PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22299597-0	2012	Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.	Pentosan Sulfuric Polyester	0-20	TIMP metallopeptidase inhibitor 3	Homo sapiens	61-67	
31359422-0	2020	Thermodynamic profiles of the interactions of suramin, chondroitin sulfate, and pentosan polysulfate with the inhibitory domain of TIMP-3.	Pentosan Sulfuric Polyester	80-100	TIMP metallopeptidase inhibitor 3	Homo sapiens	131-137	
31359422-4	2020	Here, we report the thermodynamics of the interactions of the sGAG-binding N-domain of TIMP-3 with chondroitin sulfate, pentosan polysulfate, and suramin in solution using isothermal titration calorimetry.	Pentosan Sulfuric Polyester	120-140	TIMP metallopeptidase inhibitor 3	Homo sapiens	87-93	
22299597-1	2012	The semi-synthetic sulfated polysaccharide PPS (pentosan polysulfate) increases affinity between the aggrecan-degrading ADAMTSs (adamalysins with thrombospondin motifs) and their endogenous inhibitor, TIMP (tissue inhibitor of metalloproteinases)-3.	Pentosan Sulfuric Polyester	43-46	TIMP metallopeptidase inhibitor 3	Homo sapiens	207-248	
22299597-1	2012	The semi-synthetic sulfated polysaccharide PPS (pentosan polysulfate) increases affinity between the aggrecan-degrading ADAMTSs (adamalysins with thrombospondin motifs) and their endogenous inhibitor, TIMP (tissue inhibitor of metalloproteinases)-3.	Pentosan Sulfuric Polyester	48-68	TIMP metallopeptidase inhibitor 3	Homo sapiens	207-248	
22299597-2	2012	In the present study we demonstrate that PPS mediates the formation of a high-affinity trimolecular complex with ADAMTS-5 and TIMP-3.	Pentosan Sulfuric Polyester	41-44	TIMP metallopeptidase inhibitor 3	Homo sapiens	126-132	
22299597-6	2012	These results suggest that PPS enhances the affinity between ADAMTS-5 and TIMP-3 by forming electrostatically driven trimolecular complexes under physiological conditions.	Pentosan Sulfuric Polyester	27-30	TIMP metallopeptidase inhibitor 3	Homo sapiens	74-80