PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2464199-2 1988 In contrast to a current hypothesis the antithrombin III independent effect of PPS on blood coagulation is not caused by preventing the binding of the factors IX, IXa, X, Xa, VIII, V, Va and II onto procoagulant phospholipids. Pentosan Sulfuric Polyester 79-82 serpin family C member 1 Homo sapiens 40-56 7588997-2 1995 Addition of OSXS or SP-54 enhanced the complexation of thrombin with HC-II or with both AT-III and HC-II depending upon the concentration and the duration of the interactions of the sulfated compounds with plasma. Pentosan Sulfuric Polyester 20-25 serpin family C member 1 Homo sapiens 88-94 7588997-3 1995 During the 30 s interaction, OSXS and SP-54 enhanced both AT-III-thrombin and HC-II-thrombin interaction while heparin was more selective and enhanced only the AT-III-thrombin interaction. Pentosan Sulfuric Polyester 38-43 serpin family C member 1 Homo sapiens 58-64 7588997-5 1995 The complexations of AT-III-thrombin and HC-II-thrombin were reversed in the presence of 200 micrograms/ml of SP-54 during a 30 s interaction or in presence of 100 micrograms/ml of OSXS during a 2 min interaction. Pentosan Sulfuric Polyester 110-115 serpin family C member 1 Homo sapiens 21-27 2478364-0 1989 The heparin and pentosan polysulfate binding sites of human antithrombin overlap but are not identical. Pentosan Sulfuric Polyester 16-36 serpin family C member 1 Homo sapiens 60-72 2478364-8 1989 On the other hand, pentosan polysulfate protects only Lys-125 and causes no appreciable conformational change, although it is also capable of enhancing the antithrombin-thrombin interaction. Pentosan Sulfuric Polyester 19-39 serpin family C member 1 Homo sapiens 156-168 2478364-9 1989 These data clearly demonstrate that the heparin and pentosan polysulfate binding sites of antithrombin overlap (at Lys-125) but are not identical. Pentosan Sulfuric Polyester 52-72 serpin family C member 1 Homo sapiens 90-102 2464199-11 1988 We postulate therefore that the antithrombin III independent inhibitory effect of PPS on thrombin generation on blood coagulation is by interaction with factor VIIIa. Pentosan Sulfuric Polyester 82-85 serpin family C member 1 Homo sapiens 32-48 2464199-12 1988 This effect is additional to the heparin-like action of PPS, i.e. potentiation of the activity of antithrombin III and/or heparin cofactor II. Pentosan Sulfuric Polyester 56-59 serpin family C member 1 Homo sapiens 98-114 2436331-2 1986 Heparin and pentosan polysulfate (PPS) interact in plasma with antithrombin III (AT III) and Heparin cofactor II (HC II) respectively. Pentosan Sulfuric Polyester 12-32 serpin family C member 1 Homo sapiens 81-87 2442830-3 1987 The sulfated xylans were more effective than heparin or SP-54 in potentiating the AT-III inhibition of amidolysis of H-D-Phe-Pip-Arg-pNa (S-2238) by thrombin (IIa) or amidolysis of Bz-Ile-Glu-Gly-Arg-pNa (S-2222) by Xa. Pentosan Sulfuric Polyester 56-61 serpin family C member 1 Homo sapiens 82-88 2442830-4 1987 Study of the high affinity binding of the xylan sulfates to AT-III-Sepharose column showed that the amount of the xylan sulfate recovered in the eluates from this peak was greatly increased with an increase in molecular weight (MW). Pentosan Sulfuric Polyester 42-56 serpin family C member 1 Homo sapiens 60-66 2442830-4 1987 Study of the high affinity binding of the xylan sulfates to AT-III-Sepharose column showed that the amount of the xylan sulfate recovered in the eluates from this peak was greatly increased with an increase in molecular weight (MW). Pentosan Sulfuric Polyester 42-55 serpin family C member 1 Homo sapiens 60-66 2443128-12 1987 Reversal of the inhibitory effects of heparin and pentosan polysulphate was associated with the accelerated formation of 125I-thrombin-antithrombin III and 125I-thrombin-heparin cofactor complexes respectively. Pentosan Sulfuric Polyester 50-71 serpin family C member 1 Homo sapiens 135-151 2436331-2 1986 Heparin and pentosan polysulfate (PPS) interact in plasma with antithrombin III (AT III) and Heparin cofactor II (HC II) respectively. Pentosan Sulfuric Polyester 34-37 serpin family C member 1 Homo sapiens 81-87 2421433-0 1986 Pentosan polysulphate: activation of heparin cofactor II or antithrombin III according to molecular weight fractionation. Pentosan Sulfuric Polyester 0-21 serpin family C member 1 Homo sapiens 60-76 2579452-1 1985 Pentosan polysulphate is an heparin analogue which acts via an antithrombin III (AT III) independent pathway. Pentosan Sulfuric Polyester 0-21 serpin family C member 1 Homo sapiens 63-79 2579452-7 1985 The marked effect of pentosan polysulphate on thrombin and factor Xa generation in these patients is due to its AT III independent mechanism of action. Pentosan Sulfuric Polyester 21-42 serpin family C member 1 Homo sapiens 112-118 2579452-1 1985 Pentosan polysulphate is an heparin analogue which acts via an antithrombin III (AT III) independent pathway. Pentosan Sulfuric Polyester 0-21 serpin family C member 1 Homo sapiens 81-87 6209821-0 1984 Identification of heparin cofactor II as the principal plasma cofactor for the antithrombin activity of pentosan polysulphate (SP54). Pentosan Sulfuric Polyester 104-125 serpin family C member 1 Homo sapiens 79-91 6209821-1 1984 In antithrombin III depleted plasma only a slight reduction was observed in thrombin inhibitory activity due to potentiation by dermatan sulphate or by pentosan polysulphate (SP54). Pentosan Sulfuric Polyester 152-173 serpin family C member 1 Homo sapiens 3-19 6209821-1 1984 In antithrombin III depleted plasma only a slight reduction was observed in thrombin inhibitory activity due to potentiation by dermatan sulphate or by pentosan polysulphate (SP54). Pentosan Sulfuric Polyester 175-179 serpin family C member 1 Homo sapiens 3-19 6209821-0 1984 Identification of heparin cofactor II as the principal plasma cofactor for the antithrombin activity of pentosan polysulphate (SP54). Pentosan Sulfuric Polyester 127-131 serpin family C member 1 Homo sapiens 79-91 6193602-1 1983 Pentosan polysulphate (PPS, Hemoclar, MW 6,700) was observed to have a low affinity for ATIII-Sepharose eluting at 0.3M NaCl. Pentosan Sulfuric Polyester 0-21 serpin family C member 1 Homo sapiens 88-93 6207810-0 1984 Effect of a pentosan polysulphate upon thrombin and factor Xa inactivation by antithrombin III. Pentosan Sulfuric Polyester 12-33 serpin family C member 1 Homo sapiens 78-94 6207810-7 1984 In the presence of pentosan polysulphate the dissociation constant for the initial complex of antithrombin III and thrombin was shown to be reduced from approx. Pentosan Sulfuric Polyester 19-40 serpin family C member 1 Homo sapiens 94-110 6193602-1 1983 Pentosan polysulphate (PPS, Hemoclar, MW 6,700) was observed to have a low affinity for ATIII-Sepharose eluting at 0.3M NaCl. Pentosan Sulfuric Polyester 23-26 serpin family C member 1 Homo sapiens 88-93 6193602-7 1983 The antiheparin effect of PPS was also observed in a purified system in obviating the heparin potentiation of the rate of inhibition of thrombin by antithrombin III. Pentosan Sulfuric Polyester 26-29 serpin family C member 1 Homo sapiens 148-164 6193602-8 1983 Observations showed that at higher concentrations of PPS it acted by directly inhibiting thrombin without the intervention of antithrombin III but also to potentiate the rate of fibrin monomer polymerization. Pentosan Sulfuric Polyester 53-56 serpin family C member 1 Homo sapiens 126-142 6179183-5 1982 Our data indicate that pentosan polysulphate has more marked effects in vivo than in vitro, that the action of the drug on clotting is mediated mainly via an At III-independent pathway, and that its effects are not confined to the coagulation system. Pentosan Sulfuric Polyester 23-44 serpin family C member 1 Homo sapiens 158-164 6155418-2 1980 We have investigated the potentiation of AT-III inhibition of factors Xa, IIa, and plasmin by the heparinoid substance SP-54. Pentosan Sulfuric Polyester 119-124 serpin family C member 1 Homo sapiens 41-47 6155418-4 1980 SP-54 potentiated AT-III inhibition of factors Xa and IIa in the absence of heparin. Pentosan Sulfuric Polyester 0-5 serpin family C member 1 Homo sapiens 18-24 6155418-6 1980 SP-54 also potentiated the AT-III inhibition of plasmin action. Pentosan Sulfuric Polyester 0-5 serpin family C member 1 Homo sapiens 27-33 7371952-0 1980 Inhibition by antithrombin III of carrageenan- and xylan SP54-induced aggregation of human blood platelets [proceedings]. Pentosan Sulfuric Polyester 51-61 serpin family C member 1 Homo sapiens 14-30 15000687-2 2004 Heparin and pentosan polysulfate stabilized antithrombin III; this resulted in decrease in ultrasonic-induced formation of the aggregate and latent forms. Pentosan Sulfuric Polyester 12-32 serpin family C member 1 Homo sapiens 44-60