PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27721159-4	2017	Mechanism study indicated that PSI improved the CPT/HCPT induced apoptosis in lung cancer cells through mitochondria pathway including cytochrome C release and activation of caspase-9 and -3 cascades.	Camptothecin	48-51	cytochrome c, somatic	Homo sapiens	135-147	
33882408-4	2021	Here we report the novel interaction between the endogenous family member B-so-called ANP32B-and endogenous cytochrome c in cells undergoing camptothecin-induced DNA damage.	Camptothecin	141-153	cytochrome c, somatic	Homo sapiens	108-120	
20138027-7	2010	This study identified five lead compounds such as thapsigargin, tunicamycine, MG132, kaempferol and camptothecin that could induce cytochrome C release in both wild type and Bax deficient cells with equal potency.	Camptothecin	100-112	cytochrome c, somatic	Homo sapiens	131-143	
11925121-13	2002	An intact cytochrome c pathway was demonstrated in C33A cells leading to cleavage of caspase 3 after camptothecin treatment.	Camptothecin	101-113	cytochrome c, somatic	Homo sapiens	10-22	
19885006-3	2009	Camptothecin caused apoptosis in SiHa cells by inducing mitochondrial membrane permeability changes that lead to the loss of mitochondrial membrane potential, decreased Bcl-2 levels, cytochrome c release, caspase-3 activation, formation of reactive oxygen species and depletion of GSH.	Camptothecin	0-12	cytochrome c, somatic	Homo sapiens	183-195	
12538580-7	2003	The mechanism of protection afforded by muscarinic receptor activation from camptothecin-induced apoptotic signaling involved blockade of mitochondrial cytochrome c release associated with a bolstering of mitochondrial bcl-2 levels and blockade of the translocation of Bax to mitochondria.	Camptothecin	76-88	cytochrome c, somatic	Homo sapiens	152-164	
11997243-0	2002	Polyamine depletion prevents camptothecin-induced apoptosis by inhibiting the release of cytochrome c.	Camptothecin	29-41	cytochrome c, somatic	Homo sapiens	89-101	
11997243-7	2002	Depletion of polyamines prevented camptothecin-induced release of cytochrome c from mitochondria and decreased the activity of caspase-9 and caspase-3.	Camptothecin	34-46	cytochrome c, somatic	Homo sapiens	66-78	
19885006-5	2009	These results suggest that camptothecin may cause cell death in SiHa cells by inducing changes in mitochondrial membrane permeability, which leads to cytochrome c release and activation of caspase-3.	Camptothecin	27-39	cytochrome c, somatic	Homo sapiens	150-162	
11139283-0	2000	Increased mitochondrial cytochrome c levels and mitochondrial hyperpolarization precede camptothecin-induced apoptosis in Jurkat cells.	Camptothecin	88-100	cytochrome c, somatic	Homo sapiens	24-36	
11139283-2	2000	In the present study, we showed that, in Jurkat human T cells, camptothecin-induced apoptosis is preceded by (i) an increase in cytochrome c and subunit IV of cytochrome c oxidase (COX IV) levels in mitochondria; and (ii) an elevation of the mitochondrial membrane potential (Delta(Psi)m).	Camptothecin	63-75	cytochrome c, somatic	Homo sapiens	128-140	
11139283-2	2000	In the present study, we showed that, in Jurkat human T cells, camptothecin-induced apoptosis is preceded by (i) an increase in cytochrome c and subunit IV of cytochrome c oxidase (COX IV) levels in mitochondria; and (ii) an elevation of the mitochondrial membrane potential (Delta(Psi)m).	Camptothecin	63-75	cytochrome c, somatic	Homo sapiens	159-171	
10915781-8	2000	As a corollary, the cytosolic levels of cytochrome c were significantly higher in AS versus C cells, which correlated with approximately 2- and approximately 3-fold higher activation of caspase-9 and -3, respectively, in AS versus C cells in response to camptothecin.	Camptothecin	254-266	cytochrome c, somatic	Homo sapiens	40-52	
10845773-6	2000	However, Bax-dependent cytochrome c release still occurs in camptothecin-treated caspase 3-deficient cortical neurons.	Camptothecin	60-72	cytochrome c, somatic	Homo sapiens	23-35	
9446803-6	1998	Furthermore, when PC3 cells were treated with a panel of apoptosis-inducing agents, it was found that camptothecin, bleomycin, VP16 and TNF-alpha induced varying amounts of cytosolic accumulation of cytochrome c either prior to or concurrent with PARP cleavage while vinblastine and BHPP did not.	Camptothecin	102-114	cytochrome c, somatic	Homo sapiens	199-211