PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26442273-0 2015 Post-Exercise Skeletal Muscle Glycogen Related to Plasma Cytokines and Muscle IL-6 Protein Content, but not Muscle Cytokine mRNA Expression. Glycogen 30-38 interleukin 6 Homo sapiens 78-82 23086036-3 2013 Acute IL-6 exposure increased glycogen synthesis, glucose uptake, and signal transducer and activator of transcription 3 (STAT3) phosphorylation in cultured myotubes from normal glucose tolerant subjects. Glycogen 30-38 interleukin 6 Homo sapiens 6-10 19575453-7 2009 In hepatocytes, insulin-stimulated glycogen synthesis and insulin-dependent phosphorylation of Akt-kinase were attenuated synergistically by prior incubation with IL-6 and/or PGE(2) while insulin receptor autophosphorylation was barely affected. Glycogen 35-43 interleukin 6 Homo sapiens 163-167 20691261-10 2010 Furthermore, IL-6 trans-signaling was important for refilling of hepatocyte glycogen stores, which were depleted 24 h after CCl4 treatment. Glycogen 76-84 interleukin 6 Homo sapiens 13-17 23037942-7 2013 Importantly, contraction-dependent IL-6 up-regulation was markedly suppressed in the presence of high levels of glucose along with increased glycogen accumulations. Glycogen 141-149 interleukin 6 Homo sapiens 35-39 23037942-8 2013 Experimental manipulation of intracellular glycogen contents by modulating available glucose or pyruvate during a certain EPS period further established the suppressive effect of glycogen accumulations on contraction-induced IL-6 up-regulation, which appeared to be independent of calcineurin activity. Glycogen 43-51 interleukin 6 Homo sapiens 225-229 23037942-8 2013 Experimental manipulation of intracellular glycogen contents by modulating available glucose or pyruvate during a certain EPS period further established the suppressive effect of glycogen accumulations on contraction-induced IL-6 up-regulation, which appeared to be independent of calcineurin activity. Glycogen 179-187 interleukin 6 Homo sapiens 225-229 17363741-10 2007 IL-6 also increased skeletal muscle glucose incorporation into glycogen, as well as glucose oxidation (1.5- and 1.3-fold, respectively; P < 0.05). Glycogen 63-71 interleukin 6 Homo sapiens 0-4 17993646-4 2008 Here we show that rapamycin, the inhibitor of mTOR signaling, rescues insulin signaling and glycogen synthesis from IL-6 inhibition in HepG2 hepatocarcinoma cells as well as in mouse primary hepatocytes. Glycogen 92-100 interleukin 6 Homo sapiens 116-120 17346285-0 2008 Interleukin-6 and its mRNA responses in exercise and recovery: relationship to muscle glycogen. Glycogen 86-94 interleukin 6 Homo sapiens 0-13 17346285-1 2008 Increases in circulating interleukin-6 (IL-6) during exhaustive exercise have been suggested to be related to declining muscle glycogen. Glycogen 127-135 interleukin 6 Homo sapiens 25-38 17346285-1 2008 Increases in circulating interleukin-6 (IL-6) during exhaustive exercise have been suggested to be related to declining muscle glycogen. Glycogen 127-135 interleukin 6 Homo sapiens 40-44 17346285-2 2008 We addressed two hypotheses: (a) exhaustive exercise on two occasions will result in similar decreases in glycogen and increases in circulating IL-6 and its muscle mRNA; (b) increasing the rate of glycogen restoration via high-carbohydrate feeding in recovery will be associated with more rapid declines in muscle mRNA and circulating IL-6. Glycogen 197-205 interleukin 6 Homo sapiens 335-339 16945991-4 2006 IL-6 increased glucose incorporation into glycogen, glucose uptake, lactate production, and fatty acid uptake and oxidation, concomitant with increased phosphorylation of AMP-activated protein kinase (AMPK), signal transducer and activator of transcription 3, and ERK1/2. Glycogen 42-50 interleukin 6 Homo sapiens 0-4 16945991-8 2006 In summary, IL-6 increases glycogen synthesis via a PI3-kinase-dependent mechanism and enhances lipid oxidation via an AMPK-dependent mechanism in skeletal muscle. Glycogen 27-35 interleukin 6 Homo sapiens 12-16 16945991-9 2006 Thus, IL-6 directly promotes skeletal muscle differentiation and regulates muscle substrate utilization, promoting glycogen storage and lipid oxidation. Glycogen 115-123 interleukin 6 Homo sapiens 6-10 16099893-4 2005 In the present study, we aimed to investigate the effect of exercise, training, and glycogen availability, factors known to affect IL-6, on the regulation of gene expression of the IL-6R in human skeletal muscle. Glycogen 84-92 interleukin 6 Homo sapiens 131-135 16843089-7 2006 Nonosmotic stimulation of arginine vasopressin secretion may be mediated in part by enhanced release of muscle-derived interleukin-6 during glycogen depletion, linking exertional rhabdomyolysis to the pathogenesis of EAH. Glycogen 140-148 interleukin 6 Homo sapiens 119-132 15755769-0 2005 Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt. Glycogen 44-52 interleukin 6 Homo sapiens 0-13 15755769-1 2005 Previous studies showed an insulin-"desensitizing" action of IL-6 on glycogen synthesis in hepatocytes. Glycogen 69-77 interleukin 6 Homo sapiens 61-65 15755769-3 2005 Because these data indicate a possible tissue-specific effect of IL-6, we investigated the influence of IL-6 on insulin-stimulated glycogen synthesis in these cells. Glycogen 131-139 interleukin 6 Homo sapiens 104-108 15755769-6 2005 Accordingly, IL-6 enhanced glycogen synthesis in the presence of 3 and 10 nM insulin, whereas IL-6 alone had only a marginal effect. Glycogen 27-35 interleukin 6 Homo sapiens 13-17 15755769-9 2005 Together, our data demonstrate a novel insulin-sensitizing function of IL-6 on glycogen synthesis in skeletal muscle cells and indicate that IL-6 exerts cell/tissue-specific effects on insulin action. Glycogen 79-87 interleukin 6 Homo sapiens 71-75 15294041-5 2004 The IL-6 gene is rapidly activated during exercise, and the activation of this gene is further enhanced when muscle glycogen content is low. Glycogen 116-124 interleukin 6 Homo sapiens 4-8 15059966-5 2004 Total fluorescence (PRE vs. POST) and glycogen-dependent fluorescence (LOW vs. HIGH) of IL-6 protein were quantitated using Metamorph software. Glycogen 38-46 interleukin 6 Homo sapiens 88-92 15059966-8 2004 At POST, IL-6 protein was greater (P<0.05) in HIGH compared with LOW glycogen fibers, which coincided with type 2 fibers. Glycogen 72-80 interleukin 6 Homo sapiens 9-13 15059966-10 2004 At POST, however, IL-6 mRNA appeared predominantly in type 2 fibers, which also had higher glycogen content (P<0.05). Glycogen 91-99 interleukin 6 Homo sapiens 18-22 15304377-2 2004 Because 1) IL-6 mRNA expression in contracting skeletal muscle is enhanced by low muscle glycogen content, and 2) IL-6 increases lipolysis and oxidation of fatty acids, we hypothesized that regular exercise training, associated with increased levels of resting muscle glycogen and enhanced capacity to oxidize fatty acids, would lead to a less-pronounced increase of skeletal muscle IL-6 mRNA in response to acute exercise. Glycogen 102-110 interleukin 6 Homo sapiens 24-28 15345683-0 2004 Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction. Glycogen 46-54 interleukin 6 Homo sapiens 157-161 15072962-0 2004 Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability. Glycogen 129-137 interleukin 6 Homo sapiens 106-110 15072962-11 2004 Furthermore, the mRNA abundance of IL-6 and IL-8 appears to be influenced by glycogen availability in the contracting muscle. Glycogen 77-85 interleukin 6 Homo sapiens 35-39 14608461-3 2004 Glycogen deficiency is associated with increased expression of local cytokines (interleukin-6, IL-6), decreased expression of glucose transporters, increased cortisol and decreased insulin secretion and beta-adrenergic stimulation. Glycogen 0-8 interleukin 6 Homo sapiens 80-93 14608461-3 2004 Glycogen deficiency is associated with increased expression of local cytokines (interleukin-6, IL-6), decreased expression of glucose transporters, increased cortisol and decreased insulin secretion and beta-adrenergic stimulation. Glycogen 0-8 interleukin 6 Homo sapiens 95-99 12509497-9 2003 The pre-exercise muscle glycogen concentration tended to correlate with the arteriovenous IL-6 concentration difference at rest, and the postexercise glycogen concentration was inversely correlated with IL-6 release during the final 35 min of exercise. Glycogen 24-32 interleukin 6 Homo sapiens 90-94 12794182-2 2003 During exercise, muscle IL-6 mRNA levels and plasma IL-6 levels are increased and further augmented when intramuscular glycogen levels are low. Glycogen 119-127 interleukin 6 Homo sapiens 24-28 14686092-6 2003 However, it is clear that IL-6 production is activated by intracellular calcium levels, mitogen-activated protein kinases, reduced glycogen availability and other cytokines such as IL-1 beta. Glycogen 131-139 interleukin 6 Homo sapiens 26-30 15633585-2 2004 Since muscle metabolism in elderly subjects relies on glycogen more than younger subjects, it is possible that aging is associated with an altered production of muscle-derived IL-6 during exercise. Glycogen 54-62 interleukin 6 Homo sapiens 176-180 12937023-3 2003 IL-6 was released from the leg already after 10 min of exercise in the glycogen-depleted state, whereas no significant release was observed at any time in the loaded state. Glycogen 71-79 interleukin 6 Homo sapiens 0-4 12937023-7 2003 After 60 min of exercise in the glycogen-depleted state, individual values of alpha2-AMPK activity correlated significantly (r = 0.87, P < 0.006) with individual values of IL-6 release as well as with average IL-6 release over the entire 60 min (r = 0.86, P < 0.006). Glycogen 32-40 interleukin 6 Homo sapiens 175-179 12937023-7 2003 After 60 min of exercise in the glycogen-depleted state, individual values of alpha2-AMPK activity correlated significantly (r = 0.87, P < 0.006) with individual values of IL-6 release as well as with average IL-6 release over the entire 60 min (r = 0.86, P < 0.006). Glycogen 32-40 interleukin 6 Homo sapiens 212-216 12937023-9 2003 Alternatively, both AMPK and IL-6 are independent sensors of a low muscle glycogen concentration during exercise. Glycogen 74-82 interleukin 6 Homo sapiens 29-33 12690457-2 2003 The transcription rate for IL-6 in muscle nuclei isolated from muscle biopsies during exercise is very high and is enhanced further when muscle glycogen content is low. Glycogen 144-152 interleukin 6 Homo sapiens 27-31 12509497-9 2003 The pre-exercise muscle glycogen concentration tended to correlate with the arteriovenous IL-6 concentration difference at rest, and the postexercise glycogen concentration was inversely correlated with IL-6 release during the final 35 min of exercise. Glycogen 150-158 interleukin 6 Homo sapiens 203-207 12509497-12 2003 The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor. Glycogen 66-74 interleukin 6 Homo sapiens 42-46 12509497-12 2003 The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor. Glycogen 66-74 interleukin 6 Homo sapiens 127-131 12453891-8 2002 Finally, a 1.5-h preincubation of primary hepatocytes with IL-6 inhibits insulin-induced glycogen synthesis by 75%. Glycogen 89-97 interleukin 6 Homo sapiens 59-63 2105658-0 1990 Interleukin 6 stimulates hepatic glucose release from prelabeled glycogen pools. Glycogen 65-73 interleukin 6 Homo sapiens 0-13 14609022-8 2003 The IL-6 production is modulated by the glycogen content in muscles, and IL-6 thus works as an energy sensor. Glycogen 40-48 interleukin 6 Homo sapiens 4-8 12498381-5 2002 The primary function of the additional IL-6 may be to regulate the supply of carbohydrate as muscle reserves of glycogen become depleted. Glycogen 112-120 interleukin 6 Homo sapiens 39-43 11687509-0 2001 Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. Glycogen 102-110 interleukin 6 Homo sapiens 34-38 11687509-4 2001 Increases in plasma IL-6 during exercise were significantly higher (P<0.05) in the low-glycogen (16-fold) trial verses the control (10-fold) trial. Glycogen 90-98 interleukin 6 Homo sapiens 20-24 11687509-5 2001 Transcriptional activation of the IL-6 gene in skeletal muscle was also higher in the low-glycogen trial; it increased by about 40-fold after 90 min of exercise and about 60-fold after 180 min of exercise. Glycogen 90-98 interleukin 6 Homo sapiens 34-38 11687509-6 2001 Muscle IL-6 mRNA followed a similar but delayed pattern, increasing by more than 100-fold in the low-glycogen trial and by about 30-fold in the control trial. Glycogen 101-109 interleukin 6 Homo sapiens 7-11 11687509-7 2001 These data demonstrate that exercise activates transcription of the IL-6 gene in working skeletal muscle, a response that is dramatically enhanced when glycogen levels are low. Glycogen 152-160 interleukin 6 Homo sapiens 68-72 11687509-8 2001 These findings also support the hypothesis that IL-6 may be produced by contracting myofibers when glycogen levels become critically low as a means of signaling the liver to increase glucose production. Glycogen 99-107 interleukin 6 Homo sapiens 48-52 11731593-0 2001 Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. Glycogen 99-107 interleukin 6 Homo sapiens 0-13 11731593-3 2001 This study tests the hypothesis that the exercise-induced IL-6 release from contracting muscle is linked to the intramuscular glycogen availability. Glycogen 126-134 interleukin 6 Homo sapiens 58-62 11731593-10 2001 Intramuscular IL-6 mRNA levels increased with exercise in both legs, but this increase was augmented in the leg having the lowest glycogen content at end-ex. Glycogen 130-138 interleukin 6 Homo sapiens 14-18 11731593-15 2001 This study demonstrates that glycogen availability is associated with alterations in the rate of IL-6 production and release in contracting skeletal muscle. Glycogen 29-37 interleukin 6 Homo sapiens 97-101 7628063-4 1994 IL-6 produced a transient increase in plasma glucagon that was mirrored by elevated plasma glucose and a depletion of hepatic glycogen. Glycogen 126-134 interleukin 6 Homo sapiens 0-4 27150832-2 2016 Glycogen availability is a potent stimulator of IL-6 secretion. Glycogen 0-8 interleukin 6 Homo sapiens 48-52 35264090-6 2022 IL-6 increases GLUT-4 vesicle mobilization to muscle cell periphery, increasing the glucose transport into the cell, and also glycogen synthesis. Glycogen 126-134 interleukin 6 Homo sapiens 0-4 32597030-8 2020 On day 3, muscle glycogen content before exercise was negatively correlated with serum iron level (immediately after exercise, 3 hr after exercise), serum hepcidin level immediately after exercise, and plasma IL-6 level immediately after exercise (p < .05). Glycogen 17-25 interleukin 6 Homo sapiens 209-213 29946898-6 2018 IL-6 affected also the mitochondrial membrane potential together with elevated mitochondrial superoxide generation, and glycogen deposition was reduced. Glycogen 120-128 interleukin 6 Homo sapiens 0-4 27729872-8 2016 In summary, this study showed that muscle IL-6, IL-8, and MCP-1 mRNA expression after 75-km cycling was unrelated to glycogen depletion and muscle damage, with change in muscle glycogen related to plasma IL-6, and changes in serum myoglobin and cortisol related to the chemotactic cytokines IL-8 and MCP-1. Glycogen 177-185 interleukin 6 Homo sapiens 204-208