines and growth hormone, created a condition promoting potassium uptake in muscle cells. Potassium 117-126 insulin Homo sapiens 31-38 2936967-4 1985 In the literature there is evidence for an increased sensitivity of the muscle membrane to insulin with an increased potassium-shift inside the cell in hypokalaemic periodic paralysis. Potassium 117-126 insulin Homo sapiens 91-98 6441716-0 1984 Effects of potassium supplementation on insulin binding and insulin action in human obesity: protein-modified fast and refeeding. Potassium 11-20 insulin Homo sapiens 40-47 2988116-3 1985 Among the regulatory processes of internal potassium balance, the importance of adrenergic stimuli/drugs, of acid-base balance, and of magnesium and insulin is stressed. Potassium 43-52 insulin Homo sapiens 149-156 3908322-3 1985 On the other hand, the insulin-induced shift of potassium into the cell interior is transient and appears to be of little consequence for long-term blood pressure control. Potassium 48-57 insulin Homo sapiens 23-30 3003299-5 1985 In control studies there was a profound fall in serum glucose and plasma potassium after insulin, associated with increments in plasma renin activity, which correlated with those of aldosterone but not with those of ACTH and cortisol. Potassium 73-82 insulin Homo sapiens 89-96 3003299-7 1985 During converting enzyme inhibition the insulin-induced decrements in glucose and potassium, as well as the increments in ACTH, cortisol and aldosterone, were similar to those observed in control studies, whereas the increments in plasma renin activity were much greater. Potassium 82-91 insulin Homo sapiens 40-47 2412077-1 1985 The stimulation of insulin secretion from the beta cells of the islets of Langerhans appears to be mediated by a decrease in the cell-membrane potassium-ion permeability. Potassium 143-152 insulin Homo sapiens 19-26 3926198-3 1985 The mean (SD) serum potassium concentration on presentation to hospital with ketoacidosis was significantly higher in patients treated with a pump (5.7 (1.1) mmol(mEq)/l) than those treated with conventional injections of insulin (4.9(0.9) mmol/l; p less than 0.01). Potassium 20-29 insulin Homo sapiens 222-229 3926504-0 1985 Insulin in vivo increases the in vitro fall of plasma potassium concentration in human venous blood. Potassium 54-63 insulin Homo sapiens 0-7 3926504-2 1985 Blood obtained 15 min after the intravenous administration of insulin (0.67 nmol kg-1 body weight) and incubated under the same conditions showed a significantly greater fall in the mean plasma potassium concentration of 0.33 mmol l-1 (SEM 0.09, P less than 0.05, n = 6). Potassium 194-203 insulin Homo sapiens 62-69 3926504-4 1985 The transfer of plasma from pre-insulin blood samples to blood cells obtained 15 min after insulin administration and vice versa indicated that the fall in plasma potassium concentration was a property of the 15 min post-insulin blood cells, presumably erythrocytes, rather than the plasma. Potassium 163-172 insulin Homo sapiens 32-39 3926504-4 1985 The transfer of plasma from pre-insulin blood samples to blood cells obtained 15 min after insulin administration and vice versa indicated that the fall in plasma potassium concentration was a property of the 15 min post-insulin blood cells, presumably erythrocytes, rather than the plasma. Potassium 163-172 insulin Homo sapiens 91-98 3926504-4 1985 The transfer of plasma from pre-insulin blood samples to blood cells obtained 15 min after insulin administration and vice versa indicated that the fall in plasma potassium concentration was a property of the 15 min post-insulin blood cells, presumably erythrocytes, rather than the plasma. Potassium 163-172 insulin Homo sapiens 91-98 6441716-0 1984 Effects of potassium supplementation on insulin binding and insulin action in human obesity: protein-modified fast and refeeding. Potassium 11-20 insulin Homo sapiens 60-67 6441716-3 1984 The maintenance of normal potassium balance and normal serum potassium levels with oral potassium-chloride supplementation was associated with higher peripheral levels of insulin (P less than 0.01) and improvement of peripheral glucose utilization (P less than 0.01) whereas the binding of insulin to monocytes was unchanged. Potassium 26-35 insulin Homo sapiens 171-178 6441716-3 1984 The maintenance of normal potassium balance and normal serum potassium levels with oral potassium-chloride supplementation was associated with higher peripheral levels of insulin (P less than 0.01) and improvement of peripheral glucose utilization (P less than 0.01) whereas the binding of insulin to monocytes was unchanged. Potassium 61-70 insulin Homo sapiens 171-178 6441716-4 1984 The data suggest that potassium depletion during protein-modified fast causes a decrease of the peripheral levels of insulin and a resistance to insulin action at the postreceptors sites which is reversed by potassium supply. Potassium 22-31 insulin Homo sapiens 117-124 6441716-4 1984 The data suggest that potassium depletion during protein-modified fast causes a decrease of the peripheral levels of insulin and a resistance to insulin action at the postreceptors sites which is reversed by potassium supply. Potassium 22-31 insulin Homo sapiens 145-152 6441716-4 1984 The data suggest that potassium depletion during protein-modified fast causes a decrease of the peripheral levels of insulin and a resistance to insulin action at the postreceptors sites which is reversed by potassium supply. Potassium 208-217 insulin Homo sapiens 145-152 6395043-3 1984 The thyroid hormones, the androgens, the growth hormone and the insulin facilitate the penetration of potassium into the cells (rK+ hormones). Potassium 102-111 insulin Homo sapiens 64-71 6388326-5 1984 Cellular uptake of potassium is regulated by insulin, acid-base status, aldosterone, and adrenergic activity. Potassium 19-28 insulin Homo sapiens 45-52 6376911-5 1983 In contrast to glucose and lipid metabolism, the plasma amino acid and potassium lowering effects of insulin are normal in uremic individuals. Potassium 71-80 insulin Homo sapiens 101-108 6380335-1 1984 An assessment of continuous glucose-insulin-potassium infusion, and traditional treatment. Potassium 44-53 insulin Homo sapiens 36-43 6380335-3 1984 Twelve diabetics received continuous glucose-insulin-potassium (GIK) infusion for at least 4 hours after surgery terminated. Potassium 53-62 insulin Homo sapiens 45-52 6378152-5 1984 Patients with myotonia congenita had elevated potassium levels in the basal state and a greater fall in potassium level during the insulin clamp procedure than controls. Potassium 104-113 insulin Homo sapiens 131-138 6375230-4 1984 Serum potassium levels, however, showed a significant greater decline with infusions of porcine insulin (4.2 +/- 0.1 to 3.5 +/- 0.1 mmol/l) compared with human insulin (4.2 +/- 0.1 to 3.7 +/- 0.1 mmol/l) at 50 mU/kg/h (P less than 0.05). Potassium 6-15 insulin Homo sapiens 96-103 6375230-5 1984 Potassium levels were significantly lower during the porcine insulin infusion at 105 and 120 min and at 15 and 30 min after stopping the infusion. Potassium 0-9 insulin Homo sapiens 61-68 6375230-8 1984 Thus a small but significant greater decline in potassium levels with similar glucose requirements was found during iv administration of porcine insulin compared with human insulin. Potassium 48-57 insulin Homo sapiens 145-152 6375445-1 1984 Use of continuous intravenous insulin-glucose-potassium infusions. Potassium 46-55 insulin Homo sapiens 30-37 6142577-7 1984 Since insulin opposes the increase in serum potassium by stimulating cellular uptake of this cation, the enhanced rise in serum potassium in response to arginine hydrochloride during the SS-28 infusion is likely due to the potent insulin suppressing effect of SS-28. Potassium 128-137 insulin Homo sapiens 230-237 6371371-5 1984 Under basal conditions the acute increase in plasma glucose and insulin after glucose loading was accompanied by a significant decrease (P less than 0.01) in plasma cortisol and aldosterone and by a significant increase in plasma renin activity (P less than 0.01); plasma potassium was decreased slightly but not significantly. Potassium 272-281 insulin Homo sapiens 64-71 6364842-0 1984 Insulin-mediated potassium uptake is normal in uremic and healthy subjects. Potassium 17-26 insulin Homo sapiens 0-7 6364842-1 1984 We examined the ability of physiological hyperinsulinemia to enhance potassium and glucose uptake by splanchnic and peripheral tissues in 12 chronically uremic subjects by using the euglycemic insulin clamp technique in combination with hepatic and femoral venous catheterization. Potassium 69-78 insulin Homo sapiens 46-53 6364842-6 1984 These results indicate that insulin-mediated potassium uptake is not altered by uremia. Potassium 45-54 insulin Homo sapiens 28-35 6325904-4 1984 On exposure to a 1-mM potassium solution, with or without insulin, the cells depolarized to about -50 mV, and became inexcitable. Potassium 22-31 insulin Homo sapiens 58-65 6398960-0 1984 Influence of electrolyte depletion and aldosterone on insulin induced changes in plasma concentration and renal excretion of sodium and potassium. Potassium 136-145 insulin Homo sapiens 54-61 6367467-0 1984 Plasma potassium changes in anuric hyperglycemia treated with insulin. Potassium 7-16 insulin Homo sapiens 62-69 6367467-7 1984 CONCLUSIONS: When only parenteral insulin is used for treatment and acid-base balances and body weights do not change during treatment in anuric hyperglycemia: a) The change in potassium concentration is dependent on the starting plasma potassium concentration, b) hyperkalemic patients will drop their plasma potassium concentration toward normal, and c) hypokalemic patients may not need potassium replacement. Potassium 177-186 insulin Homo sapiens 34-41 7040195-4 1982 Human insulin produced a significantly smaller decrease in serum potassium (2p less than 0.01). Potassium 65-74 insulin Homo sapiens 6-13 7042430-7 1982 Since the diabetic subjects were found to have an intact insulin response to the glucose load, it is suggested that resistance to insulin-stimulated potassium uptake into cells might be involved in the pathogenesis of the paradoxical hyperkalaemia induced by acute hyperglycaemia. Potassium 149-158 insulin Homo sapiens 130-137 6398959-0 1984 Effects of insulin on plasma concentration and renal excretion of sodium and potassium. Potassium 77-86 insulin Homo sapiens 11-18 6132848-3 1983 After insulin withdrawal during the saline infusion, glucose and potassium levels rose markedly (delta maximum: glucose, 12.0 +/- 1.5 mmol/l; potassium, 0.73 +/- 0.12 mmol/l), while glucagon showed a slight, but significant increment (delta maximum: 10.6 +/- 1.0 pmol/ml, p less than 0.05). Potassium 65-74 insulin Homo sapiens 6-13 6765549-0 1982 Less pronounced changes in serum potassium and epinephrine during hypoglycemia induced by human insulin (recombinant DNA). Potassium 33-42 insulin Homo sapiens 96-103 6765549-4 1982 The differences in serum potassium concentrations are caused by a lower epinephrine response to hypoglycemia induced by human insulin in comparison to purified porcine insulin. Potassium 25-34 insulin Homo sapiens 126-133 7051887-1 1982 Use of continuous intravenous infusion of insulin-glucose-potassium solution. Potassium 58-67 insulin Homo sapiens 42-49 6761199-0 1982 Regulation of serum potassium during insulin-induced hypoglycemia. Potassium 20-29 insulin Homo sapiens 37-44 6761199-2 1982 Under these conditions (minimal plasma glucose 27.4 +/- 1 mg/dl) the decrease of serum potassium concentration (0.9 mVal/L) is mediated by two mechanisms: insulin-induced (0.48 mVal/L) and epinephrine-induced (0.42 mVal/L) cellular uptake of potassium. Potassium 87-96 insulin Homo sapiens 155-162 6761199-2 1982 Under these conditions (minimal plasma glucose 27.4 +/- 1 mg/dl) the decrease of serum potassium concentration (0.9 mVal/L) is mediated by two mechanisms: insulin-induced (0.48 mVal/L) and epinephrine-induced (0.42 mVal/L) cellular uptake of potassium. Potassium 242-251 insulin Homo sapiens 155-162 6751813-4 1982 The lowest level of potassium (3.39 +/- 0.09 mval/l) is observed 45 min following insulin application. Potassium 20-29 insulin Homo sapiens 82-89 6124125-0 1982 Potassium homeostasis during hyperinsulinemia: effect of insulin level, beta-blockade, and age. Potassium 0-9 insulin Homo sapiens 34-41 6124125-6 1982 These results suggest the presence of a regulatory mechanism influencing insulin-mediated alterations in plasma potassium. Potassium 112-121 insulin Homo sapiens 73-80 6123453-1 1982 This study was made to investigate the mechanisms of the changes in serum potassium during a period of insulin-induced hypoglycemia. Potassium 74-83 insulin Homo sapiens 103-110 6123453-2 1982 The following experiments were performed: I) A relationship was observed between the amount of insulin dosage and the levels of serum potassium, blood sugar, and plasma cyclic AMP or plasma cyclic GMP in normal controls and rats. Potassium 134-143 insulin Homo sapiens 95-102 6123453-11 1982 The results obtained were as follows: 1) There was a significant logarithmic dose-response relationship between insulin dose and maximum per cent decrease in serum potassium, and maximum per cent increase in plasma cyclic AMP. Potassium 164-173 insulin Homo sapiens 112-119 6123453-12 1982 (p less than 0.02 approximately 0.01) 2) A significant positive correlation was observed between the maximum per cent decrease in serum potassium and the maximum per cent increase in plasma cyclic AMP during the period of insulin-induced hypoglycemia. Potassium 136-145 insulin Homo sapiens 222-229 6123453-17 1982 These results may indicate that a decrease of serum potassium levels during the period of insulin-induced hypoglycemia in both the early and late phases is caused by different mechanisms. Potassium 52-61 insulin Homo sapiens 90-97 6123453-19 1982 It was suggested that beta-adrenoreceptor play a role in a decrease of serum potassium, especially 30 minutes after a injection of insulin. Potassium 77-86 insulin Homo sapiens 131-138 6987815-2 1980 Multiple factors, including the level of renal function, acid base status, activity of the renin-angiotension-aldosterone system, and the availability of insulin, normally interact to control the serum potassium concentration. Potassium 202-211 insulin Homo sapiens 154-161 7295860-2 1981 In two normaldosteronemic insulin-dependent diabetic patients during high sodium intake and insulin withdrawal infusion of hypertonic glucose induced a paradoxical elevation of serum potassium levels, while no such abnormalities were found in two other diabetics despite of lower plasma aldosterone levels. Potassium 183-192 insulin Homo sapiens 26-33 7295860-2 1981 In two normaldosteronemic insulin-dependent diabetic patients during high sodium intake and insulin withdrawal infusion of hypertonic glucose induced a paradoxical elevation of serum potassium levels, while no such abnormalities were found in two other diabetics despite of lower plasma aldosterone levels. Potassium 183-192 insulin Homo sapiens 92-99 7009278-4 1981 The paradoxical rise in serum potassium with hyperglycemia was corrected in all by concomitant administration of insulin or pretreatment with a mineralocorticoid. Potassium 30-39 insulin Homo sapiens 113-120 7011086-3 1981 The relevance of the concept of glucose-induced hyperkalaemia is discussed and it is suggested that intravenous infusion of insulin during and after operation might have decreased the rises in serum potassium. Potassium 199-208 insulin Homo sapiens 124-131 6990783-0 1980 Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man. Potassium 63-72 insulin Homo sapiens 26-33 6767908-6 1980 The patients of the low dose insulin infusion regimen needed less insulin, potassium and bicarbonate and reached earlier a bloodglucose level of 300 mg/dl. Potassium 75-84 insulin Homo sapiens 29-36 6756014-4 1982 By means of exogenous high insulin and potassium supply with glucose infusion the potassium-shifting is improved, the FFA-level is lowered and the incidence of arrhythmias is reduced as sinusrhythm is induced. Potassium 82-91 insulin Homo sapiens 27-34 7033089-4 1981 Human insulin produced a significantly smaller decrease in serum potassium (2p less than 0.01). Potassium 65-74 insulin Homo sapiens 6-13 6268928-6 1981 Several hormones (insulin, aldosterone, catecholamines, glucagon, and growth hormone) may have roles in internal potassium balance. Potassium 113-122 insulin Homo sapiens 18-25 6786952-6 1981 Those patients receiving insulin demonstrated a gain of total body potassium (p less than 0.001). Potassium 67-76 insulin Homo sapiens 25-32 7021278-11 1981 Insulin levels, similar to those found after a meal, rapidly reversed the effects of glucagon on non-esterified fatty acid, glucose and potassium. Potassium 136-145 insulin Homo sapiens 0-7 6111930-6 1981 Several hormones, including insulin and epinephrine, have been shown to play an important role in the maintenance of normal extrarenal potassium metabolism. Potassium 135-144 insulin Homo sapiens 28-35 6770336-3 1980 Insulin secretion in response to glucose, potassium and tolbutamide was lower in a Sr2+ than in a Ca2+ medium, even at the optimum concentration of 2.5 mmol/l. Potassium 42-51 insulin Homo sapiens 0-7 515720-6 1979 However, in the non-ketotic patients low-dose insulin therapy resulted in a delayed fall in blood glucose and distinctly diminished potassium retention. Potassium 132-141 insulin Homo sapiens 46-53 459246-6 1979 In a juvenile-onset diabetic subject, the impairment of cellular potassium uptake at higher plasma potassium was magnified so that infused potassium was virtually confined to the ECF compartment until exogenous insulin was given. Potassium 65-74 insulin Homo sapiens 211-218 459246-7 1979 This implies a permissive rather than a regulatory role for endogenous insulin in facilitating cellular entry of excess potassium. Potassium 120-129 insulin Homo sapiens 71-78 918352-2 1977 The abnormal serum potassium response developed in spite of a normal insulin release and was abolished by pharmacological doses of mineralocorticoids in two. Potassium 19-28 insulin Homo sapiens 69-76 681448-0 1978 Protection of the ischaemic myocardium by glucose-insulin-potassium infusion assessed by ventricular function and electron microscopy. Potassium 58-67 insulin Homo sapiens 50-57 647213-6 1978 In all experiments there was a direct relation between a fall in serum potassium concentration and the fall in plasma glucose concentration irrespective of the mechanism that reduced the glucose concentration.These results indicate that in uncontrolled diabetics low-dose insulin infusions lower the blood glucose concentration entirely by reducing glucose production from the liver and that the effect of insulin on potassium transport is independent of its effect on glucose uptake. Potassium 71-80 insulin Homo sapiens 272-279 647213-6 1978 In all experiments there was a direct relation between a fall in serum potassium concentration and the fall in plasma glucose concentration irrespective of the mechanism that reduced the glucose concentration.These results indicate that in uncontrolled diabetics low-dose insulin infusions lower the blood glucose concentration entirely by reducing glucose production from the liver and that the effect of insulin on potassium transport is independent of its effect on glucose uptake. Potassium 71-80 insulin Homo sapiens 406-413 647213-6 1978 In all experiments there was a direct relation between a fall in serum potassium concentration and the fall in plasma glucose concentration irrespective of the mechanism that reduced the glucose concentration.These results indicate that in uncontrolled diabetics low-dose insulin infusions lower the blood glucose concentration entirely by reducing glucose production from the liver and that the effect of insulin on potassium transport is independent of its effect on glucose uptake. Potassium 417-426 insulin Homo sapiens 272-279 620577-3 1978 In four patients the glucose-insulin-potassium solution was instilled directly into the right pulmonary artery from the tip of the Swan-Ganz catheter. Potassium 37-46 insulin Homo sapiens 29-36 145813-4 1977 Potassium stimulates insulin and aldosterone secretion and increases Na-K ATPase in the distal nephron, so promoting its own redistribution or excretion. Potassium 0-9 insulin Homo sapiens 21-28 855379-4 1977 After treatment with insulin, most of these serum levels approached the normal, except for serum potassium and magnesium. Potassium 97-106 insulin Homo sapiens 21-28 958001-4 1976 Potassium repletion resulted in improvement of the patient"s glucose tolerance test, with a decrease in the peak glucose level from 184 mg/100ml to 130 mg/100ml and an increase in the peak insulin level from 46 muU/ml to 85 muU/ml. Potassium 0-9 insulin Homo sapiens 189-196 792421-1 1976 This article briefly reviews the effects of potassium on insulin release. Potassium 44-53 insulin Homo sapiens 57-64 958001-7 1976 Insulin-induced hypoglycemia resulted in a depressed growth hormone response of 8 ng/ml when the patient was potassium-deficient, but a normal response of 30 ng/ml after potassium repletion. Potassium 109-118 insulin Homo sapiens 0-7 958001-7 1976 Insulin-induced hypoglycemia resulted in a depressed growth hormone response of 8 ng/ml when the patient was potassium-deficient, but a normal response of 30 ng/ml after potassium repletion. Potassium 170-179 insulin Homo sapiens 0-7 1247857-4 1976 The infusion produced an average fall in plasma potassium from 3-99 to 3-10 mmol/l, which was associated with an increase in plasma glucose and serum insulin, suggesting that this arose from a shift of potassium from the extracellular to the intracellular space. Potassium 202-211 insulin Homo sapiens 150-157 937206-3 1976 The glucose-insulin-potassium solution was composed of 300 g of glucose, 50 units of regular insulin and 80 mEq of potassium ion per liter, and was infused at a rate of 1.5 ml/kg per hour through the right atrial port of an indwelling Swan-Ganz thermodilution catheter. Potassium 20-29 insulin Homo sapiens 12-19 769633-4 1976 Our studies emphasize the crucial roles played by insulin and aldosterone in regulating the serum potassium concentration in man, and the need to avoid hyperglycemia in patients with combined insulin and aldosterone deficiency. Potassium 98-107 insulin Homo sapiens 50-57 948788-0 1976 [Effect of insulin on total potassium level in patients with diabetes mellitus]. Potassium 28-37 insulin Homo sapiens 11-18 53719-8 1975 However, small doses of insulin led to a poor retention of potassium. Potassium 59-68 insulin Homo sapiens 24-31 4918328-6 1970 60 mM potassium ion, on the other hand, not only restores the insulin secretory response to glucose (200 mg/100 ml) but results in an added stimulation of insulin secretion in the presence of DPH. Potassium 6-15 insulin Homo sapiens 62-69 4216389-4 1974 Whole-body potassium (ratio of observed to expected) was initially reduced in most of the patients requiring insulin. Potassium 11-20 insulin Homo sapiens 109-116 4216389-6 1974 The increase in whole-body potassium in the individual patients varied over a wide range, and in patients who were treated with insulin it was often of a similar magnitude to that observed in patients in diabetic ketoacidosis. Potassium 27-36 insulin Homo sapiens 128-135 4533064-0 1974 Letter: Initiation of the potassium-depleted state of the cirrhotic-a carbohydrate, insulin and aldosterone conspiracy? Potassium 26-35 insulin Homo sapiens 84-91 4799348-1 1973 Mode of insulin action on the cell: separative effect of insulin on potassium and glucose transfer of myocardium. Potassium 68-77 insulin Homo sapiens 57-64 4710366-0 1973 Evidence for a role of endogenous insulin and glucagon in the regulation of potassium homeostasis. Potassium 76-85 insulin Homo sapiens 34-41 4707706-0 1973 Role of insulin in the transfer of infused potassium to tissue. Potassium 43-52 insulin Homo sapiens 8-15 1200041-2 1975 Severe hyperkalemia associated with spontaneous hyperglycemia as well as with the intravenous infusions of glucose occurred in an insulin-requiring diabetic patient in the absence of potassium administration, the use of diuretics which inhibit urinary potassium excretion or acidemia. Potassium 252-261 insulin Homo sapiens 130-137 1200041-5 1975 In this patient, the serum potassium concentration increases after the intravenous infusions of glucose because there is insufficient aldosterone and insulin to reverse the transfer of potassium to the extracellular fluid which normally occurs after hypertonic infusions of glucose. Potassium 27-36 insulin Homo sapiens 150-157 1230136-3 1975 The insulin-like effect of lithium on carbohydrate metabolism and correlated ions (phosphates, calcium, magnesium, potassium) at cell membrane level is then discussed. Potassium 115-124 insulin Homo sapiens 4-11 1228745-4 1975 Total potassium level had a tendency to normalization after treatment with insulin, potassium salts and vitamins. Potassium 6-15 insulin Homo sapiens 75-82 807496-0 1975 Early insulin release and its response to potassium supplementation in protein-calorie malnutrition. Potassium 42-51 insulin Homo sapiens 6-13 807496-3 1975 This suggests that impaired insulin secretion in PMC is in part due to a potassium mediated disturbance of insulin release. Potassium 73-82 insulin Homo sapiens 28-35 1124397-0 1975 Mechanism of insulin-induced paralysis of muscles from potassium-depleted rats. Potassium 55-64 insulin Homo sapiens 13-20 1124397-1 1975 Zinc-free insulin elicited a reduction in the potassium conductance of muscle fibers from potassium-depleted muscle, which led to depolarization, blockage of action-poteintial mechanism, and paralysis. Potassium 46-55 insulin Homo sapiens 10-17 1124397-1 1975 Zinc-free insulin elicited a reduction in the potassium conductance of muscle fibers from potassium-depleted muscle, which led to depolarization, blockage of action-poteintial mechanism, and paralysis. Potassium 90-99 insulin Homo sapiens 10-17 1120786-8 1975 Urinary potassium (UKV) and phosphate (UPV) excretion were also both decreased during insulin administration; UKV decreased from 66 plus or minus 9 to 21 plus or minus 1 mueq/min (P smaller than 0.005), and tupv decreased from 504 plus or minus 93 to 230 plus or minus 43 mug/min (P smaller than 0.01). Potassium 8-17 insulin Homo sapiens 86-93 1229805-1 1975 The effect of propranolol on adrenaline- and insulin-induced changes in blood glucose pyruvate, lactate, phosphorus and potassium were examined in 29 apparently healthy volunteers. Potassium 120-129 insulin Homo sapiens 45-52 1229805-3 1975 There was no significant change in the blood glucose curve after insulin whereas insulin-induced increases in pyruvate and lactate were reduced by 44% +/- 17.7 (mean +/- SEM) and 78% +/- 5.4 respectively, and the fall in phosphorus by 48% +/- 3.1; the decrease in potassium, however, was not significantly modified. Potassium 264-273 insulin Homo sapiens 81-88 182367-8 1975 An insulin-induced configurational change in the plasma membrane could simultaneously account for the effects of insulin on sodium and potassium permeability and the action on facilitated transport. Potassium 135-144 insulin Homo sapiens 3-10 182367-8 1975 An insulin-induced configurational change in the plasma membrane could simultaneously account for the effects of insulin on sodium and potassium permeability and the action on facilitated transport. Potassium 135-144 insulin Homo sapiens 113-120 4918328-6 1970 60 mM potassium ion, on the other hand, not only restores the insulin secretory response to glucose (200 mg/100 ml) but results in an added stimulation of insulin secretion in the presence of DPH. Potassium 6-15 insulin Homo sapiens 155-162 4176948-0 1968 Effect of potassium on blood-sugar and plasma-insulin levels in patients undergoing peritoneal dialysis and haemodialysis. Potassium 10-19 insulin Homo sapiens 46-53 5736238-0 1968 [Effects of various doses of insulin on potassium and sodium content in the brain tissue and blood serum]. Potassium 40-49 insulin Homo sapiens 29-36 5701380-0 1968 [Changes of potassium in relation to blood sugar and the insulin effect in diabetic children]. Potassium 12-21 insulin Homo sapiens 57-64 5668632-0 1968 Treatment of angina pectoris of effort with infusion of insulin potassium and dextrose solution. Potassium 64-73 insulin Homo sapiens 56-63 5748209-0 1968 [Influence of insulin and vasopressin on potassium distribution in tissues]. Potassium 41-50 insulin Homo sapiens 14-21 6076985-0 1967 [Participation of potassium in the tissue response to insulin]. Potassium 18-27 insulin Homo sapiens 54-61 6017996-0 1967 Insulin effects on gastric secretion and blood electrolytes modified by injected potassium. Potassium 81-90 insulin Homo sapiens 0-7 4952748-0 1966 Reversal of insulin inhibition of gastric secretion by intravenous injection of potassium. Potassium 80-89 insulin Homo sapiens 12-19 4229837-0 1966 [The effect of insulin on the transport of potassium in skeletal muscles]. Potassium 43-52 insulin Homo sapiens 15-22 14020469-0 1963 The action of insulin on the blood potassium and phosphate in endocrine disorders. Potassium 35-44 insulin Homo sapiens 14-21 13964352-0 1962 The effect of insulin on gastric secretion of potassium. Potassium 46-55 insulin Homo sapiens 14-21 14450728-0 1961 The effect of insulin on gastric secretion of potassium. Potassium 46-55 insulin Homo sapiens 14-21 14472695-0 1961 [Relation between potassium and insulin effect in the isolated muscle]. Potassium 18-27 insulin Homo sapiens 32-39 14478163-0 1961 Experimental studies of the electrocardiographic effect of potassium solution on a toad"s heart in the presence of insulin and glucose. Potassium 59-68 insulin Homo sapiens 115-122 13652970-0 1959 Effect of insulin on potassium transfer in human and chicken erythrocytes. Potassium 21-30 insulin Homo sapiens 10-17 13607824-0 1958 [Effect of insulin on plasma sodium and potassium in pigeons]. Potassium 40-49 insulin Homo sapiens 11-18 13550246-0 1958 The relation of potassium deficiency to muscular paralysis by insulin. Potassium 16-25 insulin Homo sapiens 62-69 13250792-0 1955 [Variations of plasma sodium, potassium and magnesium under the effect of insulin]. Potassium 30-39 insulin Homo sapiens 74-81 13483699-0 1957 [In vitro studies on relation between potassium deficiency, muscular paralysis & insulin]. Potassium 38-47 insulin Homo sapiens 85-92 13364718-0 1956 The potassium uptake and rate of oxygen consumption of isolated frog skeletal muscle in the presence of insulin and lactate. Potassium 4-13 insulin Homo sapiens 104-111 13086766-0 1953 [Insulin hypoglycemia as element of different serum-erythrocyte distributions of potassium and sodium]. Potassium 81-90 insulin Homo sapiens 1-8 13107633-0 1953 Mechanisms of insulin and epinephrine effect on the level of plasma potassium. Potassium 68-77 insulin Homo sapiens 14-21 13055983-0 1953 Epinephrine and insulin effect on potassium mobilization; relationship of lipid and carbohydrate metabolism. Potassium 34-43 insulin Homo sapiens 16-23 14958479-0 1952 The electrocardiographic and plasma potassium changes after adrenalin and insulin injections. Potassium 36-45 insulin Homo sapiens 74-81 14906298-0 1951 The effect of epinephrine and insulin on the plasma potassium level. Potassium 52-61 insulin Homo sapiens 30-37 14791434-0 1950 The influence of carbohydrates and insulin on the potassium content of leucocytes and muscle. Potassium 50-59 insulin Homo sapiens 35-42 14857892-0 1951 The influence of glucose and insulin upon the potassium concentration of serum and cerebrospinal fluid. Potassium 46-55 insulin Homo sapiens 29-36 33861146-11 2021 Potassium levels were also associated with insulin-mediated reductions in AP (r=0.52, P=0.002). Potassium 0-9 insulin Homo sapiens 43-50 33423833-8 2021 Redistribution of potassium ions from the bloodstream into the cells is based on intravenous insulin or nebulized beta2-agonists. Potassium 18-27 insulin Homo sapiens 93-100 33993515-0 2021 Reduced Alternative Insulin Dosing in Hyperkalemia: a Meta-Analysis of Effects on Hypoglycemia and Potassium Reduction. Potassium 99-108 insulin Homo sapiens 20-27 33993515-3 2021 This meta-analysis was performed to determine the impact of alternative insulin dosing on hypoglycemia and potassium reduction in patients with hyperkalemia. Potassium 107-116 insulin Homo sapiens 72-79 33993515-11 2021 CONCLUSIONS: Alternative insulin dosing strategies for hyperkalemia management resulted in less hypoglycemia and severe hypoglycemia without compromising potassium reduction compared to standard dose. Potassium 154-163 insulin Homo sapiens 25-32