PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12790799-4	2003	It was found that FFA (0.4 mM oleate/complexed to 0.5% bovine serum albumin) inhibited IGF-I-induced activation of protein kinase B (PKB) in the pancreatic beta-cell line (INS-1), but this was alleviated in the presence of the general PKC inhibitor (Go6850; 1 microM).	Oleic Acid	30-36	insulin 1	Rattus norvegicus	172-177	
15561927-9	2004	In conclusion, INS-1e cells display a PPAR-gamma tone that is symmetrically modulated and competitively stimulated by oleate.	Oleic Acid	118-124	insulin 1	Rattus norvegicus	15-20	
10760474-4	2000	INS-1 cell glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE) lipids are demonstrated here by electrospray ionization mass spectrometry to contain a lower fraction of molecules with arachidonate and a higher fraction with oleate as sn-2 substituent than native islets.	Oleic Acid	236-242	insulin 1	Rattus norvegicus	0-5	
12205102-0	2002	Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid.	Oleic Acid	67-77	insulin 1	Rattus norvegicus	47-52	
12205102-4	2002	Here, we show that UCP2 mRNA and protein levels were increased after a 48-h exposure of INS-1(832/13) beta-cells to oleic acid (0.5 mm) by activation of the UCP2 promoter.	Oleic Acid	116-126	insulin 1	Rattus norvegicus	88-93	
10760474-5	2000	Palmitic acid supplementation induces little change in these INS-1 cell lipids, but supplementation with linoleate or arachidonate induces a large rise in the fraction of INS-1 cell GPC species with polyunsaturated sn-2 substituents and a fall in oleate-containing species to yield a GPC profile similar to native islets.	Oleic Acid	108-114	insulin 1	Rattus norvegicus	171-176	
10512366-0	1999	Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1.	Oleic Acid	14-20	insulin 1	Rattus norvegicus	113-118	
10484365-2	1999	INS-1 beta-cells were exposed to 0.4 mM oleate for 3 days and subsequently incubated at 5 or 25 mM glucose, after which various parameters were measured.	Oleic Acid	40-46	insulin 1	Rattus norvegicus	0-5	
9032094-11	1997	Prolonged exposure of INS-1 cells to palmitate, oleate, and linoleate markedly altered the glucose-induced insulin response, resulting in high basal insulin release and a suppression of glucose-induced insulin secretion.	Oleic Acid	48-54	insulin 1	Rattus norvegicus	22-27	
31816355-0	2020	Palmitate and oleate modify membrane fluidity and kinase activities of INS-1E beta-cells alongside altered metabolism-secretion coupling.	Oleic Acid	14-20	insulin 1	Rattus norvegicus	71-76	
31816355-10	2020	Each of the tested fatty acids functionally modified INS-1E beta-cell, oleate inducing the strongest effects.	Oleic Acid	71-77	insulin 1	Rattus norvegicus	53-58	
25934392-6	2015	A clear hypersensitivity to submaximal glucose concentrations was evident in INS-1 cells cultured in excess nutrients such that the 25% of maximal (S0.25) glucose-stimulated insulin secretion was significantly reduced in cells cultured in 11 mm glucose (S0.25 = 3.5 mm) and 4 mm glucose with oleate (S0.25 = 4.5 mm) compared with 4 mm glucose alone (S0.25 = 5.7 mm).	Oleic Acid	292-298	insulin 1	Rattus norvegicus	77-82