PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17031514-5 2007 We evaluated growth-inhibitory activity of flavanone and 2"-OH flavanone against highly proliferative human lung cancer cells (A549) via anchorage-independent and -dependent colony formation assay, and further showed that treatment of flavanone resulted in a G1 cell cycle arrest with reduction of cyclin D, E and cyclin-dependent kinase (CDK) 2, while treatment of 2"-OH flavanone led to a G2/M phase accumulation with reduction of cyclin B, D and Cdc2. flavanone 43-52 cyclin dependent kinase 1 Homo sapiens 449-453