PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29788500-12 2018 CD47 activation likely disrupts nitric oxide ( NO) signaling and promotes leukocyte-endothelial interactions. Nitric Oxide 32-44 CD47 molecule Homo sapiens 0-4 34205047-2 2021 Moreover, TSP1/CD47 interaction has been found to be associated with platelet hyperaggregability and impaired nitric oxide response, exacerbating progression in IRI and PAH. Nitric Oxide 110-122 CD47 molecule Homo sapiens 15-19 29979224-17 2018 Furthermore, we identified direct targeting of CD47 by microRNA-155 as a novel mechanism of myocardial and vascular contractile depression in sepsis, promoting microvascular endothelial cell and vascular insensitivity to thrombospondin-1-mediated inhibition of nitric oxide production and nitric oxide-mediated vasorelaxation, respectively. Nitric Oxide 261-273 CD47 molecule Homo sapiens 47-51 29979224-17 2018 Furthermore, we identified direct targeting of CD47 by microRNA-155 as a novel mechanism of myocardial and vascular contractile depression in sepsis, promoting microvascular endothelial cell and vascular insensitivity to thrombospondin-1-mediated inhibition of nitric oxide production and nitric oxide-mediated vasorelaxation, respectively. Nitric Oxide 289-301 CD47 molecule Homo sapiens 47-51 20923780-8 2010 These results reveal that anti-angiogenic signaling through CD47 is highly redundant and extends beyond inhibition of nitric oxide signaling to global inhibition of VEGFR2 signaling. Nitric Oxide 118-130 CD47 molecule Homo sapiens 60-64 25482981-3 2015 We investigated whether blocking the CD47/thrombospondin-1 inhibitory action on nitric oxide signaling with a monoclonal antibody specific to CD47 (CD47mAb400) would reduce IRI in liver grafts. Nitric Oxide 80-92 CD47 molecule Homo sapiens 37-41 25482981-3 2015 We investigated whether blocking the CD47/thrombospondin-1 inhibitory action on nitric oxide signaling with a monoclonal antibody specific to CD47 (CD47mAb400) would reduce IRI in liver grafts. Nitric Oxide 80-92 CD47 molecule Homo sapiens 142-146 25482981-3 2015 We investigated whether blocking the CD47/thrombospondin-1 inhibitory action on nitric oxide signaling with a monoclonal antibody specific to CD47 (CD47mAb400) would reduce IRI in liver grafts. Nitric Oxide 80-92 CD47 molecule Homo sapiens 148-158 27331362-3 2016 Steatotic livers are more susceptible to ischemia-reperfusion injury (IRI), which is exacerbated by the thrombospondin-1/CD47 pathway through inhibition of nitric oxide signaling. Nitric Oxide 156-168 CD47 molecule Homo sapiens 121-125 18187671-3 2008 The recent discovery that thrombospondin-1 acts via CD47 to inhibit nitric oxide signaling throughout the vascular system has given new importance and perhaps a unifying mechanism of action to these enigmatic proteins. Nitric Oxide 68-80 CD47 molecule Homo sapiens 52-56