PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33140051-8 2020 Mechanistically, the STAT1/IRF1 axis activated by TNF-alpha and IFN-gamma co-treatment induced iNOS for the production of nitric oxide. Nitric Oxide 122-134 tumor necrosis factor Homo sapiens 50-59 32964397-0 2021 Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-alpha-Induced Expression of Glial Fibrillary Acid Protein. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 72-81 33278357-3 2021 Mechanistically, TNF-alpha and IFN-gamma co-treatment activated the JAK/STAT1/IRF1 axis, inducing nitric oxide production and driving caspase-8/FADD-mediated PANoptosis. Nitric Oxide 98-110 tumor necrosis factor Homo sapiens 17-26 32815569-6 2020 Owing to its plethora of surface receptors, pericytes respond to inflammatory mediators such as CCL2 (monocyte chemoattractant protein-1) and tumor necrosis factor-alpha, in turn secreting CCL2, nitric oxide, and several cytokines. Nitric Oxide 195-207 tumor necrosis factor Homo sapiens 142-169 33180271-0 2021 Correction to: Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-alpha-Induced Expression of Glial Fibrillary Acid Protein. Nitric Oxide 15-27 tumor necrosis factor Homo sapiens 87-96 33422158-7 2020 In RAW264.7 macrophages, the RMs inhibited the lipopolysaccharide-induced activation of p65/NF-kappaB, which in turn suppressed the transcription of its downstream inducible nitric oxide synthase, and cytokine genes such as interleukin-1beta and tumor necrosis factor-alpha . Nitric Oxide 174-186 tumor necrosis factor Homo sapiens 246-273 32819257-6 2020 The effect of propofol on TNF-alpha-modulated nitric oxide production was measured by a nitrate reductase assay kit. Nitric Oxide 46-58 tumor necrosis factor Homo sapiens 26-35 31756325-4 2020 In favour of this model, genomewide DNA methylation profiling of endothelial cells treated with TNF and different (-)-epicatechin metabolites revealed specific DNA methylation changes in gene networks controlling cell adhesion-extravasation endothelial hyperpermeability as well as gamma-aminobutyric acid, renin-angiotensin and nitric oxide hypertension pathways. Nitric Oxide 329-341 tumor necrosis factor Homo sapiens 96-99 32819257-9 2020 Further, we found TNF-alpha treat-ment could increase the expression of PIM-1, then activate the phosphorylation of eNOS and induce the release of nitric ox-ide (NO). Nitric Oxide 147-160 tumor necrosis factor Homo sapiens 18-27 31724838-9 2019 RESULTS: Nitric oxide (NO) bioavailability was reduced by TNFalpha and both EMPA and DAPA restored NO levels in TNFalpha-stimulated HCAECs. Nitric Oxide 9-21 tumor necrosis factor Homo sapiens 58-66 30165404-5 2019 TNF-alpha, generated either in small vessels or within the perivascular adipose tissue (PVAT) of patients with obesity, stimulates reactive oxygen species generation, mainly through NAD(P)H oxidase activation, which in turn reduces nitric oxide (NO) availability. Nitric Oxide 232-244 tumor necrosis factor Homo sapiens 0-9 30918580-5 2019 Moreover, the treatment with BC and Lyc reduced the TNF-alpha-induced nuclear translocation of NF-kappaB (image flow cytometry) by preserving bioavailability of nitric oxide (NO, flow cytometry, and cGMP EIA kit assay), a key vasoactive molecule. Nitric Oxide 161-173 tumor necrosis factor Homo sapiens 52-61 30291324-8 2019 Inhibition of nitric oxide (NO) production significantly increased the sensitivity of cells from the normal pregnancies to TNFalpha but not in the high risk group establishing a functional role for NO in this system. Nitric Oxide 14-26 tumor necrosis factor Homo sapiens 123-131 30486522-3 2018 The mechanism is mainly by inhibiting the activation of nuclear factor (NF-kappaB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors. Nitric Oxide 335-347 tumor necrosis factor Homo sapiens 298-307 29162452-0 2018 DT-13 ameliorates TNF-alpha-induced nitric oxide production in the endothelium in vivo and in vitro. Nitric Oxide 36-48 tumor necrosis factor Homo sapiens 18-27 29805311-3 2018 We first demonstrated that the upregulation of SelS enhances the levels of nitric oxide and endothelial nitric oxide synthase in tumor necrosis factor- (TNF-) alpha-treated human umbilical vein endothelial cells (HUVECs). Nitric Oxide 75-87 tumor necrosis factor Homo sapiens 129-164 29431638-3 2018 We report here that the nitric oxide (NO) donor glyceryl trinitrate (GTN) converts TNFalpha, generated from immune cells or cancer cells stimulated by chemotherapy, into a prodeath mediator in colon and mammary cancer cells. Nitric Oxide 24-36 tumor necrosis factor Homo sapiens 83-91 29162452-3 2018 This study aimed to explore the protective effect of DT-13 on endothelium through regulating of nitric oxide production induced by Tumor necrosis factor-alpha (TNF-alpha). Nitric Oxide 96-108 tumor necrosis factor Homo sapiens 131-158 29162452-3 2018 This study aimed to explore the protective effect of DT-13 on endothelium through regulating of nitric oxide production induced by Tumor necrosis factor-alpha (TNF-alpha). Nitric Oxide 96-108 tumor necrosis factor Homo sapiens 160-169 29162452-5 2018 Enzyme-linked immunosorbent assay (ELISA) results demonstrated that DT-13 could suppress the TNF-alpha-induced upregulation of reactive oxygen species (ROS), tumor necrosis factor receptor (TNFR), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and nitric oxide in vivo dose-dependently and suppressed production of nitric oxide in vitro as shown by DAF-FMDA. Nitric Oxide 266-278 tumor necrosis factor Homo sapiens 93-102 29162452-5 2018 Enzyme-linked immunosorbent assay (ELISA) results demonstrated that DT-13 could suppress the TNF-alpha-induced upregulation of reactive oxygen species (ROS), tumor necrosis factor receptor (TNFR), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and nitric oxide in vivo dose-dependently and suppressed production of nitric oxide in vitro as shown by DAF-FMDA. Nitric Oxide 333-345 tumor necrosis factor Homo sapiens 93-102 27982222-6 2016 Cell responses to TNF-a, was evaluated by application of this cytokine to cultured cells (100 ng/mL) for 24 h, followed by evaluation of reactive oxygen species (ROS), nitric oxide (NO) and CCL5 production (n=36). Nitric Oxide 168-180 tumor necrosis factor Homo sapiens 18-23 27430329-14 2016 The in vitro studies indicated that chloroform fraction at 15 mug/ml more effectively inhibited the TNF-alpha induced synthesis of NFkB (85.0 +- 8.12 %, IC50 = 5.98 mug/ml) and LPS-instigated nitric oxide (78.23 +- 2.39 %, IC50 = 6.59 mug/ml) synthesis. Nitric Oxide 192-204 tumor necrosis factor Homo sapiens 100-109 26731042-1 2016 AIM: In this study, we investigated the protective effect of ferulic acid (FA) on nitric oxide (NO) production in tumor necrosis factor (TNF)-alpha-stimulated inflammatory human umbilical vein endothelial cells (HUVECs), and elucidated the mechanism(s) involved. Nitric Oxide 82-94 tumor necrosis factor Homo sapiens 114-147 26732386-5 2016 This study aimed to determine the effect of CTS on TNF-alpha-induced increased endothelial permeability, monocyte adhesion, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), monocyte chemoattractant protein 1 (MCP-1) and impaired nitric oxide production in human umbilical vein endothelial cells (HUVECs), all of which are early events occurring in atherogenesis. Nitric Oxide 286-298 tumor necrosis factor Homo sapiens 51-60 26732386-6 2016 We showed that CTS significantly suppressed TNF-alpha-induced increased endothelial permeability, monocyte adhesion, sICAM-1, sVCAM-1 and MCP-1, and restored nitric oxide production. Nitric Oxide 158-170 tumor necrosis factor Homo sapiens 44-53 25651915-7 2015 SSeo also reduced TNF-alpha-induced production of pro-inflammatory mediators such as nitric oxide and prostaglandin E2 and inhibited inducible nitric oxide synthase and cyclooxygenase-2 expression in HASMCs. Nitric Oxide 85-97 tumor necrosis factor Homo sapiens 18-27 26447211-6 2015 The most recognized of these factors are the anti-angiogenic sFlt-1 and pro-inflammatory TNF-alpha and AT1-AA, which promote endothelial dysfunction by reducing levels of the provasodilator nitric oxide and stimulating production of the potent vasoconstrictor endothelin-1 and reactive oxygen species. Nitric Oxide 190-202 tumor necrosis factor Homo sapiens 89-98 25912222-1 2015 Tumor necrosis factor (TNFalpha) is a pro-inflammatory cytokine which mediates via nitric oxide (NO) several carcinogenic processes. Nitric Oxide 83-95 tumor necrosis factor Homo sapiens 0-21 25912222-1 2015 Tumor necrosis factor (TNFalpha) is a pro-inflammatory cytokine which mediates via nitric oxide (NO) several carcinogenic processes. Nitric Oxide 83-95 tumor necrosis factor Homo sapiens 23-31 26221205-6 2015 Various cytokines IL-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-14, TNF-alpha and IFN-gamma are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins. Nitric Oxide 194-206 tumor necrosis factor Homo sapiens 91-100 25838201-3 2015 We hypothesized that sevoflurane can protect against tumor necrosis factor (TNF)-alpha-induced endothelial dysfunction through promoting the production of endothelium-dependent nitric oxide (NO). Nitric Oxide 177-189 tumor necrosis factor Homo sapiens 53-86 25072865-6 2014 Importantly, we show that the citrate exported from mitochondria via CIC and its downstream metabolic intermediate, acetyl-coenzyme A, are necessary for TNFalpha or IFNgamma to induce nitric oxide and prostaglandin production. Nitric Oxide 184-196 tumor necrosis factor Homo sapiens 153-161 25006397-3 2013 In control human lung endothelial cell cultures, tumor necrosis factor alpha-induced nitric oxide (NO) production and S-nitrosation (SNO) of Cav-1 Cys-156 were associated with Src displacement and activation, Cav-1 Tyr-14 phosphorylation, and destabilization of Cav-1 oligomers within 5 minutes that could be blocked by eNOS or Src inhibition. Nitric Oxide 85-97 tumor necrosis factor Homo sapiens 49-76 24831467-0 2014 IFN-gamma and TNF-alpha are involved during Alzheimer disease progression and correlate with nitric oxide production: a study in Algerian patients. Nitric Oxide 93-105 tumor necrosis factor Homo sapiens 14-23 25120637-0 2014 Protective effects of Guanxin Shutong capsule drug-containing serum on tumor necrosis factor-alpha-induced endothelial dysfunction through nicotinamide adenine dinucleotide phosphate oxidase and the nitric oxide pathway. Nitric Oxide 199-211 tumor necrosis factor Homo sapiens 71-98 24525631-5 2014 The effect of ropivacaine on TNFalpha-induced nitric oxide generation, co-immunoprecipitation of TNF-receptor-1 with p85, neutrophil adhesion, and endothelial barrier disruption were assessed. Nitric Oxide 46-58 tumor necrosis factor Homo sapiens 29-37 24695240-0 2014 Nitric oxide (NO) reversed TNF-alpha inhibition of trophoblast interaction with endothelial cellular networks. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 27-36 24486907-1 2014 Exposure to pro-inflammatory cytokines, such as Angiotensin II, endothelin-1 or TNF leads to endothelial dysfunction, characterized by the reduced production of nitric oxide via endothelial nitric oxide synthase (eNOS). Nitric Oxide 161-173 tumor necrosis factor Homo sapiens 80-83 24525631-2 2014 Proinflammatory cytokines, such as tumor necrosis factor-alpha (TNFalpha), activate Src via phosphatidylinositide 3-kinase/Akt-dependent nitric oxide generation, a process initiated by recruitment of phosphatidylinositide 3-kinase regulatory subunit p85 to TNF-receptor-1. Nitric Oxide 137-149 tumor necrosis factor Homo sapiens 35-62 24525631-2 2014 Proinflammatory cytokines, such as tumor necrosis factor-alpha (TNFalpha), activate Src via phosphatidylinositide 3-kinase/Akt-dependent nitric oxide generation, a process initiated by recruitment of phosphatidylinositide 3-kinase regulatory subunit p85 to TNF-receptor-1. Nitric Oxide 137-149 tumor necrosis factor Homo sapiens 64-72 24060108-4 2014 Treatment with pro-inflammatory cytokines mainly tumor necrosis factor-alpha, interleukin 1-beta, and interferon-gamma induces an increase in inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production. Nitric Oxide 152-164 tumor necrosis factor Homo sapiens 49-76 25405415-8 2014 TNFa also caused a significant increase in nitric oxide without changes in glutathione. Nitric Oxide 43-55 tumor necrosis factor Homo sapiens 0-4 25405415-9 2014 TQ administered to the cells prior to a challenge with TNFa resulted in a decrease in nitric oxide and an increase in glutathione which may be a possible mechanism to reduce inflammation and reduce oxidation. Nitric Oxide 86-98 tumor necrosis factor Homo sapiens 55-59 23706710-8 2013 TNFA GA and IL5 CC and TNFA GA and IL1A CC were 2 epistatic predictors of exhaled nitrogen monoxide decrease during follow-up (P = .02 and P = .004, respectively). Nitric Oxide 82-99 tumor necrosis factor Homo sapiens 0-4 24086172-0 2013 Martentoxin, a large-conductance Ca(2+)-activated K(+) channel inhibitor, attenuated TNF-alpha-induced nitric oxide release by human umbilical vein endothelial cells. Nitric Oxide 103-115 tumor necrosis factor Homo sapiens 85-94 24086172-2 2013 In the present study, we investigated the pharmacological effects of martentoxin on regulating the production of nitric oxide induced by TNF-alpha in human umbilical vein endothelial cells (HUVECs). Nitric Oxide 113-125 tumor necrosis factor Homo sapiens 137-146 24086172-3 2013 We found that, 1, 10 and 100 micromol/L martentoxin decreased nitric oxide production by HUVECs exposed to 10 ng/mL TNF for 6, 12 and 24 hours. Nitric Oxide 62-74 tumor necrosis factor Homo sapiens 116-119 23706710-8 2013 TNFA GA and IL5 CC and TNFA GA and IL1A CC were 2 epistatic predictors of exhaled nitrogen monoxide decrease during follow-up (P = .02 and P = .004, respectively). Nitric Oxide 82-99 tumor necrosis factor Homo sapiens 23-27 23132229-7 2012 Furthermore, treatment of HaCaT human keratinocytes with TNF-alpha increased the levels of nitric oxide (NO), IL-6 and IL-8 (32.21 +- 5.71 muM vs. 3.22 +- 0.98 muM; 203.96 +- 13.16 pg/ml vs. 13.57 +- 3.75 pg/ml; and 301.24 +- 30.17 pg/ml vs. 29.06 +- 10.91 pg/ml, respectively) in the culture media. Nitric Oxide 91-103 tumor necrosis factor Homo sapiens 57-66 22526394-4 2012 TNF-alpha also increased the production of inducible nitric oxide synthase (iNOS), nitric oxide (NO), and intercellular adhesion molecule 1 (ICAM-1) through activation of p38 mitogen-activated protein kinase (MAPK) from HT-29 cells. Nitric Oxide 53-65 tumor necrosis factor Homo sapiens 0-9 22922824-7 2012 In contrast, NOS2A-expression and nitric oxide (NO)-release were not affected by trauma but significantly increased by TNF-alpha. Nitric Oxide 34-46 tumor necrosis factor Homo sapiens 119-128 22777418-2 2012 We hypothesized that d-glucosamine (d-GlcN) and Thiamet-G, two agents that increase protein O-GlcNAcylation via different mechanisms, inhibit TNF-alpha-induced oxidative stress and vascular dysfunction by suppressing inducible nitric oxide (NO) synthase (iNOS) expression. Nitric Oxide 227-239 tumor necrosis factor Homo sapiens 142-151 22777005-7 2012 Tumor necrosis factor-alpha increased nitric oxide production and caused similar increase in SNO as PAF. Nitric Oxide 38-50 tumor necrosis factor Homo sapiens 0-27 22636782-0 2012 Bacterium-generated nitric oxide hijacks host tumor necrosis factor alpha signaling and modulates the host cell cycle in vitro. Nitric Oxide 20-32 tumor necrosis factor Homo sapiens 46-73 24795496-9 2012 Downstream mechanisms of TNF-enhanced sleep include nitric oxide, adenosine, prostaglandins and activation of nuclear factor kappa B. Neuronal use induces cortical neurons to express TNF and if applied directly to cortical columns TNF induces a functional sleep-like state within the column. Nitric Oxide 52-64 tumor necrosis factor Homo sapiens 25-28 21833550-0 2012 Nitric oxide potentiates TNF-alpha-induced neurotoxicity through suppression of NF-kappaB. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 25-34 22040060-10 2012 TNF-alpha production of macrophages with the nitric oxide (NO) inhibitor-treatment increased after carbon-ion broad-beam. Nitric Oxide 45-57 tumor necrosis factor Homo sapiens 0-9 21400477-5 2011 Procatabolic responses to IL-1beta and TNFalpha, such as release of glycosaminoglycan, nitric oxide, and matrix metalloproteinases 3 and 13 were determined by dimethylmethylene blue assay, Griess reaction, and Western blotting, respectively, in cartilage explants and chondrocytes with and without knockdown of AMPKalpha by small interfering RNA. Nitric Oxide 87-99 tumor necrosis factor Homo sapiens 39-47 22117546-0 2011 Interaction of the nitric oxide signaling system with the sphingomyelin cycle and peroxidation on transmission of toxic signal of tumor necrosis factor-alpha in ischemia-reperfusion. Nitric Oxide 19-31 tumor necrosis factor Homo sapiens 130-157 22117546-4 2011 The role of a proinflammatory cytokine TNF-alpha in apoptosis and ischemia-reperfusion and mechanisms of its cytotoxic action, which involve nitric oxide, the sphingomyelin cycle, and lipid peroxidation are discussed. Nitric Oxide 141-153 tumor necrosis factor Homo sapiens 39-48 21611811-0 2011 IL-12- and IL-18-mediated, nitric oxide-induced apoptosis in TNF-alpha-mediated osteoclastogenesis of bone marrow cells. Nitric Oxide 27-39 tumor necrosis factor Homo sapiens 61-70 20815659-1 2010 The inflammatory cytokines tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) stimulate production of the inflammatory mediators prostaglandin E2 (PGEgamma), prostacyclin (PGIgamma), and nitric oxide (NO) in cultured lung epithelial cells. Nitric Oxide 207-219 tumor necrosis factor Homo sapiens 27-54 21675854-3 2011 TNF-alpha has a multifactorial effect in hepatic IRI because of the many interactions between TNF-alpha and reactive oxygen species, nitric oxide, adhesion molecules, and various cytokines and chemokines. Nitric Oxide 133-145 tumor necrosis factor Homo sapiens 0-9 20815659-1 2010 The inflammatory cytokines tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) stimulate production of the inflammatory mediators prostaglandin E2 (PGEgamma), prostacyclin (PGIgamma), and nitric oxide (NO) in cultured lung epithelial cells. Nitric Oxide 207-219 tumor necrosis factor Homo sapiens 56-64 20633260-0 2010 Resistance of Leishmania (Viannia) braziliensis to nitric oxide: correlation with antimony therapy and TNF-alpha production. Nitric Oxide 51-63 tumor necrosis factor Homo sapiens 103-112 20804613-8 2010 Tumor necrosis factor-alpha (TNF-alpha), lipopolysaccharide (LPS) and diethyl maleate (DEM) significantly increased taurine uptake, but H2O2 and nitric oxide (NO) donor decreased taurine uptake in the cells. Nitric Oxide 145-157 tumor necrosis factor Homo sapiens 0-27 20804613-8 2010 Tumor necrosis factor-alpha (TNF-alpha), lipopolysaccharide (LPS) and diethyl maleate (DEM) significantly increased taurine uptake, but H2O2 and nitric oxide (NO) donor decreased taurine uptake in the cells. Nitric Oxide 145-157 tumor necrosis factor Homo sapiens 29-38 20237583-0 2010 Nitric oxide and calcium signaling regulate myocardial tumor necrosis factor-alpha expression and cardiac function in sepsis. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 55-82 20125033-6 2010 TNF increased intracellular superoxide and hydrogen peroxide production accompanied by increases of inducible nitric oxide synthase (iNOS) protein expression and nitric oxide production. Nitric Oxide 110-122 tumor necrosis factor Homo sapiens 0-3 20093623-9 2010 Incubation with nitric oxide donor sodium nitroprusside significantly ameliorated the inhibition of tumor necrosis factor-alpha on EPC proliferation, but incubation with endothelial nitric oxide synthase inhibitor l-NAME and PI3K inhibitor markedly attenuated the effect of RW on EPC proliferation. Nitric Oxide 16-28 tumor necrosis factor Homo sapiens 100-127 19819972-0 2009 Short-term regulation of tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes is mediated through the inducible nitric oxide synthase/nitric oxide-dependent pathway. Nitric Oxide 126-138 tumor necrosis factor Homo sapiens 25-52 19877030-0 2009 Tumor necrosis factor alpha and interleukin-1beta modulate calcium and nitric oxide signaling in mechanically stimulated osteocytes. Nitric Oxide 71-83 tumor necrosis factor Homo sapiens 0-27 19273197-6 2009 In patients with moderate to severe forms of CHF, TNF-alpha leads to the formation of nitrotyrosine and consumption of nitric oxide by virtue of activation of myeloperoxidase. Nitric Oxide 119-131 tumor necrosis factor Homo sapiens 50-59 19057417-0 2009 Rapid nitric oxide-dependent effects of tumor necrosis factor-alpha on suprachiasmatic nuclei neuronal activity. Nitric Oxide 6-18 tumor necrosis factor Homo sapiens 40-67 19057417-6 2009 TNF-alpha, levels of which show circadian variation in the brain and increase during inflammatory conditions and aging, may thus through nitric oxide induction modulate SCN electrical output to affect downstream circadian rhythms. Nitric Oxide 137-149 tumor necrosis factor Homo sapiens 0-9 19604438-0 2009 Short-term effect of anti-TNF-alpha therapy on nitric oxide production in patients with severe rheumatoid arthritis. Nitric Oxide 47-59 tumor necrosis factor Homo sapiens 26-35 19604438-13 2009 CONCLUSIONS: Our results show, for the first time, a short-term effect of anti-TNF-alpha therapy on the levels of nitric oxide production. Nitric Oxide 114-126 tumor necrosis factor Homo sapiens 79-88 18983746-0 2008 TNF-alpha and IL-6 affect human sperm function by elevating nitric oxide production. Nitric Oxide 60-72 tumor necrosis factor Homo sapiens 0-9 19241202-1 2009 Myeloid cells respond to external stimuli such as gram negative bacterial lipopolysaccharides (LPS) or endotoxin by producing a large array of intermediates and proteins, including the pro-inflammatory cytokines such as, tumor necrosis factor-alpha (TNF-alpha), free radicals, nitric oxide, and other intermediates. Nitric Oxide 277-289 tumor necrosis factor Homo sapiens 221-248 19241202-1 2009 Myeloid cells respond to external stimuli such as gram negative bacterial lipopolysaccharides (LPS) or endotoxin by producing a large array of intermediates and proteins, including the pro-inflammatory cytokines such as, tumor necrosis factor-alpha (TNF-alpha), free radicals, nitric oxide, and other intermediates. Nitric Oxide 277-289 tumor necrosis factor Homo sapiens 250-259 18035449-0 2008 TGF beta 1 and TNF alpha potentiate nitric oxide production in astrocyte cultures by recruiting distinct subpopulations of cells to express NOS-2. Nitric Oxide 36-48 tumor necrosis factor Homo sapiens 15-24 18508038-3 2008 The data presented here demonstrate that mild activation of primary astrocytes with low or "sub-optimal" concentrations of MPTP (1 microM) and the inflammatory cytokine tumor necrosis factor alpha (10 pg/ml) and interferon gamma (1 ng/ml) results in selective induction of Nos1 mRNA and protein, increased production of nitric oxide (NO), and a significant elevation in global protein nitration. Nitric Oxide 320-332 tumor necrosis factor Homo sapiens 169-196 19075734-4 2008 TNF-alpha expression after stroke stimulates expression of tissue factor and adhesion molecules for leukocytes, release of interleukin-1 (IL-1), nitric oxide, factor VIII/von Willebrand factor, platelet-activating factor and endothelin, suppression of the thrombomodulin-protein C-protein S system, reduction of tissue-plasminogen activator and release of plasminogen activator inhibitor-1. Nitric Oxide 145-157 tumor necrosis factor Homo sapiens 0-9 18293202-0 2008 TNF-alpha alters nitric oxide- and endothelium-derived hyperpolarizing factor-mediated vasodilatation in human omental arteries. Nitric Oxide 17-29 tumor necrosis factor Homo sapiens 0-9 18293202-4 2008 However, TNF-alpha did attenuate nitric oxide- (NO) and prostacyclin-independent endothelial-mediated relaxation. Nitric Oxide 33-45 tumor necrosis factor Homo sapiens 9-18 17576200-2 2007 In the present paper, we show that the TNF-induced phosphorylation of GLO1 occurs primarily on the NO (nitric oxide)-responsive form of GLO1. Nitric Oxide 103-115 tumor necrosis factor Homo sapiens 39-42 18824875-0 2008 Nitric oxide involvement in TNF-alpha and IL-1 beta-mediated changes in human mesangial cell MMP-9 and TIMP-1. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 28-37 18824875-3 2008 Therefore we examined the potential role of nitric oxide (NO) in the regulation of MMP-9 and TIMP-1 by tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) using the human mesangial cell line (HMCL). Nitric Oxide 44-56 tumor necrosis factor Homo sapiens 133-142 17519233-1 2007 Certain patients suffering from chronic diseases such as AIDS or cancer experience a constant cellular secretion of tumor necrosis factor alpha and other pro-inflammatory cytokines that results in a continuous release of nitric oxide (*NO) to the bloodstream. Nitric Oxide 221-233 tumor necrosis factor Homo sapiens 116-143 17354225-8 2007 In summary, high levels of AS expression, which may be required for several arginine-dependent processes in cancer, including the production of nitric oxide, proline, pyrimidines and polyamines, is regulated by TNF-alpha and may provide an important molecular pathway linking inflammation and metabolism to ovarian tumorigenesis. Nitric Oxide 144-156 tumor necrosis factor Homo sapiens 211-220 17496212-0 2007 Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells. Nitric Oxide 78-90 tumor necrosis factor Homo sapiens 0-27 17496212-1 2007 Endothelial dysfunction associated with elevated serum levels of TNF-alpha observed in diabetes, obesity, and congenital heart disease results, in part, from the impaired production of endothelial nitric oxide (NO). Nitric Oxide 197-209 tumor necrosis factor Homo sapiens 65-74 17374495-0 2007 Regulation of NF-kappaB activation and nuclear translocation by exogenous nitric oxide (NO) donors in TNF-alpha activated vascular endothelial cells. Nitric Oxide 74-86 tumor necrosis factor Homo sapiens 102-111 17567463-6 2007 Nitric oxide donor (S-nitroso-N-acetylpenicillamine) inhibited Bid cleavage, the MPT, and caspase activation and reduced TNF-alpha- and Fas-mediated cell killing. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 121-130 17402996-11 2007 Rectal nitric oxide levels parallel down-regulation of inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin-1beta and interferon-gamma and may serve as a quantitative biomarker of intestinal inflammation. Nitric Oxide 7-19 tumor necrosis factor Homo sapiens 88-115 17251380-3 2007 Here, we use a model in which the multifunctional cytokine nitric oxide counterbalances TNF-alpha-induced apoptosis, to define a role for membrane trafficking in the process of endothelial cell survival signaling. Nitric Oxide 59-71 tumor necrosis factor Homo sapiens 88-97 17143541-7 2007 The latter compounds directly damage cell membranes and act as intracellular chemical messengers stimulating proapoptotic systems such as CD95 and TNF-alpha, which in turn can activate nitric oxide (NO) metabolism. Nitric Oxide 185-197 tumor necrosis factor Homo sapiens 147-156 17070777-0 2006 Involvement of Syk kinase in TNF-induced nitric oxide production by airway epithelial cells. Nitric Oxide 41-53 tumor necrosis factor Homo sapiens 29-32 16730193-2 2006 Sphingosine/ceramide and nitric oxide have been associated with apoptosis induced by TNF-alpha; however, signaling mechanisms of TNF-alpha-induced apoptosis in cardiac myocytes are not well defined. Nitric Oxide 25-37 tumor necrosis factor Homo sapiens 85-94 17026986-2 2006 Both nitric oxide (NO) and reactive oxygen species may play a dual role (i.e., inhibiting or promoting) in TNF-alpha-induced endothelial cell apoptosis. Nitric Oxide 5-17 tumor necrosis factor Homo sapiens 107-116 16645484-9 2006 Human monocytes treated with a nitric oxide donor also express large amounts of interleukin-1 receptor-associated kinase-M, apparently under the control of tumor necrosis factor-alpha. Nitric Oxide 31-43 tumor necrosis factor Homo sapiens 156-183 16567019-3 2006 Within cartilage and synovium, pro-inflammatory cytokines, particularly IL-1b and TNF-a, auto-catalytically stimulate their own production and induce chondrocytes to produce additional catabolic mediators, including proteases, chemokines, nitric oxide, and prostaglandins. Nitric Oxide 239-251 tumor necrosis factor Homo sapiens 82-87 16540955-13 2006 In fact, strategies aimed at inhibiting IL-1 action, including IL-1 receptor antagonist, ischemic preconditioning, and nitric oxide donor, increased systemic sTNFR2 and decreased free TNF, following ROLT. Nitric Oxide 119-131 tumor necrosis factor Homo sapiens 159-162 16540955-14 2006 Similarly, nitric oxide synthesis inhibition in the preconditioned group, which increased IL-1alpha and lung damage, reduced systemic sTNFR2 and increased free TNF levels. Nitric Oxide 11-23 tumor necrosis factor Homo sapiens 135-138 16755653-0 2006 Tumor necrosis factor-alpha protects synovial cells from nitric oxide induced apoptosis through phosphoinositide 3-kinase Akt signal transduction. Nitric Oxide 57-69 tumor necrosis factor Homo sapiens 0-27 16755653-6 2006 RESULTS: A 24-h TNF-a treatment prevented FLS apoptosis induced by nitric oxide (NO) donor sodium nitroprusside dihydrate (SNP), achieving 70% protection. Nitric Oxide 67-79 tumor necrosis factor Homo sapiens 16-21 16413574-0 2006 Activation of JNK and xanthine oxidase by TNF-alpha impairs nitric oxide-mediated dilation of coronary arterioles. Nitric Oxide 60-72 tumor necrosis factor Homo sapiens 42-51 16740225-8 2006 Nitric oxide production is stimulated by TNF-alpha, so the latter is also implicated in the apoptotic process. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 41-50 16413574-3 2006 Herein, we examined whether TNF can affect endothelium-dependent nitric oxide (NO)-mediated dilation of coronary arterioles to adenosine and whether inflammatory signaling pathways such as mitogen-activated protein kinases, ceramide sphingolipids, and oxidative stress are involved in the TNF-mediated effect. Nitric Oxide 65-77 tumor necrosis factor Homo sapiens 28-31 15979106-2 2005 Previous results showed that hydrogen peroxide and TNF-alpha increase extracellular inosine concentration in cultured Sertoli cells and this nucleoside protects Sertoli cells against hydrogen peroxide induced damage and participates in TNF-alpha induced nitric oxide production. Nitric Oxide 254-266 tumor necrosis factor Homo sapiens 51-60 16399681-5 2006 Intracerebral infusion with the nitric oxide donor sodium nitroprusside (SNP) caused neurodegeneration and demyelination that were markedly increased in the brain of TNF-alpha- and IL-1beta/TNF-alpha-deficient mice compared with IL-1beta-deficient and wild-type mice. Nitric Oxide 32-44 tumor necrosis factor Homo sapiens 166-175 16399681-5 2006 Intracerebral infusion with the nitric oxide donor sodium nitroprusside (SNP) caused neurodegeneration and demyelination that were markedly increased in the brain of TNF-alpha- and IL-1beta/TNF-alpha-deficient mice compared with IL-1beta-deficient and wild-type mice. Nitric Oxide 32-44 tumor necrosis factor Homo sapiens 190-199 16269668-8 2006 We found that nitric oxide generated through this pathway has a biological role, because it inhibits the expression of E-selectin and the adhesion of dendritic cells to the endothelium stimulated by TNF-alpha. Nitric Oxide 14-26 tumor necrosis factor Homo sapiens 199-208 17059693-0 2006 Nitric oxide induces SOCS-1 expression in human monocytes in a TNF-alpha-dependent manner. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 63-72 16328964-0 2006 Extracellular inosine participates in tumor necrosis factor-alpha induced nitric oxide production in cultured Sertoli cells. Nitric Oxide 74-86 tumor necrosis factor Homo sapiens 38-65 16328964-7 2006 These results suggest that extracellular inosine acts as intermediary in TNF-alpha stimulated nitric oxide production in cultured Sertoli cells. Nitric Oxide 94-106 tumor necrosis factor Homo sapiens 73-82 16343789-6 2006 Lipoteichoic acid-activated glial cells produced nitric oxide and pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta) that contributed to lipoteichoic acid-induced blood-brain barrier disruption, since the direct treatment of the endothelial monolayer with tumor necrosis factor-alpha or interleukin-1beta increased blood-brain barrier permeability, whereas the pre-treatment of lipoteichoic acid-activated glial cells with antibodies against these two cytokines blocked lipoteichoic acid effects. Nitric Oxide 49-61 tumor necrosis factor Homo sapiens 284-311 16311916-2 2005 The expression of inducible nitric oxide synthase (iNOS) and generation of nitric oxide in response to IFN-gamma and TNF-alpha is important in control of infection. Nitric Oxide 28-40 tumor necrosis factor Homo sapiens 117-126 15979106-2 2005 Previous results showed that hydrogen peroxide and TNF-alpha increase extracellular inosine concentration in cultured Sertoli cells and this nucleoside protects Sertoli cells against hydrogen peroxide induced damage and participates in TNF-alpha induced nitric oxide production. Nitric Oxide 254-266 tumor necrosis factor Homo sapiens 236-245 16283110-2 2005 IL-1 and TNFalpha enhance nitric oxide (NO) production in OA cartilage through the inducible nitric oxide synthase (iNOS) pathway and NO mediates many of the destructive effects of these cytokines. Nitric Oxide 26-38 tumor necrosis factor Homo sapiens 9-17 15853748-9 2005 For example, TNF-alpha is known to play an important role in promoting inflammation by upregulating expression of cell adhesion molecules on endothelial cells and stimulating the production of reactive oxygen intermediates, nitric oxide and prostaglandins. Nitric Oxide 224-236 tumor necrosis factor Homo sapiens 13-22 15546721-2 2004 Specifically, the 2-(12-hydroxy-dodecyl)-2,5,7,8-tetramethyl-chroman-6-ol, the TFA bearing 12 carbon atoms on the side chain (n=12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS)-activated microglia. Nitric Oxide 182-194 tumor necrosis factor Homo sapiens 234-243 15757665-1 2005 The potential use of alpha-cyclodextrin and its hydrophilic alpha-cyclodextrin derivatives (alpha-CyDs) as antagonists against lipopolysaccharide (LPS), which stimulates the nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production as well as nuclear factor-kappaB (NF-kappaB) activation in macrophages was examined. Nitric Oxide 174-186 tumor necrosis factor Homo sapiens 196-223 15757665-1 2005 The potential use of alpha-cyclodextrin and its hydrophilic alpha-cyclodextrin derivatives (alpha-CyDs) as antagonists against lipopolysaccharide (LPS), which stimulates the nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production as well as nuclear factor-kappaB (NF-kappaB) activation in macrophages was examined. Nitric Oxide 174-186 tumor necrosis factor Homo sapiens 225-234 15488873-1 2004 It has been recently hypothesized that both TNFalpha and anti TNFalpha treatment have a stimulating effect on nitric oxide synthesis and release. Nitric Oxide 110-122 tumor necrosis factor Homo sapiens 44-52 15471850-2 2004 Cytokines such as interleukin-1 (IL-1), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) mediate beta-cell dysfunction and islet degeneration, in part, through the induction of the inducible isoform of nitric-oxide synthase and the production of nitric oxide by beta-cells. Nitric Oxide 271-283 tumor necrosis factor Homo sapiens 74-101 15471850-2 2004 Cytokines such as interleukin-1 (IL-1), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) mediate beta-cell dysfunction and islet degeneration, in part, through the induction of the inducible isoform of nitric-oxide synthase and the production of nitric oxide by beta-cells. Nitric Oxide 271-283 tumor necrosis factor Homo sapiens 103-112 15488873-1 2004 It has been recently hypothesized that both TNFalpha and anti TNFalpha treatment have a stimulating effect on nitric oxide synthesis and release. Nitric Oxide 110-122 tumor necrosis factor Homo sapiens 62-70 15618842-3 2004 Terlipressin has recently been shown in an animal model of cirrhosis to suppress endotoxin-induced TNF-alpha-mediated upregulation of iNOS, thereby preventing overproduction of nitric oxide and restoring normal vascular tone. Nitric Oxide 177-189 tumor necrosis factor Homo sapiens 99-108 15223066-2 2004 A beta(25-35) upregulated the cytokine (TNF-alpha/IL-1 beta)-induced expression of iNOS and the production of nitric oxide (NO) in astrocytes, which were inhibited by vitamin E. Nitric Oxide 110-122 tumor necrosis factor Homo sapiens 40-49 15293554-0 2004 Effects of antioxidant and nitric oxide on chemokine production in TNF-alpha-stimulated human dermal microvascular endothelial cells. Nitric Oxide 27-39 tumor necrosis factor Homo sapiens 67-76 15283847-12 2004 We observed a definite correlation between nitric oxide release and TNF-alpha production, irrespective of low or high production in MDR-TB or fresh cases, respectively. Nitric Oxide 43-55 tumor necrosis factor Homo sapiens 68-77 15219804-0 2004 Effects of antioxidants and nitric oxide on TNF-alpha-induced adhesion molecule expression and NF-kappaB activation in human dermal microvascular endothelial cells. Nitric Oxide 28-40 tumor necrosis factor Homo sapiens 44-53 15275867-0 2004 Nitric oxide activates the expression of IRAK-M via the release of TNF-alpha in human monocytes. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 67-76 12404124-3 2002 Nitric oxide has previously been shown to exert a cyclic GMP-dependent inhibition of early apoptotic events triggered by TNF-alpha in the U937 monocytic cell line. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 121-130 14555283-2 2003 This study determined whether nicorandil, a potassium channel opener, and nitric oxide (NO) donor could inhibit the release of tumour necrosis factor alpha (TNFalpha) from lymphocytes. Nitric Oxide 74-86 tumor necrosis factor Homo sapiens 157-165 12759366-1 2003 Nitric oxide (NO*) and cAMP-dependent protein kinase (PKA) inhibitors up-regulate tumor necrosis factor alpha (TNFalpha) by decreasing Sp1 binding to a proximal GC box element. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 82-109 12759366-1 2003 Nitric oxide (NO*) and cAMP-dependent protein kinase (PKA) inhibitors up-regulate tumor necrosis factor alpha (TNFalpha) by decreasing Sp1 binding to a proximal GC box element. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 111-119 12480916-0 2002 TNF-alpha protects human primary articular chondrocytes from nitric oxide-induced apoptosis via nuclear factor-kappaB. Nitric Oxide 61-73 tumor necrosis factor Homo sapiens 0-9 12480916-2 2002 In the present study, we tested how TNF-alpha influences chondrocyte survival in response to nitric oxide (NO)-related apoptotic signals, which are abundant during rheumatoid arthritis. Nitric Oxide 93-105 tumor necrosis factor Homo sapiens 36-45 12399621-0 2002 Exogenous nitric oxide inhibits tumor necrosis factor-alpha- or interleukin-1-beta-induced monocyte chemoattractant protein-1 expression in human mesangial cells. Nitric Oxide 10-22 tumor necrosis factor Homo sapiens 32-59 12843254-7 2003 The neuronal damage caused by TNF-alpha is dependent on both nitric oxide and caspase pathways. Nitric Oxide 61-73 tumor necrosis factor Homo sapiens 30-39 12846989-4 2003 Glial cells can release deleterious compounds such as proinflammatory cytokines (TNF-alpha, Il-1beta, IFN-gamma), which may act by stimulating nitric oxide production in glial cells, or which may exert a more direct deleterious effect on dopaminergic neurons by activating receptors that contain intracytoplasmic death domains involved in apoptosis. Nitric Oxide 143-155 tumor necrosis factor Homo sapiens 81-90 12697682-14 2003 TNF alpha increased both nitric oxide synthase-II mRNA and protein, and the nitric oxide donor sodium nitroprusside decreased IGF-I mRNA levels in C2C12 cells. Nitric Oxide 25-37 tumor necrosis factor Homo sapiens 0-9 12776910-3 2003 MCs are located throughout the human body and, upon allergen exposure, they are stimulated via the immunoglobulin E (IgE) receptor (Fc(epsilon)RI) to release several pro-inflammatory mediators such as tumor necrosis factor (TNF), reactive oxygen species such as nitric oxide (NO), proteases, and lipid-derived mediators. Nitric Oxide 262-274 tumor necrosis factor Homo sapiens 201-222 12404124-5 2002 We found that activation of both acid and neutral sphingomyelinases, triggered in the first minutes after U937 cell stimulation with TNF-alpha, is regulated in an inhibitory fashion by nitric oxide, working through generation of cyclic GMP and activation of protein kinase G. Using a range of inhibitors selective for either sphingomyelinase we found that the acid sphingomyelinase contributes to activation of the initiator caspase-8 and early DNA fragmentation and that inhibition of the acid enzyme by nitric oxide accounts for cyclic GMP-dependent early protection from apoptosis. Nitric Oxide 185-197 tumor necrosis factor Homo sapiens 133-142 12404124-5 2002 We found that activation of both acid and neutral sphingomyelinases, triggered in the first minutes after U937 cell stimulation with TNF-alpha, is regulated in an inhibitory fashion by nitric oxide, working through generation of cyclic GMP and activation of protein kinase G. Using a range of inhibitors selective for either sphingomyelinase we found that the acid sphingomyelinase contributes to activation of the initiator caspase-8 and early DNA fragmentation and that inhibition of the acid enzyme by nitric oxide accounts for cyclic GMP-dependent early protection from apoptosis. Nitric Oxide 505-517 tumor necrosis factor Homo sapiens 133-142 11911993-1 2002 This study examines immediate nitric oxide (NO) release from monocytes following interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) challenge in patients with complex regional pain syndrome (CRPS). Nitric Oxide 30-42 tumor necrosis factor Homo sapiens 145-172 12154205-1 2002 OBJECTIVE: To compare the time- and concentration-dependent effects of tumour necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) on the induction of nitric oxide synthase (NOS), the production of nitric oxide (NO) and the expression of aggrecan and hyaluronan (HA) in chondrocytes. Nitric Oxide 165-177 tumor necrosis factor Homo sapiens 101-110 12135128-0 2002 Increased nitric oxide in proportion to the severity of heart failure in patients with dilated cardiomyopathy: close correlation of tumor necrosis factor-alpha with systemic and local production of nitric oxide. Nitric Oxide 10-22 tumor necrosis factor Homo sapiens 132-159 12135128-0 2002 Increased nitric oxide in proportion to the severity of heart failure in patients with dilated cardiomyopathy: close correlation of tumor necrosis factor-alpha with systemic and local production of nitric oxide. Nitric Oxide 198-210 tumor necrosis factor Homo sapiens 132-159 11911993-1 2002 This study examines immediate nitric oxide (NO) release from monocytes following interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) challenge in patients with complex regional pain syndrome (CRPS). Nitric Oxide 30-42 tumor necrosis factor Homo sapiens 174-183 12133311-1 2002 OBJECTIVE: To investigate the effect of polysaccharide sulfate 916 (PS916) on the production of nitric oxide (NO) in ECV304 cells induced by tumor necrosis factor-alpha (TNF alpha), interleukin-1 beta (IL-1 beta) and H(2)O(2) in vitro. Nitric Oxide 96-108 tumor necrosis factor Homo sapiens 141-168 12133311-1 2002 OBJECTIVE: To investigate the effect of polysaccharide sulfate 916 (PS916) on the production of nitric oxide (NO) in ECV304 cells induced by tumor necrosis factor-alpha (TNF alpha), interleukin-1 beta (IL-1 beta) and H(2)O(2) in vitro. Nitric Oxide 96-108 tumor necrosis factor Homo sapiens 170-179 11752021-4 2002 The induction of IP-10 and Mig mRNA and protein expression by IFN-gamma plus TNF-alpha was strongly inhibited by nitric oxide (NO) donors, such as sodium nitroprusside or S-nitroso-N-acetylpenicillamine, but not by cGMP analogues. Nitric Oxide 113-125 tumor necrosis factor Homo sapiens 77-86 11950256-0 2002 Effects of TNFalpha-antagonists on nitric oxide production in human cartilage. Nitric Oxide 35-47 tumor necrosis factor Homo sapiens 11-19 11854621-6 2002 Further, inhibition of nitric oxide (NO) synthase by L-NAME potentiated the TNF-alpha response, suggesting a protective role for endogenously produced NO in these two cell lines. Nitric Oxide 23-35 tumor necrosis factor Homo sapiens 76-85 11443053-4 2001 Although S-nitroso-N-acetylpenicillamine, a nitric oxide (NO) donor, also increased TNF-alpha production, NO exposure led to phosphorylation of p38 MAPK, not p42/44 MAPK. Nitric Oxide 44-56 tumor necrosis factor Homo sapiens 84-93 11724645-6 2001 In addition, IL-1beta was more potent than TNFalpha in inducing nitric oxide in both arthritides, and TNFalpha alone was almost ineffective in cells from rheumatoid arthritis patients. Nitric Oxide 64-76 tumor necrosis factor Homo sapiens 43-51 11795313-6 2001 Conversely, our laboratory has identified nitric oxide-independent mechanisms that limit TNF signal transduction. Nitric Oxide 42-54 tumor necrosis factor Homo sapiens 89-92 11742038-1 2001 The proinflammatory cytokines, interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNFalpha), and interferon gamma (IFNgamma), are cytotoxic to pancreatic islet beta cells, possibly by inducing nitric oxide and/or oxygen radical production in the beta cells. Nitric Oxide 201-213 tumor necrosis factor Homo sapiens 90-98 11583967-2 2001 In this report we demonstrate that nitric oxide-independent killing of co-cultured mesangial cells by interferon-gamma/lipopolysaccharide-activated M(phi) is suppressed by binding/ingestion of apoptotic cells and is mediated by tumor necrosis factor (TNF). Nitric Oxide 35-47 tumor necrosis factor Homo sapiens 228-249 11583967-2 2001 In this report we demonstrate that nitric oxide-independent killing of co-cultured mesangial cells by interferon-gamma/lipopolysaccharide-activated M(phi) is suppressed by binding/ingestion of apoptotic cells and is mediated by tumor necrosis factor (TNF). Nitric Oxide 35-47 tumor necrosis factor Homo sapiens 251-254 11583967-3 2001 Thus, soluble TNF receptor-1 significantly inhibited induction of mesangial cell apoptosis by 1) rodent M(phi) in the presence of nitric oxide synthase inhibitors or 2) human M(phi), both situations in which nitric oxide release was minimal. Nitric Oxide 130-142 tumor necrosis factor Homo sapiens 14-17 11518677-2 2001 Nitric oxide (NO) protects from apoptosis induced by Fas and TNF-alpha. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 61-70 11290515-1 2001 We tested the hypothesis that endothelial cell nitric oxide synthase (ecNOS) mediates the tumor necrosis factor (TNF)-alpha-induced increase in nitric oxide (NO) and albumin permeability in pulmonary microvessel endothelial monolayers (PEM). Nitric Oxide 47-59 tumor necrosis factor Homo sapiens 90-123 11413232-4 2001 We found that tumor necrosis factor-alpha and interferon-gamma exert synergistic inhibitory action on Schwann cell viability via the production of nitric oxide (NO) and ceramide (cer). Nitric Oxide 147-159 tumor necrosis factor Homo sapiens 14-41 11440974-0 2001 Tumor necrosis factor-alpha induces fibronectin synthesis in coronary artery smooth muscle cells by a nitric oxide-dependent posttranscriptional mechanism. Nitric Oxide 102-114 tumor necrosis factor Homo sapiens 0-27 11571673-0 2001 Estrogenic status influences nitric oxide-regulated TNF-alpha release from human peripheral blood monocytes. Nitric Oxide 29-41 tumor necrosis factor Homo sapiens 52-61 11303732-0 2001 Divergent effects of ischemia/reperfusion and nitric oxide donor on TNFalpha mRNA accumulation in rat organs. Nitric Oxide 46-58 tumor necrosis factor Homo sapiens 68-76 11085984-4 2001 In particular, in many systems nitric oxide (NO) has been shown to protect cells from TNF-alpha-induced apoptosis. Nitric Oxide 31-43 tumor necrosis factor Homo sapiens 86-95 11292287-0 2001 Nitric oxide-mediated expression of Bcl-2 and Bcl-xl and protection from tumor necrosis factor-alpha-mediated apoptosis in porcine endothelial cells after exposure to low concentrations of xenoreactive natural antibody. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 73-100 11292287-5 2001 RESULTS: The cells acquired resistance to tumor necrosis factor-alpha-mediated apoptosis (50-100% reduction at 6 hr) and up-regulated expression of Bcl-2 and Bcl-xl; sustained expression was accompanied by inducible nitric oxide (NO) synthase expression and by enhanced production of NO by EC. Nitric Oxide 216-228 tumor necrosis factor Homo sapiens 42-69 11401420-1 2001 Treatment of MC3T3E-1 osteoblast cultures with combined interferon- gamma(IFN- gamma), lipopolysaccharide (LPS) and tumor necrosis factor- alpha(TNF- alpha) induces expressions of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), resulting in sustained releases of large amounts of nitric oxide and IL-6. Nitric Oxide 190-202 tumor necrosis factor Homo sapiens 145-155 11160388-0 2001 beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. Nitric Oxide 106-118 tumor necrosis factor Homo sapiens 63-71 11003590-6 2000 Cell treatment with the NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME; 1 mmol/l) significantly diminished the TNF-alpha-mediated sustained downregulation of UCP-2 expression, whereas cell treatment with a nitric oxide (NO) donor (10(-3) mol/l S-nitroso-L-glutathione) mimicked the TNF-alpha effect on UCP-2 expression. Nitric Oxide 216-228 tumor necrosis factor Homo sapiens 121-130 11120352-6 2000 They produce antithrombotic and thrombotic factors such as t-PA and PAI-1 and respond to TNFalpha, an important factor correlated with the inflammatory process by modifying growth characteristics by producing cytokines such as GM-CSF by expressing ICAM-1 on the surface and by producing large amounts of nitric oxide and endothelin. Nitric Oxide 304-316 tumor necrosis factor Homo sapiens 89-97 11191629-3 2000 First the induction of nitric oxide by lipopolysaccharide (LPS), tumor necrosis factor alpha (TNFalpha), interferon gamma (IFNgamma), alone or their combination, was studied in C6 glioma cells. Nitric Oxide 23-35 tumor necrosis factor Homo sapiens 65-92 11191629-3 2000 First the induction of nitric oxide by lipopolysaccharide (LPS), tumor necrosis factor alpha (TNFalpha), interferon gamma (IFNgamma), alone or their combination, was studied in C6 glioma cells. Nitric Oxide 23-35 tumor necrosis factor Homo sapiens 94-102 11044777-3 2000 TNF-alpha, one of these cytokines, leads to the production of nitric oxide (NO), a potent inflammatory mediator, by induction of inducible NO synthase. Nitric Oxide 62-74 tumor necrosis factor Homo sapiens 0-9 11192310-4 2001 The hypothesis of this study was to determine if TNF-alpha would stimulate iNOS and its product nitric oxide (NO) similarly in immortalized macrophage and cardiac myocytes. Nitric Oxide 96-108 tumor necrosis factor Homo sapiens 49-58 11003590-0 2000 Nitric oxide-dependent downregulation of adipocyte UCP-2 expression by tumor necrosis factor-alpha. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 71-98 10936489-5 2000 As a response to the Pb/lipopolysaccharide induced release of TNF-alpha, the cocultured hepatocytes increased their nitric oxide (NO) content sixfold when compared with lipopolysaccharide alone and downregulated the negatively regulated acute phase protein albumin. Nitric Oxide 116-128 tumor necrosis factor Homo sapiens 62-71 11037976-3 2000 In vitro TNF70-80 and recombinant human TNF (hTNF) acted with interferon gamma (IFN-gamma) to reduce bacterial replication and to induce synthesis of bactericidal nitric oxide (NO) in BCG-infected, bone marrow-derived murine macrophages. Nitric Oxide 163-175 tumor necrosis factor Homo sapiens 9-12 11037976-3 2000 In vitro TNF70-80 and recombinant human TNF (hTNF) acted with interferon gamma (IFN-gamma) to reduce bacterial replication and to induce synthesis of bactericidal nitric oxide (NO) in BCG-infected, bone marrow-derived murine macrophages. Nitric Oxide 163-175 tumor necrosis factor Homo sapiens 45-49 11026650-5 2000 In the condition after pretreatment with the nitric oxide (NO) synthase inhibitor N(G)-monomethyl-L-arginine, the vascular effect of TNF-alpha on basal FVR was diminished, and the ACh-induced maximal dilatory response was significantly blunted after TNF-alpha compared with before TNF-alpha (minimal FVR: 30.4 +/- 12.0 vs. 12.3 +/- 4.2 units; p < 0.05). Nitric Oxide 45-57 tumor necrosis factor Homo sapiens 133-142 11026650-5 2000 In the condition after pretreatment with the nitric oxide (NO) synthase inhibitor N(G)-monomethyl-L-arginine, the vascular effect of TNF-alpha on basal FVR was diminished, and the ACh-induced maximal dilatory response was significantly blunted after TNF-alpha compared with before TNF-alpha (minimal FVR: 30.4 +/- 12.0 vs. 12.3 +/- 4.2 units; p < 0.05). Nitric Oxide 45-57 tumor necrosis factor Homo sapiens 250-259 11026650-5 2000 In the condition after pretreatment with the nitric oxide (NO) synthase inhibitor N(G)-monomethyl-L-arginine, the vascular effect of TNF-alpha on basal FVR was diminished, and the ACh-induced maximal dilatory response was significantly blunted after TNF-alpha compared with before TNF-alpha (minimal FVR: 30.4 +/- 12.0 vs. 12.3 +/- 4.2 units; p < 0.05). Nitric Oxide 45-57 tumor necrosis factor Homo sapiens 250-259 10982547-0 2000 Nitric oxide provokes tumor necrosis factor-alpha expression in adult feline myocardium through a cGMP-dependent pathway. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 22-49 11006006-1 2000 IL-2-activated killer lymphocytes (LAK cells) secrete inflammatory cytokines such as interferon-gamma (IFN-gamma) and tumor necrosis factor alpha (TNFalpha) that can induce nitric oxide (NO) synthesis. Nitric Oxide 173-185 tumor necrosis factor Homo sapiens 118-145 11006006-1 2000 IL-2-activated killer lymphocytes (LAK cells) secrete inflammatory cytokines such as interferon-gamma (IFN-gamma) and tumor necrosis factor alpha (TNFalpha) that can induce nitric oxide (NO) synthesis. Nitric Oxide 173-185 tumor necrosis factor Homo sapiens 147-155 10981965-1 2000 Hypotension and shock observed in sepsis, SIRS, and tumor necrosis factor (TNF) or cytokine-based cancer treatment are the consequence of excessive nitric oxide (NO) production and subsequent soluble guanylate cyclase (sGC)-mediated vascular smooth muscle relaxation. Nitric Oxide 148-160 tumor necrosis factor Homo sapiens 52-73 10981965-1 2000 Hypotension and shock observed in sepsis, SIRS, and tumor necrosis factor (TNF) or cytokine-based cancer treatment are the consequence of excessive nitric oxide (NO) production and subsequent soluble guanylate cyclase (sGC)-mediated vascular smooth muscle relaxation. Nitric Oxide 148-160 tumor necrosis factor Homo sapiens 75-78 10843894-0 2000 Nitric oxide modulation of TNF-alpha-induced cardiac contractile dysfunction is concentration dependent. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 27-36 11167545-0 2000 Oral administration of a nitric oxide synthase inhibitor enhances de novo mammalian angiogenesis mediated by TNF-alpha, saline and mast-cell secretion. Nitric Oxide 25-37 tumor necrosis factor Homo sapiens 109-118 10777484-0 2000 Nitric oxide inhibits the tumor necrosis factor alpha -regulated endocytosis of human dendritic cells in a cyclic GMP-dependent way. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 26-53 21340969-1 2000 In 1990, several studies reported that an enhanced formation of endogenous nitric oxide (NO) contributes to the hypotension caused by endotoxin and tumor-necrosis factor-alpha (TNFalpha) (1-3). Nitric Oxide 75-87 tumor necrosis factor Homo sapiens 148-175 10788433-3 2000 In C6 glioma cells, tumor necrosis factor-alpha (TNF-alpha) concomitantly potentiated the stimulation of nitric oxide (NO) and BH(4) production induced by IFN-gamma and interleukin-1beta. Nitric Oxide 105-117 tumor necrosis factor Homo sapiens 20-47 10788433-3 2000 In C6 glioma cells, tumor necrosis factor-alpha (TNF-alpha) concomitantly potentiated the stimulation of nitric oxide (NO) and BH(4) production induced by IFN-gamma and interleukin-1beta. Nitric Oxide 105-117 tumor necrosis factor Homo sapiens 49-58 10905622-4 2000 Our recent studies indicate the ability of cytokines, e.g., tumor necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-1beta) and interferon-gamma (IFNgamma), to induce the inducible nitric oxide (iNOS) and secretory phospholipase A2 (sPLA2) genes in immortalized astrocytes (DITNC) (Li et al., J. Interferon and Cytokine Res. Nitric Oxide 186-198 tumor necrosis factor Homo sapiens 60-87 10905622-4 2000 Our recent studies indicate the ability of cytokines, e.g., tumor necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-1beta) and interferon-gamma (IFNgamma), to induce the inducible nitric oxide (iNOS) and secretory phospholipase A2 (sPLA2) genes in immortalized astrocytes (DITNC) (Li et al., J. Interferon and Cytokine Res. Nitric Oxide 186-198 tumor necrosis factor Homo sapiens 89-97 10955247-0 2000 Relationships between concentrations of tumor necrosis factor-alpha and nitric oxide in follicular fluid and oocyte quality. Nitric Oxide 72-84 tumor necrosis factor Homo sapiens 40-67 10955247-1 2000 PURPOSE: Our objective was to explain a relationship between concentrations of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) in follicular fluid, oocyte quality, and outcomes of in vitro fertilization--embryo transfer (IVF-ET). Nitric Oxide 123-135 tumor necrosis factor Homo sapiens 79-106 10955247-1 2000 PURPOSE: Our objective was to explain a relationship between concentrations of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) in follicular fluid, oocyte quality, and outcomes of in vitro fertilization--embryo transfer (IVF-ET). Nitric Oxide 123-135 tumor necrosis factor Homo sapiens 108-117 10755468-0 2000 Tumor necrosis factor alpha enhances the cytotoxicity induced by nitric oxide in cultured cerebral endothelial cells. Nitric Oxide 65-77 tumor necrosis factor Homo sapiens 0-27 10733867-2 2000 This brief hypothesis outlines my views that nitric oxide-mediated alpha-tubulin posttranslational nitrotyrosination may be a major mechanism through which TNF-alpha exerts its cytotoxic effects on cancer cells. Nitric Oxide 45-57 tumor necrosis factor Homo sapiens 156-165 10680642-12 2000 Thus, exogenous or endogenous substitution of nitric oxide diminishes the expression of endothelial intercellular adhesion molecule 1 and its mRNA following tumor necrosis factor alpha stimulation. Nitric Oxide 46-58 tumor necrosis factor Homo sapiens 157-184 10903807-0 2000 Inhibition of NO production in macrophages by IL-13 is counteracted by Herpes simplex virus infection through tumor necrosis factor-alpha-induced activation of NK-kappa B. Interleukin (IL)-13 is known to antagonize many interferon (IFN)-gamma-activated functions in macrophages and among these, nitric oxide (NO) production. Nitric Oxide 295-307 tumor necrosis factor Homo sapiens 110-137 10792026-0 2000 Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 22-49 10792026-3 2000 We have investigated the role of two messengers, ceramide and nitric oxide (NO), on the apoptotic pathway activated in human monocytic U937 cells by tumor necrosis factor-alpha (TNF-alpha) working at its p55 receptor. Nitric Oxide 62-74 tumor necrosis factor Homo sapiens 149-176 10792026-3 2000 We have investigated the role of two messengers, ceramide and nitric oxide (NO), on the apoptotic pathway activated in human monocytic U937 cells by tumor necrosis factor-alpha (TNF-alpha) working at its p55 receptor. Nitric Oxide 62-74 tumor necrosis factor Homo sapiens 178-187 10802225-10 2000 These results suggest a causal association between reduced endogenous nitric oxide production, reduced intracellular GSH, and Fas- and TNF-alpha-mediated neutrophil apoptosis, whereas enhanced neutrophil survival mediated by dibutyryl cyclic adenosine monophosphate is associated with increased nitrite generation and maintenance of intracellular GSH. Nitric Oxide 70-82 tumor necrosis factor Homo sapiens 135-144 10615072-1 2000 We tested the hypothesis that protein kinase (PK)G activation in response to nitric oxide ((*)NO) mediates tumor necrosis factor (TNF)-alpha-induced activation of the transcription factor activating protein-1 (AP-1) in pulmonary microvessel endothelial monolayers (PEM). Nitric Oxide 77-89 tumor necrosis factor Homo sapiens 107-128 10615072-1 2000 We tested the hypothesis that protein kinase (PK)G activation in response to nitric oxide ((*)NO) mediates tumor necrosis factor (TNF)-alpha-induced activation of the transcription factor activating protein-1 (AP-1) in pulmonary microvessel endothelial monolayers (PEM). Nitric Oxide 77-89 tumor necrosis factor Homo sapiens 130-140 21340969-1 2000 In 1990, several studies reported that an enhanced formation of endogenous nitric oxide (NO) contributes to the hypotension caused by endotoxin and tumor-necrosis factor-alpha (TNFalpha) (1-3). Nitric Oxide 75-87 tumor necrosis factor Homo sapiens 177-185 10842021-9 2000 Besides nitric oxide production of tumor necrosis factor-alpha was also enhanced. Nitric Oxide 8-20 tumor necrosis factor Homo sapiens 35-62 10559188-0 1999 A Sp1 binding site of the tumor necrosis factor alpha promoter functions as a nitric oxide response element. Nitric Oxide 78-90 tumor necrosis factor Homo sapiens 26-53 11112001-20 2000 Activation of cytokines and the NO pathway seem to be involved in this vasomotor dysfunction The association between cardiac nitric oxide production and TNF-alpha in this group indicates a chronic high immunologic process, which may represent an early and important target for therapy and prevention of TxCAD. Nitric Oxide 125-137 tumor necrosis factor Homo sapiens 153-162 10638671-3 2000 The aim of the present study was to investigate whether inactivation of PARS influences the delayed myocardial necrosis and the production of the proinflammatory cytokine tumor necrosis factor alpha (TNFalpha), the anti-inflammatory cytokine interleukin-10 (IL-10), and the free radical nitric oxide in the late stage of myocardial reperfusion injury. Nitric Oxide 287-299 tumor necrosis factor Homo sapiens 171-198 10435757-2 1999 The objective of this study was to examine the effects of a water-soluble cigarette smoke extract (CSE) and/or respiratory syncytial virus (RSV) infection on release from monocytes of the blood from donors of tumour necrosis factor alpha (TNF-alpha) and nitric oxide (NO). Nitric Oxide 254-266 tumor necrosis factor Homo sapiens 239-248 10579391-7 1999 Chicken TNF-like factor stimulated macrophages by inducing morphological changes, enhancing Ia-expression, nitric oxide (NO) production and by synergising with interferon (IFN)-gamma in the induction of NO release from macrophages. Nitric Oxide 107-119 tumor necrosis factor Homo sapiens 8-11 10528145-1 1999 In the present work, we demonstrated that chemically different nitric oxide (NO)-releasing compounds inhibit tumor necrosis factor alpha (TNF-alpha)-induced polymorphonuclear leukocyte adhesion to endothelial cells in vitro. Nitric Oxide 63-75 tumor necrosis factor Homo sapiens 109-136 10528145-1 1999 In the present work, we demonstrated that chemically different nitric oxide (NO)-releasing compounds inhibit tumor necrosis factor alpha (TNF-alpha)-induced polymorphonuclear leukocyte adhesion to endothelial cells in vitro. Nitric Oxide 63-75 tumor necrosis factor Homo sapiens 138-147 10415049-0 1999 Human NK cells express endothelial nitric oxide synthase, and nitric oxide protects them from activation-induced cell death by regulating expression of TNF-alpha. Nitric Oxide 35-47 tumor necrosis factor Homo sapiens 152-161 10433867-4 1999 In this later condition, TNF could be responsible for further ventricular remodelling; down-regulation of myocardial contractility; increased rate of apoptosis of the endothelial cell and of the myocytes, alteration of the expression and function of the enzymes regulating nitric oxide production and, of course, the induction of cachexia resulting in further peripheral muscle dysfunction. Nitric Oxide 273-285 tumor necrosis factor Homo sapiens 25-28 10446825-4 1999 We hypothesized the following: a) TNF-alpha and IL-1beta directly depress human myocardial function; b) together, TNF-alpha and IL-1beta act synergistically to depress human myocardial function; and c) inhibition of ceramidase or nitric oxide synthase attenuates myocardial depression induced by TNF-alpha or IL-1beta by limiting proximal cytokine signaling or production of myocardial nitric oxide (NO). Nitric Oxide 230-242 tumor necrosis factor Homo sapiens 34-43 10446825-4 1999 We hypothesized the following: a) TNF-alpha and IL-1beta directly depress human myocardial function; b) together, TNF-alpha and IL-1beta act synergistically to depress human myocardial function; and c) inhibition of ceramidase or nitric oxide synthase attenuates myocardial depression induced by TNF-alpha or IL-1beta by limiting proximal cytokine signaling or production of myocardial nitric oxide (NO). Nitric Oxide 230-242 tumor necrosis factor Homo sapiens 114-123 10446825-4 1999 We hypothesized the following: a) TNF-alpha and IL-1beta directly depress human myocardial function; b) together, TNF-alpha and IL-1beta act synergistically to depress human myocardial function; and c) inhibition of ceramidase or nitric oxide synthase attenuates myocardial depression induced by TNF-alpha or IL-1beta by limiting proximal cytokine signaling or production of myocardial nitric oxide (NO). Nitric Oxide 230-242 tumor necrosis factor Homo sapiens 114-123 9887205-3 1999 This study utilized an in vitro cardiac myocyte assay to evaluate the potential mechanistic role of nitric oxide (NO) and cGMP in depression of myocyte contractility induced by TNF-alpha, IL-1beta, TNF-alpha + IL-1beta (at low concentrations), and human septic shock serum (HSS). Nitric Oxide 100-112 tumor necrosis factor Homo sapiens 177-186 10373483-0 1999 Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. Nitric Oxide 91-103 tumor necrosis factor Homo sapiens 0-27 10358077-2 1999 A combination of the pro-inflammatory cytokines interleukin (IL)-1alpha, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha induces nitric oxide synthase mRNA expression and nitric oxide (NO) generation in the human colon carcinoma cell line HT-29. Nitric Oxide 143-155 tumor necrosis factor Homo sapiens 101-134 10102977-0 1999 Nitric oxide-releasing NSAIDs inhibit interleukin-1beta converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFalpha. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 154-162 10329352-1 1999 Reactive oxygen and nitrogen intermediates (ROI, RNI), such as superoxide anion, nitric oxide (NO) and peroxynitrite, are present in villous trophoblasts and mediate TNF-alpha-induced apoptosis in other cell types. Nitric Oxide 81-93 tumor necrosis factor Homo sapiens 166-175 10085086-3 1999 TNF protected neurons against hypoxia- or nitric oxide-induced injury, with an increase in the anti-apoptotic proteins Bcl-2 and Bcl-x as determined by Western blot and reverse transcriptase-polymerase chain reaction analysis. Nitric Oxide 42-54 tumor necrosis factor Homo sapiens 0-3 10085086-8 1999 These findings indicate that induction of Bcl-2 and Bcl-x expression through NFkappaB activation is involved in the neuroprotective action of TNF against hypoxia- or nitric oxide-induced injury. Nitric Oxide 166-178 tumor necrosis factor Homo sapiens 142-145 9887205-3 1999 This study utilized an in vitro cardiac myocyte assay to evaluate the potential mechanistic role of nitric oxide (NO) and cGMP in depression of myocyte contractility induced by TNF-alpha, IL-1beta, TNF-alpha + IL-1beta (at low concentrations), and human septic shock serum (HSS). Nitric Oxide 100-112 tumor necrosis factor Homo sapiens 198-207 9888267-13 1999 There is evidence to suggest that nitric oxide may also play a role in leukemic cell differentiation and that 1,25(OH)2D3 may influence endogenous nitric oxide production either by directly increasing tumor necrosis factor-alpha (TNF-alpha) or through a secondary mediator such as the C-type lectin CD23. Nitric Oxide 147-159 tumor necrosis factor Homo sapiens 201-228 9928254-2 1998 iNOS can be induced by transcriptional activation to produce nitric oxide (NO) in response to a challenge with the pro-inflammatory cytokines TNF-alpha and IFN-gamma. Nitric Oxide 61-73 tumor necrosis factor Homo sapiens 142-151 9713511-8 1998 It occurs mostly through type I (p55) TNF receptors, probably involves a calphostin-C sensitive protein kinase C activity and requires synthesis of proteins (it is inhibited by actinomycin D or cycloheximide) and of inducible nitric oxide (NO) synthase (it is inhibited by NG-methyl-L-arginine or aminoguanidine). Nitric Oxide 226-238 tumor necrosis factor Homo sapiens 38-41 9731067-0 1998 The induction of nitric oxide by interleukin-12 and tumor necrosis factor-alpha in human natural killer cells: relationship with the regulation of lytic activity. Nitric Oxide 17-29 tumor necrosis factor Homo sapiens 52-79 9793069-1 1998 Nitric oxide (NO) is produced by nitric oxide synthases (cNOS and iNOS) in endothelial cells upon stimulation by various agents like Ca(2+)-calmodulin, cytokines and TNF. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 166-169 9691088-3 1998 Treatment of human islets with a combination of tumor necrosis factor (TNF) + lipopolysaccharide (LPS) + interferon-gamma (IFN-gamma) stimulates inducible nitric oxide synthase (iNOS) expression, nitric oxide production, and inhibits glucose-stimulated insulin secretion. Nitric Oxide 155-167 tumor necrosis factor Homo sapiens 48-69 9691088-3 1998 Treatment of human islets with a combination of tumor necrosis factor (TNF) + lipopolysaccharide (LPS) + interferon-gamma (IFN-gamma) stimulates inducible nitric oxide synthase (iNOS) expression, nitric oxide production, and inhibits glucose-stimulated insulin secretion. Nitric Oxide 155-167 tumor necrosis factor Homo sapiens 71-74 9691088-6 1998 These results indicate that the inhibitory effects of TNF + LPS + IFN-gamma are mediated by nitric oxide, produced by the actions of IL-1 released endogenously within human islets. Nitric Oxide 92-104 tumor necrosis factor Homo sapiens 54-57 12152850-6 1998 IL-1, IL-2 and TNF and of eicosanoids and augment the concentrations of nitric oxide and anti-oxidants and enhance the apoptotic death of the pro-inflammatory T cells may be benefit in the management of SLE. Nitric Oxide 72-84 tumor necrosis factor Homo sapiens 15-18 9699892-5 1998 Expression of VCAM-1 in endothelial cells after exposure to tumour necrosis factor-alpha (TNF-alpha) or interleukin 1beta (IL-1beta) was quantified by ELISA and shown to be partially inhibited by 17beta-estradiol (40-60% inhibition) or by S-nitroso-L-glutathione, a nitric oxide donor (20-25%). Nitric Oxide 266-278 tumor necrosis factor Homo sapiens 90-99 9631139-2 1998 AIDS patients show increased serum tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma levels, which synergize with HIV-1-produced nitric oxide (NO) to augment viral replication. Nitric Oxide 141-153 tumor necrosis factor Homo sapiens 35-69 9715820-6 1998 TNF-alpha exerts a negative inotropic effect both directly and indirectly, this latter being mediated by enhancement of nitric oxide production. Nitric Oxide 120-132 tumor necrosis factor Homo sapiens 0-9 9401054-1 1997 Induction of nitric oxide synthase (iNOS) and production of the toxic metabolite nitric oxide (NO) is one of the interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) regulated effector mechanisms that can lead to apoptosis of haemopoietic progenitor cells. Nitric Oxide 13-25 tumor necrosis factor Homo sapiens 176-185 9719467-8 1998 Furthermore, the cytokines IL-1, TNFalpha, and IFNgamma are cytotoxic to beta-cells, in large part by inducing the formation of oxygen free radicals, nitric oxide, and peroxynitrite in the beta-cells themselves. Nitric Oxide 150-162 tumor necrosis factor Homo sapiens 33-41 9388267-1 1997 Nitric oxide (NO) has emerged as an important endogenous inhibitor of apoptosis, and here we report that NO prevents hepatocyte apoptosis initiated by the removal of growth factors or exposure to TNFalpha or anti-Fas antibody. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 196-204 9403543-9 1997 Tumor necrosis factor alpha induced an increase in cGMP cell content and in the CO and nitric oxide release to the medium. Nitric Oxide 87-99 tumor necrosis factor Homo sapiens 0-27 9573098-5 1998 When RAW264.7 cells were pretreated with human TNF or TNF(70-80) in the presence of IFN-gamma, there was a dose-dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants. Nitric Oxide 234-246 tumor necrosis factor Homo sapiens 47-50 9573098-5 1998 When RAW264.7 cells were pretreated with human TNF or TNF(70-80) in the presence of IFN-gamma, there was a dose-dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants. Nitric Oxide 234-246 tumor necrosis factor Homo sapiens 54-57 9549416-5 1998 In an inflammatory shock state, cytokines, like interleukin-1 and tumor necrosis factor-alpha, induce a separate, high-output form of the enzyme that synthesizes nitric oxide in both endothelial and smooth-muscle cells. Nitric Oxide 162-174 tumor necrosis factor Homo sapiens 43-93 9403543-1 1997 BACKGROUND: An increase in cyclic guanosine 3",5"-monophosphate (cGMP) due to nitric oxide generation is known to participate in the mediation of the tumor necrosis factor alpha (TNF-alpha) effect in type II cells. Nitric Oxide 78-90 tumor necrosis factor Homo sapiens 150-177 9403543-1 1997 BACKGROUND: An increase in cyclic guanosine 3",5"-monophosphate (cGMP) due to nitric oxide generation is known to participate in the mediation of the tumor necrosis factor alpha (TNF-alpha) effect in type II cells. Nitric Oxide 78-90 tumor necrosis factor Homo sapiens 179-188 9441836-0 1997 The nitric oxide donor SIN-1 protects endothelial cells from tumor necrosis factor-alpha-mediated cytotoxicity: possible role for cyclic GMP and heme oxygenase. Nitric Oxide 4-16 tumor necrosis factor Homo sapiens 61-88 9369379-0 1997 Nitric oxide mediates down regulation of lipoprotein lipase activity induced by tumor necrosis factor-alpha in brown adipocytes. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 80-107 9392005-3 1997 In addition, we have observed that ligation of CD23 on keratinocytes induced type II nitric oxide synthase (iNOS), leading to the release of nitric oxide (NO) and proinflammatory cytokines (TNF-alpha, IL-6). Nitric Oxide 85-97 tumor necrosis factor Homo sapiens 190-199 9369379-2 1997 Recent evidence suggests that the effect of TNF-alpha over various cells is related to the enhanced production of nitric oxide (NO). Nitric Oxide 114-126 tumor necrosis factor Homo sapiens 44-53 9375993-6 1997 TNF and some other cytokines are able to induce nitric oxide production, which depresses cardiac function and can induce apoptosis. Nitric Oxide 48-60 tumor necrosis factor Homo sapiens 0-3 9254084-12 1997 Both IL-1Ra and TNF alpha are known to induce fever, malaise, leukocytosis, and nitric oxide synthesis and to mediate ischemic and traumatic brain injuries. Nitric Oxide 80-92 tumor necrosis factor Homo sapiens 16-25 9176264-0 1997 Endothelial barrier dysfunction and p42 oxidation induced by TNF-alpha are mediated by nitric oxide. Nitric Oxide 87-99 tumor necrosis factor Homo sapiens 61-70 9199501-0 1997 Nitric oxide protects endothelial cells from tumor necrosis factor-alpha-mediated cytotoxicity: possible involvement of cyclic GMP. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 45-72 9215702-4 1997 These results indicate that TNF-alpha induces the adhesion of neuroblastoma cells via nitric oxide. Nitric Oxide 86-98 tumor necrosis factor Homo sapiens 28-37 9215702-7 1997 Thus TNF-alpha induces the in vitro adhesion/differentiation of human neuroblastoma cells through nitric oxide synthesized by a calcium-independent inducible form of nitric oxide synthase, clearly indicating that isoform II of nitric oxide synthase can be expressed in human neuronal cell types. Nitric Oxide 98-110 tumor necrosis factor Homo sapiens 5-14 9176264-1 1997 We tested the hypothesis that nitric oxide (.NO) mediates tumor necrosis factor-alpha (TNF-alpha)-induced alterations in permeability and actin of pulmonary artery endothelial monolayers (PAEM). Nitric Oxide 30-42 tumor necrosis factor Homo sapiens 58-85 9176264-1 1997 We tested the hypothesis that nitric oxide (.NO) mediates tumor necrosis factor-alpha (TNF-alpha)-induced alterations in permeability and actin of pulmonary artery endothelial monolayers (PAEM). Nitric Oxide 30-42 tumor necrosis factor Homo sapiens 87-96 9010456-1 1997 In a murine model of rickettsial disease in which, as in human rickettsioses, endothelial cells are the major target of infection, depletion of IFN-gamma or TNF-alpha converts a sublethal infection into a uniformly fatal disease with overwhelming rickettsial growth and decreased nitric oxide (NO) synthesis. Nitric Oxide 280-292 tumor necrosis factor Homo sapiens 157-166 9038216-0 1997 Nitric oxide increases tumor necrosis factor production in differentiated U937 cells by decreasing cyclic AMP. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 23-44 9038216-1 1997 Nitric oxide (NO) increases tumor necrosis factor (TNF) synthesis in human peripheral blood mononuclear cells by a cGMP-independent mechanism. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 28-49 9038216-1 1997 Nitric oxide (NO) increases tumor necrosis factor (TNF) synthesis in human peripheral blood mononuclear cells by a cGMP-independent mechanism. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 51-54 9034139-7 1997 Endothelial-derived nitric oxide (NO) as well as exogenous NO donors inhibited TNF-alpha-induced cysteine protease activation. Nitric Oxide 20-32 tumor necrosis factor Homo sapiens 79-88 9187937-7 1997 However, coincubation with NG-monomethyl-L-arginine, an inhibitor of nitric oxide (NO) synthesis, inhibited the upregulation of Fas induced by IL-1 and TNF-alpha. Nitric Oxide 69-81 tumor necrosis factor Homo sapiens 152-161 9812557-6 1997 It is suggested that the production of nitric oxide is augmented and could be induced by endotoxin and TNF alpha. Nitric Oxide 39-51 tumor necrosis factor Homo sapiens 103-112 8974009-1 1996 In the presence of interferon-gamma (IFN-gamma), human tumor necrosis factor-alpha (Hu-TNF-alpha), which binds to murine TNF-alpha receptor type 1 (TNF-R1) but not to murine TNF-R2, was effective in inducing nitric oxide (NO) production in spleen-derived macrophages (M phi), albeit at concentrations 12.5-fold greater than those required by murine TNF-alpha (Mu-TNF-alpha), to achieve the same result. Nitric Oxide 208-220 tumor necrosis factor Homo sapiens 55-82 8843783-2 1996 We examined the ability of human type II pneumocytes to produce nitric oxide (NO) in the presence of TNF-alpha as well as the role of NO and prostaglandin (PG) E2 in the transduction of the cytokine signal. Nitric Oxide 64-76 tumor necrosis factor Homo sapiens 101-110 8936560-4 1996 Furthermore, findings clearly demonstrated that J774A.1 cells stimulated with recombinant human TNF (1 x 10(4) units/ml) can effectively produce nitric oxide in the presence of endotoxin, and the production was dependent on the dose of endotoxin (0.01-10 micrograms/ml). Nitric Oxide 145-157 tumor necrosis factor Homo sapiens 96-99 8917029-0 1996 Role of nitric oxide in recombinant tumor necrosis factor-alpha-induced circulatory shock: a study in patients treated for cancer with isolated limb perfusion. Nitric Oxide 8-20 tumor necrosis factor Homo sapiens 36-63 8917029-9 1996 CONCLUSIONS: The hypothesis that in humans, TNF-alpha induces vasodilation and shock through activation of inducible nitric-oxide synthase and subsequent formation of excessive quantities of nitric oxide is not substantiated by our results. Nitric Oxide 191-203 tumor necrosis factor Homo sapiens 44-53 8917029-10 1996 Normal nitric oxide metabolite concentrations were found in the presence of high TNF-alpha concentrations and shock. Nitric Oxide 7-19 tumor necrosis factor Homo sapiens 81-90 8769879-7 1996 The cognate mast cell line RBL-2H3, when subjected to an antigenic stimulus, released tumor necrosis factor-alpha which, together with exogenous interleukin-1 beta (or interferon-gamma), induced astroglia to produce neurotoxic quantities of nitric oxide. Nitric Oxide 241-253 tumor necrosis factor Homo sapiens 86-113 8722965-0 1996 Levels of nitric oxide correlate with high levels of tumor necrosis factor alpha in cerebrospinal fluid samples from children with bacterial meningitis. Nitric Oxide 10-22 tumor necrosis factor Homo sapiens 53-80 8923042-4 1996 The results are compatible with the well-known capacity of TNF-alpha to enhance production of nitric oxide, and suggest that nitric oxide may be of physiologic importance in hemorrhagic fever with renal syndrome. Nitric Oxide 94-106 tumor necrosis factor Homo sapiens 59-68 8609750-2 1996 Nitric oxide (NO) exerts a negative inotropic effect on the myocardium and is produced by NO-synthase, an inducible form of which (iNOS) is stimulated by tumour necrosis factor (TNF-alpha). Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 178-187 8845178-3 1996 Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages. Nitric Oxide 18-30 tumor necrosis factor Homo sapiens 164-173 8809229-0 1996 Nitric oxide inhibits LPS-induced tumor necrosis factor synthesis in vitro and in vivo. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 34-55 8603997-6 1996 However, production of neopterin, a presumed primate homologue of nitric oxide in lower animals, was increased in THP-1 cells stimulated with INF-gamma plus TNF-alpha and alpha-MSH significantly inhibited this production. Nitric Oxide 66-78 tumor necrosis factor Homo sapiens 157-166 8809229-1 1996 The effect of nitric oxide (NO) on LPS-stimulated TNF-alpha synthesis has been studied in vitro and in vivo. Nitric Oxide 14-26 tumor necrosis factor Homo sapiens 50-59 8618866-3 1995 Tumor necrosis factor alpha (TNF-alpha) produced by activated macrophages enhances nitric oxide-dependent cytotoxicity in host defense against E. histolytica. Nitric Oxide 83-95 tumor necrosis factor Homo sapiens 29-38 7484279-1 1995 Nitric oxide (NO) has been reported to inhibit osteoclastic bone resorption, yet potent stimulators of bone resorption, such as interleukin-1 (IL-1) and tumor necrosis factor (TNF), are known to stimulate NO production. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 153-174 7492275-0 1995 Both prostaglandin E2 and nitric oxide sequentially mediate the tumor necrosis factor alpha-induced inhibition of surfactant synthesis by human type II pneumocytes. Nitric Oxide 26-38 tumor necrosis factor Homo sapiens 64-91 7492275-2 1995 OBJECTIVES: To examine the ability of human type II pneumocytes to produce nitric oxide (NO) in the presence of TNF-alpha and, in addition, to explore the role of this radical in the transduction of the cytokine signal. Nitric Oxide 75-87 tumor necrosis factor Homo sapiens 112-121 7489995-5 1995 In addition, pharmacological doses of the nitric oxide (NO) donor sodium nitroprusside conferred complete protection against TNF alpha-induced liver injury in galactosamine-sensitized mice, suggesting a possible link between IL-1- and NO-induced protection. Nitric Oxide 42-54 tumor necrosis factor Homo sapiens 125-134 8597057-3 1995 Pharmacological doses of the nitric oxide (NO) donor sodium nitroprusside (SNP) also conferred complete protection against TNF toxicity, suggesting a possible link between IL-1- and NO-induced protection. Nitric Oxide 29-41 tumor necrosis factor Homo sapiens 123-126 8520738-1 1995 Tumor necrosis factor-alpha (TNF-alpha) is released in inflammatory lung conditions, raising airway nitric oxide (NO) concentrations through the cytokine-mediated induction of nitric oxide synthase (NOS). Nitric Oxide 100-112 tumor necrosis factor Homo sapiens 0-27 8520738-1 1995 Tumor necrosis factor-alpha (TNF-alpha) is released in inflammatory lung conditions, raising airway nitric oxide (NO) concentrations through the cytokine-mediated induction of nitric oxide synthase (NOS). Nitric Oxide 100-112 tumor necrosis factor Homo sapiens 29-38 7575617-1 1995 Human retinal pigment epithelial (RPE) cells in culture respond to a mixture of cytokines (IFN-gamma, IL-1 beta, TNF-alpha) by producing large amounts of nitric oxide. Nitric Oxide 154-166 tumor necrosis factor Homo sapiens 113-122 7575568-5 1995 The nitric oxide synthase inhibitor, NG-amino-L-homoarginine (NAHA), inhibited TNF-alpha-stimulated IL-8 promoter activity by 60%. Nitric Oxide 4-16 tumor necrosis factor Homo sapiens 79-88 7484279-1 1995 Nitric oxide (NO) has been reported to inhibit osteoclastic bone resorption, yet potent stimulators of bone resorption, such as interleukin-1 (IL-1) and tumor necrosis factor (TNF), are known to stimulate NO production. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 176-179 7720092-0 1995 The upregulating effect of dexamethasone on tumor necrosis factor production is mediated by a nitric oxide-producing cytochrome P450. Nitric Oxide 94-106 tumor necrosis factor Homo sapiens 44-65 7538426-2 1995 Since TNF-alpha can increase interferon gamma (IFN-gamma)-dependent nitric oxide (NO) production, we studied whether LPL may synergize with IFN-gamma for the induction of macrophage NO production. Nitric Oxide 68-80 tumor necrosis factor Homo sapiens 6-15 7536712-5 1995 However, the enhancement of nitric oxide production induced by 8-Br-cGMP was significantly prevented by coincubation with neutralizing antibody against tumor necrosis factor-alpha. Nitric Oxide 28-40 tumor necrosis factor Homo sapiens 152-179 7529028-6 1995 The inhibitory effects of TNF alpha (300 pM) were not blocked by pretreating the cells with the cyclooxygenase inhibitor aspirin (100 microM), the 5-lipoxygenase inhibitor CGS 8515 (3 microM), or the nitric oxide synthase inhibitor nitro-iminoethyl-L-ornithine (100 microM), suggesting that neither arachidonic acid metabolites nor nitric oxide were mediators of the inhibitory effect. Nitric Oxide 200-212 tumor necrosis factor Homo sapiens 26-35 7795174-0 1995 Endogenous nitric oxide production by human monocytic cells regulates LPS-induced TNF production. Nitric Oxide 11-23 tumor necrosis factor Homo sapiens 82-85 8074665-7 1994 Nitric oxide chemical donor, SIN-1, induced TNF-alpha release from eosinophils. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 44-53 7743368-0 1994 Serum levels of end products of nitric oxide synthesis correlate positively with tumor necrosis factor alpha and negatively with body temperature in patients with postoperative abdominal sepsis. Nitric Oxide 32-44 tumor necrosis factor Homo sapiens 81-108 8589335-6 1995 Nitric oxide (NO) initially appears to play an important role in these events by stabilizing the TNF alpha-mediated hepatic microvascular inflammatory response to acute ethanol ingestion, thereby helping to protect the liver from ischaemia and leucocyte induced oxidative injury. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 97-106 7524082-4 1994 Nitric oxide production by epithelial cells was enhanced by culture in the presence of interferon gamma, interleukin 1 beta, tumor necrosis factor alpha, and lipopolysaccharide; the NOS activity expressed under these conditions showed less dependence on calcium, reminiscent of other inducible forms of NOS. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 87-152 7522054-1 1994 Human articular chondrocytes can be induced by IL-1 beta, TNF-alpha or LPS to release high levels of nitric oxide. Nitric Oxide 101-113 tumor necrosis factor Homo sapiens 58-67 8024067-3 1994 We have examined the extent of synergy between recombinant human TNF and either recombinant human IL-1 alpha or recombinant human IL-1 beta in producing hypoglycemia and increasing plasma levels of nitric oxide in malaria (Plasmodium vinckei)-infected CBA mice. Nitric Oxide 198-210 tumor necrosis factor Homo sapiens 65-68 8025986-2 1994 BACKGROUND: Tumor necrosis factor-alpha (TNF alpha), which we and others have shown to be elevated in patients with severe congestive heart failure (CHF), is involved in the regulation of nitric oxide metabolism. Nitric Oxide 188-200 tumor necrosis factor Homo sapiens 12-39 8025986-2 1994 BACKGROUND: Tumor necrosis factor-alpha (TNF alpha), which we and others have shown to be elevated in patients with severe congestive heart failure (CHF), is involved in the regulation of nitric oxide metabolism. Nitric Oxide 188-200 tumor necrosis factor Homo sapiens 41-50 8025986-3 1994 Whether increased concentrations of TNF alpha affect nitric oxide-mediated vasodilation in patients with CHF has not been studied previously. Nitric Oxide 53-65 tumor necrosis factor Homo sapiens 36-45 7512570-1 1994 In cultured vascular smooth muscle cells (VSMC), inflammatory cytokines such as interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha stimulated nitric oxide (NO) production via the expression of an inducible type of NO synthase (iNOS). Nitric Oxide 154-166 tumor necrosis factor Homo sapiens 115-142 8144975-0 1994 Nitric oxide regulates endotoxin-induced TNF-alpha production by human neutrophils. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 41-50 8144975-1 1994 We studied the effect of nitric oxide on LPS-induced TNF-alpha production by human neutrophils. Nitric Oxide 25-37 tumor necrosis factor Homo sapiens 53-62 8144975-7 1994 The up-regulation of TNF-alpha production by nitric oxide was not associated with increased amounts of LPS-induced TNF-alpha mRNA, and was not reproduced by exposing neutrophils to cGMP analogues. Nitric Oxide 45-57 tumor necrosis factor Homo sapiens 21-30 8050458-2 1994 This may be due to increased biosynthesis of the potent vasodilator nitric oxide (NO) induced by cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), which are known to be generated during IL-2 therapy. Nitric Oxide 68-80 tumor necrosis factor Homo sapiens 145-154 7510778-0 1994 Tumor necrosis factor-alpha (TNF-alpha), interferon-gamma, and interleukin-6 but not TNF-beta induce differentiation of neuroblastoma cells: the role of nitric oxide. Nitric Oxide 153-165 tumor necrosis factor Homo sapiens 0-27 7510778-3 1994 The induction of neuroblastoma cell differentiation by TNF-alpha and IFN-gamma can be specifically inhibited by a nitric oxide (NO) synthase inhibitor, L-NG-monomethylarginine. Nitric Oxide 114-126 tumor necrosis factor Homo sapiens 55-64 7534178-1 1994 In vascular smooth muscle cells (VSMC), inflammatory cytokines such as interleukin 1 (IL1) and tumour necrosis factor alpha (TNF alpha) stimulate nitric oxide (NO) production via the expression of an inducible type of NO synthase (iNOS). Nitric Oxide 146-158 tumor necrosis factor Homo sapiens 125-134 7690209-0 1993 Tumor necrosis factor inhibits stimulated but not basal release of nitric oxide. Nitric Oxide 67-79 tumor necrosis factor Homo sapiens 0-21 7743332-2 1994 The purpose of this study was to 1) determine if interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNF alpha) elicit the release of endothelium-derived relaxing factor (EDRF) and nitric oxide derived from the constitutive nitric oxide synthase present in vascular endothelium, and 2) determine if these cytokines alter endotoxin-mediated decreases in EDRF bioactivity and nitric oxide production. Nitric Oxide 192-204 tumor necrosis factor Homo sapiens 83-110 7743332-2 1994 The purpose of this study was to 1) determine if interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNF alpha) elicit the release of endothelium-derived relaxing factor (EDRF) and nitric oxide derived from the constitutive nitric oxide synthase present in vascular endothelium, and 2) determine if these cytokines alter endotoxin-mediated decreases in EDRF bioactivity and nitric oxide production. Nitric Oxide 192-204 tumor necrosis factor Homo sapiens 112-121 7743332-2 1994 The purpose of this study was to 1) determine if interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNF alpha) elicit the release of endothelium-derived relaxing factor (EDRF) and nitric oxide derived from the constitutive nitric oxide synthase present in vascular endothelium, and 2) determine if these cytokines alter endotoxin-mediated decreases in EDRF bioactivity and nitric oxide production. Nitric Oxide 235-247 tumor necrosis factor Homo sapiens 83-110 7743332-2 1994 The purpose of this study was to 1) determine if interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNF alpha) elicit the release of endothelium-derived relaxing factor (EDRF) and nitric oxide derived from the constitutive nitric oxide synthase present in vascular endothelium, and 2) determine if these cytokines alter endotoxin-mediated decreases in EDRF bioactivity and nitric oxide production. Nitric Oxide 235-247 tumor necrosis factor Homo sapiens 112-121 8245346-9 1993 Through induction of tetrahydrobiopterin synthesis (as reflected by increased neopterin), tumor necrosis factor-alpha may affect nitric oxide synthesis. Nitric Oxide 129-141 tumor necrosis factor Homo sapiens 90-117 8216333-0 1993 Nitric oxide-releasing agents enhance cytokine-induced tumor necrosis factor synthesis in human mononuclear cells. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 55-76 8216333-1 1993 In septic shock tumor necrosis factor (TNF) leads to increased nitric oxide (NO) production by induction of NO synthase. Nitric Oxide 63-75 tumor necrosis factor Homo sapiens 16-37 8216333-1 1993 In septic shock tumor necrosis factor (TNF) leads to increased nitric oxide (NO) production by induction of NO synthase. Nitric Oxide 63-75 tumor necrosis factor Homo sapiens 39-42 8499487-6 1993 Thus, although cytokine-inducible nitric oxide production is emerging as an effective antitumour mechanism, here, TNF clearly exerted potent antitumour activity against U937A cells through a nitric-oxide-independent mechanism. Nitric Oxide 191-203 tumor necrosis factor Homo sapiens 114-117 8335941-2 1993 In our study, using microglial/neuronal cell cocultures primed with IFN-gamma, we found that both LPS and TNF-alpha triggered neuronal cell injury (impairment of gamma-aminobutyric acid uptake and neuronal loss) via a nitric oxide mechanism. Nitric Oxide 218-230 tumor necrosis factor Homo sapiens 106-115 8335573-1 1993 Tumor necrosis factor-alpha (TNF-alpha) stimulates nitric oxide (NO) in vascular endothelium by induction of the enzyme NO synthase II (NOS II). Nitric Oxide 51-63 tumor necrosis factor Homo sapiens 0-27 8499487-0 1993 Nitric oxide is produced during TNF killing of U937A cells but does not contribute to the cytotoxic process. Nitric Oxide 0-12 tumor necrosis factor Homo sapiens 32-35 8499487-2 1993 As free radicals are considered likely candidates in the cytotoxic action of TNF, we examined nitric oxide production in TNF-sensitive U937A and TNF-resistant U937A/R cells and its potential role in TNF-induced cytotoxicity. Nitric Oxide 94-106 tumor necrosis factor Homo sapiens 77-80 8499487-2 1993 As free radicals are considered likely candidates in the cytotoxic action of TNF, we examined nitric oxide production in TNF-sensitive U937A and TNF-resistant U937A/R cells and its potential role in TNF-induced cytotoxicity. Nitric Oxide 94-106 tumor necrosis factor Homo sapiens 121-124 8499487-2 1993 As free radicals are considered likely candidates in the cytotoxic action of TNF, we examined nitric oxide production in TNF-sensitive U937A and TNF-resistant U937A/R cells and its potential role in TNF-induced cytotoxicity. Nitric Oxide 94-106 tumor necrosis factor Homo sapiens 121-124 8499487-2 1993 As free radicals are considered likely candidates in the cytotoxic action of TNF, we examined nitric oxide production in TNF-sensitive U937A and TNF-resistant U937A/R cells and its potential role in TNF-induced cytotoxicity. Nitric Oxide 94-106 tumor necrosis factor Homo sapiens 121-124 8335573-1 1993 Tumor necrosis factor-alpha (TNF-alpha) stimulates nitric oxide (NO) in vascular endothelium by induction of the enzyme NO synthase II (NOS II). Nitric Oxide 51-63 tumor necrosis factor Homo sapiens 29-38 1465986-0 1992 Graft-infiltrating cell nitric oxide production is stimulated by TNF alpha. Nitric Oxide 24-36 tumor necrosis factor Homo sapiens 65-74 8459516-7 1993 The biochemical changes induced by TNF and IL-1 include increased synthesis of nitric oxide, prostaglandins, platelet-activating factor, and endothelial cell adhesion molecules. Nitric Oxide 79-91 tumor necrosis factor Homo sapiens 35-38 8383325-2 1993 In this report we demonstrate that the cytokine combination of human recombinant interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) induces the formation of nitric oxide by human islets. Nitric Oxide 212-224 tumor necrosis factor Homo sapiens 113-140 8383325-2 1993 In this report we demonstrate that the cytokine combination of human recombinant interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) induces the formation of nitric oxide by human islets. Nitric Oxide 212-224 tumor necrosis factor Homo sapiens 142-151 8428504-5 1993 RESULTS: Oxygen-derived free radicals (i.e., superoxide anion) and cytokines (i.e., TNF) contribute to this endothelial dysfunction, which is characterized by a loss of endothelium-derived relaxing factor, now known to be identical to nitric oxide. Nitric Oxide 235-247 tumor necrosis factor Homo sapiens 84-87 7686326-4 1993 The observed inhibition of the TNF-alpha-induced permeability increase on preincubation with DEX would suggest a role for nitric oxide (NO) in mediating the permeability response. Nitric Oxide 122-134 tumor necrosis factor Homo sapiens 31-40 8269593-7 1993 Serotonin agonists may have utility in increasing nitric oxide synthesis in response to TNF or to agents that induce TNF as part of their antitumour action. Nitric Oxide 50-62 tumor necrosis factor Homo sapiens 88-91 24578389-1 2015 AIMS: We assessed the impact of vascular and perivascular tumour necrosis factor-alpha (TNF-alpha) on the endothelin (ET)-1/nitric oxide (NO) system and the molecular pathways involved in small arteries from visceral fat of obese patients (Obese) and Controls. Nitric Oxide 124-136 tumor necrosis factor Homo sapiens 88-97 1330900-0 1992 Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-alpha and IFN-gamma through a nitric oxide-dependent mechanism. Nitric Oxide 120-132 tumor necrosis factor Homo sapiens 86-95 2109093-9 1990 These results suggest (a) that endothelial cells produce nitric oxide in response to immunomodulators and (b) that endothelial cell-derived nitric oxide plays a role in the development of hypotension in patients treated with tumor necrosis factor or interleukins. Nitric Oxide 57-69 tumor necrosis factor Homo sapiens 225-246 2109093-9 1990 These results suggest (a) that endothelial cells produce nitric oxide in response to immunomodulators and (b) that endothelial cell-derived nitric oxide plays a role in the development of hypotension in patients treated with tumor necrosis factor or interleukins. Nitric Oxide 140-152 tumor necrosis factor Homo sapiens 225-246 2333306-8 1990 Our findings suggest that excessive nitric oxide production mediates the hypotensive effect of TNF. Nitric Oxide 36-48 tumor necrosis factor Homo sapiens 95-98 1610403-3 1992 Recombinant human TNF-alpha stimulated nitric oxide production equally from both murine strains while endotoxin stimulated nitric oxide production only by C3H/HeN mice. Nitric Oxide 39-51 tumor necrosis factor Homo sapiens 18-27 34908254-8 2021 Hyperglycemia also increases serum Nitric Oxide (NO), which decreases neutrophil motility and reduces the synthesis and release of various inflammatory mediators such as TNF-alpha and IL-1beta, IL-6. Nitric Oxide 35-47 tumor necrosis factor Homo sapiens 170-179 34917185-2 2022 Elevated levels of tumor necrosis factor alpha (TNF-alpha), a major pro-inflammatory cytokine, are involved in endothelial cell activation of medium and large arteries, leading to increased endothelial permeability, generation of superoxide anion radical and hydrogen peroxide, and decreased availability of nitric oxide (NO). Nitric Oxide 308-320 tumor necrosis factor Homo sapiens 19-46 34917185-2 2022 Elevated levels of tumor necrosis factor alpha (TNF-alpha), a major pro-inflammatory cytokine, are involved in endothelial cell activation of medium and large arteries, leading to increased endothelial permeability, generation of superoxide anion radical and hydrogen peroxide, and decreased availability of nitric oxide (NO). Nitric Oxide 308-320 tumor necrosis factor Homo sapiens 48-57 34455178-11 2021 RESULTS: After the stimulation of HaCaT cells with TNF-alpha/IFN-gamma, RDL considerably reduced the release of inflammatory mediators such as nitric oxide (NO), PEG2 and other cytokines. Nitric Oxide 143-155 tumor necrosis factor Homo sapiens 51-60 35237507-4 2022 M1 is characterized by expressing a large amount of inducible nitric oxide synthase and TNF-alpha, and exert anti-tumor activity by promoting pro-inflammatory and immune responses. Nitric Oxide 62-74 tumor necrosis factor Homo sapiens 88-97 35251471-10 2022 Concentrations of nitric oxide and its metabolites (peroxynitrite) were significantly higher in the plasma of hypoxic exercisers with an associated increase in inflammatory mediators (GE: myeloperoxidase, tumor necrosis factor-alpha) and lysosomal exoglycosidase activity (GE: N-acetyl-beta-hexosaminidase, beta-glucuronidase). Nitric Oxide 18-30 tumor necrosis factor Homo sapiens 209-236 35158163-6 2022 TNFalpha induced mitochondrial superoxide generation from neutrophils and monocytes, myeloperoxidase (MPO)-derived reactive oxygen species (ROS) from neutrophils, and nitric oxide from lymphocytes and monocytes. Nitric Oxide 167-179 tumor necrosis factor Homo sapiens 0-8 35625746-5 2022 Markers of inflammation, such as C-reactive protein, tumor-necrosis-factor alpha, and interleukin 6, provide insight into the disease and markers that negatively influence nitric-oxide bioavailability and promote oxidative stress. Nitric Oxide 172-184 tumor necrosis factor Homo sapiens 53-80 35129780-6 2022 Accordingly, this leads to alteration in several downstream signaling pathways such as nitric oxide synthesizing machinery, natural killer cells" cytotoxicity through inducing the expression of its activating ligands such as MICA/B, ULBP2, CD155, and ICAM-1 and trimming of the immune-suppressive cytokines such as TNF-alpha and IL-10. Nitric Oxide 87-99 tumor necrosis factor Homo sapiens 315-324