PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25187989-2 2014 In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in adult flies. Octopamine 67-77 tiwaz Drosophila melanogaster 179-182 25187989-4 2014 Of note, our study reveals that TfAP-2 and Twz regulate octopamine signaling to initiate feeding; then octopamine, in a negative feedback loop, induces expression of Dsk to inhibit consummatory behavior. Octopamine 56-66 tiwaz Drosophila melanogaster 43-46 24142897-0 2014 Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila. Octopamine 72-82 tiwaz Drosophila melanogaster 60-63 24142897-2 2014 Interestingly, our study demonstrates that the Drosophila obesity-linked homologs Transcription factor AP-2 (TfAP-2; TFAP2B in humans) and Tiwaz (Twz; KCTD15 in humans) interact to modify male behavior by controlling the expression of Tyramine beta-hydroxylase and Vesicular monanime transporter, genes necessary for octopamine production and secretion. Octopamine 317-327 tiwaz Drosophila melanogaster 146-149 24142897-5 2014 We conclude that genetically manipulating the obesity-linked homologs TfAP-2 and Twz is sufficient to affect octopamine signaling, which in turn modulates Drosophila male behavior through the regulation of the satiation hormone Dsk. Octopamine 109-119 tiwaz Drosophila melanogaster 81-84