PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30741951-3 2019 Earlier studies have shown that bovine alpha -lactalbumin made lethal to tumor cells (BAMLET) becomes cytotoxic against cancer cells in complex with oleic acid {Hoque, M. et. Oleic Acid 149-159 lactalbumin alpha Bos taurus 39-57 31825621-6 2020 We investigated the interactions between oleic acid monolayer and alpha-lactalbumin in the presence of Ca2+ in the bulk and the effect of varied experimental conditions on the complex stability. Oleic Acid 41-51 lactalbumin alpha Bos taurus 66-83 30706714-0 2019 Temperature, pH, and Molecular Packing Effects on the Penetration of Oleic Acid Monolayer by alpha-Lactalbumin. Oleic Acid 69-79 lactalbumin alpha Bos taurus 93-110 30706714-1 2019 Recently, we reported on the interfacial behavior of mixed oleic acid (OA)-alpha-lactalbumin monolayer and its relevance in the formation of tumoricidal HAMLET (human alpha-lactalbumin made lethal to tumor cells)-like complex. Oleic Acid 59-69 lactalbumin alpha Bos taurus 75-92 24039698-2 2013 We report in this study that the oleic acid complex of bovine alpha-lactalbumin (BAMLET) is hemolytic to human erythrocytes as well as to those derived from some other mammals. Oleic Acid 33-43 lactalbumin alpha Bos taurus 62-79 27060481-3 2016 We expect that the thermodynamic properties obtained from this study would serve as a useful reference for investigating the binding of other hydrophobic ligands such as oleic acid to apo-BLA, because oleic acid is known to have tumor-selective cytotoxicity when complexed with partially unfolded alpha-lactalbumin. Oleic Acid 170-180 lactalbumin alpha Bos taurus 297-314 27060481-3 2016 We expect that the thermodynamic properties obtained from this study would serve as a useful reference for investigating the binding of other hydrophobic ligands such as oleic acid to apo-BLA, because oleic acid is known to have tumor-selective cytotoxicity when complexed with partially unfolded alpha-lactalbumin. Oleic Acid 201-211 lactalbumin alpha Bos taurus 297-314 27109252-0 2016 Behaviour of oleic acid-depleted bovine alpha-lactalbumin made LEthal to tumor cells (BAMLET). Oleic Acid 13-23 lactalbumin alpha Bos taurus 40-57 26669176-1 2015 The structure changes of alpha-lactalbumin after binding oleic acid and linoleic acid, including hydrophobic amino acids, hydrophobic regions, tertiary structure, secondary structure, was studied by intrinsic fluorescence, ANS-binding intrinsic fluorescence and circular dichroism spectrum, respectively. Oleic Acid 57-67 lactalbumin alpha Bos taurus 25-42 26669176-3 2015 It can be seen from the fluorescence spectra that a significant red-shift from 331.07 to 337.67 nm and 337.60 nm of alpha-lactalbumin occurred after binding of oleic acid and linoleic acid, respectively. Oleic Acid 160-170 lactalbumin alpha Bos taurus 116-133 26101738-1 2015 Lipid-protein complexes comprised of oleic acid (OA) non-covalently coupled to human/bovine alpha-lactalbumin, named HAMLET/BAMLET, display cytotoxic properties against cancer cells. Oleic Acid 37-47 lactalbumin alpha Bos taurus 92-109 27731329-1 2016 Bovine alpha-lactalbumin (BLA) forms cytotoxic complexes with oleic acid (OA) that perturbs tumor cell membranes, but molecular determinants of these membrane-interactions remain poorly understood. Oleic Acid 62-72 lactalbumin alpha Bos taurus 7-24 27731329-1 2016 Bovine alpha-lactalbumin (BLA) forms cytotoxic complexes with oleic acid (OA) that perturbs tumor cell membranes, but molecular determinants of these membrane-interactions remain poorly understood. Oleic Acid 74-76 lactalbumin alpha Bos taurus 7-24 25913522-0 2015 Oleic acid complex of bovine alpha-lactalbumin induces eryptosis in human and other erythrocytes by a Ca(2+)-independent mechanism. Oleic Acid 0-10 lactalbumin alpha Bos taurus 29-46 24408789-1 2014 BAMLET (Bovine Alpha-lactalbumin Made LEthal to Tumors) is a member of the family of the HAMLET-like complexes, a novel class of protein-based anti-cancer complexes that incorporate oleic acid and deliver it to cancer cells. Oleic Acid 182-192 lactalbumin alpha Bos taurus 15-32 23916586-0 2013 Cytotoxicity of bovine alpha-lactalbumin: oleic acid complexes correlates with the disruption of lipid membranes. Oleic Acid 42-52 lactalbumin alpha Bos taurus 23-40 23916586-1 2013 HAMLET/BAMLET (Human/Bovine alpha-Lactalbumin Made Lethal to Tumors) is a tumoricidal substance composed of partially unfolded human/bovine alpha-lactalbumin (HLA/BLA) and several oleic acid (OA) molecules. Oleic Acid 180-190 lactalbumin alpha Bos taurus 28-45 20232795-1 2010 A complex of alpha-lactalbumin with oleic acid, also known as HAMLET/BAMLET (human/bovine alpha-lactalbumin made lethal to tumor cells), causes apoptosis-like death in tumor cells but has little effect on healthy differentiated cells. Oleic Acid 36-46 lactalbumin alpha Bos taurus 90-107 22814573-0 2012 Influence of pH on the structure and oleic acid binding ability of bovine alpha-lactalbumin. Oleic Acid 37-47 lactalbumin alpha Bos taurus 74-91 21457462-0 2011 The toxicity of bovine alpha-lactalbumin made lethal to tumor cells is highly dependent on oleic acid and induces killing in cancer cell lines and noncancer-derived primary cells. Oleic Acid 91-101 lactalbumin alpha Bos taurus 23-40 19497410-4 2009 Our data here indicate that the structural characteristics of these aggregates are similar to those of HAMLET/BAMLET (human/bovine alpha-lactalbumin made lethal to tumor cells), a complex of the partially unfolded alpha-lactalbumin with oleic acid. Oleic Acid 237-247 lactalbumin alpha Bos taurus 131-148 19968717-1 2010 The complexes formed by partially folded human and bovine alpha-lactalbumin with oleic acid (OA) have been reported to display selective apoptotic activity against tumor cells. Oleic Acid 81-91 lactalbumin alpha Bos taurus 58-75 19968717-1 2010 The complexes formed by partially folded human and bovine alpha-lactalbumin with oleic acid (OA) have been reported to display selective apoptotic activity against tumor cells. Oleic Acid 93-95 lactalbumin alpha Bos taurus 58-75 20053771-5 2010 Here, we show that complex of bovine alpha-lactalbumin and oleic acid (BAMLET), the bovine counterpart of HAMLET, kills tumor cells via a mechanism involving lysosomal membrane permeabilization. Oleic Acid 59-69 lactalbumin alpha Bos taurus 37-54 19497410-4 2009 Our data here indicate that the structural characteristics of these aggregates are similar to those of HAMLET/BAMLET (human/bovine alpha-lactalbumin made lethal to tumor cells), a complex of the partially unfolded alpha-lactalbumin with oleic acid. Oleic Acid 237-247 lactalbumin alpha Bos taurus 214-231 16920042-0 2006 Structural changes of alpha-lactalbumin induced by low pH and oleic acid. Oleic Acid 62-72 lactalbumin alpha Bos taurus 22-39 16935298-0 2006 Oleic acid inhibits amyloid formation of the intermediate of alpha-lactalbumin at moderately acidic pH. Oleic Acid 0-10 lactalbumin alpha Bos taurus 61-78 16935298-1 2006 The effects of oleic acid on amyloid formation of Ca2+-depleted bovine alpha-lactalbumin (apo-BLA) at low pH and the biological impact of the effects were investigated by using thioflavin T, Congo red, far-UV circular dichroism, atomic force microscopy, transmission electron microscopy, and other biophysical methods. Oleic Acid 15-25 lactalbumin alpha Bos taurus 71-88 16920042-1 2006 The effects of low pH and oleic acid on conformation and association state of Ca2+-depleted bovine alpha-lactalbumin (apo-BLA) have been studied by electrospray ionization mass spectrometry, fluorescence spectroscopy, and circular dichroism. Oleic Acid 26-36 lactalbumin alpha Bos taurus 99-116 16920042-5 2006 Our data provide insight into the mechanism of pH-dependent and oleic acid-dependent structural changes and oligomerization of alpha-lactalbumin, and will be helpful to the understanding of the apoptosis-inducing function of multimeric alpha-lactalbumin in which oleic acid is a necessary cofactor. Oleic Acid 64-74 lactalbumin alpha Bos taurus 236-253 16920042-5 2006 Our data provide insight into the mechanism of pH-dependent and oleic acid-dependent structural changes and oligomerization of alpha-lactalbumin, and will be helpful to the understanding of the apoptosis-inducing function of multimeric alpha-lactalbumin in which oleic acid is a necessary cofactor. Oleic Acid 263-273 lactalbumin alpha Bos taurus 127-144 16920042-5 2006 Our data provide insight into the mechanism of pH-dependent and oleic acid-dependent structural changes and oligomerization of alpha-lactalbumin, and will be helpful to the understanding of the apoptosis-inducing function of multimeric alpha-lactalbumin in which oleic acid is a necessary cofactor. Oleic Acid 263-273 lactalbumin alpha Bos taurus 236-253 16332122-6 2005 Besides, the thermal stability of apo-alpha-lactalbumin decreased with the binding of oleic acid. Oleic Acid 86-96 lactalbumin alpha Bos taurus 38-55 35607417-0 2022 Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with alpha-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy. Oleic Acid 12-22 lactalbumin alpha Bos taurus 79-96 12360528-0 2002 Molten globule of bovine alpha-lactalbumin at neutral pH induced by heat, trifluoroethanol, and oleic acid: a comparative analysis by circular dichroism spectroscopy and limited proteolysis. Oleic Acid 96-106 lactalbumin alpha Bos taurus 25-42 12360528-1 2002 The calcium-depleted form of alpha-lactalbumin (alpha-LA) at neutral pH can be induced to adopt a partly folded state or molten globule upon moderate heating, by dissolving the protein in aqueous TFE or by adding oleic acid. Oleic Acid 213-223 lactalbumin alpha Bos taurus 29-46 12360528-1 2002 The calcium-depleted form of alpha-lactalbumin (alpha-LA) at neutral pH can be induced to adopt a partly folded state or molten globule upon moderate heating, by dissolving the protein in aqueous TFE or by adding oleic acid. Oleic Acid 213-223 lactalbumin alpha Bos taurus 48-56 12360528-4 2002 CD spectra revealed that the molten globule of apo-alpha-LA can be obtained upon mild heating at 45 degrees C, as well as at room temperature in the presence of 15% TFE or by adding to the protein solution 7.5 equivalents of oleic acid. Oleic Acid 225-235 lactalbumin alpha Bos taurus 51-59 12360528-9 2002 Similar sites of preferential cleavage have been observed with the TFE- and oleic acid-induced molten globule of apo-alpha-LA. Oleic Acid 76-86 lactalbumin alpha Bos taurus 117-125 35607417-3 2022 Here, we prepared oleic acid-modified mesoporous silica nanoparticles (OA-MSNs) conjugated with bovine alpha-lactalbumin, a lipoprotein complex resembling BAMLET formed on the surface of MSNs (MSN-BAMLET) to load the anticancer drug of docetaxel (DTX). Oleic Acid 18-28 lactalbumin alpha Bos taurus 103-120 33025647-0 2020 Improved antitumor activity and IgE/IgG-binding ability of alpha-Lactalbumin/beta-lactoglobulin induced by ultrasonication prior to binding with oleic acid. Oleic Acid 145-155 lactalbumin alpha Bos taurus 59-76 32694279-0 2021 The novel therapeutic potential of bovine alpha-lactalbumin made lethal to tumour cells and oleic acid in oral squamous cell carcinoma. Oleic Acid 92-102 lactalbumin alpha Bos taurus 42-59 33025647-1 2020 Bovine alpha-lactalbumin (alpha-La)/beta-lactoglobulin (beta-Lg) was pretreated through ultrasonic treatment and subsequently binding with oleic acid (OA) by heat treatment. Oleic Acid 139-149 lactalbumin alpha Bos taurus 7-24