PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23408466-8 2013 Risperidone induced a higher UCP1 mRNA (P = 0.003) and a lower orexin mRNA (P = 0.001) than placebo. Risperidone 0-11 hypocretin Mus musculus 63-69 19084548-11 2009 UCP1 (p<0.01) and UCP3 (p<0.05) mRNA expressions were greater in risperidone-treated mice compared to controls, whereas, orexin mRNA expression was lower in risperidone-treated mice (p<0.01). Risperidone 163-174 hypocretin Mus musculus 127-133 19084548-12 2009 These results suggest that risperidone-induced weight gain in mice is a consequence of increased energy intake and reduced activity, while the elevation in body temperature may be a result of thermogenic effect of food intake and elevated UCP1, UCP3, and a reduced hypothalamic orexin expression. Risperidone 27-38 hypocretin Mus musculus 278-284