PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9150254-9 1997 These studies indicate that cholesterol does influence the expression of SCD specifically in the liver and suggest that the product, oleic acid, is preferentially esterified to cholesterol in the liver. Oleic Acid 133-143 stearoyl-CoA desaturase Rattus norvegicus 73-76 8996638-1 1996 The relative contribution of stearoyl-CoA desaturase and 1-acylglycerophosphocholine (1-acyl-GPC) acyltransferase, which are induced by peroxisome proliferators, to the increase in the proportion of oleic acid in C-2 position of phosphatidylcholine (PtdCho) in the liver of rats was investigated. Oleic Acid 199-209 stearoyl-CoA desaturase Rattus norvegicus 29-52 8996638-3 1996 With administration of these peroxisome proliferators, the proportion of oleic acid in C-2 position of PtdCho in hepatic microsomes was increased in commensurate with the increase in activities of stearoyl-CoA desaturase and 1-acyl-GPC acyltransferase. Oleic Acid 73-83 stearoyl-CoA desaturase Rattus norvegicus 197-220 8996638-4 1996 Multiple regression analysis revealed that although there is a high correlation among the three parameters examined, the partial correlation between the proportion of oleic acid in the C-2 position and the activity of stearoyl-CoA desaturase is significantly higher than that between the proportion of oleic acid in the C-2 position and the activity of 1-acyl-GPC acyltransferase. Oleic Acid 167-177 stearoyl-CoA desaturase Rattus norvegicus 218-241 8996638-4 1996 Multiple regression analysis revealed that although there is a high correlation among the three parameters examined, the partial correlation between the proportion of oleic acid in the C-2 position and the activity of stearoyl-CoA desaturase is significantly higher than that between the proportion of oleic acid in the C-2 position and the activity of 1-acyl-GPC acyltransferase. Oleic Acid 302-312 stearoyl-CoA desaturase Rattus norvegicus 218-241 8996638-5 1996 The contribution of stearoyl-CoA desaturase to the increase in the proportion of oleic acid in the C-2 position thus appears greater than that of 1-acyl-GPC acyltransferase. Oleic Acid 81-91 stearoyl-CoA desaturase Rattus norvegicus 20-43 21664496-1 2012 In the present study, we tested the hypothesis that cardiac substrate utilization is affected by oleic acid originating from the endogenous conversion of stearate by stearoyl-CoA desaturase and from the diet. Oleic Acid 97-107 stearoyl-CoA desaturase Rattus norvegicus 166-189 7845382-11 1994 This work also demonstrated a significant contribution of the stearoyl-CoA desaturase system to the high levels of oleic acid present in this kind of hepatoma cells. Oleic Acid 115-125 stearoyl-CoA desaturase Rattus norvegicus 62-85 34301719-5 2021 The fatty acid product of SCD, oleic acid, fully rescues this toxicity in early cultures, suggesting on-target toxicity. Oleic Acid 31-41 stearoyl-CoA desaturase Rattus norvegicus 26-29 6137751-4 1983 Stearoyl-CoA desaturase activity in the liver microsomes of rats in the CO + Fe group (2.55 +/- 0.17 nmol oleate produced/min/mg protein) was about half of that in the HCNO + Fe (4.76 +/- 0.15) and FF + Fe (5.38 +/- 0.18) diet groups. Oleic Acid 106-112 stearoyl-CoA desaturase Rattus norvegicus 0-23 25362535-1 2014 Fibrates have been reported to elevate the hepatic proportion of oleic acid (18:1n-9) through inducing stearoyl-CoA desaturase (SCD). Oleic Acid 65-75 stearoyl-CoA desaturase Rattus norvegicus 103-126 31255704-4 2019 The present study examined the effects of stearoyl-CoA desaturase 1 (SCD1)-metabolized precursors and products, notably oleic acid, on the compensatory capacity of beta-cells and their relationship with regulation of the FoxO1 and Wnt pathways. Oleic Acid 120-130 stearoyl-CoA desaturase Rattus norvegicus 42-67 31255704-4 2019 The present study examined the effects of stearoyl-CoA desaturase 1 (SCD1)-metabolized precursors and products, notably oleic acid, on the compensatory capacity of beta-cells and their relationship with regulation of the FoxO1 and Wnt pathways. Oleic Acid 120-130 stearoyl-CoA desaturase Rattus norvegicus 69-73 29409806-0 2018 Vitamin A deficiency induces endoplasmic reticulum stress and apoptosis in pancreatic islet cells: Implications of stearoyl-CoA desaturase 1-mediated oleic acid synthesis. Oleic Acid 150-160 stearoyl-CoA desaturase Rattus norvegicus 115-140 29409806-6 2018 On the other hand, it significantly decreased the SCD1 protein, which corroborated with reduced MUFA levels, particularly, oleic acid (C18:1), when compared to the control and HFr groups. Oleic Acid 123-133 stearoyl-CoA desaturase Rattus norvegicus 50-54 29409806-7 2018 In conclusion, chronic vitamin A deficiency altered the structure and functions of pancreas by diminishing the islet cells, possibly by inducing cellular stress-mediated apoptosis and decreasing SCD1-mediated oleic acid (C18:1) synthesis. Oleic Acid 209-219 stearoyl-CoA desaturase Rattus norvegicus 195-199 33041516-6 2020 Next, oleic acid blocked the reduction of the thickness of C2C12 myotubes and the increase of the endoplasmic reticulum stress induced by SCD inhibitor. Oleic Acid 6-16 stearoyl-CoA desaturase Rattus norvegicus 138-141 30622312-9 2019 SCD1 converts saturated FAs, e.g. palmitate and stearate, to monounsaturated FAs, palmitoleate and oleate, which are the predominant substrates for triglyceride synthesis. Oleic Acid 88-94 stearoyl-CoA desaturase Rattus norvegicus 0-4 30943799-0 2019 Omega-3 fatty acid decreases oleic acid by decreasing SCD-1 expression in the liver and kidney of a cyclosporine-induced nephropathy rat model. Oleic Acid 29-39 stearoyl-CoA desaturase Rattus norvegicus 54-59 25362535-1 2014 Fibrates have been reported to elevate the hepatic proportion of oleic acid (18:1n-9) through inducing stearoyl-CoA desaturase (SCD). Oleic Acid 65-75 stearoyl-CoA desaturase Rattus norvegicus 128-131 24836198-4 2014 Upon silencing stearoyl-CoA desaturase-1 (SCD-1), a key enzyme in oleic acid synthesis by RNA of interference mostly prevented the effect of albumin but not that of albumin plus oleic acid, suggesting that the oleic acid synthesized due to the effect of albumin would be responsible for the increase in neuron migration. Oleic Acid 178-188 stearoyl-CoA desaturase Rattus norvegicus 42-47 24836198-0 2014 Oleic acid synthesized by stearoyl-CoA desaturase (SCD-1) in the lateral periventricular zone of the developing rat brain mediates neuronal growth, migration and the arrangement of prospective synapses. Oleic Acid 0-10 stearoyl-CoA desaturase Rattus norvegicus 26-49 24836198-0 2014 Oleic acid synthesized by stearoyl-CoA desaturase (SCD-1) in the lateral periventricular zone of the developing rat brain mediates neuronal growth, migration and the arrangement of prospective synapses. Oleic Acid 0-10 stearoyl-CoA desaturase Rattus norvegicus 51-56 24836198-4 2014 Upon silencing stearoyl-CoA desaturase-1 (SCD-1), a key enzyme in oleic acid synthesis by RNA of interference mostly prevented the effect of albumin but not that of albumin plus oleic acid, suggesting that the oleic acid synthesized due to the effect of albumin would be responsible for the increase in neuron migration. Oleic Acid 66-76 stearoyl-CoA desaturase Rattus norvegicus 15-40 24836198-4 2014 Upon silencing stearoyl-CoA desaturase-1 (SCD-1), a key enzyme in oleic acid synthesis by RNA of interference mostly prevented the effect of albumin but not that of albumin plus oleic acid, suggesting that the oleic acid synthesized due to the effect of albumin would be responsible for the increase in neuron migration. Oleic Acid 66-76 stearoyl-CoA desaturase Rattus norvegicus 42-47 24836198-4 2014 Upon silencing stearoyl-CoA desaturase-1 (SCD-1), a key enzyme in oleic acid synthesis by RNA of interference mostly prevented the effect of albumin but not that of albumin plus oleic acid, suggesting that the oleic acid synthesized due to the effect of albumin would be responsible for the increase in neuron migration. Oleic Acid 178-188 stearoyl-CoA desaturase Rattus norvegicus 42-47 20626566-3 2010 In this study, we show that the rate-limiting enzyme in oleic acid synthesis, stearoyl-CoA desaturase (SCD-1), is located in the periventricular zone of the brain of newborn rats, simultaneously to an increase in the amount of free oleic acid in the forebrain. Oleic Acid 56-66 stearoyl-CoA desaturase Rattus norvegicus 78-101 23539346-8 2013 These results suggest the possibility that up-regulation of gene expression of Elovl6 along with SCD1 is indispensable to elevate the proportions and contents of oleic acid in the liver. Oleic Acid 162-172 stearoyl-CoA desaturase Rattus norvegicus 97-101 20626566-3 2010 In this study, we show that the rate-limiting enzyme in oleic acid synthesis, stearoyl-CoA desaturase (SCD-1), is located in the periventricular zone of the brain of newborn rats, simultaneously to an increase in the amount of free oleic acid in the forebrain. Oleic Acid 56-66 stearoyl-CoA desaturase Rattus norvegicus 103-108 20626566-3 2010 In this study, we show that the rate-limiting enzyme in oleic acid synthesis, stearoyl-CoA desaturase (SCD-1), is located in the periventricular zone of the brain of newborn rats, simultaneously to an increase in the amount of free oleic acid in the forebrain. Oleic Acid 232-242 stearoyl-CoA desaturase Rattus norvegicus 78-101 20626566-3 2010 In this study, we show that the rate-limiting enzyme in oleic acid synthesis, stearoyl-CoA desaturase (SCD-1), is located in the periventricular zone of the brain of newborn rats, simultaneously to an increase in the amount of free oleic acid in the forebrain. Oleic Acid 232-242 stearoyl-CoA desaturase Rattus norvegicus 103-108 20626566-4 2010 In addition, the spatio-temporal presence of albumin - the signal that promotes oleic acid synthesis - and that of GAP-43 are correlated with that of SCD-1. Oleic Acid 80-90 stearoyl-CoA desaturase Rattus norvegicus 150-155 20626566-7 2010 In conclusion, our results suggest that albumin up-regulates axonogenesis in the striatum by increasing the amount of the neurotrophic factor oleic acid synthesized by SCD-1 in the periventricular zone of the newborn brain. Oleic Acid 142-152 stearoyl-CoA desaturase Rattus norvegicus 168-173 15099403-4 2004 Beside its role in membrane synthesis, oleate could act as a neurotrophic factor, involved in signal transduction pathways via activation of protein kinases C. RESULTS: In situ hybridization and immunohistochemistry demonstrated a strong up-regulation of SCD at mRNA and protein level in regenerating neurons of the rat facial nucleus whereas non-regenerating Clarke"s and Red nucleus neurons did not show an induction of this gene. Oleic Acid 39-45 stearoyl-CoA desaturase Rattus norvegicus 255-258 17538229-5 2007 The activity of palmitoly-CoA chain elongase, which is involved in the biosynthesis of oleic acid in concert with SCD, was not significantly altered when Zucker obese rats received pioglitazone. Oleic Acid 87-97 stearoyl-CoA desaturase Rattus norvegicus 114-117 20382866-8 2010 Using promoter-reporter gene (luciferase) constructs transfected into both HEK 293 and McA-RH7777 cells (kidney- and liver-derived cell lines, respectively), we showed the activity of the SCD promoter from 4 different species (mouse, human, pig, and sheep) to be reduced in a dose-dependent manner by addition of unsaturated fatty acids to the media, with linoleic acid being more potent than oleic acid after a 24-h treatment at 60 microM. Oleic Acid 359-369 stearoyl-CoA desaturase Rattus norvegicus 188-191 19365601-8 2009 The ratio of stearic acid (C18:0) to oleic acid (C18:1) in the liver was increased by olmesartan, indicating a reduction in the in vivo activity of SCD-1. Oleic Acid 37-47 stearoyl-CoA desaturase Rattus norvegicus 148-153 14977874-0 2004 A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension. Oleic Acid 75-85 stearoyl-CoA desaturase Rattus norvegicus 117-142 12788519-0 2003 Role of oleic acid as a neurotrophic factor is supported in vivo by the expression of GAP-43 subsequent to the activation of SREBP-1 and the up-regulation of stearoyl-CoA desaturase during postnatal development of the brain. Oleic Acid 8-18 stearoyl-CoA desaturase Rattus norvegicus 158-181