PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3035039-10 1987 Insulin had a similar but less pronounced effect on the concentration and composition of lipoproteins secreted in the presence of oleate. Oleic Acid 130-136 insulin Homo sapiens 0-7 2861168-12 1985 Free fatty acids proved effective in increasing monocyte insulin binding (14% with 1 mmol/l oleic acid) in vitro. Oleic Acid 92-102 insulin Homo sapiens 57-64 2872764-2 1986 Oleate, 2 mmol/l, increased the output rates of pancreatic somatostatin, glucagon and insulin. Oleic Acid 0-6 insulin Homo sapiens 86-93 33879968-0 2021 Oleic acid to stearic acid ratio might be a potential marker for insulin resistance in non-obese Japanese. Oleic Acid 0-10 insulin Homo sapiens 65-72 5966104-0 1966 [Action of insulin on intestinal absorption of lipids (research with I-131 labeled oleic acid)]. Oleic Acid 83-93 insulin Homo sapiens 11-18 33839491-0 2021 Probiotics-rich emulsion improves insulin signalling in Palmitate/Oleate-challenged human hepatocarcinoma cells through the modulation of Fetuin-A/TLR4-JNK-NF-kappaB pathway. Oleic Acid 66-72 insulin Homo sapiens 34-41 33561215-10 2021 In age- and sex-adjusted models for insulin resistance, MUFAs (OR: 1.26) and oleic acid (OR: 1.25) were positively, and PUFAs (OR: 0.81), particularly linoleic acid (OR: 0.78), were inversely associated with HOMA-IR. Oleic Acid 77-87 insulin Homo sapiens 36-43 33879968-6 2021 The oleic acid/stearic acid ratio exhibited a positive correlation with the logmatic transformed triglyceride/high-density lipoprotein cholesterol ratio and the fasting triglycerides-glucose index, both of which were used as markers for insulin resistance. Oleic Acid 4-14 insulin Homo sapiens 237-244 33879968-10 2021 In conclusion, oleic acid/stearic acid ratio might be a useful marker for insulin resistance in non-obese Japanese subjects. Oleic Acid 15-25 insulin Homo sapiens 74-81 32806641-0 2020 Oleic Acid Protects Against Insulin Resistance by Regulating the Genes Related to the PI3K Signaling Pathway. Oleic Acid 0-10 insulin Homo sapiens 28-35 33631425-0 2021 Oleic Acid and Eicosapentaenoic Acid Reverse Palmitic Acid-induced Insulin Resistance in Human HepG2 Cells via the Reactive Oxygen Species / JUN Pathway. Oleic Acid 0-10 insulin Homo sapiens 67-74 32125563-0 2020 Current perspectives of oleic acid: Regulation of molecular pathways in mitochondrial and endothelial functioning against insulin resistance and diabetes. Oleic Acid 24-34 insulin Homo sapiens 122-129 32806641-11 2020 CONCLUSIONS: Our in vitro results suggest a detrimental role of palmitic acid on the expression of gene related to insulin signaling pathway, with oleic acid being the one with the higher and more beneficial effects. Oleic Acid 147-157 insulin Homo sapiens 115-122 32423875-4 2020 The transdermal insulin permeation was promoted by microwave (2450 MHz/1 mW) > oleic acid (monounsaturated) ~ linoleic acid (double unsaturated bonds). Oleic Acid 79-89 insulin Homo sapiens 16-23 29996652-0 2018 Alginate-C18 Conjugate Nanoparticles Loaded in Tripolyphosphate-Cross-Linked Chitosan-Oleic Acid Conjugate-Coated Calcium Alginate Beads as Oral Insulin Carrier. Oleic Acid 86-96 insulin Homo sapiens 145-152 32694809-4 2019 ELOVL6 promotes an increase in phospholipid oleic acid, which modifies plasma membrane fluidity and enhances insulin signalling. Oleic Acid 44-54 insulin Homo sapiens 109-116 30719005-2 2018 To address this problem, the oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis and their mediator molecules have been investigated in the insulin releasing beta cells exposed to palmitic and/or oleic acid. Oleic Acid 216-226 insulin Homo sapiens 160-167 31840531-4 2019 Insulin resistance was defined by assessing alpha hydroxybutyrate, lynoleoyl glycerolphosphocoline, oleic acid, and insulin (Quantose IR), whereas the presence of NAFLD was defined by serologic determinations (Fibromax) and liver transient elastography (Fibroscan). Oleic Acid 100-110 insulin Homo sapiens 0-7 26923704-13 2016 Linoleic acid, but not oleic acid or the sum of long-chain omega 3 fatty acids (w3), was associated with increased appendicular lean mass and decreased trunk adipose mass and insulin resistance. Oleic Acid 3-13 insulin Homo sapiens 175-182 28584168-6 2017 However, an exposure to palmitate, oleate or their combination reduced insulin-stimulated glucose uptake. Oleic Acid 35-41 insulin Homo sapiens 71-78 29864915-0 2018 Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells. Oleic Acid 95-105 insulin Homo sapiens 73-80 29864915-4 2018 Here, we evaluate the effects of DHC on oleic acid (OA)-induced lipid accumulation, oxidative stress and insulin resistance and the underlying mechanism in L02 and HepG2 cells. Oleic Acid 40-50 insulin Homo sapiens 105-112 29864915-4 2018 Here, we evaluate the effects of DHC on oleic acid (OA)-induced lipid accumulation, oxidative stress and insulin resistance and the underlying mechanism in L02 and HepG2 cells. Oleic Acid 52-54 insulin Homo sapiens 105-112 29290500-2 2018 However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits beneficial effects on insulin sensitivity, and the dietary palmitic acid:oleic acid ratio impacts diabetes risk in humans. Oleic Acid 92-102 insulin Homo sapiens 133-140 29290500-3 2018 Here we review recent mechanistic insights into the beneficial effects of oleic acid compared with palmitic acid on insulin resistance and T2DM, including its anti-inflammatory actions, and its capacity to inhibit endoplasmic reticulum (ER) stress, prevent attenuation of the insulin signaling pathway, and improve beta cell survival. Oleic Acid 74-84 insulin Homo sapiens 116-123 29290500-3 2018 Here we review recent mechanistic insights into the beneficial effects of oleic acid compared with palmitic acid on insulin resistance and T2DM, including its anti-inflammatory actions, and its capacity to inhibit endoplasmic reticulum (ER) stress, prevent attenuation of the insulin signaling pathway, and improve beta cell survival. Oleic Acid 74-84 insulin Homo sapiens 276-283 29064290-0 2017 Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators. Oleic Acid 10-20 insulin Homo sapiens 72-79 29064290-2 2017 RESULTS: Starting from quercetin and oleic acid, that have effect on insulin secretion, a small set of hybrid molecules was synthesized. Oleic Acid 37-47 insulin Homo sapiens 69-76 19192424-1 2009 In humans, insulin sensitivity is relatively impaired by diets that are low in oleic acid (OA), a cis monounsaturated fatty acid (MUFA), or rich in trans MUFA or palmitic acid (PA), a saturated fatty acid (FA). Oleic Acid 79-89 insulin Homo sapiens 11-18 25536389-0 2015 Effect of NAD on PARP-mediated insulin sensitivity in oleic acid treated hepatocytes. Oleic Acid 54-64 insulin Homo sapiens 31-38 24353137-8 2014 Total fatty acids and unsaturated fatty acids such as oleic acid and linoleic acid showed an inverse significant correlation with insulin resistance. Oleic Acid 54-64 insulin Homo sapiens 130-137 23460021-0 2013 Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism. Oleic Acid 0-6 insulin Homo sapiens 73-80 23460021-10 2013 CONCLUSIONS/INTERPRETATION: Overall, these findings indicate that oleate prevents ER stress, inflammation and insulin resistance in palmitate-exposed skeletal muscle cells by activating AMPK. Oleic Acid 66-72 insulin Homo sapiens 110-117 26344902-4 2015 In the present study, we demonstrate that oleate preconditioning, as well as coincubation, completely prevented palmitate-induced markers of inflammatory signaling, insulin resistance and cytotoxicity in C2C12 myotubes. Oleic Acid 42-48 insulin Homo sapiens 165-172 26226227-3 2015 Our results suggest that the modulatory role of insulin on the responses of hypothalamic FA-sensing systems to changes in circulating levels of OL or OCT was of minor importance in contrast to the mammalian model. Oleic Acid 144-146 insulin Homo sapiens 48-55 26226227-5 2015 In liver and Brockmann bodies, insulin treatment enhanced the responses to OL or OCT treatment in parameters related to FA sensing. Oleic Acid 75-77 insulin Homo sapiens 31-38 25536389-4 2015 Furthermore, treatment with PJ34 reversed the oleic acid-induced decrease in intracellular NAD concentration, while exogenous NAD protected cells against oleic acid-induced insulin insensitivity. Oleic Acid 154-164 insulin Homo sapiens 173-180 25536389-7 2015 Taken together, these data suggest that NAD depletion by PARP1 activation is essential for the modulation of insulin sensitivity in oleic acid-induced lipotoxicity. Oleic Acid 132-142 insulin Homo sapiens 109-116 25846498-6 2015 Oleic acid suppressed the toxic effects of palmitic acid on ER stress activation, lipoapoptosis and insulin resistance. Oleic Acid 0-10 insulin Homo sapiens 100-107 25846498-9 2015 In conclusion, this is the first study highlighting the activation of S6K1 by palmitic acid as a common and novel mechanism by which its inhibition by oleic acid prevents ER stress, lipoapoptosis and insulin resistance in hepatocytes. Oleic Acid 151-161 insulin Homo sapiens 200-207 22209682-0 2012 Oleic acid activates peroxisome proliferator-activated receptor delta to compensate insulin resistance in steatotic cells. Oleic Acid 0-10 insulin Homo sapiens 84-91 22209682-2 2012 Oleic acid (OA) is known to induce hepatic steatosis with normal insulin sensitivity; however, the mechanism is still unknown. Oleic Acid 0-10 insulin Homo sapiens 65-72 22209682-2 2012 Oleic acid (OA) is known to induce hepatic steatosis with normal insulin sensitivity; however, the mechanism is still unknown. Oleic Acid 12-14 insulin Homo sapiens 65-72 19622194-0 2009 Oleate protects against palmitate-induced insulin resistance in L6 myotubes. Oleic Acid 0-6 insulin Homo sapiens 42-49 19622194-1 2009 Oleate has been shown to protect against palmitate-induced insulin resistance. Oleic Acid 0-6 insulin Homo sapiens 59-66 19622194-2 2009 The present study investigates mechanisms involved in the interaction between oleate and palmitate on insulin-stimulated glucose uptake by L6 skeletal muscle cells. Oleic Acid 78-84 insulin Homo sapiens 102-109 19622194-5 2009 Cells incubated with oleate up to 750 micromol/l maintained a significant increase in insulin-stimulated glucose uptake. Oleic Acid 21-27 insulin Homo sapiens 86-93 19192424-1 2009 In humans, insulin sensitivity is relatively impaired by diets that are low in oleic acid (OA), a cis monounsaturated fatty acid (MUFA), or rich in trans MUFA or palmitic acid (PA), a saturated fatty acid (FA). Oleic Acid 91-93 insulin Homo sapiens 11-18 19083476-1 2008 Oleate (C18:1) is, besides palmitate (C16:0), the most abundant fatty acid in the human diet, and its involvement in the development of insulin resistance is broadly discussed. Oleic Acid 0-6 insulin Homo sapiens 136-143 20409874-5 2007 Insulin suppressed plasma linoleate and oleate similarly in CKD (81%, 84%) and NT subjects (84%, 85%, respectively; P = NS) but less in HT patients (67%, 70%, P < .05 vs. CKD and NT). Oleic Acid 29-35 insulin Homo sapiens 0-7 18281277-0 2008 Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells. Oleic Acid 0-6 insulin Homo sapiens 34-41 17804680-8 2007 The insulin response was lower to meals rich in oleic acid or EPA and DHA than to meals rich in palmitic acid or linoleic acid (P < 0.01). Oleic Acid 48-58 insulin Homo sapiens 4-11 17097017-12 2006 Oleate and palmitate treatment did not influence basal glucose transport (without insulin stimulation), whereas insulin-stimulated glucose transport was inhibited after overnight oleate and palmitate treatment in preadipocytes and adipocytes. Oleic Acid 179-185 insulin Homo sapiens 112-119 17922004-7 2007 We also show that oleic acid treatment decreases the insulin sensitivity of heart muscle cells, and this sensitivity is completely restored by transfection with SNAP23. Oleic Acid 18-28 insulin Homo sapiens 53-60 17384440-0 2007 Prolonged treatment of primary hepatocytes with oleate induces insulin resistance through p38 mitogen-activated protein kinase. Oleic Acid 48-54 insulin Homo sapiens 63-70 17097017-13 2006 In 3T3-L1 preadipocytes, insulin resistance could be achieved at 0.125 mmol/L oleate or palmitate (P < 0.05, respectively), and the inhibition was dose dependent. Oleic Acid 78-84 insulin Homo sapiens 25-32 17097017-19 2006 CONCLUSIONS: Oleic acid and palmitic acid may induce insulin resistance in 3T3-L1 adipocytes and preadipocytes. Oleic Acid 13-23 insulin Homo sapiens 53-60 16711601-4 2006 Oleate-treated fat cells also showed exaggerated basal lipolysis and weak response to insulin in both lipolysis regulation and glucose uptake. Oleic Acid 0-6 insulin Homo sapiens 86-93 16920849-0 2006 Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid. Oleic Acid 158-168 insulin Homo sapiens 100-107 15935394-0 2005 Mechanisms of oleic acid deterioration in insulin secretion: role in the pathogenesis of type 2 diabetes. Oleic Acid 14-24 insulin Homo sapiens 42-49 15935394-4 2005 Elevated expression of PPI, PDX-1 and GLUT2 was also observed after treatment of the islets with oleic acid, which may partially contribute to the increased basal insulin secretion. Oleic Acid 97-107 insulin Homo sapiens 163-170 15919610-8 2005 In contrast, leptin (10 ng/ml) and insulin (0.60 ng/ml)) stimulated the uptake of oleic acid (7.4+/-2.3 nmol/mg protein) in human adipose cells, SGBS cells by 1.28- and 2.48-fold (P<0.05), respectively. Oleic Acid 82-92 insulin Homo sapiens 35-42 15355510-7 2004 Inhibition of PI 3-kinase blocked insulin- and oleate-induced translocation of IMPDH and reduced oleate-induced lipid accumulation. Oleic Acid 97-103 insulin Homo sapiens 34-41 15734839-3 2005 Studies of palmitic acid and oleic acid metabolism in human myotubes established from control and type 2 diabetic subjects under conditions of acute high concentrations of insulin and/or glucose may solve these questions. Oleic Acid 29-39 insulin Homo sapiens 172-179 15734839-4 2005 Total oleic acid and palmitic acid uptake in myotubes was increased during acute insulin stimulation (P < 0.01) but not under acute, high-glucose concentrations, and no differences were found between the groups. Oleic Acid 6-16 insulin Homo sapiens 81-88 15654918-4 2005 Acute insulin exposure increased (14)C-oleate uptake and levels of free fatty acids (FFA) and triacylglycerol (TAG). Oleic Acid 39-45 insulin Homo sapiens 6-13 15654918-5 2005 Palmitate pre-treatment further increased oleate uptake, both under basal conditions and in the presence of insulin, with a marked increase in the phospholipid (PL) fraction, with a concomitant reduction in oleate oxidation. Oleic Acid 42-48 insulin Homo sapiens 108-115 15448091-3 2004 A 72-h culture of islets in the presence of palmitate or oleate resulted in a marked decrease in glucose-induced insulin release assessed in 1-h static incubations. Oleic Acid 57-63 insulin Homo sapiens 113-120 15723548-0 2005 Oleate-mediated stimulation of microsomal triglyceride transfer protein (MTP) gene promoter: implications for hepatic MTP overexpression in insulin resistance. Oleic Acid 0-6 insulin Homo sapiens 140-147 11272131-6 2001 [3H]oleic acid (OA) uptake in AGAT-overexpressing myotubes increased 34% (P = 0.027) upon insulin stimulation. Oleic Acid 4-14 insulin Homo sapiens 90-97 12670494-7 2003 These data suggest that elevated plasma oleic acid levels observed in obese, insulin-resistant subjects result in endothelial dysfunction, at least in part, through an increase in ET-1 expression. Oleic Acid 40-50 insulin Homo sapiens 77-84 12643112-2 2001 Oleic acid seems to offer a slight advantage over linoleic acid in reducing plasma glucose, insulin levels, total cholesterol, low-density lipoproteins (LDLs), and triglycerides, but may also have atherogenic properties through another mechanism. Oleic Acid 0-10 insulin Homo sapiens 92-99 14713277-0 2004 Oleic acid from cooking oils is associated with lower insulin resistance in the general population (Pizarra study). Oleic Acid 0-10 insulin Homo sapiens 54-61 14713277-13 2004 CONCLUSION: There is an association between the intake of oleic acid, the composition of oleic acid in plasma phospholipids and peripheral insulin action. Oleic Acid 58-68 insulin Homo sapiens 139-146 14713277-13 2004 CONCLUSION: There is an association between the intake of oleic acid, the composition of oleic acid in plasma phospholipids and peripheral insulin action. Oleic Acid 89-99 insulin Homo sapiens 139-146 11137176-3 2001 Palmitic acid (C 16:0) significantly suppressed cell viability, and suppressed insulin secretion at 24 h. Treatment with oleic acid (C 18:1) or linoleic acid (C 18:2) enhanced basal insulin secretion and diminished glucose-stimulated insulin secretion (GSIS) at 48 h. In these groups, there were no differences in cell viability as compared to cells treated without FFA. Oleic Acid 121-131 insulin Homo sapiens 79-86 11137176-3 2001 Palmitic acid (C 16:0) significantly suppressed cell viability, and suppressed insulin secretion at 24 h. Treatment with oleic acid (C 18:1) or linoleic acid (C 18:2) enhanced basal insulin secretion and diminished glucose-stimulated insulin secretion (GSIS) at 48 h. In these groups, there were no differences in cell viability as compared to cells treated without FFA. Oleic Acid 121-131 insulin Homo sapiens 182-189 7926053-3 1994 The rephosphorylation of cytidylyltransferase after an oleate-mediated dephosphorylation and translocation to membranes was increased after 2 min in the presence of insulin or epidermal growth factor by 99% and 76%, respectively, compared with controls. Oleic Acid 55-61 insulin Homo sapiens 165-172 10700478-0 2000 Diabetes and the Mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity. Oleic Acid 60-70 insulin Homo sapiens 74-81 10700478-2 2000 We examined the effect of an oleic-acid-rich diet on insulin resistance and endothelium-dependent vasoreactivity in type 2 diabetes. Oleic Acid 29-39 insulin Homo sapiens 53-60 10700478-8 2000 Insulin-stimulated (1 ng/ml) glucose transport was significantly greater on the oleic- acid-rich diet (0.56+/-0.17 vs. 0.29+/-0.14 nmol/10(5) cells/3 min, p<0.0001). Oleic Acid 80-91 insulin Homo sapiens 0-7 7745004-4 1995 Exposure to 0.125 mmol/L palmitate or oleate for 48 h during tissue culture (RPMI-1640 and 5.5 mmol/L glucose) inhibited the postculture insulin response to 27 mmol/L glucose by 40% and 42% (P < 0.01 for difference). Oleic Acid 38-44 insulin Homo sapiens 137-144 7827358-1 1994 The influence of elevated levels of oleate on insulin-stimulated 3-0-methylglucose transport was assessed in vitro, in isolated skeletal muscle obtained from patients with type 2 (non-insulin-dependent) diabetes mellitus (n = 7) and control subjects (n = 8). Oleic Acid 36-42 insulin Homo sapiens 46-53 10830281-9 2000 The addition of exogenous oleate or palmitate potentiated glucose-stimulated insulin secretion 2-fold and was unaffected by PMA-induced down-regulation. Oleic Acid 26-32 insulin Homo sapiens 77-84 10767564-1 2000 The purpose of this study was to evaluate the effectiveness and the toxicity of polyunsaturated fatty acid, such as oleic acid, eicosapentaenoic acid (DHA), as potential absorption enhancer for rectal delivery of insulin, using a water-in-oil-in water (W/O/W) multiple emulsion. Oleic Acid 116-126 insulin Homo sapiens 213-220 10471131-4 1999 However, we observed that obese hypertensive patients have elevated plasma concentrations of non-esterified fatty acids (NEFAs), including oleic acid, which are highly resistant to suppression by insulin. Oleic Acid 139-149 insulin Homo sapiens 196-203 9300238-3 1997 We tested this hypothesis by assessing the chronic effect of oleic acid on glucose metabolism and its relationship with glucose-induced insulin release in beta HC9 cells in tissue culture. Oleic Acid 61-71 insulin Homo sapiens 136-143 8914923-4 1996 Insulin also reduced [3H]oleic acid uptake up to 35%, depending on insulin concentration and decreased the amount of fatty acid esterified into the phospholipids and neutral lipids by 28 and 70%, respectively. Oleic Acid 25-35 insulin Homo sapiens 0-7 8914923-7 1996 Hence, insulin altered not only fatty acid uptake, as determined by cis-parinaric and oleic acid uptake, but also altered the intracellular oleic acid esterification. Oleic Acid 86-96 insulin Homo sapiens 7-14 8914923-7 1996 Hence, insulin altered not only fatty acid uptake, as determined by cis-parinaric and oleic acid uptake, but also altered the intracellular oleic acid esterification. Oleic Acid 140-150 insulin Homo sapiens 7-14 8941640-6 1996 Oleate, but not octanoate, requires carnitine binding to gain access to the mitochondrial matrix; hence, if glucose and/or insulin limit long-chain fatty acid entrance into the mitochondria, then, during the clamp, long-chain acylcarnitine formation should be decreased, causing a decrease in oleate, but not octanoate, oxidation. Oleic Acid 0-6 insulin Homo sapiens 123-130 8825422-9 1996 Both oleic acid and PMA potentiated glucose-induced insulin release but oleic acid, in contrast to PMA, was unable to initiate insulin release in the presence of substimulatory concentrations of glucose. Oleic Acid 5-15 insulin Homo sapiens 52-59 35406631-0 2022 Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells. Oleic Acid 98-104 insulin Homo sapiens 52-59 34704121-11 2022 CONCLUSIONS/INTERPRETATION: Lipid-induced myocellular insulin resistance is likely more pronounced with palmitate than with oleate and is associated with PKC isoforms activation and inhibitory insulin signalling. Oleic Acid 124-130 insulin Homo sapiens 193-200 34446138-0 2021 Stearoyl CoA Desaturase 1 and Inositol-Requiring Protein 1alpha Determine the Efficiency of Oleic Acid in Alleviating Silica Nanoparticle-Induced Insulin Resistance. Oleic Acid 92-102 insulin Homo sapiens 146-153 8299435-10 1993 Higher intakes of saturated fat, oleic acid, and linoleic acid were each positively related to higher fasting insulin values. Oleic Acid 33-43 insulin Homo sapiens 110-117 16353347-8 1993 Similarly preincubation with 2.0 mM oleate, which, unlike palmitate, is not known to produce protein acylation, resulted in proportional decreases in insulin receptor binding and receptor-mediated internalization and degradation. Oleic Acid 36-42 insulin Homo sapiens 150-157 1660268-10 1991 In addition, in the presence of a sustained increase in oleic acid concentration, there is a decrease in the action of insulin to inhibit triacylglycerol secretion. Oleic Acid 56-66 insulin Homo sapiens 119-126 34136157-3 2021 An insulin-resistant HepG2 cell model induced by glucose, fructose, oleic acid, and palmitic acid was adopted to investigate the effects of maca extracts on regulating glucose and lipid metabolism in this study. Oleic Acid 68-78 insulin Homo sapiens 3-10 35246864-0 2022 Glucose and oleic acid mediate cellular alterations in GLP-1-induced insulin-positive differentiating UCBMSCs. Oleic Acid 12-22 insulin Homo sapiens 69-76 35246864-1 2022 Coordinated effects of glucose and oleic acid on glucagon-like peptide-1 (GLP-1) mediated differentiation of insulin-positive differentiating umbilical cord mesenchymal stromal cells (dUCBMSCs) was studied using a co-culture of NCI-H716 (GLP-1+) and UCBMSCs (insulin+). Oleic Acid 35-45 insulin Homo sapiens 109-116 2677202-2 1989 The presence of oleate (complexed to 3% albumin at a molar ratio of 1.7:1) resulted in a 3.5-fold stimulation of apoB secretion that was apparent after only 3 h. Insulin halved the rate of apoB output and the inhibition was detectable within the physiological insulin range, but was not apparent until 12-16 h. Albumin in the culture medium had a dose-dependent inhibitory effect on apoB production. Oleic Acid 16-22 insulin Homo sapiens 162-169 2677202-2 1989 The presence of oleate (complexed to 3% albumin at a molar ratio of 1.7:1) resulted in a 3.5-fold stimulation of apoB secretion that was apparent after only 3 h. Insulin halved the rate of apoB output and the inhibition was detectable within the physiological insulin range, but was not apparent until 12-16 h. Albumin in the culture medium had a dose-dependent inhibitory effect on apoB production. Oleic Acid 16-22 insulin Homo sapiens 260-267