PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11675494-1 2001 In addition to its well-established role in responding to phosphate starvation, the cyclin-dependent kinase Pho85 has been implicated in a number of other physiological responses of the budding yeast Saccharomyces cerevisiae, including synthesis of glycogen. Glycogen 249-257 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 108-113 24022486-3 2013 The Pho85-Pcl10 complex is a key regulator of glycogen metabolism by phosphorylating the substrate Gsy2, the predominant, nutritionally regulated form of glycogen synthase. Glycogen 46-54 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 4-15 12518234-1 2003 PHO85 is a versatile gene in Saccharomyces cerevisiae, which is involved in metabolism of inorganic phosphate and usage of carbon source, accumulation of glycogen, regulation of protein stability and cell cycle control. Glycogen 154-162 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 0-5 11943203-0 2002 Analysis of respiratory mutants reveals new aspects of the control of glycogen accumulation by the cyclin-dependent protein kinase Pho85p. Glycogen 70-78 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 131-137 11943203-4 2002 We show here that pho85 coq3 mutants have dephosphorylated and active glycogen synthase yet do not maintain glycogen reserves. Glycogen 70-78 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 18-23 11943203-6 2002 This suggested the existence of inputs from Pho85p into glycogen storage, independent of Pcl8p and Pcl10p, and acting antagonistically. Glycogen 56-64 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 44-50 12096123-10 2002 (2001) Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p. Glycogen 46-54 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 161-167 11602261-0 2001 The yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p. Glycogen 65-73 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 121-127 11602261-4 2001 Pho85p thus affects glycogen accumulation through multiple Cdks composed of different cyclin partners. Glycogen 20-28 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 0-6 11675494-4 2001 We demonstrate that Pho85 controls the expression of not only previously identified glycogen synthetic genes, but also a significant regulon of genes involved in the cellular response to environmental stress. Glycogen 84-92 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 20-25 11021944-4 2000 The mobilization of glycogen was a specific trait resulting from a defect in mitochondrial function that could not be suppressed by mutations in the cAMP- and Pho85 protein kinase-dependent nutrient-sensing pathways, and by other mutations which favour glycogen synthesis. Glycogen 20-28 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 159-164 11486014-0 2001 Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p. Glycogen 39-47 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 154-160 11486014-10 2001 Pho85p is a cyclin-dependent protein kinase that antagonizes SNF1 control of glycogen synthesis. Glycogen 77-85 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 0-6 11069666-1 2000 Saccharomyces cerevisiae strains lacking a functional Pho85 cyclin-dependent kinase (cdk) exhibit a complex phenotype, including deregulation of phosphatase genes controlled by the transcription factor Pho4, slow growth on rich media, failure to grow using galactose, lactate or glycerol as a carbon source and hyperaccumulation of glycogen. Glycogen 332-340 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 54-59 9593297-1 1998 PHO85 is a cyclin-dependent kinase (CDK) with roles in phosphate and glycogen metabolism and cell cycle progression. Glycogen 69-77 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 0-5 9843683-2 1998 PHO85 encodes the catalytic subunit of a cyclin-dependent kinase (Cdk) in budding yeast and functions in phosphate and glycogen metabolism. Glycogen 119-127 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 0-5 9584169-0 1998 Cyclin partners determine Pho85 protein kinase substrate specificity in vitro and in vivo: control of glycogen biosynthesis by Pcl8 and Pcl10. Glycogen 102-110 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 26-31 9584169-3 1998 Pho85 has also been implicated as a kinase that phosphorylates and negatively regulates glycogen synthase (Gsy2), and deletion of PHO85 causes glycogen overaccumulation. Glycogen 88-96 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 0-5 9584169-10 1998 Mutation of PHO85 suppressed the glycogen storage deficiency of snf1 or glc7-1 mutants in which glycogen synthase is locked in an inactive state. Glycogen 33-41 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 12-17 9584169-12 1998 This genetic result suggests an additional role for Pho85 in the negative regulation of glycogen accumulation that is independent of Pcl8 and Pcl10. Glycogen 88-96 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 52-57 10740818-2 2000 Pho85 was originally discovered as a regulator of phosphate metabolism but roles for Pho85 in glycogen biosynthesis, actin regulation and cell cycle progression have since been discovered. Glycogen 94-102 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 85-90 8754836-0 1996 Pho85p, a cyclin-dependent protein kinase, and the Snf1p protein kinase act antagonistically to control glycogen accumulation in Saccharomyces cerevisiae. Glycogen 104-112 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 0-6 8754836-4 1996 In a screen for second site suppressors of the glycogen storage defect of snf1 cells, we identified a mutant gene that restored glycogen accumulation and which was allelic with PHO85, which encodes a member of the cyclin-dependent kinase family. Glycogen 47-55 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 177-182 8754836-4 1996 In a screen for second site suppressors of the glycogen storage defect of snf1 cells, we identified a mutant gene that restored glycogen accumulation and which was allelic with PHO85, which encodes a member of the cyclin-dependent kinase family. Glycogen 128-136 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 177-182 8754836-5 1996 In cells with disrupted PHO85 genes, we observed hyperaccumulation of glycogen, activation of glycogen synthase, and impaired glycogen synthase kinase activity. Glycogen 70-78 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 24-29 9426135-2 1997 Cells carrying a disruption of the PHO85 gene inappropriately express both PHO5 and GSY2, resulting in the increase in phosphate scavenging and hyperaccumulation of glycogen in nutrient-rich conditions. Glycogen 165-173 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 35-40 9426135-3 1997 Constitutive activation of PKA in a pho85 mutant suppresses the hyperaccumulation of glycogen. Glycogen 85-93 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 36-41 9426135-4 1997 This work presents data to show that, at least in part, the suppression of glycogen biosynthesis upon activation of PKA in a pho85 mutant results from the suppression of GSY2 expression. Glycogen 75-83 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 125-130 8722762-0 1996 Deletion of the gene encoding the cyclin-dependent protein kinase Pho85 alters glycogen metabolism in Saccharomyces cerevisiae. Glycogen 79-87 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 66-71 8722762-2 1996 We described several unique phenotypes associated with the deletion of the PHO85 gene including growth defects on a variety of carbon sources and hyperaccumulation of glycogen in rich medium high in Pi. Glycogen 167-175 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 75-80 8722762-3 1996 Hyperaccumulation of glycogen in the pho85 strains is independent of other APase regulatory molecules and is not signaled through Snfl kinase. Glycogen 21-29 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 37-42 8722762-4 1996 However, constitutive activation of cAPK suppresses the hyperaccumulation of glycogen in a pho85 mutant. Glycogen 77-85 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 91-96 8722762-5 1996 Mutation of the type-1 protein phosphatase encoded by GLC7 only partially suppresses the glycogen phenotype of the pho85 mutant. Glycogen 89-97 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 115-120 8722762-7 1996 This work provides evidence that Pho85 has functions in addition to transcriptional regulation of APase and cell-cycle progression including the regulation of glycogen levels in the cell and may provide a link between the nutritional state of the cell and these growth related responses. Glycogen 159-167 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 33-38