PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17584603-3	2007	It has been demonstrated that 6-thio-GTP, a metabolite of azathioprine, specifically inhibits Vav1-Rac activity in T lymphocytes.	Azathioprine	58-70	vav 1 oncogene	Mus musculus	94-98	
32277014-6	2020	Treatment of K-RasG12D and K-RasG12D/Vav1 mice with azathioprine, an immune-suppressor drug which inhibits Vav1"s activity as a GDP/GTP exchange factor, dramatically reduced the number of malignant lesions.	Azathioprine	52-64	vav 1 oncogene	Mus musculus	37-41	
32277014-6	2020	Treatment of K-RasG12D and K-RasG12D/Vav1 mice with azathioprine, an immune-suppressor drug which inhibits Vav1"s activity as a GDP/GTP exchange factor, dramatically reduced the number of malignant lesions.	Azathioprine	52-64	vav 1 oncogene	Mus musculus	107-111	
25977335-6	2015	The purine analogue azathioprine, well known for its function as an anti-inflammatory compound, was recently shown to function by inhibiting Vav1 signaling in immune cells.	Azathioprine	20-32	vav 1 oncogene	Mus musculus	141-145	
25977335-7	2015	We therefore hypothesized that azathioprine could also inhibit Vav1 in pancreatic tumor cells to reduce its proinvasive functions.	Azathioprine	31-43	vav 1 oncogene	Mus musculus	63-67	
25977335-8	2015	Indeed, we have found that treatment of cultured pancreatic tumor cells with azathioprine inhibited Vav1-dependent invasive cell migration and matrix degradation, through inhibition of Rac and Cdc42 signaling.	Azathioprine	77-89	vav 1 oncogene	Mus musculus	100-104	
25977335-11	2015	These inhibitory effects were mediated through Vav1, as Vav1-negative cell lines and tumors were largely resistant to azathioprine treatment.	Azathioprine	118-130	vav 1 oncogene	Mus musculus	47-51	
25977335-11	2015	These inhibitory effects were mediated through Vav1, as Vav1-negative cell lines and tumors were largely resistant to azathioprine treatment.	Azathioprine	118-130	vav 1 oncogene	Mus musculus	56-60	
25977335-12	2015	These findings demonstrate that azathioprine and related compounds could be potent antimetastatic agents for Vav1-positive pancreatic tumors.	Azathioprine	32-44	vav 1 oncogene	Mus musculus	109-113