PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23214140-1 2012 Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis, catalyzing the rate-limiting step in the overall de novo synthesis of monounsaturated fatty acids, mainly oleate and palmitoleate from staroyl- and palmitoyl-CoA, respectively. Oleic Acid 175-181 stearoyl-CoA desaturase Homo sapiens 0-23 23214140-1 2012 Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis, catalyzing the rate-limiting step in the overall de novo synthesis of monounsaturated fatty acids, mainly oleate and palmitoleate from staroyl- and palmitoyl-CoA, respectively. Oleic Acid 175-181 stearoyl-CoA desaturase Homo sapiens 25-28 33612070-8 2021 Furthermore, treatment with supplemental oleate counteracted the SCD1-induced NF-kappaB activation and downstream effects. Oleic Acid 41-47 stearoyl-CoA desaturase Homo sapiens 65-69 34446138-3 2021 It has been well established that stearoyl CoA desaturase (SCD1) and its major product oleic acid elicited beneficial effects in restoring ER homeostasis. Oleic Acid 87-97 stearoyl-CoA desaturase Homo sapiens 34-57 34446138-3 2021 It has been well established that stearoyl CoA desaturase (SCD1) and its major product oleic acid elicited beneficial effects in restoring ER homeostasis. Oleic Acid 87-97 stearoyl-CoA desaturase Homo sapiens 59-63 34446138-9 2021 Collectively, downregulation of SCD1 and excess accumulation of IRE1alpha protein prevented the beneficial effects of exogenous oleic acid on IR induced by ER stress. Oleic Acid 128-138 stearoyl-CoA desaturase Homo sapiens 32-36 35358687-8 2022 Conversely, the overexpression of SCD1 or exogenous administration of its product oleic acid augmented plasma membrane fluidity and rescued in vitro invasive migration in HCC cells cultured on soft substrates, mimicking the effects imposed by high matrix stiffness. Oleic Acid 82-92 stearoyl-CoA desaturase Homo sapiens 34-38 33450374-8 2021 The product of SCD1 oleic acid can restore the viability of ovarian cancer spheroids inhibited by deprivation of iron. Oleic Acid 20-30 stearoyl-CoA desaturase Homo sapiens 15-19 33010452-7 2021 The stearoyl-CoA desaturase 1 (SCD1) index 1 (palmitoleate/palmitate) and index 2 (oleate/stearate) were reduced in T1DM (p<0.0001 for all). Oleic Acid 52-58 stearoyl-CoA desaturase Homo sapiens 4-29 33010452-7 2021 The stearoyl-CoA desaturase 1 (SCD1) index 1 (palmitoleate/palmitate) and index 2 (oleate/stearate) were reduced in T1DM (p<0.0001 for all). Oleic Acid 52-58 stearoyl-CoA desaturase Homo sapiens 31-35 31139819-9 2019 The portion of palmitoleic acid and oleic acid were increased in SCD-overexpressing parasites, compared with the RH parental strain, indicating that T. gondii indeed is competent for unsaturated fatty acid synthesis. Oleic Acid 21-31 stearoyl-CoA desaturase Homo sapiens 65-68 31936134-1 2020 In many tissues, stearoyl-CoA desaturase 1 (SCD1) catalyzes the biosynthesis of monounsaturated fatty acids (MUFAS),(i.e., palmitoleate and oleate) from their saturated fatty acid (SFA) precursors (i.e., palmitate and stearate), influencing cellular membrane physiology and signaling, leading to broad effects on human physiology. Oleic Acid 129-135 stearoyl-CoA desaturase Homo sapiens 17-42 31936134-1 2020 In many tissues, stearoyl-CoA desaturase 1 (SCD1) catalyzes the biosynthesis of monounsaturated fatty acids (MUFAS),(i.e., palmitoleate and oleate) from their saturated fatty acid (SFA) precursors (i.e., palmitate and stearate), influencing cellular membrane physiology and signaling, leading to broad effects on human physiology. Oleic Acid 129-135 stearoyl-CoA desaturase Homo sapiens 44-48 31270077-5 2019 Conversely, over-expression of SCD1 or exogenous administration of its C16:1 and C18:1 products, palmitoleicic acid or oleate, protected cells from death. Oleic Acid 119-125 stearoyl-CoA desaturase Homo sapiens 31-35 31796987-10 2020 Treatment with the SCD products oleate or palmitoleate reversed inflammation and endoplasmic reticulum stress. Oleic Acid 32-38 stearoyl-CoA desaturase Homo sapiens 19-22 31255704-8 2019 The overexpression of human SCD1 that was accompanied by endogenously generated oleic acid also led to an increase in the nuclear abundance of FoxO1. Oleic Acid 80-90 stearoyl-CoA desaturase Homo sapiens 28-32 30448348-7 2019 These metabolic adaptations are linked to high Scd1 expression, needed for the de novo production of oleic acid, the main FA used by ACAT. Oleic Acid 101-111 stearoyl-CoA desaturase Homo sapiens 47-51 30876460-6 2019 Oleic acid (OA, a kind of MUFA, the SCD1 enzymatic product) was used to simulate a high lipid metabolic environment and detected the affection on the cytotoxic effect of TKIs (Gefitinib and osimertinib) in cell lines with EGFR-activating mutations. Oleic Acid 0-10 stearoyl-CoA desaturase Homo sapiens 36-40 30876460-11 2019 Additionally oleic acid (OA, a kind of MUFA, the SCD1 enzymatic product) abrogates the cytotoxic effect of both Gefitinib and osimertinib in cell lines with EGFR-activating mutations. Oleic Acid 13-23 stearoyl-CoA desaturase Homo sapiens 49-53 29605251-1 2018 Stearoyl Co A desaturase (SCD) is a rate-limiting lipogenic enzyme that plays an integral role in catalyzing the synthesis of monounsaturated fatty acids, chiefly oleate and palmitoleate. Oleic Acid 163-169 stearoyl-CoA desaturase Homo sapiens 0-24 29605251-1 2018 Stearoyl Co A desaturase (SCD) is a rate-limiting lipogenic enzyme that plays an integral role in catalyzing the synthesis of monounsaturated fatty acids, chiefly oleate and palmitoleate. Oleic Acid 163-169 stearoyl-CoA desaturase Homo sapiens 26-29 29089222-2 2017 SCD1 catalyzes the synthesis of monounsaturated fatty acids (MUFAs), mainly oleate and palmitoleate, which are important in controlling weight gain in response to feeding high carbohydrate diets. Oleic Acid 76-82 stearoyl-CoA desaturase Homo sapiens 0-4 29849946-0 2018 Pivotal role of human stearoyl-CoA desaturases (SCD1 and 5) in breast cancer progression: oleic acid-based effect of SCD1 on cell migration and a novel pro-cell survival role for SCD5. Oleic Acid 90-100 stearoyl-CoA desaturase Homo sapiens 48-58 29849946-5 2018 We showed that the addition of oleic acid, the main SCD1 product, nullified the inhibitory effects produced on MCF-7 and MDA-MB-231 cell migration by SCD1 depletion (pharmacological or siRNA-based). Oleic Acid 31-41 stearoyl-CoA desaturase Homo sapiens 52-56 29849946-5 2018 We showed that the addition of oleic acid, the main SCD1 product, nullified the inhibitory effects produced on MCF-7 and MDA-MB-231 cell migration by SCD1 depletion (pharmacological or siRNA-based). Oleic Acid 31-41 stearoyl-CoA desaturase Homo sapiens 150-154 29117333-0 2017 Oleic acid stimulation of motility of human extravillous trophoblast cells is mediated by stearoyl-CoA desaturase-1 activity. Oleic Acid 0-10 stearoyl-CoA desaturase Homo sapiens 90-115 25001539-6 2014 This is evidenced by the inhibition of apoptosis induced through ORCTL3 when the SCD-1 product oleic acid is exogenously supplemented or when SCD-1 is co-transfected in the transformed cells. Oleic Acid 95-105 stearoyl-CoA desaturase Homo sapiens 81-86 28442322-11 2017 Additionally, bovine serum albumin conjugated with oleic acid, an SCD1 product, prevented cell growth inhibition and ER stress responses by T-3764518, indicating that these outcomes were not attributable to off-target effects. Oleic Acid 51-61 stearoyl-CoA desaturase Homo sapiens 66-70 26676854-5 2015 Measures of hepatocyte-specific function and triglyceride accumulation in later stages were strongly inhibited a minimum of -29% (P < 0.05) by SCD1 inhibitor in the early stage of hepatic differentiation and effectively reversed (>30%, P < 0.01) by the addition of oleate. Oleic Acid 274-280 stearoyl-CoA desaturase Homo sapiens 146-150 25023287-8 2014 Overexpression of SCD1 or supplementation with oleic acid, which is a catalytic product of SCD1 abolished the inhibition of autophagy by 28c. Oleic Acid 47-57 stearoyl-CoA desaturase Homo sapiens 91-95 23318055-5 2013 Close examination identified this molecule as an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs. Oleic Acid 112-122 stearoyl-CoA desaturase Homo sapiens 62-85 23318055-5 2013 Close examination identified this molecule as an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs. Oleic Acid 112-122 stearoyl-CoA desaturase Homo sapiens 87-91 23000367-2 2013 The enzyme stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is the rate-limiting enzyme in the synthesis of monounsaturated fatty acids such as palmitoleic acid (16:1 n-7) and oleic acid (18:1 n-9). Oleic Acid 145-155 stearoyl-CoA desaturase Homo sapiens 11-34 23000367-2 2013 The enzyme stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is the rate-limiting enzyme in the synthesis of monounsaturated fatty acids such as palmitoleic acid (16:1 n-7) and oleic acid (18:1 n-9). Oleic Acid 145-155 stearoyl-CoA desaturase Homo sapiens 36-39 21045174-5 2011 SCD1 activity was estimated from the ratio of oleate (C18:1) to stearate (C18:0) within lipid subfractions. Oleic Acid 46-52 stearoyl-CoA desaturase Homo sapiens 0-4 22057664-4 2012 Stearoyl-CoA desaturase 1 (scd1) catalyses the production of monounsaturated fatty acids (e.g. oleic acid) and its expression is associated with lipogenesis induction and with atherosclerosis development. Oleic Acid 95-105 stearoyl-CoA desaturase Homo sapiens 0-25 22057664-4 2012 Stearoyl-CoA desaturase 1 (scd1) catalyses the production of monounsaturated fatty acids (e.g. oleic acid) and its expression is associated with lipogenesis induction and with atherosclerosis development. Oleic Acid 95-105 stearoyl-CoA desaturase Homo sapiens 27-31 21391224-10 2011 By contrast, opposite deregulation of some of these genes (FASN, SCD1, and THSRP) was observed in fat HepaRG cells induced by oleic acid overload, supporting the conclusion that different mechanisms were involved in the induction of steatosis by drugs and oleic acid. Oleic Acid 126-136 stearoyl-CoA desaturase Homo sapiens 65-69 23154679-1 2012 OBJECTIVE: Subcutaneous (SC) adipose tissue stearic acid (18:0) content and stearoyl-CoA desaturase-1 (SCD1)-mediated production of oleic acid (18:1) have been suggested to be altered in obesity. Oleic Acid 132-142 stearoyl-CoA desaturase Homo sapiens 76-101 23154679-1 2012 OBJECTIVE: Subcutaneous (SC) adipose tissue stearic acid (18:0) content and stearoyl-CoA desaturase-1 (SCD1)-mediated production of oleic acid (18:1) have been suggested to be altered in obesity. Oleic Acid 132-142 stearoyl-CoA desaturase Homo sapiens 103-107 22457791-7 2012 Two reference SCD1 inhibitors show low-nanomolar cytotoxicity that is offset by at least two orders of magnitude by exogenous oleate. Oleic Acid 126-132 stearoyl-CoA desaturase Homo sapiens 14-18 21565896-4 2011 Here we show that genistein, an isoflavone abundant in soybeans, decreased the levels of SCD1 protein in H460 human lung adenocarcinoma cells, consequently reducing the rate of biosynthesis of oleic acid as well as its presence in cancer cell lipids. Oleic Acid 193-203 stearoyl-CoA desaturase Homo sapiens 89-93 21179554-2 2010 This change in fatty acid metabolism is associated with overexpression of stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation of saturated fatty acids into monounsaturated fatty acids (e.g., oleic acid). Oleic Acid 208-218 stearoyl-CoA desaturase Homo sapiens 74-99 20713121-4 2011 Furthermore, oleic acid, the main product of SCD1 reaction, is the predominant fatty acid of human adipose tissue triacylglycerols, associating SCD1 with the development of obesity and the metabolic syndrome. Oleic Acid 13-23 stearoyl-CoA desaturase Homo sapiens 45-49 20713121-4 2011 Furthermore, oleic acid, the main product of SCD1 reaction, is the predominant fatty acid of human adipose tissue triacylglycerols, associating SCD1 with the development of obesity and the metabolic syndrome. Oleic Acid 13-23 stearoyl-CoA desaturase Homo sapiens 144-148 21179554-2 2010 This change in fatty acid metabolism is associated with overexpression of stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation of saturated fatty acids into monounsaturated fatty acids (e.g., oleic acid). Oleic Acid 208-218 stearoyl-CoA desaturase Homo sapiens 101-105 20086206-2 2010 The Delta5 and Delta9 desaturase activities are indexed by the efficient conversion of [1-(14)C]-eicosatrienoic acid (C20:3, cis-8,11,14) to (14)C-arachidonic acid (C20:4, cis-5,8,11,14) and the conversion of [1-(14)C]-stearic acid to (14)C-oleic acid (C18:1, cis-9), respectively. Oleic Acid 240-251 stearoyl-CoA desaturase Homo sapiens 15-32 20597504-3 2010 The ALA-supplemented diet decreased significantly the SCD activity in MLD and SAT, resulting in a reduced relative concentration of oleic acid in muscle. Oleic Acid 132-142 stearoyl-CoA desaturase Homo sapiens 54-57 20613975-8 2010 This hypothesis was further reinforced by the observation that exogenous oleic acid reverses the anti-growth effect of SCD and ACC inhibitors. Oleic Acid 73-83 stearoyl-CoA desaturase Homo sapiens 119-122 20613975-9 2010 Finally, exogenous oleic acid restored the globally decreased levels of cell lipids in cells undergoing a blockade of SCD activity, indicating that active lipid synthesis is required for the fatty acid-mediated restoration of proliferation in SCD1-inhibited cells. Oleic Acid 19-29 stearoyl-CoA desaturase Homo sapiens 118-121 20613975-9 2010 Finally, exogenous oleic acid restored the globally decreased levels of cell lipids in cells undergoing a blockade of SCD activity, indicating that active lipid synthesis is required for the fatty acid-mediated restoration of proliferation in SCD1-inhibited cells. Oleic Acid 19-29 stearoyl-CoA desaturase Homo sapiens 243-247 15260504-1 2004 Stearoyl-acyl carrier protein Delta(9) desaturase (Delta9D) produces oleic acid, a nutritionally valuable fatty acid containing a cis double bond between C-9 and C-10. Oleic Acid 69-79 stearoyl-CoA desaturase Homo sapiens 30-49 18599738-1 2008 Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network. Oleic Acid 87-93 stearoyl-CoA desaturase Homo sapiens 0-32 18599738-1 2008 Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network. Oleic Acid 87-93 stearoyl-CoA desaturase Homo sapiens 34-38 15260504-1 2004 Stearoyl-acyl carrier protein Delta(9) desaturase (Delta9D) produces oleic acid, a nutritionally valuable fatty acid containing a cis double bond between C-9 and C-10. Oleic Acid 69-79 stearoyl-CoA desaturase Homo sapiens 51-58 15009660-6 2004 The time course of MAP-2 expression during brain development coincides with that of stearoyl-CoA desaturase, the limiting enzyme of oleic acid synthesis, indicating that both phenomena coincide during development. Oleic Acid 132-142 stearoyl-CoA desaturase Homo sapiens 84-107 12401889-1 2002 Stearoyl-CoA desaturase (SCD) is expressed at high levels in several human tissues and is required for the biosynthesis of oleate (18:1) and palmitoleate (16:1). Oleic Acid 123-129 stearoyl-CoA desaturase Homo sapiens 0-23 12401889-1 2002 Stearoyl-CoA desaturase (SCD) is expressed at high levels in several human tissues and is required for the biosynthesis of oleate (18:1) and palmitoleate (16:1). Oleic Acid 123-129 stearoyl-CoA desaturase Homo sapiens 25-28 11414710-1 2001 Stearoyl-CoA desaturase (SCD) is a microsomal enzyme required for the biosynthesis of oleate (C18:1) and palmitoleate (C16:1) which are the major monounsaturated fatty acids of membrane phospholipids, triglycerides and cholesterol esters. Oleic Acid 86-92 stearoyl-CoA desaturase Homo sapiens 0-23 11397803-1 2001 Stearoyl-CoA desaturase (SCD) is a regulatory enzyme involved in the synthesis of the monounsaturated fatty acids palmitoleate and oleate. Oleic Acid 120-126 stearoyl-CoA desaturase Homo sapiens 0-23 11397803-1 2001 Stearoyl-CoA desaturase (SCD) is a regulatory enzyme involved in the synthesis of the monounsaturated fatty acids palmitoleate and oleate. Oleic Acid 120-126 stearoyl-CoA desaturase Homo sapiens 25-28 11414710-1 2001 Stearoyl-CoA desaturase (SCD) is a microsomal enzyme required for the biosynthesis of oleate (C18:1) and palmitoleate (C16:1) which are the major monounsaturated fatty acids of membrane phospholipids, triglycerides and cholesterol esters. Oleic Acid 86-92 stearoyl-CoA desaturase Homo sapiens 25-28 11396956-1 2001 Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids mainly oleate (C18:1) and palmitoleate (C16:1) which are the major monounsaturated fatty acids of membrane phospholipids, cholesterol esters, waxes, and triglycerides. Oleic Acid 127-133 stearoyl-CoA desaturase Homo sapiens 0-23 11396956-1 2001 Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids mainly oleate (C18:1) and palmitoleate (C16:1) which are the major monounsaturated fatty acids of membrane phospholipids, cholesterol esters, waxes, and triglycerides. Oleic Acid 127-133 stearoyl-CoA desaturase Homo sapiens 25-28 1279471-3 1992 Stearoyl CoA desaturase (SCD) catalyzes a key step in the biosynthesis of oleic acid (C18:1, n-9), a major fatty acid in myelin. Oleic Acid 74-84 stearoyl-CoA desaturase Homo sapiens 0-23 1279471-3 1992 Stearoyl CoA desaturase (SCD) catalyzes a key step in the biosynthesis of oleic acid (C18:1, n-9), a major fatty acid in myelin. Oleic Acid 74-84 stearoyl-CoA desaturase Homo sapiens 25-28