PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17603793-6	2007	In addition, depletion of XRCC1 resulted in a significantly increased sensitivity to the alkylating agent methyl methanesulfonate and the thymidine base analog 5-hydroxymethyl-2"-deoxyuridine, a slightly increased sensitivity to ethyl methanesulfonate and 1,3-bis(2-chloroethyl)-1-nitrosourea, and no change in the response to camptothecin.	Camptothecin	327-339	X-ray repair cross complementing 1	Homo sapiens	26-31	
29100039-9	2017	Xrcc1-/- cells are hypersensitive to the DNA-protein cross-link inducing agent camptothecin (CPT) and the DNA oxidative agent H2O2 due in part to compromised PNKP-mediated repair.	Camptothecin	79-91	X-ray repair cross complementing 1	Homo sapiens	0-5	
29100039-9	2017	Xrcc1-/- cells are hypersensitive to the DNA-protein cross-link inducing agent camptothecin (CPT) and the DNA oxidative agent H2O2 due in part to compromised PNKP-mediated repair.	Camptothecin	93-96	X-ray repair cross complementing 1	Homo sapiens	0-5	
19604089-1	2009	AIMS: A recent study found that variation in camptothecin pharmacodynamic genes (TOP1, PARP1, TDP1 and XRCC1) correlated with efficacy and risk of neutropenia in irinotecan-treated cancer patients (median dose: 180 mg/m2), which suggests that these genes might predict outcomes to irinotecan-based therapies.	Camptothecin	45-57	X-ray repair cross complementing 1	Homo sapiens	103-108	
18347181-3	2008	CDC45L, NFKB1, PARP1, TDP1, and XRCC1 have been shown to influence the cytotoxic action of camptothecins, including irinotecan.	Camptothecin	91-104	X-ray repair cross complementing 1	Homo sapiens	32-37