PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11839759-2	2002	However, a number of physiological stimuli (e.g. endothelial shear-stress, insulin) are known to activate endothelial nitric oxide (eNOS) via a non-classical, "calcium-independent" pathway.	Nitric Oxide	118-130	insulin	Bos taurus	75-82	
11230783-1	2001	It has been proposed that an important component of glucose disposal is insulin-mediated vasodilation via a nitric oxide (NO)-dependent mechanism.	Nitric Oxide	108-120	insulin	Bos taurus	72-79	
11229429-1	2001	Insulin increases skeletal muscle blood flow in healthy young subjects by a nitric oxide (NO)-dependent mechanism.	Nitric Oxide	76-88	insulin	Bos taurus	0-7	
16099860-2	2005	In cultured ECs, however, supraphysiological (e.g. >or=10 nM) insulin concentrations are typically used to study insulin receptor (IR) signaling pathways and nitric oxide generation.	Nitric Oxide	161-173	insulin	Bos taurus	65-72	
19608646-0	2009	The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide production.	Nitric Oxide	92-104	insulin	Bos taurus	62-69	
19608646-2	2009	Here we examined whether insulin modulates nitric oxide (NO) production by regulating eNOS subcellular localization.	Nitric Oxide	43-55	insulin	Bos taurus	25-32	
21171439-1	2001	AIM: In order to explore the regulation of the production of nitric oxide (NO) and the expression of nitric oxide synthase (NOS) gene in bovine aortic endothelial cells (BAEC) by insulin.	Nitric Oxide	61-73	insulin	Bos taurus	179-186	
10726917-1	2000	Insulin increases skeletal muscle blood flow in healthy young subjects by a nitric oxide (NO)-dependent mechanism.	Nitric Oxide	76-88	insulin	Bos taurus	0-7	
7981980-6	1994	As the pentose cycle is a major source of NADPH which is required for the synthesis of nitric oxide (the endothelium relaxing factor), insulin may play a role in regulating NO generation in endothelial cells by modulating the pentose cycle activity.	Nitric Oxide	87-99	insulin	Bos taurus	135-142	
16373398-0	2006	Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium.	Nitric Oxide	87-99	insulin	Bos taurus	47-54	
16373398-3	2006	Because DHEA may augment insulin sensitivity, we hypothesized that DHEA mimics vascular actions of insulin to acutely activate signaling pathways in endothelium-mediating production of nitric oxide (NO) and endothelin 1 (ET-1).	Nitric Oxide	185-197	insulin	Bos taurus	99-106	
12944390-3	2003	The vascular action of insulin to stimulate endothelial production of nitric oxide (NO), leading to vasodilation and increased blood flow is an important component of insulin-stimulated whole body glucose utilization.	Nitric Oxide	70-82	insulin	Bos taurus	23-30	
12944390-3	2003	The vascular action of insulin to stimulate endothelial production of nitric oxide (NO), leading to vasodilation and increased blood flow is an important component of insulin-stimulated whole body glucose utilization.	Nitric Oxide	70-82	insulin	Bos taurus	167-174