PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25168137-6	2007	This region also encompasses the proton sensor E306 that is required for the activation of TREK-1 by cytosolic acidosis.	Tocopherols	47-51	potassium two pore domain channel subfamily K member 2	Homo sapiens	91-97	
25168137-7	2007	Protonation of E306 increases channel-phospholipid interaction leading to TREK-1 opening without direct-mechanical stimulation.	Tocopherols	15-19	potassium two pore domain channel subfamily K member 2	Homo sapiens	74-80	
12065410-5	2002	We demonstrate that the conversion of a specific glutamate residue (E306) to an alanine in this region locks TREK-1 in the open configuration and abolishes the cAMP/PKA down-modulation.	Tocopherols	68-72	potassium two pore domain channel subfamily K member 2	Homo sapiens	109-115	
12065410-7	2002	We conclude that protonation of E306 tunes the TREK-1 mechanical setpoint and thus sets lipid sensitivity.	Tocopherols	32-36	potassium two pore domain channel subfamily K member 2	Homo sapiens	47-53	
15577940-4	2005	This region also encompasses the proton sensor E306 that is required for activation of TREK-1 by cytosolic acidosis.	Tocopherols	47-51	potassium two pore domain channel subfamily K member 2	Homo sapiens	87-93	
15577940-5	2005	Protonation of E306 drastically tightens channel-phospholipid interaction and leads to TREK-1 opening at atmospheric pressure.	Tocopherols	15-19	potassium two pore domain channel subfamily K member 2	Homo sapiens	87-93