PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25927932-5 2015 Here, we show that knockdown of cyclin D3 a partner of CDK6 and E2 a partner of CDK2 had a major impact in SAMHD1 phosphorylation and inactivation and led to decreased dNTP levels and inhibition of HIV-1 at the reverse transcription step in primary human macrophages. Parathion 168-172 cyclin dependent kinase 6 Homo sapiens 55-59 25927932-8 2015 Our results confirm the fundamental role of the CDK6-cyclin D3 pair in controlling CDK2-dependent SAMHD1 phosphorylation and dNTP pool in primary macrophages. Parathion 125-129 cyclin dependent kinase 6 Homo sapiens 48-52 25015816-7 2014 Our findings identify a direct relationship between control of the cell cycle by CDK6 and SAMHD1 activity, which is important for replication of lentiviruses, as well as other viruses whose replication may be regulated by intracellular dNTP availability. Parathion 236-240 cyclin dependent kinase 6 Homo sapiens 81-85