PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11956484-0 2002 Tumor necrosis factor-alpha and interleukin-1beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice. Nitric Oxide 76-88 interleukin 1 beta Mus musculus 32-49 11956484-1 2002 PURPOSE: We investigated the participation of nitric oxide in ifosfamide induced hemorrhagic cystitis in mice, and the involvement of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta in the induction of nitric oxide production in this model. Nitric Oxide 215-227 interleukin 1 beta Mus musculus 172-194 11342558-11 2001 Furthermore, SOCS-1 also suppressed the cellular effects that require the combined presence of IL-1 beta and IFN-gamma: induction of nitric oxide production and apoptosis. Nitric Oxide 133-145 interleukin 1 beta Mus musculus 95-104 10484338-0 1999 Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages. Nitric Oxide 19-31 interleukin 1 beta Mus musculus 51-59 10484338-1 1999 On the basis of previous work demonstrating nitric oxide (NO)-mediated inhibition of nuclear factor-kappaB (NF-kappaB) DNA binding, we hypothesized that NO downregulates NF-kappaB-dependent interleukin-1beta (IL-1beta) production in an ANA-1 macrophage model of lipopolysaccharide (LPS) stimulation. Nitric Oxide 44-56 interleukin 1 beta Mus musculus 190-207 10484338-1 1999 On the basis of previous work demonstrating nitric oxide (NO)-mediated inhibition of nuclear factor-kappaB (NF-kappaB) DNA binding, we hypothesized that NO downregulates NF-kappaB-dependent interleukin-1beta (IL-1beta) production in an ANA-1 macrophage model of lipopolysaccharide (LPS) stimulation. Nitric Oxide 44-56 interleukin 1 beta Mus musculus 209-217 10477397-1 1999 Combinations of cytokines, including interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma), induce nitric oxide (NO) production and cell death in pancreatic islet cells. Nitric Oxide 107-119 interleukin 1 beta Mus musculus 37-54 10477397-1 1999 Combinations of cytokines, including interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma), induce nitric oxide (NO) production and cell death in pancreatic islet cells. Nitric Oxide 107-119 interleukin 1 beta Mus musculus 56-64 10413302-1 1999 We previously demonstrated that the addition of proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma) caused induction of mRNAs for inducible nitric oxide (NO) synthase and GTP cyclohydrolase I, a rate-limiting enzyme for 5,6,7,8-tetrahydrobiopterin (BH4) biosynthesis, and produced their end-products, NO and BH4, in osteoblastic cells. Nitric Oxide 185-197 interleukin 1 beta Mus musculus 104-121 10194539-2 1999 IL-1beta is released by activated macrophages resident within islets, and its cytotoxic actions include a stimulation of nitric oxide (NO) production and the initiation of apoptosis. Nitric Oxide 121-133 interleukin 1 beta Mus musculus 0-8 10452106-0 1999 Inhibitory effects of nitric oxide and interleukin-10 on production of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in mouse alveolar macrophages. Nitric Oxide 22-34 interleukin 1 beta Mus musculus 100-118 10452106-8 1999 CONCLUSION: Both endogenous and exogenous nitric oxide and IL-10 had inhibitory effects on the LPS-induced TNF alpha, IL-1 beta, and IL-6 secretions in mouse AM. Nitric Oxide 42-54 interleukin 1 beta Mus musculus 118-127 9989930-5 1999 On the other hand, nitric oxide was a factor of the deleterious effects of IL-1beta, TNF-alpha, and ST on pancreatic islets. Nitric Oxide 19-31 interleukin 1 beta Mus musculus 75-83 9780184-0 1998 Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme). Nitric Oxide 0-12 interleukin 1 beta Mus musculus 22-30 9609731-1 1998 Cytomix, a mixture of interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta, induces nitric oxide (NO) production in lung epithelial cell lines. Nitric Oxide 100-112 interleukin 1 beta Mus musculus 73-90 9195135-6 1997 IL-1 beta caused a more than 10-fold increase in medium nitrite production, an indication of nitric oxide production, which was blocked by S-methyl-L-thiocitrulline. Nitric Oxide 93-105 interleukin 1 beta Mus musculus 0-9 9088945-1 1997 Nitric oxide has been shown to mediate beta-cell destruction in rodent islets exposed to interleukin 1 beta in culture. Nitric Oxide 0-12 interleukin 1 beta Mus musculus 89-107 9010679-4 1996 TNF and IL-6 were significantly reduced in serum 2 h and 24 h respectively after CLP, interleukin-1 beta (IL-1 beta) was reduced in liver 4 h after CLP, nitric oxide (NO) and serum amyloid A (SAA) were significantly reduced 8 and 24 h respectively after CLP. Nitric Oxide 153-165 interleukin 1 beta Mus musculus 86-104 9010679-4 1996 TNF and IL-6 were significantly reduced in serum 2 h and 24 h respectively after CLP, interleukin-1 beta (IL-1 beta) was reduced in liver 4 h after CLP, nitric oxide (NO) and serum amyloid A (SAA) were significantly reduced 8 and 24 h respectively after CLP. Nitric Oxide 153-165 interleukin 1 beta Mus musculus 106-115 7536171-1 1995 Interleukin-1 beta (IL-1 beta) has been suggested to mediate beta-cell destruction in insulin-dependent diabetes mellitus (IDDM) by inducing nitric oxide production. Nitric Oxide 141-153 interleukin 1 beta Mus musculus 0-18 7536171-1 1995 Interleukin-1 beta (IL-1 beta) has been suggested to mediate beta-cell destruction in insulin-dependent diabetes mellitus (IDDM) by inducing nitric oxide production. Nitric Oxide 141-153 interleukin 1 beta Mus musculus 20-29 7536171-10 1995 However, after incubation with IL-1 beta in vitro, both NOD and NMRI islets responded with a marked increase in nitric oxide production. Nitric Oxide 112-124 interleukin 1 beta Mus musculus 31-40 7948748-0 1994 TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide. Nitric Oxide 124-136 interleukin 1 beta Mus musculus 62-71 8003032-2 1994 TNF alpha, IL-1 beta, and LPS caused a dose- and time-dependent increase of nitrite (NO2-), the stable metabolite of nitric oxide (NO), in conditioned media over 48 hours, while IFN gamma had a minimal effect. Nitric Oxide 117-129 interleukin 1 beta Mus musculus 11-20 7512249-0 1993 Interferon-gamma and interleukin-1 beta induce nitric oxide formation from primary mouse astrocytes. Nitric Oxide 47-59 interleukin 1 beta Mus musculus 21-39 7506289-0 1993 Interleukin-1 beta induces nitric oxide production by a mouse pituitary tumour cell line (AtT20/D16). Nitric Oxide 27-39 interleukin 1 beta Mus musculus 0-18 1731791-0 1992 Interleukin-1 beta induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets. Nitric Oxide 27-39 interleukin 1 beta Mus musculus 0-18 1731791-1 1992 The aim of this investigation was to further characterize the process of interleukin-1 beta (IL-1 beta) induced nitric oxide production in isolated pancreatic islets. Nitric Oxide 112-124 interleukin 1 beta Mus musculus 73-91 1731791-1 1992 The aim of this investigation was to further characterize the process of interleukin-1 beta (IL-1 beta) induced nitric oxide production in isolated pancreatic islets. Nitric Oxide 112-124 interleukin 1 beta Mus musculus 93-102 33878544-5 2021 In vitro cell experiments, the inflammatory response in chondrocytes is mediated via interleukin-1beta (IL-1beta), which led to abnormal secretion of pro-inflammatory factors, such as prostaglandin E2 (PGE2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cyclooxygenase-2 (COX-2), nitric oxide (NO) and inducible nitric oxide synthase (iNOS). Nitric Oxide 298-310 interleukin 1 beta Mus musculus 85-102 32033881-6 2020 Anti-inflammatory activity of QD was confirmed by the suppression of nitric oxide (NO) production in response to interleukin-1beta in cultured hepatocytes. Nitric Oxide 69-81 interleukin 1 beta Mus musculus 113-130 31626919-9 2019 Mechanistically, miR-124 directly targeted signal transducer and activator of transcription 3 (STAT3) in BV2 cells; in addition, upregulation of miR-124 inhibited the increase of inducible nitric oxide synthetase and proinflammatory cytokines, including IL-6, IL-1beta, TNF-alpha, and MCP-1, in LPS-stimulated BV2 cells. Nitric Oxide 189-201 interleukin 1 beta Mus musculus 260-268 30919410-0 2019 Brucella abortus nitric oxide metabolite regulates inflammasome activation and IL-1beta secretion in murine macrophages. Nitric Oxide 17-29 interleukin 1 beta Mus musculus 79-87 30748031-6 2019 IFN-gamma was vital for induction of the nitric oxide producing enzyme, iNOS, in infected joints, and nitric oxide directly inhibited IL-1beta production and inflammasome activation in Brucella-infected macrophages in vitro. Nitric Oxide 102-114 interleukin 1 beta Mus musculus 134-142 30896805-4 2019 The data revealed that Peimine not only suppressed IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2, but also reduced the protein levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). Nitric Oxide 82-94 interleukin 1 beta Mus musculus 51-59 30942801-6 2019 IL-1beta-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6) were all inhibited significantly by Pm pretreatment in vitro. Nitric Oxide 31-43 interleukin 1 beta Mus musculus 0-8 30395837-1 2018 Mast cells and Kupffer cells secrete interleukin (IL)-1beta, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha, which stimulate excess nitric oxide (NO) producing-inducible NO synthase (iNOS). Nitric Oxide 147-159 interleukin 1 beta Mus musculus 37-59 30145061-7 2018 By quantifying the production of Nitric oxide (NO), we further report that the pretreatment of IL-1beta fails to produce the nitric oxide. Nitric Oxide 33-45 interleukin 1 beta Mus musculus 95-103 30327995-7 2018 Our results showed that NJK14047 markedly reduced the production of nitric oxide and prostaglandin E2 by downregulating the expression of various proinflammatory mediators such as nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha and interleukin-1beta in LPS-induced BV2 microglia. Nitric Oxide 68-80 interleukin 1 beta Mus musculus 253-270 30160278-5 2018 Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner. Nitric Oxide 73-85 interleukin 1 beta Mus musculus 18-35 30160278-5 2018 Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner. Nitric Oxide 73-85 interleukin 1 beta Mus musculus 37-45 29656318-6 2018 Of the eight imidazoles tested, methyl 1-allyl-2-(4-fluorophenyl)-5-phenyl-1H-imidazole-4-acetate (8) inhibited nitric oxide metabolites and pro-inflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) secretion in J774 macrophages stimulated with LPS. Nitric Oxide 112-124 interleukin 1 beta Mus musculus 189-197 29473075-5 2018 In vitro, monascin treatment inhibited the IL-1beta-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6). Nitric Oxide 110-122 interleukin 1 beta Mus musculus 43-51 29399292-4 2018 RESULTS: Following stimulation of BV2 cells by LPS, exposure to BCE significantly reduced the generation of nitric oxide as well as mRNA levels of numerous inflammatory factors such as inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), interleukin 1 beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha). Nitric Oxide 108-120 interleukin 1 beta Mus musculus 251-269 29399292-4 2018 RESULTS: Following stimulation of BV2 cells by LPS, exposure to BCE significantly reduced the generation of nitric oxide as well as mRNA levels of numerous inflammatory factors such as inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), interleukin 1 beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha). Nitric Oxide 108-120 interleukin 1 beta Mus musculus 271-279 28624598-8 2017 This in turn led to the blockade of iNOS and COX-2, thereby inhibiting the production of nitric oxide and pro inflammatory cytokines such as TNF-alpha, IL-6, MCP-1 and IL-1beta. Nitric Oxide 89-101 interleukin 1 beta Mus musculus 168-176 28370033-4 2017 Under defined ELF-EMF exposure conditions, the production of nitric oxide and pro-inflammatory cytokines, TNF-alpha, IL-1beta, and IL-6, were increased in RAW 264.7 cells and the expression of those genes was also upregulated. Nitric Oxide 61-73 interleukin 1 beta Mus musculus 117-125 28193826-8 2017 Furthermore, administration of the IL-1beta receptor antagonist, anakinra, efficiently decreased nitric oxide production and vascular proliferation and restored peritoneal function in mouse models of peritonitis, even in mice treated with standard-of-care antibiotherapy. Nitric Oxide 97-109 interleukin 1 beta Mus musculus 35-43 28214532-5 2017 Furthermore, depletion of endogenous SMN by RNA interference enhanced the IL-1beta-induced activation of IKK and production of inflammatory mediators such as TNF-alpha and nitric oxide in BV2 cells. Nitric Oxide 172-184 interleukin 1 beta Mus musculus 74-82 28066148-1 2017 The present study aimed to show that pro-inflammatory cytokines [tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and interleukin (IL)-1beta] synergistically induce the production of nitric oxide (NO) production in mouse mesangial cells, which play an important role in inflammatory glomerular injury. Nitric Oxide 193-205 interleukin 1 beta Mus musculus 128-150 26554632-7 2016 These drugs suppressed the ability of lipopolysaccharide to stimulate the synthesis and secretion of nitric oxide and inflammatory cytokines and chemokines, such as IL6, IL1beta, CXCL2, and CSF3, in macrophage-like RAW264.7 cells. Nitric Oxide 101-113 interleukin 1 beta Mus musculus 170-177 26615818-2 2015 In vitro, LPS-induced nitric oxide (NO) production was significantly inhibited by MBF extracts via suppressing the expression of proinflammatory molecules, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1 beta (IL-beta) and IL-6. Nitric Oxide 22-34 interleukin 1 beta Mus musculus 232-250 26086107-4 2015 In response to lipopolysaccharide (LPS), the reducing effect of 20(S)-Rg3 and 20(R)-Rg3 on nitric oxide led to an increase in the survival time of mice after lethal endotoxin-induced shock, and excess levels of NO inhibited IL-1beta production via the S-nitrosylation of the NLRP3 inflammasome. Nitric Oxide 91-103 interleukin 1 beta Mus musculus 224-232 25585625-8 2015 We demonstrate that IL-1beta-treated GPR40(-/-) chondrocytes secret more inflammatory mediators (nitric oxide, interleukin-6, prostaglandin E2) and active catabolic enzymes (metalloproteinase-2, -9 [MMP-2, MMP-9]), and show decreased anabolism (glycoaminoglycan) compared to GPR40(+/+) cells. Nitric Oxide 97-109 interleukin 1 beta Mus musculus 20-28 24905526-4 2014 Among the synthesized derivatives, the BECT [But-2-enedioic acid bis-(2-carboxy-5-trifluoromethyl-phenyl) ester] significantly decreased production of nitric oxide and other pro-inflammatory cytokines including tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in microglial cells. Nitric Oxide 151-163 interleukin 1 beta Mus musculus 240-257 24192281-5 2014 In response to the addition of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma to the culture medium, primary osteoblasts showed increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) at early time points and decreases in cell viability. Nitric Oxide 200-212 interleukin 1 beta Mus musculus 57-103 23609920-2 2013 Meanwhile, cytokines, such as interleukin-1beta (IL-1beta), stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to beta-cell damage. Nitric Oxide 80-92 interleukin 1 beta Mus musculus 30-47 23609920-2 2013 Meanwhile, cytokines, such as interleukin-1beta (IL-1beta), stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to beta-cell damage. Nitric Oxide 80-92 interleukin 1 beta Mus musculus 49-57 23664095-5 2013 Comparing to the IL-1R1(-/-) mice, infected WT mice with functional IL-1beta signaling had higher gastritis scores, higher IL-1beta and iNOS mRNA expression, higher nitric oxide (NO) production and increased frequency of E-cadherin (E-cad) methylation at all the time points analyzed. Nitric Oxide 165-177 interleukin 1 beta Mus musculus 68-76 23318584-2 2013 Here we show that nitric oxide (NO) inhibited the NLRP3-mediated ASC pyroptosome formation, caspase-1 activation and IL-1beta secretion in myeloid cells from both mice and humans. Nitric Oxide 18-30 interleukin 1 beta Mus musculus 117-125 22633410-4 2012 The decrease in nitric oxide production was accompanied by a decrease in the transcripts of several proinflammatory cytokines, most dramatically interleukin-1beta. Nitric Oxide 16-28 interleukin 1 beta Mus musculus 145-162 21372137-1 2011 Interleukin-1beta (IL-1beta) induces cell death in chondrocytes in a nitric oxide (NO)- and reactive oxygen species (ROS)-dependent manner. Nitric Oxide 69-81 interleukin 1 beta Mus musculus 0-17 21372137-1 2011 Interleukin-1beta (IL-1beta) induces cell death in chondrocytes in a nitric oxide (NO)- and reactive oxygen species (ROS)-dependent manner. Nitric Oxide 69-81 interleukin 1 beta Mus musculus 19-27 19179618-0 2009 Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes. Nitric Oxide 34-46 interleukin 1 beta Mus musculus 0-17 18957167-4 2008 Dendritic cells exposed to lipopolysaccharide, lipoteichoic acid or interleukin (IL)-1beta exhibited increased production of IL-12 p70 and tumour necrosis factor alpha, increased formation of reactive oxygen species (ROS) and nitric oxide (NO), and elevation of intracellular Ca2+ levels. Nitric Oxide 226-238 interleukin 1 beta Mus musculus 68-90 18559654-12 2008 Thus, activation of P2X(7) receptor amplifies LPS-induced hyporeactivity in mouse endothelium-intact aorta, which is associated with IL-1beta-mediated release of nitric oxide by iNOS. Nitric Oxide 162-174 interleukin 1 beta Mus musculus 133-141 18383346-7 2008 As far as mechanisms for oxidative stress defence are concerned, we observed that treatment with IL-1beta+TNFalpha decreases cellular glutathione content and increases glutathione release into the extracellular space while stimulating superoxide anion and nitric oxide production as well as H(2)O(2) release. Nitric Oxide 256-268 interleukin 1 beta Mus musculus 97-105 18387518-4 2008 Dendritic cells exposed to lipopolysaccharide, lipoteichoic acid and IL-1beta exhibited increase in the production of IL-12 p70 and TNF-alpha, increase in the formation of reactive oxygen species and nitric oxide, and elevation of intracellular Ca2+ levels. Nitric Oxide 200-212 interleukin 1 beta Mus musculus 69-77 17032168-2 2006 We previously showed that LPS-induced IL-1beta expression was regulated by a Stat1-dependent, nitric oxide (NO)-mediated mechanism. Nitric Oxide 94-106 interleukin 1 beta Mus musculus 38-46 16174862-5 2006 TSA treatment of cells stably transfected with an iNOS promoter-luciferase construct inhibited IL-1beta induction of endogenous nitric oxide and iNOS protein production and iNOS promoter-luciferase activity. Nitric Oxide 128-140 interleukin 1 beta Mus musculus 95-103 16338964-0 2006 Src activation of NF-kappaB augments IL-1beta-induced nitric oxide production in mesangial cells. Nitric Oxide 54-66 interleukin 1 beta Mus musculus 37-45 16109400-1 2005 Pituicytes, the astrocytic glial cells of the neural lobe, are known to secrete interleukin-6 and nitric oxide upon stimulation with various inflammatory mediators, i.e. interleukin-1beta. Nitric Oxide 98-110 interleukin 1 beta Mus musculus 170-187 16109400-3 2005 The aim of the present study was to investigate the effect of nitric oxide on interleukin-1beta induced interleukin-6 secretion. Nitric Oxide 62-74 interleukin 1 beta Mus musculus 78-95 16109400-9 2005 Co-stimulation with interferon-gamma and interleukin-1beta induced a significant nitric oxide release. Nitric Oxide 81-93 interleukin 1 beta Mus musculus 41-58 16023781-1 2005 In rodent islets, exposure to interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma) induces expression of inducible nitric oxide synthase (iNOS) and subsequent nitric oxide (NO) formation, which may inhibit islet function. Nitric Oxide 124-136 interleukin 1 beta Mus musculus 30-47 16023781-1 2005 In rodent islets, exposure to interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma) induces expression of inducible nitric oxide synthase (iNOS) and subsequent nitric oxide (NO) formation, which may inhibit islet function. Nitric Oxide 124-136 interleukin 1 beta Mus musculus 49-57 15466171-2 2004 The nitric oxide synthase (NOS2) is induced by inflammatory cytokines, e.g., tumor necrosis factor alpha and interleukin 1beta, and produces nitric oxide (NO*), a critical mediator of the inflammatory response. Nitric Oxide 4-16 interleukin 1 beta Mus musculus 109-126 12657566-1 2003 Proinflammatry cytokines, tumor necrosis factor-alpha combined with interleukin-1beta, induce excessive production of nitric oxide (NO) and its cytotoxic metabolite peroxynitrite (ONOO-) via inducible nitric oxide synthase (iNOS) in murine osteoblasts. Nitric Oxide 118-130 interleukin 1 beta Mus musculus 68-85 12898012-2 2003 Interleukin-1beta (IL-1beta) has been reported to cause suppression of insulin secretion from pancreatic islets via induction of inducible nitric oxide synthase (iNOS) followed by nitric oxide (NO) production. Nitric Oxide 139-151 interleukin 1 beta Mus musculus 0-17 12898012-2 2003 Interleukin-1beta (IL-1beta) has been reported to cause suppression of insulin secretion from pancreatic islets via induction of inducible nitric oxide synthase (iNOS) followed by nitric oxide (NO) production. Nitric Oxide 139-151 interleukin 1 beta Mus musculus 19-27