PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29161006-0 2018 ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum alpha-Glucosidase II Exhibiting Antiflaviviral Activity. 1-Deoxynojirimycin 4-7 sucrase-isomaltase Homo sapiens 56-73 17222224-3 2007 Previous studies showed that the disruption of early ER N-glycan processing by deoxynojirimycin (DNJ), an inhibitor of alpha-glucosidase, suppresses tyrosinase enzymatic activity and melanogenesis. 1-Deoxynojirimycin 79-95 sucrase-isomaltase Homo sapiens 119-136 17222224-3 2007 Previous studies showed that the disruption of early ER N-glycan processing by deoxynojirimycin (DNJ), an inhibitor of alpha-glucosidase, suppresses tyrosinase enzymatic activity and melanogenesis. 1-Deoxynojirimycin 97-100 sucrase-isomaltase Homo sapiens 119-136 33979163-1 2021 1-Deoxynojirimycin, an alpha-glucosidase inhibitor, possesses various biological activities such as antitumor, antidiabetic, and antiviral effects. 1-Deoxynojirimycin 0-18 sucrase-isomaltase Homo sapiens 23-40 33979163-4 2021 Among them, compound 10, a conjugate of 1-deoxynojirimycin and kaempferol linked through an undecane chain, exhibited excellent lipophilicity, antiproliferative effects, and alpha-glucosidase inhibitory activity. 1-Deoxynojirimycin 40-58 sucrase-isomaltase Homo sapiens 174-191 30098884-9 2019 This study elucidated the detailed interaction mechanism of DNJ with glucoamylase, which will be helpful for pharmaceutical companies to design new alpha-glucosidase inhibitor drugs based on polyhydroxylated alkaloids compound like DNJ. 1-Deoxynojirimycin 60-63 sucrase-isomaltase Homo sapiens 148-165 29897983-1 2018 1-Deoxynojirimycin (DNJ) is a potent alpha-glucosidase inhibitor and thus beneficial for prevention of diabetes. 1-Deoxynojirimycin 0-18 sucrase-isomaltase Homo sapiens 37-54 29897983-1 2018 1-Deoxynojirimycin (DNJ) is a potent alpha-glucosidase inhibitor and thus beneficial for prevention of diabetes. 1-Deoxynojirimycin 20-23 sucrase-isomaltase Homo sapiens 37-54 16528036-4 2006 alpha-Glucosidase inhibitors derived from the glucose analogue deoxynojirimycin (DNJ) inhibit viral morphogenesis in cellulo via perturbation of the N-glycosylation pathway and hence the misfolding of viral glycoproteins that depend on certain N-glycans for correct folding. 1-Deoxynojirimycin 63-79 sucrase-isomaltase Homo sapiens 0-17 16528036-4 2006 alpha-Glucosidase inhibitors derived from the glucose analogue deoxynojirimycin (DNJ) inhibit viral morphogenesis in cellulo via perturbation of the N-glycosylation pathway and hence the misfolding of viral glycoproteins that depend on certain N-glycans for correct folding. 1-Deoxynojirimycin 81-84 sucrase-isomaltase Homo sapiens 0-17 15771446-3 2005 Although d-DNJ and d-galacto-DNJ are known to be powerful competitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the nM range, l-DNJ and l-galacto-DNJ were noncompetitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the muM range. 1-Deoxynojirimycin 9-14 sucrase-isomaltase Homo sapiens 84-101 15771446-3 2005 Although d-DNJ and d-galacto-DNJ are known to be powerful competitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the nM range, l-DNJ and l-galacto-DNJ were noncompetitive inhibitors of alpha-glucosidase and alpha-galactosidase, respectively, with K(i) values in the muM range. 1-Deoxynojirimycin 9-14 sucrase-isomaltase Homo sapiens 233-250 2964235-1 1988 Administration in vivo of the alpha-glucosidase inhibitors 1-deoxynojirimycin and its derivatives BAY m 1099 (miglitol) and BAY o 1248 resulted in a dose- and time-dependent decrease in the rate of hepatic glycogenolysis induced by glucagon. 1-Deoxynojirimycin 59-77 sucrase-isomaltase Homo sapiens 30-47 30712980-0 2019 Use of a deoxynojirimycin-fluorophore conjugate as a cell-specific imaging probe targeting alpha-glucosidase on cell membranes. 1-Deoxynojirimycin 9-25 sucrase-isomaltase Homo sapiens 91-108 30712980-2 2019 1-Deoxynojirimycin (DNJ) can be actively captured by cells which express the surface membrane protein alpha-glucosidase. 1-Deoxynojirimycin 0-18 sucrase-isomaltase Homo sapiens 102-119 30712980-2 2019 1-Deoxynojirimycin (DNJ) can be actively captured by cells which express the surface membrane protein alpha-glucosidase. 1-Deoxynojirimycin 20-23 sucrase-isomaltase Homo sapiens 102-119 29161006-5 2018 ToP-DNJ inhibits ER alpha-glucosidase II at low micromolar concentrations and selectively accumulates in the liver in vivo. 1-Deoxynojirimycin 4-7 sucrase-isomaltase Homo sapiens 20-37 22841093-3 2012 As a result, deoxynojirimycin, as a potential alpha-glucosidase inhibitor, was found. 1-Deoxynojirimycin 13-29 sucrase-isomaltase Homo sapiens 46-63 27956035-0 2017 Synthesis and characterization of novel, conjugated, fluorescent DNJ derivatives for alpha-glucosidase recognition. 1-Deoxynojirimycin 65-68 sucrase-isomaltase Homo sapiens 85-102 27956035-3 2017 The two synthetic conjugates, DNJ-CF31 and DNJ-Me 2, exhibited improved alpha-glucosidase inhibitory effects compared to DNJ and miglitol. 1-Deoxynojirimycin 30-33 sucrase-isomaltase Homo sapiens 72-89 26356422-0 2015 Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent alpha-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors. 1-Deoxynojirimycin 10-26 sucrase-isomaltase Homo sapiens 127-144 23582447-5 2013 Increasing alkyl linker length between DNJ and triazole groups increases alpha-glucosidase inhibition and reduces the production of viral progeny RNA and the maturation of the envelope polypeptide. 1-Deoxynojirimycin 39-42 sucrase-isomaltase Homo sapiens 73-90