PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16608354-6 2006 These results, together with the presence of a significant kinetic isotope effect when deuterated amine substrate (RND2) is used, implicate a mechanism in which the amine undergoes preequilibrium coordination to aluminum and proton transfer to a kappa2-amidate ligand to yield an Al(kappa2-amidate)2(kappa1-carboxamide)(NHR) complex, followed by rate-limiting intramolecular delivery of the amido ligand (NHR) to the neutral Al(III)-activated kappa1-carboxamide. kappa1-carboxamide 300-318 Rho family GTPase 2 Homo sapiens 115-119