PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15907466-4 2005 Our analysis reveals that deacetylation of histone H4-lysine 16 (K16), which is critical for silencing in vivo, is also critical for the binding of Sir3 and Sir4 to histone H4 peptides in vitro. histone h4-lysine 43-60 chromatin-silencing protein SIR3 Saccharomyces cerevisiae S288C 148-152