PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15838309-2 2004 However, the potential modulatory role of nitrogen monoxide in compensating the ET-1-induced ischemic stress is not fully elucidated. Nitric Oxide 42-59 endothelin 1 Canis lupus familiaris 80-84 9822453-2 1998 Although endothelin-1 (ET-1) has been implicated as a vasoconstricting and growth-promoting peptide of endothelial origin, it may more importantly function as an autocrine factor and release vasodilatory substances such as nitric oxide by mechanisms linked to the endothelin-B (ETB) receptor subtype. Nitric Oxide 223-235 endothelin 1 Canis lupus familiaris 9-21 9822453-2 1998 Although endothelin-1 (ET-1) has been implicated as a vasoconstricting and growth-promoting peptide of endothelial origin, it may more importantly function as an autocrine factor and release vasodilatory substances such as nitric oxide by mechanisms linked to the endothelin-B (ETB) receptor subtype. Nitric Oxide 223-235 endothelin 1 Canis lupus familiaris 23-27 8760103-0 1996 Nitric oxide attenuates endothelin-1-induced vasoconstriction in canine stomach. Nitric Oxide 0-12 endothelin 1 Canis lupus familiaris 24-36 8794819-0 1996 Roles of prostaglandins and nitric oxide in the effect of endothelin-1 on renal hemodynamics. Nitric Oxide 28-40 endothelin 1 Canis lupus familiaris 58-70 8794819-1 1996 It is known that endothelin-1 stimulates the release of nitric oxide and prostaglandins in various vascular beds. Nitric Oxide 56-68 endothelin 1 Canis lupus familiaris 17-29 8794819-2 1996 We designed the present study to analyze the roles of prostaglandins and nitric oxide in the effect of endothelin-1 on the regulation of renal hemodynamics and renin release. Nitric Oxide 73-85 endothelin 1 Canis lupus familiaris 103-115 8794819-6 1996 Endothelin-1 infusion produced a dose-dependent reduction in renal blood flow after blockade of nitric oxide and prostaglandins. Nitric Oxide 96-108 endothelin 1 Canis lupus familiaris 0-12 8794819-12 1996 Therefore, the present study demonstrates that the release of nitric oxide and prostaglandins might modulate the effects of endothelin-1 on the renal circulation. Nitric Oxide 62-74 endothelin 1 Canis lupus familiaris 124-136 8794819-13 1996 The present findings suggest that the differential vasoconstrictive effects of endothelin-1 on preglomerular and postglomerular vessels are associated with its stimulation of nitric oxide and prostaglandin production. Nitric Oxide 175-187 endothelin 1 Canis lupus familiaris 79-91 8760103-2 1996 The purpose of our present study was to examine the role of nitric oxide in regulating ET-1-induced vasoconstriction under normal conditions and after ischemia-reperfusion. Nitric Oxide 60-72 endothelin 1 Canis lupus familiaris 87-91 8760103-5 1996 Our findings are consistent with the hypothesis that nitric oxide modulates responses to ET-1 under normal conditions, and loss of this vasodilator after ischemia-reperfusion results in an augmented response to ET-1. Nitric Oxide 53-65 endothelin 1 Canis lupus familiaris 89-93 8750709-7 1995 Thus, endothelin-1 produces marked cerebral venoconstriction that could be mainly mediated by activation of endothelin ETA receptors, may be dependent on extracellular Ca2+, and may be independent of endothelium, nitric oxide and prostanoids. Nitric Oxide 213-225 endothelin 1 Canis lupus familiaris 6-18 7867388-7 1994 These findings indicate that endogenous nitric oxide is an inhibitory modulator of hypoxic pulmonary vasoconstriction and that nitric oxide inhibits the production of endothelin-1 in vivo and in cultured vascular endothelial cells. Nitric Oxide 127-139 endothelin 1 Canis lupus familiaris 167-179 8750709-3 1995 The response to endothelin-1 was also recorded in veins pretreated with the nitric oxide synthesis inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME, 10(-4) M), or the cyclooxygenase inhibitor, meclofenamate (10(-5) M), and in veins without endothelium or placed in medium without Ca2+ but with EDTA (0.1 mM). Nitric Oxide 76-88 endothelin 1 Canis lupus familiaris 16-28 8587363-8 1995 Our results indicate that pressor responses to ET-1 and S6b in the isolated canine liver are modulated by concomitant release of vasodilator mediators, including prostacyclin and nitric oxide. Nitric Oxide 179-191 endothelin 1 Canis lupus familiaris 47-51 7867388-0 1994 Inhibition of nitric oxide synthesis increases the secretion of endothelin-1 in vivo and in cultured endothelial cells. Nitric Oxide 14-26 endothelin 1 Canis lupus familiaris 64-76 7541937-0 1995 Renal actions of endothelin-1 and endothelin-3: interactions with the prostaglandin system and nitric oxide. Nitric Oxide 95-107 endothelin 1 Canis lupus familiaris 17-29 7842397-1 1994 Cyclic GMP (cGMP) dependent vasodilating agents (natriuretic peptides, nitric oxide) inhibit secretion of endothelin-1 (ET-1) in cultured endothelial cells. Nitric Oxide 71-83 endothelin 1 Canis lupus familiaris 106-118 7867388-1 1994 The aim of this study is to investigate the effects of nitric oxide, formed from L-arginine, on the production of endothelin-1 in vivo and in cultured endothelial cells. Nitric Oxide 55-67 endothelin 1 Canis lupus familiaris 114-126 7842397-1 1994 Cyclic GMP (cGMP) dependent vasodilating agents (natriuretic peptides, nitric oxide) inhibit secretion of endothelin-1 (ET-1) in cultured endothelial cells. Nitric Oxide 71-83 endothelin 1 Canis lupus familiaris 120-124 1334347-6 1992 The BK"s suppression of the ET-1-induced vasoconstriction was partly reversed by additions of each 10(-5) of Ng-nitro-L-arginine, a substrate inhibitor of nitric oxide, methylene blue, an inhibitor of soluble guanylate cyclase, or indomethacin, an inhibitor of cyclooxygenase. Nitric Oxide 155-167 endothelin 1 Canis lupus familiaris 28-32