PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31713483-1 2019 PURPOSE: To explorer the role and potential mechanism of miR-212-3p in neuropathic pain regulation. 6-chloro-2-(1-piperazinyl)pyrazine 61-67 membrane associated ring-CH-type finger 8 Rattus norvegicus 57-60 31713483-5 2019 Besides, miR-212-3p agomir was intrathecal injected into CCI rats and expression of key apoptotic proteins were determined by western blot. 6-chloro-2-(1-piperazinyl)pyrazine 13-26 membrane associated ring-CH-type finger 8 Rattus norvegicus 9-12 31713483-6 2019 Furthermore, dual luciferase reporter assay was used to determine the binding of miR-212-3p and 3" untranslated region (3"UTR) of NaV1.3 and the expression levels of NaV1.3 were measured by western blot and RT-qPCR. 6-chloro-2-(1-piperazinyl)pyrazine 85-91 membrane associated ring-CH-type finger 8 Rattus norvegicus 81-84 31713483-8 2019 miR-212-3p were decreased in response to CCI. 6-chloro-2-(1-piperazinyl)pyrazine 4-10 membrane associated ring-CH-type finger 8 Rattus norvegicus 0-3 31713483-9 2019 Intrathecal injection of miR-212-3p agomir into CCI rats improved the PWT and PWL, decreased the IL-1beta, IL-6 and TNF-alpha, decreased the expression levels of BCL2 associated X, apoptosis regulator (Bax), cleaved caspase-3 and increased the expression levels BCL2 apoptosis regulator (Bcl-2). 6-chloro-2-(1-piperazinyl)pyrazine 29-42 membrane associated ring-CH-type finger 8 Rattus norvegicus 25-28 31713483-10 2019 The results of dual luciferase reporter assay showed miR-212-3p could directly bind with 3"UTR of NaV1.3. 6-chloro-2-(1-piperazinyl)pyrazine 57-63 membrane associated ring-CH-type finger 8 Rattus norvegicus 53-56 31713483-11 2019 And the expression of NaV1.3 was up regulated in CCI rats intrathecal injected with miR-ctrl, whereas that was decreased in CCI rats intrathecal injected with miR-212-3p agomir. 6-chloro-2-(1-piperazinyl)pyrazine 163-169 membrane associated ring-CH-type finger 8 Rattus norvegicus 159-162