PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18074035-1 2007 BACKGROUND: Nitrosylcobalamin (NO-Cbl) is a chemotherapeutic pro-drug derived from vitamin B12 that preferentially delivers nitric oxide (NO) to tumor cells, based upon increased receptor expression. Nitric Oxide 124-136 Cbl proto-oncogene Homo sapiens 34-37 26246372-1 2015 The interaction with nitric oxide (NO) is an important aspect of the biological activity of vitamin B12 (Cbl). Nitric Oxide 21-33 Cbl proto-oncogene Homo sapiens 105-108 11978125-1 2002 Electrochemistry and Raman spectroscopy have shown that aquocob(III)alamin (Cbl(III)) can be reduced by nitric oxide (NO) to form Cbl(II) on an electrode surface. Nitric Oxide 104-116 Cbl proto-oncogene Homo sapiens 64-67 16847314-1 2006 We have previously demonstrated that nitrosylcobalamin (NO-Cbl), an analogue of vitamin B12 that delivers nitric oxide (NO), had potent antiproliferative activity against several human cancer cell lines. Nitric Oxide 106-118 Cbl proto-oncogene Homo sapiens 59-62 12881518-1 2003 We have previously demonstrated the anti-tumor activity of nitrosylcobalamin (NO-Cbl), an analog of vitamin B12 that delivers nitric oxide (NO) and increases the expression of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) and its receptors in human tumors. Nitric Oxide 126-138 Cbl proto-oncogene Homo sapiens 81-84 11978125-1 2002 Electrochemistry and Raman spectroscopy have shown that aquocob(III)alamin (Cbl(III)) can be reduced by nitric oxide (NO) to form Cbl(II) on an electrode surface. Nitric Oxide 104-116 Cbl proto-oncogene Homo sapiens 76-84 11978125-1 2002 Electrochemistry and Raman spectroscopy have shown that aquocob(III)alamin (Cbl(III)) can be reduced by nitric oxide (NO) to form Cbl(II) on an electrode surface. Nitric Oxide 104-116 Cbl proto-oncogene Homo sapiens 76-79 11583539-1 2001 The reduced form of aquacobalamin binds nitric oxide very effectively to yield a nitrosyl adduct, Cbl(II)-NO. Nitric Oxide 40-52 Cbl proto-oncogene Homo sapiens 98-108 9580611-1 1998 Recent reports indicate that oxidized cobalamin, Cbl(III), can interfere with the biological effects of nitric oxide (NO) on vascular and visceral smooth muscle and in other systems. Nitric Oxide 104-116 Cbl proto-oncogene Homo sapiens 49-52 9580611-8 1998 Nitric oxide also reacts rapidly and irreversibly with the superoxo complex of Cbl(III), Cbl(III)O2-, which is always present in aerated solutions of Cbl(III). Nitric Oxide 0-12 Cbl proto-oncogene Homo sapiens 79-82 9580611-8 1998 Nitric oxide also reacts rapidly and irreversibly with the superoxo complex of Cbl(III), Cbl(III)O2-, which is always present in aerated solutions of Cbl(III). Nitric Oxide 0-12 Cbl proto-oncogene Homo sapiens 89-92 9580611-8 1998 Nitric oxide also reacts rapidly and irreversibly with the superoxo complex of Cbl(III), Cbl(III)O2-, which is always present in aerated solutions of Cbl(III). Nitric Oxide 0-12 Cbl proto-oncogene Homo sapiens 89-92 33288568-3 2020 We have previously demonstrated the anti-tumor activity of a nitric oxide-donor, nitrosylcobalamin (NO-Cbl), mediated by increased expression of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) and its receptors in human tumors. Nitric Oxide 61-73 Cbl proto-oncogene Homo sapiens 103-106