PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29873790-0	2018	Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome.	Dioxins	136-142	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	32-38	
29873790-3	2018	We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities.	Dioxins	215-221	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	104-110	
29873790-3	2018	We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities.	Dioxins	215-221	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	111-116	
29873790-3	2018	We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities.	Dioxins	215-221	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	117-123	
29873790-5	2018	Tiparpfl/flCreAlb and TiparpEx3-/- mice given a single injection of 10 mug/kg dioxin did not survive beyond days 7 and 9, respectively, while all Tiparp+/+ mice survived the 30-day treatment.	Dioxins	78-84	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	0-6	
29873790-9	2018	Taken together, these data illustrate that TIPARP is an important negative regulator of AHR activity, and that its specific loss in hepatocytes is sufficient to increase sensitivity to dioxin-induced steatohepatitis and lethality.	Dioxins	185-191	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	43-49	
25975270-0	2015	Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality.	Dioxins	74-80	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	41-47	
25975270-3	2015	Here, we show that the loss of TCDD-inducible poly(ADP-ribose) polymerase (Tiparp), an ADP-ribosyltransferase and AHR repressor, increases sensitivity to dioxin-induced toxicity, steatohepatitis, and lethality.	Dioxins	154-160	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	31-73	
25975270-3	2015	Here, we show that the loss of TCDD-inducible poly(ADP-ribose) polymerase (Tiparp), an ADP-ribosyltransferase and AHR repressor, increases sensitivity to dioxin-induced toxicity, steatohepatitis, and lethality.	Dioxins	154-160	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	75-81	
25975270-4	2015	Tiparp(-/-) mice given a single injection of 100 mug/kg dioxin did not survive beyond day 5; all Tiparp(+/+) mice survived the 30-day treatment.	Dioxins	56-62	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	0-6	
25975270-5	2015	Dioxin-treated Tiparp(-/-) mice exhibited increased liver steatosis and hepatotoxicity.	Dioxins	0-6	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	15-21	
25975270-7	2015	These results reveal previously unidentified roles for Tiparp, MacroD1, and ADP-ribosylation in AHR-mediated steatohepatitis and lethality in response to dioxin.	Dioxins	154-160	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	55-61