PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16251237-0 2005 Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. Nitric Oxide 87-99 C-reactive protein Homo sapiens 18-36 16822291-6 2006 Anti-intercellular adhesion molecule-1 neutralising monoclonal antibody and nitric oxide donor, sodium nitroprusside, blocked the effect of CRP, reducing adhesion from 202% to 128% (P < 0.05) and 114% (P = 0.02) respectively. Nitric Oxide 76-88 C-reactive protein Homo sapiens 140-143 16684119-1 2006 BACKGROUND: In vitro studies have shown that C-reactive protein (CRP) attenuates nitric oxide production and inhibits angiogenesis, which may result in impaired collateral development. Nitric Oxide 81-93 C-reactive protein Homo sapiens 45-63 16684119-1 2006 BACKGROUND: In vitro studies have shown that C-reactive protein (CRP) attenuates nitric oxide production and inhibits angiogenesis, which may result in impaired collateral development. Nitric Oxide 81-93 C-reactive protein Homo sapiens 65-68 16054696-0 2006 Statins and nitric oxide reduce C-reactive protein production while inflammatory conditions persist. Nitric Oxide 12-24 C-reactive protein Homo sapiens 32-50 16054696-5 2006 Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells. Nitric Oxide 176-188 C-reactive protein Homo sapiens 72-75 15358216-4 2004 Incubation of EPCs with human recombinant CRP significantly inhibited EPC migration in response to vascular endothelial growth factor, possibly by decreasing the expression of endothelial nitric oxide synthase and subsequent nitric oxide production. Nitric Oxide 188-200 C-reactive protein Homo sapiens 42-45 15795363-0 2005 Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability. Nitric Oxide 94-106 C-reactive protein Homo sapiens 72-90 15795363-5 2005 In contrast to some previous reports, highly purified and well-characterized human CRP specifically induced hyporeactivity to phenylephrine in rings of human internal mammary artery and rat aorta that was mediated through physiological antagonism by nitric oxide (NO). Nitric Oxide 250-262 C-reactive protein Homo sapiens 83-86 15586013-10 2005 Also CRP is shown to attenuate endothelial progenitor cell survival, differentiation, and function via inhibiting nitric oxide. Nitric Oxide 114-126 C-reactive protein Homo sapiens 5-8 15309202-3 2004 The present review outlines some of the emerging data that suggest that CRP may directly promote the development of endothelial dysfunction, by affecting endothelium-derived contracting and relaxing factors such as nitric oxide, endothelin, angiotensin and interleukin-6. Nitric Oxide 215-227 C-reactive protein Homo sapiens 72-75 12689821-10 2003 CRP also decreased endothelial nitric oxide release, and this effect remained unchanged by hyperglycemia. Nitric Oxide 31-43 C-reactive protein Homo sapiens 0-3 15321699-0 2004 C-reactive protein levels determine systemic nitric oxide bioavailability in patients with coronary artery disease. Nitric Oxide 45-57 C-reactive protein Homo sapiens 0-18 15321699-2 2004 Because inflammatory cytokines experimentally reduce basal and stimulated endothelial nitric oxide (NO) release, we hypothesised that patients with elevated CRP-levels are characterised by a systemic impairment in NO bioavailability. Nitric Oxide 86-98 C-reactive protein Homo sapiens 157-160 15148294-7 2004 The proinflammatory, proatherogenic effects of CRP that have been documented in endothelial cells include the following: decreased nitric oxide and prostacyclin and increased endothelin-1, cell adhesion molecules, monocyte chemoattractant protein-1 and interleukin-8, and increased plasminogen activator inhibitor-1. Nitric Oxide 131-143 C-reactive protein Homo sapiens 47-50 15148294-9 2004 Also, CRP has been shown in vascular smooth muscle cells to increase inducible nitric oxide production, increase NFkappa(b) and mitogen-activated protein kinase activities, and, most importantly, upregulate angiotensin type-1 receptor resulting in increased reactive oxygen species and vascular smooth muscle cell proliferation. Nitric Oxide 79-91 C-reactive protein Homo sapiens 6-9 15236798-5 2004 A recent study shows that nitric oxide suppresses the activation of Stat3 by interleukin-6 in hepatocytes; Stat3 is crucial for the IL-6-mediated induction of CRP and various other acute phase reactants. Nitric Oxide 26-38 C-reactive protein Homo sapiens 159-162 15236798-6 2004 Thus, it is proposed that metformin--or AMPK---inhibits hepatic CRP production by boosting hepatic nitric oxide synthesis, which in turn impedes Stat3 activation and CRP transcription. Nitric Oxide 99-111 C-reactive protein Homo sapiens 64-67 14638413-7 2003 The Crp-Fnr regulators stand out in responding to a broad spectrum of intracellular and exogenous signals such as cAMP, anoxia, the redox state, oxidative and nitrosative stress, nitric oxide, carbon monoxide, 2-oxoglutarate, or temperature. Nitric Oxide 179-191 C-reactive protein Homo sapiens 4-7 34899053-2 2021 More than just a pure bystander, CRP directly interacts with endothelial cells to decrease endothelial nitric oxide synthase (eNOS) expression and bioactivity, decrease nitric oxide (NO) production, and increase the release of vasoconstrictors and adhesion molecules. Nitric Oxide 169-181 C-reactive protein Homo sapiens 33-36 12186793-0 2002 A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Nitric Oxide 58-70 C-reactive protein Homo sapiens 28-46 31746314-8 2020 NOx significantly predicted cIMT (P=0.014) in simple and multiple analysis (P=0.036) adjusted for Framingham score, C-reactive protein, serum creatinine and parathormone. Nitric Oxide 0-3 C-reactive protein Homo sapiens 116-134 35625746-5 2022 Markers of inflammation, such as C-reactive protein, tumor-necrosis-factor alpha, and interleukin 6, provide insight into the disease and markers that negatively influence nitric-oxide bioavailability and promote oxidative stress. Nitric Oxide 172-184 C-reactive protein Homo sapiens 33-51 35357665-16 2022 The quantification of NO levels and analysis of mRNA expressions of eNOS was to determine the nitric oxide demand caused due to OxLDL + CRP complex. Nitric Oxide 94-106 C-reactive protein Homo sapiens 136-139 30013561-0 2018 The Effect of C-Reactive Protein Isoforms on Nitric Oxide Production by U937 Monocytes/Macrophages. Nitric Oxide 45-57 C-reactive protein Homo sapiens 14-32 30013561-3 2018 It is unclear how each CRP isoform mediates nitric oxide (NO), a signaling molecule generated by NO synthase (NOS). Nitric Oxide 44-56 C-reactive protein Homo sapiens 23-26 29552019-5 2018 CRP inhibits endothelial nitric oxide production and contributes to plaque instability by increasing endothelial cell adhesion molecules expression, by promoting monocyte recruitment into the atheromatous plaque and by enzymatically binding to modified low-density lipoprotein. Nitric Oxide 25-37 C-reactive protein Homo sapiens 0-3 28846009-6 2017 RESULTS: After 12 weeks of intervention, changes in serum high-sensitivity C-reactive protein (-2171.4 +- 3189.1 vs. +696.9 +- 2774.8 ng/mL, P = 0.001) and plasma nitric oxide (+1.8 +- 4.0 vs. -0.1 +- 2.4 micromol/L, P = 0.04) in supplemented women were significantly different from those in the placebo group. Nitric Oxide 163-175 C-reactive protein Homo sapiens 75-93 29464415-5 2018 RECENT FINDINGS: We included C-reactive protein, erythrocyte sedimentation rate, white blood cell counts, procalcitonin, and nasal nitric oxide in this review and found that especially elevated C-reactive protein and erythrocyte sedimentation rate are related to a higher probability of a bacterial cause of acute rhinosinusitis. Nitric Oxide 131-143 C-reactive protein Homo sapiens 194-212 25895642-8 2015 CRP directly inhibits endothelial cell nitric oxide (NO) production via destabilizing endothelial NO synthase (eNOS). Nitric Oxide 39-51 C-reactive protein Homo sapiens 0-3 24141169-5 2014 Intraluminal treatment of pressurized arterioles with a pathophysiological level of CRP (7 microg/mL; 60 minutes) attenuated endothelium-dependent nitric oxide-mediated and prostacyclin-mediated dilations to serotonin and arachidonic acid, respectively. Nitric Oxide 147-159 C-reactive protein Homo sapiens 84-87 25445628-9 2014 Nitric oxide in Group I showed a significant positive correlation with morning stiffness (r=0.45), arthritis (r=0.43), platelet count (r=0.46), erythrocyte sedimentation rate (r=0.83), C-reactive protein (r=0.76) and Disease Activity Score (r=0.85). Nitric Oxide 0-12 C-reactive protein Homo sapiens 185-203 24141169-11 2014 CONCLUSIONS: CRP elicits endothelium-dependent oxidative stress and compromises nitric oxide-mediated and prostacyclin-mediated vasomotor function via LOX-1 activation. Nitric Oxide 80-92 C-reactive protein Homo sapiens 13-16 21980169-10 2011 Pretreatment of HAECs with sepiapterin or diethylenetriamine NONOate, both of which preserve nitric oxide (NO), resulted in attenuation of CRP"s effects on CECs and EMPs. Nitric Oxide 93-105 C-reactive protein Homo sapiens 139-142 20216206-2 2010 It works mainly in the hypothalamus at thirst signal, but given its closed connections with inflammatory and endothelial systems, also has been postulated that it may exert a regulatory control over blood pressure (BP), interacting with nitric oxide (NO) and C reactive protein (CRP). Nitric Oxide 237-249 C-reactive protein Homo sapiens 279-282 19501581-12 2009 CRP can also accelerate atherosclerosis by increasing the expression of PAI-1 and adhesion molecules in endothelial cells, inhibition of nitric oxide formation and increasing LDL uptake into macrophages. Nitric Oxide 137-149 C-reactive protein Homo sapiens 0-3 20436910-3 2010 A role of CRP to protect endothelium-derived nitric oxide (EDNO) has been suggested. Nitric Oxide 45-57 C-reactive protein Homo sapiens 10-13 20436910-3 2010 A role of CRP to protect endothelium-derived nitric oxide (EDNO) has been suggested. Nitric Oxide 59-63 C-reactive protein Homo sapiens 10-13 20436910-4 2010 We examined the association of CRP with EDNO-dependent vasomotor function and subclinical measures of atherosclerosis and arteriosclerosis in patients with raised CRP resulting from rheumatoid arthritis (RA). Nitric Oxide 40-44 C-reactive protein Homo sapiens 31-34 20436910-8 2010 CONCLUSIONS/SIGNIFICANCE: These findings argue against a causal role of CRP in atherogenesis and are consistent with a protective effect of CRP on EDNO bioavailability. Nitric Oxide 147-151 C-reactive protein Homo sapiens 140-143 19268941-2 2009 We have previously shown that CRP decreases endothelial nitric oxide synthase (eNOS) activity in endothelial cells and inhibits endothelium-dependent nitric oxide (NO)-mediated vasodilation in vitro. Nitric Oxide 56-68 C-reactive protein Homo sapiens 30-33 18436840-0 2008 C-reactive protein inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production. Nitric Oxide 50-62 C-reactive protein Homo sapiens 0-18 18254451-9 2007 CRP induces tissue factor secretion from monocytes, enhances the expression of adhesion molecules and inhibits production of nitric oxide and prostacycline by human endothelial cells. Nitric Oxide 125-137 C-reactive protein Homo sapiens 0-3 17467420-4 2007 We have previously demonstrated that C-reactive protein impairs endothelial cell nitric oxide production. Nitric Oxide 81-93 C-reactive protein Homo sapiens 37-55 17467420-6 2007 We therefore sought to determine whether endothelin-1 exposure modulates C-reactive protein"s effects on nitric oxide production via protein kinase C. METHODS: Endothelial cells were incubated with C-reactive protein (200 microg), endothelin-1 (100 nM), C-reactive protein + endothelin-1, or phosphate-buffered saline solution (control) for 24 hours. Nitric Oxide 105-117 C-reactive protein Homo sapiens 73-91 17467420-9 2007 C-reactive protein produced a 47% decrease in nitric oxide production compared with control. Nitric Oxide 46-58 C-reactive protein Homo sapiens 0-18 17467420-14 2007 CONCLUSIONS: Our results indicate that endothelin-1 exposure accentuated C-reactive protein"s impairment of endothelial nitric oxide production via synergistic inhibition of protein kinase C lambda translocation and activity. Nitric Oxide 120-132 C-reactive protein Homo sapiens 73-91