PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9797040-4	1998	Troglitazone also reduces interleukin-1alpha induced nitric oxide production in pancreatic beta-cells, which may be relevant in preventing nitric oxide mediated damage to these cells in the Type 1 diabetes process.	Nitric Oxide	53-65	interleukin 1 alpha	Mus musculus	26-44	
25047145-9	2014	In addition to the loss of GAGs and tissue mechanical properties, IL-1alpha treatment induced the expression of matrix metalloproteinases and increased the production of the inflammatory mediators nitric oxide and prostaglandin E2 .	Nitric Oxide	197-209	interleukin 1 alpha	Mus musculus	66-75	
9797040-4	1998	Troglitazone also reduces interleukin-1alpha induced nitric oxide production in pancreatic beta-cells, which may be relevant in preventing nitric oxide mediated damage to these cells in the Type 1 diabetes process.	Nitric Oxide	139-151	interleukin 1 alpha	Mus musculus	26-44	
9353295-1	1997	Treatment of mouse astrocyte cultures with combined interleukin (IL)-1alpha and tumor necrosis factor (TNF)-alpha induced expression of inducible nitric-oxide synthase (iNOS), resulting in sustained release of large amounts of nitric oxide, whereas TNF-alpha and IL-1alpha individually were unable to induce iNOS expression in astrocytes.	Nitric Oxide	227-239	interleukin 1 alpha	Mus musculus	52-75	
7508126-2	1994	In vitro exposure of murine endothelial cells to various cytokines (interferon gamma, tumor necrosis factor alpha, and interleukin 1 alpha or 1 beta) resulted in their activation to kill schistosomula through an arginine-dependent mechanism involving production of nitric oxide (NO).	Nitric Oxide	265-277	interleukin 1 alpha	Mus musculus	119-148	
9353295-1	1997	Treatment of mouse astrocyte cultures with combined interleukin (IL)-1alpha and tumor necrosis factor (TNF)-alpha induced expression of inducible nitric-oxide synthase (iNOS), resulting in sustained release of large amounts of nitric oxide, whereas TNF-alpha and IL-1alpha individually were unable to induce iNOS expression in astrocytes.	Nitric Oxide	227-239	interleukin 1 alpha	Mus musculus	263-272	
9353295-4	1997	The p38(MAPK) pathway is specifically involved in TNF-alpha/IL-1alpha-induced iNOS expression, since iNOS protein and nitric oxide release in the presence of a specific inhibitor of p38(MAPK), 4-(4-fluorophenyl)-2-2-(4-hydroxyphenyl)-5-(4-pyridyl)-imidazole (FHPI), were dramatically diminished.	Nitric Oxide	118-130	interleukin 1 alpha	Mus musculus	60-69	
33517187-5	2021	The results showed that XN has the capability to hinder the expression of nitric oxide synthase (INOS), IL-1beta-promoted inducible nitric oxide (NO), necrosis factor-alpha of tumor (TNF-alpha), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) in vitro.	Nitric Oxide	132-144	interleukin 1 alpha	Mus musculus	104-112	
34369548-8	2021	In vitro assays revealed that treatment with 18beta-GA considerably suppressed the expression of pro-inflammatory mediators and cytokines, including prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and interleukin-6 (IL-6), which were induced by IL-1beta.	Nitric Oxide	215-227	interleukin 1 alpha	Mus musculus	348-356	
34927076-4	2022	Treatment with IL-1beta and IFN-gamma stimulates expression of inducible nitric oxide synthase (iNOS) mRNA and antiviral and immune-associated genes as well as repression of islet identity factors in a subset of beta- and non-beta-endocrine cells in a nitric oxide-independent manner.	Nitric Oxide	252-264	interleukin 1 alpha	Mus musculus	15-23	
35064430-9	2022	Treatment with crude extract (TSETOH) and fractions (TSHEX, TSTOL) significantly reduced (P < 0.001) the mRNA expression of pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) and nitric oxide (NO) production in LPS-stimulated inflammation in RAW 264.7 cells in a dose-dependent manner.	Nitric Oxide	183-195	interleukin 1 alpha	Mus musculus	152-160	
33878544-5	2021	In vitro cell experiments, the inflammatory response in chondrocytes is mediated via interleukin-1beta (IL-1beta), which led to abnormal secretion of pro-inflammatory factors, such as prostaglandin E2 (PGE2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cyclooxygenase-2 (COX-2), nitric oxide (NO) and inducible nitric oxide synthase (iNOS).	Nitric Oxide	298-310	interleukin 1 alpha	Mus musculus	104-112	
33443518-9	2021	In vitro assays showed that the maltol pre-treatment significantly inhibited the expressions of multiple inflammatory factors induced by IL-1beta, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-6 (IL-6) and tumor necrosis factor (TNF-alpha).	Nitric Oxide	165-177	interleukin 1 alpha	Mus musculus	137-145	
32150895-6	2020	The present study showed that T. serrulatus venom induces the production of IL-1alpha and IL-1beta in the pancreas, which signal via IL-1R and provoke nitric oxide (NO) production as well as edema in beta-cells in islets.	Nitric Oxide	151-163	interleukin 1 alpha	Mus musculus	76-85	
32150895-6	2020	The present study showed that T. serrulatus venom induces the production of IL-1alpha and IL-1beta in the pancreas, which signal via IL-1R and provoke nitric oxide (NO) production as well as edema in beta-cells in islets.	Nitric Oxide	151-163	interleukin 1 alpha	Mus musculus	90-98