PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23573289-2 2013 In the liver, phosphorylation of glucose to glucose-6-phosphate by GCK is the first step for both glycolysis and glycogen synthesis. Glycogen 113-121 glucokinase Homo sapiens 67-70 25802718-3 2015 In the liver, phosphorylation of glucose by glucokinase promotes glycogen synthesis, whereas in the beta-cells, it results in insulin release. Glycogen 65-73 glucokinase Homo sapiens 44-55 25052034-2 2014 Conversion of glucose to glucose-6-phosphate by GK promotes glycogen synthesis in liver hepatocytes, and insulin release in the pancreatic beta-cells. Glycogen 60-68 glucokinase Homo sapiens 48-50 24226772-3 2013 In hepatocytes, GK regulates glucose uptake and glycogen synthesis, suppresses glucose production, and is subject to the endogenous inhibitor GK regulatory protein (GKRP). Glycogen 48-56 glucokinase Homo sapiens 16-18 26802463-4 2016 The synthesis of hepatic glycogen, which was consistent with the fluctuation of glycolytic key genes PFKL and PKLR that gradually decreased after birth and was more or less steady during latter suckling period, although both the mRNA levels of GCK and key glucose transporter GLUT2 presented uptrend in suckling piglets. Glycogen 25-33 glucokinase Homo sapiens 244-247 26299854-3 2015 In hepatocytes, GK controls the glucose uptake and glycogen synthesis and inhibits the glucose synthesis via the gluconeogenesis pathway. Glycogen 51-59 glucokinase Homo sapiens 16-18 23816435-13 2013 Since net hepatic glycogen storage is diminished in type 2 diabetes patients, stimulation of glycogen synthesis may contribute to the anti-hyperglycemic properties of glucokinase activation. Glycogen 93-101 glucokinase Homo sapiens 167-178 19520181-3 2009 Phosphorylation of glucose by glucokinase in the liver promotes glycogen synthesis, while in the beta-cell it results in insulin release. Glycogen 64-72 glucokinase Homo sapiens 30-41 19746978-3 2009 A GK activator has the promise of potentially affecting both the beta-cells of the pancreas, by improving glucose sensitive insulin secretion, as well as the liver, by reducing uncontrolled glucose output and restoring post-prandial glucose uptake and storage as glycogen. Glycogen 263-271 glucokinase Homo sapiens 2-4 19520181-4 2009 Activators of glucokinase increase the sensitivity of the enzyme to glucose, leading to increased insulin secretion and liver glycogen synthesis and a decrease in liver glucose output. Glycogen 126-134 glucokinase Homo sapiens 14-25 15734835-0 2005 Increased potency and efficacy of combined phosphorylase inactivation and glucokinase activation in control of hepatocyte glycogen metabolism. Glycogen 122-130 glucokinase Homo sapiens 74-85 19373249-2 2009 Glucokinase serves as a glucose sensor of the insulin-producing pancreatic islet beta-cells, controls the conversion of glucose to glycogen in the liver and regulates hepatic glucose production. Glycogen 131-139 glucokinase Homo sapiens 0-11 18381287-7 2008 In siACC1-treated cells, glucokinase protein levels were decreased by 25%, which correlated with a 36% decrease in glycogen synthesis and a 33% decrease in glycolytic flux. Glycogen 115-123 glucokinase Homo sapiens 25-36 18165236-1 2008 Glucokinase (GK, hexokinase type IV) is required for the accumulation of glycogen in adult liver and hepatoma cells. Glycogen 73-81 glucokinase Homo sapiens 0-11 18165236-1 2008 Glucokinase (GK, hexokinase type IV) is required for the accumulation of glycogen in adult liver and hepatoma cells. Glycogen 73-81 glucokinase Homo sapiens 13-15 18165236-1 2008 Glucokinase (GK, hexokinase type IV) is required for the accumulation of glycogen in adult liver and hepatoma cells. Glycogen 73-81 glucokinase Homo sapiens 17-35 18165236-8 2008 We conclude that although the GK/liver glycogen synthase tandem is ideally suited to store glycogen in liver when blood glucose is high, the substitution of HKI for GK in embryonic livers allows the HKI/liver glycogen synthase tandem to make glycogen independently of the glucose concentration in blood, although it requires huge levels of HK. Glycogen 91-99 glucokinase Homo sapiens 30-32 16403021-1 2006 Pharmacological activation or overexpression of glucokinase in hepatocytes stimulates glucose phosphorylation, glycolysis and glycogen synthesis. Glycogen 126-134 glucokinase Homo sapiens 48-59 16403021-6 2006 The concentration control coefficient of glucokinase on Glc6P (1.4-1.7) was relatively independent of glucose concentration, whereas the flux control coefficients of Glc6P (2.4-1.0) and glucokinase (3.7-1.8) on glycogen synthesis decreased with glucose concentration. Glycogen 211-219 glucokinase Homo sapiens 41-52 16403021-8 2006 The high control strength of glucokinase on glycogenic flux is explained by its concentration control coefficient on Glc6P and the high control strength of Glc6P on glycogen synthesis. Glycogen 44-52 glucokinase Homo sapiens 29-40 16403021-9 2006 It is suggested that the regulatory strength of pharmacological glucokinase activators on glycogen metabolism can be predicted from their effect on the Glc6P content. Glycogen 90-98 glucokinase Homo sapiens 64-75 15734835-1 2005 Glucokinase and phosphorylase both have a high control strength over hepatocyte glycogen metabolism and are potential therapeutic targets for type 2 diabetes. Glycogen 80-88 glucokinase Homo sapiens 0-11 15734835-2 2005 We tested whether combined phosphorylase inactivation and glucokinase activation is a more effective strategy for controlling hepatic glycogen metabolism than single-site targeting. Glycogen 134-142 glucokinase Homo sapiens 58-69 15734835-3 2005 Activation of glucokinase by enzyme overexpression combined with selective dephosphorylation of phosphorylase-a by an indole carboxamide that favors the T conformation of phosphorylase caused a greater stimulation of glycogen synthesis than the sum of either treatment alone. Glycogen 217-225 glucokinase Homo sapiens 14-25 12829248-11 2003 The changes in the intracellular distribution of liver GS and GK triggered by glucose correlate with stimulation of glycogen synthesis. Glycogen 116-124 glucokinase Homo sapiens 62-64 14988235-4 2004 In hepatocytes, GKA1 and GKA2 stimulated glucose phosphorylation, glycolysis, and glycogen synthesis to a similar extent as sorbitol, a precursor of fructose 1-phosphate, which indirectly activates GK through promoting its dissociation from GKRP. Glycogen 82-90 glucokinase Homo sapiens 16-18 12829248-7 2003 As a result, hepatic glycogen deposition from glucose is subject to a system of control in which the "controller", GS, is in turn controlled by GK. Glycogen 21-29 glucokinase Homo sapiens 144-146 11600496-0 2002 Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes. Glycogen 78-86 glucokinase Homo sapiens 32-43 11600496-1 2002 Overexpression of the glucose-phosphorylating enzyme glucokinase (GK) or members of the family of glycogen-targeting subunits of protein phosphatase-1 increases hepatic glucose disposal and glycogen synthesis. Glycogen 190-198 glucokinase Homo sapiens 53-64 11600496-1 2002 Overexpression of the glucose-phosphorylating enzyme glucokinase (GK) or members of the family of glycogen-targeting subunits of protein phosphatase-1 increases hepatic glucose disposal and glycogen synthesis. Glycogen 190-198 glucokinase Homo sapiens 66-68 11600496-2 2002 This study was undertaken to evaluate the functional properties of a novel, truncated glycogen-targeting subunit derived from the skeletal muscle isoform G(M)/R(Gl) and to compare pathways of glycogen metabolism and their regulation in cells with overexpressed targeting subunits and GK. Glycogen 86-94 glucokinase Homo sapiens 284-286 11600496-4 2002 We also found that cells with overexpressed G(M)DeltaC are unique in that glycogen was efficiently degraded in response to lowering of media glucose concentrations, stimulation with forskolin, or a combination of both maneuvers, whereas cells with overexpressed G(L), PTG, or GK exhibited impairment in one or both of these glycogenolytic signaling pathways. Glycogen 74-82 glucokinase Homo sapiens 276-278 11600496-5 2002 (2)H NMR analysis of purified glycogen revealed that hepatocytes with overexpressed GK synthesized a larger portion of their glycogen from triose phosphates and a smaller portion from tricarboxylic acid cycle intermediates than cells with overexpressed glycogen-targeting subunits. Glycogen 30-38 glucokinase Homo sapiens 84-86 11600496-5 2002 (2)H NMR analysis of purified glycogen revealed that hepatocytes with overexpressed GK synthesized a larger portion of their glycogen from triose phosphates and a smaller portion from tricarboxylic acid cycle intermediates than cells with overexpressed glycogen-targeting subunits. Glycogen 125-133 glucokinase Homo sapiens 84-86 11600496-5 2002 (2)H NMR analysis of purified glycogen revealed that hepatocytes with overexpressed GK synthesized a larger portion of their glycogen from triose phosphates and a smaller portion from tricarboxylic acid cycle intermediates than cells with overexpressed glycogen-targeting subunits. Glycogen 125-133 glucokinase Homo sapiens 84-86 11600496-6 2002 Additional evidence for activation of distinct pathways of glycogen synthesis by GK and targeting subunits is provided by the additive effect of co-overexpression of the two types of proteins upon glycogen synthesis and a much larger stimulation of glucose utilization, glucose transport, and lactate production elicited by GK. Glycogen 59-67 glucokinase Homo sapiens 81-83 11600496-6 2002 Additional evidence for activation of distinct pathways of glycogen synthesis by GK and targeting subunits is provided by the additive effect of co-overexpression of the two types of proteins upon glycogen synthesis and a much larger stimulation of glucose utilization, glucose transport, and lactate production elicited by GK. Glycogen 59-67 glucokinase Homo sapiens 324-326 11600496-6 2002 Additional evidence for activation of distinct pathways of glycogen synthesis by GK and targeting subunits is provided by the additive effect of co-overexpression of the two types of proteins upon glycogen synthesis and a much larger stimulation of glucose utilization, glucose transport, and lactate production elicited by GK. Glycogen 197-205 glucokinase Homo sapiens 81-83 11237214-6 2001 A decreased increment in liver glycogen content following meals was also found in patients with maturity-onset diabetes of the young due to glucokinase mutations (MODY-2). Glycogen 31-39 glucokinase Homo sapiens 140-151 11237214-6 2001 A decreased increment in liver glycogen content following meals was also found in patients with maturity-onset diabetes of the young due to glucokinase mutations (MODY-2). Glycogen 31-39 glucokinase Homo sapiens 163-169 9539292-3 1998 Mutations in MODY2/glucokinase result in mild chronic hyperglycaemia as a result of reduced pancreatic beta-cell responsiveness to glucose, and decreased net accumulation of hepatic glycogen and increased hepatic gluconeogenesis after meals. Glycogen 182-190 glucokinase Homo sapiens 13-18 10744755-10 2000 Under the latter conditions, glucokinase and GKRP have large and inverse control coefficients on glycogen synthesis, suggesting that a large component of the positive control coefficient of glucokinase is counterbalanced by the negative coefficient of GKRP. Glycogen 97-105 glucokinase Homo sapiens 29-40 10744755-10 2000 Under the latter conditions, glucokinase and GKRP have large and inverse control coefficients on glycogen synthesis, suggesting that a large component of the positive control coefficient of glucokinase is counterbalanced by the negative coefficient of GKRP. Glycogen 97-105 glucokinase Homo sapiens 190-201 10744755-1 2000 Glucokinase has a very high flux control coefficient (greater than unity) on glycogen synthesis from glucose in hepatocytes (Agius et al., J. Biol. Glycogen 77-85 glucokinase Homo sapiens 0-11 10744755-7 2000 It decreased the affinity of glucokinase translocation for glucose and increased the control coefficient of glucokinase on glycogen synthesis. Glycogen 123-131 glucokinase Homo sapiens 108-119 10744755-9 2000 The control coefficient of GKRP on glycogen synthesis decreased with increasing glucokinase overexpression (4-fold) at elevated glucose concentration (35 mM), which favors dissociation of glucokinase from GKRP, but not at 7.5 mM glucose. Glycogen 35-43 glucokinase Homo sapiens 80-91 10455119-5 1999 GK overexpression increases glycolysis and glycogen synthesis with a greater control coefficient on glycogen synthesis than on glycolysis. Glycogen 43-51 glucokinase Homo sapiens 0-2 10455119-5 1999 GK overexpression increases glycolysis and glycogen synthesis with a greater control coefficient on glycogen synthesis than on glycolysis. Glycogen 100-108 glucokinase Homo sapiens 0-2 9539292-3 1998 Mutations in MODY2/glucokinase result in mild chronic hyperglycaemia as a result of reduced pancreatic beta-cell responsiveness to glucose, and decreased net accumulation of hepatic glycogen and increased hepatic gluconeogenesis after meals. Glycogen 182-190 glucokinase Homo sapiens 19-30 9162575-3 1997 Mutations in glucokinase/MODY2 result in mild chronic hyperglycaemia due to reduced pancreatic beta-cell responsiveness to glucose as well as decreased net accumulation of hepatic glycogen and increased hepatic gluconeogenesis following meals. Glycogen 180-188 glucokinase Homo sapiens 13-24 9762360-9 1998 Translocation of glucokinase from the nucleus to the cytoplasm in response to precursors of fructose 1-phosphate (which cause dissociation of glucokinase from the regulatory protein) is associated with stimulation of glucose phosphorylation, glycolysis and glycogen synthesis. Glycogen 257-265 glucokinase Homo sapiens 17-28 9762360-9 1998 Translocation of glucokinase from the nucleus to the cytoplasm in response to precursors of fructose 1-phosphate (which cause dissociation of glucokinase from the regulatory protein) is associated with stimulation of glucose phosphorylation, glycolysis and glycogen synthesis. Glycogen 257-265 glucokinase Homo sapiens 142-153 9762360-10 1998 Using Metabolic Control Analysis to determine the Control Coefficient (Control Strength) of cytoplasmic (free) glucokinase on glucose metabolism it can be shown that the free glucokinase activity has a very high control strength on glycogen synthesis (CFGKJ > 1), indicating a major role of translocation of glucokinase in the control of hepatic glycogen synthesis. Glycogen 232-240 glucokinase Homo sapiens 111-122 9762360-10 1998 Using Metabolic Control Analysis to determine the Control Coefficient (Control Strength) of cytoplasmic (free) glucokinase on glucose metabolism it can be shown that the free glucokinase activity has a very high control strength on glycogen synthesis (CFGKJ > 1), indicating a major role of translocation of glucokinase in the control of hepatic glycogen synthesis. Glycogen 232-240 glucokinase Homo sapiens 175-186 9762360-10 1998 Using Metabolic Control Analysis to determine the Control Coefficient (Control Strength) of cytoplasmic (free) glucokinase on glucose metabolism it can be shown that the free glucokinase activity has a very high control strength on glycogen synthesis (CFGKJ > 1), indicating a major role of translocation of glucokinase in the control of hepatic glycogen synthesis. Glycogen 232-240 glucokinase Homo sapiens 175-186 9762360-10 1998 Using Metabolic Control Analysis to determine the Control Coefficient (Control Strength) of cytoplasmic (free) glucokinase on glucose metabolism it can be shown that the free glucokinase activity has a very high control strength on glycogen synthesis (CFGKJ > 1), indicating a major role of translocation of glucokinase in the control of hepatic glycogen synthesis. Glycogen 349-357 glucokinase Homo sapiens 111-122 9762360-10 1998 Using Metabolic Control Analysis to determine the Control Coefficient (Control Strength) of cytoplasmic (free) glucokinase on glucose metabolism it can be shown that the free glucokinase activity has a very high control strength on glycogen synthesis (CFGKJ > 1), indicating a major role of translocation of glucokinase in the control of hepatic glycogen synthesis. Glycogen 349-357 glucokinase Homo sapiens 175-186 9762360-10 1998 Using Metabolic Control Analysis to determine the Control Coefficient (Control Strength) of cytoplasmic (free) glucokinase on glucose metabolism it can be shown that the free glucokinase activity has a very high control strength on glycogen synthesis (CFGKJ > 1), indicating a major role of translocation of glucokinase in the control of hepatic glycogen synthesis. Glycogen 349-357 glucokinase Homo sapiens 175-186 9762360-11 1998 Overexpression of glucokinase in hepatocytes by adenovirus-mediated glucokinase overexpression is associated with a marked increase in glycogen synthesis. Glycogen 135-143 glucokinase Homo sapiens 18-29 9762360-11 1998 Overexpression of glucokinase in hepatocytes by adenovirus-mediated glucokinase overexpression is associated with a marked increase in glycogen synthesis. Glycogen 135-143 glucokinase Homo sapiens 68-79 9762360-13 1998 The high Control Coefficient of glucokinase on hepatic glycogen synthesis explains the abnormalities of hepatic glycogen synthesis in patients with a single mutant allele of the glucokinase gene (Maturity Onset Diabetes of the Young, type 2). Glycogen 55-63 glucokinase Homo sapiens 32-43 9762360-13 1998 The high Control Coefficient of glucokinase on hepatic glycogen synthesis explains the abnormalities of hepatic glycogen synthesis in patients with a single mutant allele of the glucokinase gene (Maturity Onset Diabetes of the Young, type 2). Glycogen 55-63 glucokinase Homo sapiens 178-189 9762360-13 1998 The high Control Coefficient of glucokinase on hepatic glycogen synthesis explains the abnormalities of hepatic glycogen synthesis in patients with a single mutant allele of the glucokinase gene (Maturity Onset Diabetes of the Young, type 2). Glycogen 112-120 glucokinase Homo sapiens 32-43 9762360-13 1998 The high Control Coefficient of glucokinase on hepatic glycogen synthesis explains the abnormalities of hepatic glycogen synthesis in patients with a single mutant allele of the glucokinase gene (Maturity Onset Diabetes of the Young, type 2). Glycogen 112-120 glucokinase Homo sapiens 178-189 9162575-3 1997 Mutations in glucokinase/MODY2 result in mild chronic hyperglycaemia due to reduced pancreatic beta-cell responsiveness to glucose as well as decreased net accumulation of hepatic glycogen and increased hepatic gluconeogenesis following meals. Glycogen 180-188 glucokinase Homo sapiens 25-30 9049484-1 1997 Mutations in glucokinase are associated with defects in insulin secretion and hepatic glycogen synthesis resulting in mild chronic hyperglycaemia, impaired glucose tolerance or diabetes mellitus. Glycogen 86-94 glucokinase Homo sapiens 13-24 34714587-2 2022 In the liver, glucokinase promotes the synthesis of glycogen, and in the pancreas, it helps in glucose-sensitive insulin release. Glycogen 52-60 glucokinase Homo sapiens 14-25 8940014-0 1996 Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis. Glycogen 94-102 glucokinase Homo sapiens 56-67 8940014-4 1996 We also determined the sensitivity of glycogen synthesis to changes in either total glucokinase overexpression or in free glucokinase activity. Glycogen 38-46 glucokinase Homo sapiens 84-95 8940014-8 1996 Glycogen synthesis determined from the incorporation of [2-3H,U-14C]glucose into glycogen at 5 mM or 10 mM glucose was very sensitive to small increases in total glucokinase activity and correlated more closely with the increase in free glucokinase activity. Glycogen 0-8 glucokinase Homo sapiens 162-173 8940014-8 1996 Glycogen synthesis determined from the incorporation of [2-3H,U-14C]glucose into glycogen at 5 mM or 10 mM glucose was very sensitive to small increases in total glucokinase activity and correlated more closely with the increase in free glucokinase activity. Glycogen 0-8 glucokinase Homo sapiens 237-248 8940014-8 1996 Glycogen synthesis determined from the incorporation of [2-3H,U-14C]glucose into glycogen at 5 mM or 10 mM glucose was very sensitive to small increases in total glucokinase activity and correlated more closely with the increase in free glucokinase activity. Glycogen 81-89 glucokinase Homo sapiens 162-173 8940014-8 1996 Glycogen synthesis determined from the incorporation of [2-3H,U-14C]glucose into glycogen at 5 mM or 10 mM glucose was very sensitive to small increases in total glucokinase activity and correlated more closely with the increase in free glucokinase activity. Glycogen 81-89 glucokinase Homo sapiens 237-248 8940014-10 1996 Expression of the sensitivity of glycogen synthesis to glucokinase activity as the control coefficient reveals that the coefficient is greater for the incorporation of 2-tritium (which occurs exclusively by the direct pathway) than for incorporation of 14C label (which involves direct and indirect pathways) and is greater at 5 mM glucose (when glucokinase is maximally sequestered at its high-affinity site) than at 10 mM glucose. Glycogen 33-41 glucokinase Homo sapiens 55-66 8940014-10 1996 Expression of the sensitivity of glycogen synthesis to glucokinase activity as the control coefficient reveals that the coefficient is greater for the incorporation of 2-tritium (which occurs exclusively by the direct pathway) than for incorporation of 14C label (which involves direct and indirect pathways) and is greater at 5 mM glucose (when glucokinase is maximally sequestered at its high-affinity site) than at 10 mM glucose. Glycogen 33-41 glucokinase Homo sapiens 346-357 8940014-11 1996 The results support the hypothesis that compartmentation of glucokinase in the hepatocyte increases the sensitivity of glycogen synthesis to small changes in total glucokinase activity and that glucose-induced translocation of glucokinase has a major role in the acute control of glycogen synthesis. Glycogen 119-127 glucokinase Homo sapiens 60-71 8940014-11 1996 The results support the hypothesis that compartmentation of glucokinase in the hepatocyte increases the sensitivity of glycogen synthesis to small changes in total glucokinase activity and that glucose-induced translocation of glucokinase has a major role in the acute control of glycogen synthesis. Glycogen 119-127 glucokinase Homo sapiens 164-175 8940014-11 1996 The results support the hypothesis that compartmentation of glucokinase in the hepatocyte increases the sensitivity of glycogen synthesis to small changes in total glucokinase activity and that glucose-induced translocation of glucokinase has a major role in the acute control of glycogen synthesis. Glycogen 119-127 glucokinase Homo sapiens 164-175 8940014-11 1996 The results support the hypothesis that compartmentation of glucokinase in the hepatocyte increases the sensitivity of glycogen synthesis to small changes in total glucokinase activity and that glucose-induced translocation of glucokinase has a major role in the acute control of glycogen synthesis. Glycogen 280-288 glucokinase Homo sapiens 60-71 8280078-15 1993 When hepatocytes were incubated with [2-3H, U-14C]glucose, the incorporation of 3H/14C label into glycogen correlated with the extent of glucokinase release. Glycogen 98-106 glucokinase Homo sapiens 137-148 8280078-16 1993 Since 2-3H is lost during conversion of glucose 6-phosphate into fructose 6-phosphate, substrate-induced translocation of glucokinase from a Mg(2+)-dependent binding site to an alternative site might favour the partitioning of glucose 6-phosphate towards glycogen, as opposed to phosphoglucoisomerase. Glycogen 255-263 glucokinase Homo sapiens 122-133 8878425-0 1996 Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects. Glycogen 17-25 glucokinase Homo sapiens 62-68 8798601-4 1996 271, 20524-20530), we demonstrated that adenovirus-mediated overexpression of glucokinase but not hexokinase I has a potent enhancing effect on glycogen synthesis in primary hepatocytes. Glycogen 144-152 glucokinase Homo sapiens 78-89 34731602-6 2021 L-GRKO blunts preprandial and early postprandial Gck expression, which ultimately affects early postprandial hepatic glucose uptake, phosphorylation, and glycogen storage. Glycogen 154-162 glucokinase Homo sapiens 49-52 30257192-1 2018 OBJECTIVE: Heterozygous inactivating mutations in GCK are associated with defects in pancreatic insulin secretion and/or hepatic glycogen synthesis leading to mild chronic hyperglycaemia of maturity onset diabetes of young type 2 (MODY2). Glycogen 129-137 glucokinase Homo sapiens 50-53 13997409-0 1963 Glucokinase and hexokinase in liver in relation to glycogen synthesis. Glycogen 51-59 glucokinase Homo sapiens 0-11 30641049-2 2019 GCK is predominantly produced in the pancreas, where it catalyzes the rate-limiting step of insulin secretion, and in the liver, where it participates in glycogen synthesis. Glycogen 154-162 glucokinase Homo sapiens 0-3 35388005-4 2022 Glucokinase is expressed in hepatocytes to regulate glycogen synthesis, and in pancreatic beta cells as a glucose sensor to initiate glycolysis and insulin signaling. Glycogen 52-60 glucokinase Homo sapiens 0-11 187069-4 1976 The model predicts that, although insulin can inhibit glucose production by lowering phosphorylase and gluconeogenesis, only an insulin-mediated induction of glucokinase can account for insulin"s action to potentiate the effect of glucose alone on glycogen synthesis. Glycogen 248-256 glucokinase Homo sapiens 158-169 33594203-4 2021 HK2 knockdown and GCK expression rewired central carbon metabolism, stimulated mitochondrial respiration and restored essential metabolic functions of normal hepatocytes such as lipogenesis, VLDL secretion, glycogen storage. Glycogen 207-215 glucokinase Homo sapiens 18-21 32539915-3 2020 GK plays an important role in promoting the synthesis of hepatic glycogen and balancing postprandial blood glucose. Glycogen 65-73 glucokinase Homo sapiens 0-2