PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16757081-6	2006	There were significant relationships between paraoxon formation from parathion (5 microM, 20 microM and 200 microM) and the CYP3A4/5, CYP2C8 and CYP1A2 mediated reactions, although only the latter two isoforms correlated significantly with the lowest parathion concentration.	Parathion	69-78	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	124-130	
16757081-6	2006	There were significant relationships between paraoxon formation from parathion (5 microM, 20 microM and 200 microM) and the CYP3A4/5, CYP2C8 and CYP1A2 mediated reactions, although only the latter two isoforms correlated significantly with the lowest parathion concentration.	Parathion	251-260	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	124-130	
12669189-7	2003	These data indicate that CYP3A4/5 and CYP2C8, which constitute up to 40% of human liver P450s, are the most significant participants in the metabolism of parathion.	Parathion	154-163	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	25-31	
10996483-5	2000	Addition of the CYP3A4 inhibitor ketoconazole to microsomal incubations resulted in 66% cholinesterase activity with diazinon, 20% with parathion and 5% with chlorpyrifos.	Parathion	136-145	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	16-22	
10996483-6	2000	The unexpected finding that CYP2D6, as well as CYP3A4, catalysed oxidative biotransformation was confirmed for chlorpyrifos and parathion using microsomes prepared from a human lymphoblastoid cell line expressing CYP2D6.	Parathion	128-137	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	47-53	
10794390-3	2000	Recent studies using cDNA expressed human CYPs have suggested that CYP3A4 is the principal human CYP involved in the oxidation of parathion and probably other organo(thio)phosphate (OP) insecticides and thus PM in this CYP might influence susceptibility to OP.	Parathion	130-139	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-73	
10484078-9	1999	Greater inhibition was produced by the less selective CYP3A inhibitors parathion, quinidine, and ketoconazole; CYP1A inhibitors were ineffective.	Parathion	71-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-59	
10414794-5	1999	The activation of parathion (200 microM) was positively correlated with nifedipine oxidation, indicating the involvement of CYP3A.	Parathion	18-27	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	124-129	
10414794-7	1999	Paraoxon formation from parathion was markedly reduced by CYP3A inhibitors.	Parathion	24-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	58-63	
10414794-10	1999	This study has determined wide interindividual variations in capacity to metabolise parathion, mainly by CYP3A, which may influence its manifest toxicity.	Parathion	84-93	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	105-110	
9023313-5	1997	Linear regression of rates of parathion oxidation with those of other microsomal CYP reactions implicated CYP3A4 in the reaction.	Parathion	30-39	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	106-112	
9023313-7	1997	CYP 3A4 expressed in lymphoblastoid cell lines was an efficient catalyst of parathion oxidation, although CYP 1A2 and 2B6 also catalyzed the activity.	Parathion	76-85	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-7	
9023313-8	1997	The CYP3A4 inhibitors ketoconazole and triacetyloleandomycin decreased the observed rate of microsomal parathion oxidation, but chemicals known to interact preferentially with other human CYP were essentially noninhibitory.	Parathion	103-112	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	4-10	
9023313-14	1997	In summary, these findings strongly implicate CYP 3A4 as the principal catalyst of parathion oxidation in human liver, although other CYP may play a lesser role.	Parathion	83-92	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	46-53	
27441453-6	2016	Using menadione as the redox-cycling chemical, we discovered that this enzymatic reaction blocks metabolic activation of parathion in rat and human liver microsomes and in recombinant CYPs important to parathion metabolism, including CYP1A2, CYP2B6, and CYP3A4.	Parathion	121-130	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	254-260	
26196221-7	2015	Moreover, parathion and bisphenol A are the activators of PXR and inducers of CYP3A4 mRNA and protein in the primary cultures of human hepatocytes.	Parathion	10-19	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	78-84