PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15834151-6	2005	Genetic analysis revealed that the flap endonucleases Slx4 and Sae2 represent new pathways parallel to Tdp1, Rad1, and Mus81 that protect cells from camptothecin toxicity.	Camptothecin	149-161	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	103-107	
12368472-3	2002	Thus, tdp1 rad1 cells (including the catalytic point mutant rad1-D869A) not only are highly sensitive to the Top1 poison camptothecin but also exhibit a TOP1-dependent growth delay.	Camptothecin	121-133	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	6-10	
11585902-5	2001	The triple mutant was also deficient in the repair of 3" phosphate lesions left by Tdp1-mediated cleavage of camptothecin-stabilized Top1-DNA covalent complexes.	Camptothecin	109-121	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	83-87	
11532027-7	2001	In the absence of RAD9, inactivation of TDP1 has a significant effect on the survival of cells following exposure to camptothecin but is without consequence for the survival of agents that do not target topoisomerase I.	Camptothecin	117-129	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	40-44	
26762090-9	2015	in the presence of Top 1 inhibitors, such as camptothecin, therefore Tdp1 is a very important target for the development of inhibitors--anticancer drugs.	Camptothecin	45-57	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	69-73	
16751265-5	2006	Cells lacking Tdp1 are hypersensitive to camptothecin, consistent with a role for Tdp1 in processing 3" phosphotyrosyl protein-DNA covalent complexes.	Camptothecin	41-53	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	14-18	
15135727-3	2004	The phenotypes of yeast strains that express this mutant show that the contribution of TDP1 to the repair of two kinds of damaged termini-induced, respectively, by camptothecin (CPT) and by bleomycin-strongly depends on enzyme activity.	Camptothecin	164-176	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	87-91	
15135727-3	2004	The phenotypes of yeast strains that express this mutant show that the contribution of TDP1 to the repair of two kinds of damaged termini-induced, respectively, by camptothecin (CPT) and by bleomycin-strongly depends on enzyme activity.	Camptothecin	178-181	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	87-91