PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24695088-5 2015 Nitric oxide was determined by methemoglobin method. Nitric Oxide 0-12 hemoglobin subunit gamma 2 Homo sapiens 31-44 27814710-3 2016 Our objectives were to: i) evaluate risk factors for methemoglobinemia in Ugandan children hospitalized with fever (study 1); and ii) investigate MHb responses in critically ill Ugandan children with severe malaria treated with inhaled nitric oxide (iNO), an oxidant that induces MHb in a dose-dependent manner (study 2). Nitric Oxide 236-248 hemoglobin subunit gamma 2 Homo sapiens 146-149 26309894-11 2015 Nitric oxide metabolite levels-blood methemoglobin and plasma nitrate-increased in patients treated with NO (both P < .05). Nitric Oxide 0-12 hemoglobin subunit gamma 2 Homo sapiens 37-50 25521918-0 2015 Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy. Nitric Oxide 97-109 hemoglobin subunit gamma 2 Homo sapiens 47-60 21079530-3 2011 Inhaled nitric oxide is rapidly inactivated on binding to hemoglobin in the formation of nitrosyl- and methemoglobin in the pulmonary vasculature. Nitric Oxide 8-20 hemoglobin subunit gamma 2 Homo sapiens 103-116 23201463-1 2013 Methemoglobinemia is a disease that results from abnormally high levels of methemoglobin (MetHb) in the red blood cell (RBC), which is caused by simultaneous uptake of oxygen (O(2)) and nitric oxide (NO) in the human lungs. Nitric Oxide 186-198 hemoglobin subunit gamma 2 Homo sapiens 75-88 23201463-1 2013 Methemoglobinemia is a disease that results from abnormally high levels of methemoglobin (MetHb) in the red blood cell (RBC), which is caused by simultaneous uptake of oxygen (O(2)) and nitric oxide (NO) in the human lungs. Nitric Oxide 186-198 hemoglobin subunit gamma 2 Homo sapiens 90-95 21445844-8 2011 During oxygenation of nitric oxide to nitrate, oxidized ferric hemoglobin is formed (methemoglobin), which can be reduced by an associated reductase. Nitric Oxide 22-34 hemoglobin subunit gamma 2 Homo sapiens 85-98 19895897-4 2010 Of potential importance to these reactions is the affinity of methemoglobin for nitrite and the reactivity of nitrite-bound methemoglobin with nitric oxide. Nitric Oxide 143-155 hemoglobin subunit gamma 2 Homo sapiens 124-137 20512540-6 2010 Thus, we review the evidence for tissue hypoxia during acute hemodilutional anemia and also explore the novel hypothesis that methemoglobin, a measurable byproduct of increased NOS-derived nitric oxide (NO), may serve as a biomarker for "anemic stress". Nitric Oxide 189-201 hemoglobin subunit gamma 2 Homo sapiens 126-139 15823089-7 2005 In air, the release of nitric oxide was recorded by the production of nitrite or the oxidation of oxyhemoglobin to methemoglobin. Nitric Oxide 23-35 hemoglobin subunit gamma 2 Homo sapiens 115-128 18243145-3 2008 Oxidation of the cell-free hemoglobin to methemoglobin, which does not effectively scavenge nitric oxide, using inhaled nitric oxide has been shown to be effective in limiting pulmonary and systemic vasoconstriction. Nitric Oxide 120-132 hemoglobin subunit gamma 2 Homo sapiens 41-54 18433566-0 2008 [Effect of inhaled nitric oxide on methemoglobin levels in children]. Nitric Oxide 19-31 hemoglobin subunit gamma 2 Homo sapiens 35-48 18225862-1 2008 The reaction of deoxyhemoglobin with nitric oxide (NO) or nitrite ions (NO 2 (-)) produces iron-nitrosyl-hemoglobin (HbNO) in contrast to the reaction with oxyhemoglobin, which produces methemoglobin and nitrate (NO 3 (-)). Nitric Oxide 37-49 hemoglobin subunit gamma 2 Homo sapiens 186-199 18158911-5 2008 Nitric oxide has been reported to react easily with oxygen captured in hemoglobin to form nitrate, but not toxic free radicals, which may result in production of methemoglobin for the cytochrome b5 to regenerate functional ferrous hemoglobin. Nitric Oxide 0-12 hemoglobin subunit gamma 2 Homo sapiens 162-175 17615278-1 2007 The reaction of nitrite with deoxyhemoglobin results in the production of nitric oxide and methemoglobin, a reaction recently proposed as an important oxygen-sensitive source of vasoactive nitric oxide during hypoxic and anoxic stress, with several animal studies suggesting that nitrite may have therapeutic potential. Nitric Oxide 189-201 hemoglobin subunit gamma 2 Homo sapiens 91-104 19554014-0 2009 Methemoglobin to cumulative nitric oxide ratio and response to inhaled nitric oxide in PPHN. Nitric Oxide 28-40 hemoglobin subunit gamma 2 Homo sapiens 0-13 12536266-0 2003 Methemoglobin formation in children with congenital heart disease treated with inhaled nitric oxide after cardiac surgery. Nitric Oxide 87-99 hemoglobin subunit gamma 2 Homo sapiens 0-13 15599162-4 2004 PATIENT: One female patient with acute respiratory distress syndrome treated with inhaled nitric oxide, who developed a simultaneous increase in blood methemoglobin and carboxyhemoglobin. Nitric Oxide 90-102 hemoglobin subunit gamma 2 Homo sapiens 151-164 12797897-1 2001 Elevation in methemoglobin is a known toxicity of inhaled nitric oxide (NO) therapy. Nitric Oxide 58-70 hemoglobin subunit gamma 2 Homo sapiens 13-26 12161242-0 2002 Association of nitric oxide dose and methemoglobin levels in patients with congenital heart disease and pulmonary hypertension. Nitric Oxide 15-27 hemoglobin subunit gamma 2 Homo sapiens 37-50 12468537-0 2003 Reactions of deoxy-, oxy-, and methemoglobin with nitrogen monoxide. Nitric Oxide 50-67 hemoglobin subunit gamma 2 Homo sapiens 31-44 11841242-6 2002 Experiments with hydroxyurea analogues indicate that nitric oxide transfer requires an unsubstituted acylhydroxylamine group and that the reactions of hydroxyurea and deoxy- and methemoglobin likely proceed by inner-sphere mechanisms. Nitric Oxide 53-65 hemoglobin subunit gamma 2 Homo sapiens 178-191 9233741-2 1997 We tested the hypothesis whether cardiopulmonary bypass increases methemoglobin formation by nitric oxide. Nitric Oxide 93-105 hemoglobin subunit gamma 2 Homo sapiens 66-79 10362425-16 1999 Patients receiving prolonged inhaled nitric oxide at doses of < or =20 ppm maintained methemoglobin levels of <3.0% and circuit concentrations of NO2 of <1 ppm. Nitric Oxide 37-49 hemoglobin subunit gamma 2 Homo sapiens 89-102 9280288-5 1997 On the other hand, nitric oxide and superoxide generated concomitantly from 3-morpholinosydnonimine (SIN-1) did not induce appreciable hemolysis, while it converted hemoglobin to methemoglobin extensively. Nitric Oxide 19-31 hemoglobin subunit gamma 2 Homo sapiens 179-192 9295837-0 1997 Circulating methemoglobin and nitrite/nitrate concentrations as indicators of nitric oxide overproduction in critically ill children with septic shock. Nitric Oxide 78-90 hemoglobin subunit gamma 2 Homo sapiens 12-25 9233741-10 1997 MEASUREMENTS AND MAIN RESULTS: For the in vivo study, nitric oxide inhalation increased methemoglobin from 0.2 +/- 0.1% to 1.2 +/- 0.7% in patients receiving nitric oxide after open-heart surgery and from 0.2 +/- 0.1% to 0.5 +/- 0.4% in ARDS/persistent pulmonary hypertension of the newborn patients (p < .01). Nitric Oxide 54-66 hemoglobin subunit gamma 2 Homo sapiens 88-101 9233741-10 1997 MEASUREMENTS AND MAIN RESULTS: For the in vivo study, nitric oxide inhalation increased methemoglobin from 0.2 +/- 0.1% to 1.2 +/- 0.7% in patients receiving nitric oxide after open-heart surgery and from 0.2 +/- 0.1% to 0.5 +/- 0.4% in ARDS/persistent pulmonary hypertension of the newborn patients (p < .01). Nitric Oxide 158-170 hemoglobin subunit gamma 2 Homo sapiens 88-101 9233741-11 1997 For the in vitro study, nitric oxide incubation of red blood cells increased methemoglobin concentration from 3.7 +/- 1.9% preoperatively to 7.4 +/- 2.4% after open-heart surgery. Nitric Oxide 24-36 hemoglobin subunit gamma 2 Homo sapiens 77-90 2093192-2 1990 Concentrations of methemoglobin in human and mouse acatalasemic hemolysates exposed to nitrogen monoxide or nitrogen dioxide were higher than those in the normal hemolysates. Nitric Oxide 87-104 hemoglobin subunit gamma 2 Homo sapiens 18-31 7542684-2 1995 We have evaluated the spectrophotometric measurement (at 401 vs. 411 nm) of nitric oxide (NO)-dependent methemoglobin formation from oxyhemoglobin in order to assess NO release from human polymorphonuclear neutrophil leukocytes (PMN). Nitric Oxide 76-88 hemoglobin subunit gamma 2 Homo sapiens 104-117 8605791-13 1996 Maximum methemoglobin concentrations were greater in patients treated for a prolonged period with 40 ppm nitric oxide. Nitric Oxide 105-117 hemoglobin subunit gamma 2 Homo sapiens 8-21 7528117-18 1995 The capacity of the test instrument to measure methemoglobin makes it particularly useful if inhaled nitric oxide therapy becomes a standard clinical practice. Nitric Oxide 101-113 hemoglobin subunit gamma 2 Homo sapiens 47-60 2167095-3 1990 Approximately 1 hr after the reaction had been started, the EPR spectra of two additional paramagnetic intermediates could be detected at low temperature (77 degrees K), a low-spin ferric methemoglobin complex with hydroxyurea (MetHb-NHOH-CO-NH2) and the hemoglobin-nitric oxide adduct (Hb2(+)-NO). Nitric Oxide 266-278 hemoglobin subunit gamma 2 Homo sapiens 188-201 2093192-4 1990 When acatalasemic mice were exposed to nitrogen monoxide, the methemoglobin concentration in the blood was higher than that in the normal mice. Nitric Oxide 39-56 hemoglobin subunit gamma 2 Homo sapiens 62-75 2093192-8 1990 These results indicated that the formation of methemoglobin from hemoglobin with nitrogen monoxide, nitrogen dioxide and nitrite ion appears to be controlled by the blood catalase. Nitric Oxide 81-98 hemoglobin subunit gamma 2 Homo sapiens 46-59 35171971-1 2022 Methemoglobin (metHb) arises from the oxidation of ferrous hemoglobin (HbFe2+, Hb) to ferric hemoglobin (HbFe3+, metHb), which is unable to bind gaseous ligands such as oxygen (O2) and carbon monoxide (CO), and binds to nitric oxide (NO) significantly slower compared to Hb. Nitric Oxide 220-232 hemoglobin subunit gamma 2 Homo sapiens 0-13 7298665-3 1981 Nitrosylhemoglobin is produced concurrently with methemoglobin as a result of reductive release of nitric oxide from nitrous acid. Nitric Oxide 99-111 hemoglobin subunit gamma 2 Homo sapiens 49-62 6311256-0 1983 Reaction of nitric oxide with heme proteins: studies on metmyoglobin, opossum methemoglobin, and microperoxidase. Nitric Oxide 12-24 hemoglobin subunit gamma 2 Homo sapiens 78-91 6135148-9 1983 Methemoglobin, a hemoprotein with a high affinity for nitric oxide, partially reversed the antiaggregatory effects, attenuated the accumulation of cyclic GMP, and inhibited the activation of guanylate cyclase by S-nitrosothiols. Nitric Oxide 54-66 hemoglobin subunit gamma 2 Homo sapiens 0-13 5784181-0 1969 Reactions of nitric oxide with methemoglobin. Nitric Oxide 13-25 hemoglobin subunit gamma 2 Homo sapiens 31-44 30621691-9 2019 The pulmonary gradient of methemoglobin was lower in PAH patients compared to controls and a higher PAW blood methemoglobin was associated with a more pronounced pulmonary vascular response to inhaled nitric oxide. Nitric Oxide 201-213 hemoglobin subunit gamma 2 Homo sapiens 110-123 32737900-13 2021 Methemoglobin levels were increased after receiving nitric oxide but were far below a toxic level of 15%. Nitric Oxide 52-64 hemoglobin subunit gamma 2 Homo sapiens 0-13 31744017-1 2020 BACKGROUND: We aimed to investigate whether the change in methemoglobin levels (DeltaMHb) predicts oxygenation response to inhaled nitric oxide (iNO) in persistent pulmonary hypertension of the newborn (PPHN) with lung disease, with or without pulmonary hypoplasia. Nitric Oxide 131-143 hemoglobin subunit gamma 2 Homo sapiens 58-71 33225304-12 2020 Maximum methemoglobin concentration after 30 minutes of breathing nitric oxide was 2.0% (1.7-2.3%). Nitric Oxide 66-78 hemoglobin subunit gamma 2 Homo sapiens 8-21 31300527-6 2019 Nitric oxide was measured by methemoglobin method. Nitric Oxide 0-12 hemoglobin subunit gamma 2 Homo sapiens 29-42 29932345-5 2018 MEASUREMENTS AND MAIN RESULTS: The primary outcome was as follows: oxidation of ferrous plasma oxyhemoglobin to ferric methemoglobin was associated with reduced postoperative acute kidney injury from 64% (control group) to 50% (nitric oxide group) (relative risk [RR], 0.78; 95% confidence interval [CI], 0.62-0.97; P = 0.014). Nitric Oxide 228-240 hemoglobin subunit gamma 2 Homo sapiens 119-132 30172035-0 2018 Utility of routine methemoglobin laboratory assays in critically ill pediatric subjects receiving inhaled nitric oxide. Nitric Oxide 106-118 hemoglobin subunit gamma 2 Homo sapiens 19-32 28622911-4 2017 In these patients, excessive intravascular hemolysis saturates scavenger mechanisms resulting in free hemoglobin in plasma that irreversibly reacts with nitric oxide to form nitrate and methemoglobin, leading to arterial thrombosis. Nitric Oxide 153-165 hemoglobin subunit gamma 2 Homo sapiens 186-199 28974829-5 2017 AIM: The aim of our study was to investigate the perioperative variations of carboxyhemoglobin and methemoglobin during urologic surgeries, and at the same time to evaluate the changes in methemoglobin as a possible indicator of nitric oxide generation. Nitric Oxide 229-241 hemoglobin subunit gamma 2 Homo sapiens 188-201 28248201-3 2017 Nitric oxide (NO) is inactivated by cell-free hemoglobin in a dioxygenation reaction that also oxidizes hemoglobin to methemoglobin, a non-oxygen-binding form of hemoglobin that readily loses heme. Nitric Oxide 0-12 hemoglobin subunit gamma 2 Homo sapiens 118-131