PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16340449-0 2005 Chronic ethanol exposure stimulates endothelial cell nitric oxide production through PI-3 kinase-and hsp90-dependent mechanisms. Nitric Oxide 53-65 heat shock protein 90 alpha family class A member 1 Homo sapiens 101-106 30828931-1 2019 OBJECTIVES: Heat shock protein 90 (HSP90) contributes to cutaneous vasodilatation during exercise in the heat through nitric oxide (NO) synthase (NOS)-dependent mechanisms in young adults. Nitric Oxide 118-130 heat shock protein 90 alpha family class A member 1 Homo sapiens 12-33 30828931-1 2019 OBJECTIVES: Heat shock protein 90 (HSP90) contributes to cutaneous vasodilatation during exercise in the heat through nitric oxide (NO) synthase (NOS)-dependent mechanisms in young adults. Nitric Oxide 118-130 heat shock protein 90 alpha family class A member 1 Homo sapiens 35-40 31263819-3 2019 Further study revealed that ART suppressed the production of nitric oxide (NO) in macrophages via inhibiting the interaction between HSP90 and inducible NO synthase (iNOS). Nitric Oxide 61-73 heat shock protein 90 alpha family class A member 1 Homo sapiens 133-138 27627558-1 2016 BACKGROUND: Hypertension-induced endothelial dysfunction is associated with an impaired bioavailability of nitric oxide regulated through interactions between nitric oxide synthase and heat shock protein-90 (Hsp-90). Nitric Oxide 107-119 heat shock protein 90 alpha family class A member 1 Homo sapiens 185-206 27627558-1 2016 BACKGROUND: Hypertension-induced endothelial dysfunction is associated with an impaired bioavailability of nitric oxide regulated through interactions between nitric oxide synthase and heat shock protein-90 (Hsp-90). Nitric Oxide 107-119 heat shock protein 90 alpha family class A member 1 Homo sapiens 208-214 25935150-0 2015 Amyloid beta peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation. Nitric Oxide 55-67 heat shock protein 90 alpha family class A member 1 Homo sapiens 132-137 24019877-2 2013 Nitric oxide (NO) is synthesised by nitric oxide synthase (NOS), which is a client protein of the molecular chaperon heat shock protein 90 (HSP90). Nitric Oxide 0-12 heat shock protein 90 alpha family class A member 1 Homo sapiens 140-145 17827253-0 2007 Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90. Nitric Oxide 0-12 heat shock protein 90 alpha family class A member 1 Homo sapiens 75-80 17337508-2 2007 The conformational state of bound Hsp90 determines whether eNOS produces nitric oxide (NO) or superoxide (O(2)(*-)). Nitric Oxide 73-85 heat shock protein 90 alpha family class A member 1 Homo sapiens 34-39 17012359-0 2007 Nitric oxide preconditioning regulates endothelial monolayer integrity via the heat shock protein 90-soluble guanylate cyclase pathway. Nitric Oxide 0-12 heat shock protein 90 alpha family class A member 1 Homo sapiens 79-100 26134567-1 2015 Heat shock protein 90 (hsp90) drives heme insertion into the beta1 subunit of soluble guanylate cyclase (sGC) beta1, which enables it to associate with a partner sGCalpha1 subunit and mature into a nitric oxide (NO)-responsive active form. Nitric Oxide 198-210 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-21 26134567-1 2015 Heat shock protein 90 (hsp90) drives heme insertion into the beta1 subunit of soluble guanylate cyclase (sGC) beta1, which enables it to associate with a partner sGCalpha1 subunit and mature into a nitric oxide (NO)-responsive active form. Nitric Oxide 198-210 heat shock protein 90 alpha family class A member 1 Homo sapiens 23-28 21063103-0 2010 Opposite effect of Hsp90alpha and Hsp90beta on eNOS ability to produce nitric oxide or superoxide anion in human embryonic kidney cells. Nitric Oxide 71-83 heat shock protein 90 alpha family class A member 1 Homo sapiens 19-29 19763143-0 2009 Just say NO: nitric oxide regulation of Hsp90. Nitric Oxide 13-25 heat shock protein 90 alpha family class A member 1 Homo sapiens 40-45 19194158-10 2009 Pretreatment with Hsp90 inhibitors abolished isoflurane-dependent nitric oxide production and decreased Hsp90-eNOS interactions. Nitric Oxide 66-78 heat shock protein 90 alpha family class A member 1 Homo sapiens 18-23 18682401-0 2008 Functional role of HSP90 complexes with endothelial nitric-oxide synthase (eNOS) and calpain on nitric oxide generation in endothelial cells. Nitric Oxide 96-108 heat shock protein 90 alpha family class A member 1 Homo sapiens 19-24 17878410-5 2007 Studies examining the interactions between NOS-3, beta-actin, and Hsp90 could potentially lead to the discovery of effective peptides for the treatment of diseases associated with impaired NOS-3 activity and nitric oxide release, such as systemic and pulmonary hypertension, atherosclerosis, and thrombotic diseases. Nitric Oxide 208-220 heat shock protein 90 alpha family class A member 1 Homo sapiens 66-71 14555685-1 2004 This study examines the notion that heat shock protein (HSP) 90 binding to nitric oxide (NO), endothelial NO synthase (eNOS), and PI3K-Akt regulate angiopoietin (Ang)-1-induced angiogenesis in porcine coronary artery endothelial cells (PCAEC). Nitric Oxide 75-87 heat shock protein 90 alpha family class A member 1 Homo sapiens 36-63 15977996-5 2005 This paper presents data on how hsp90 is important to fungi and what role it might play in human disease with possible interactions with interleukin 6 and nitric oxide. Nitric Oxide 155-167 heat shock protein 90 alpha family class A member 1 Homo sapiens 32-37 11698240-1 2001 Recent studies showed that heat shock protein 90 (HSP90) enhances nitric oxide (NO) synthesis from endothelial and neuronal NO synthase (eNOS and nNOS, respectively). Nitric Oxide 66-78 heat shock protein 90 alpha family class A member 1 Homo sapiens 27-48 11698240-1 2001 Recent studies showed that heat shock protein 90 (HSP90) enhances nitric oxide (NO) synthesis from endothelial and neuronal NO synthase (eNOS and nNOS, respectively). Nitric Oxide 66-78 heat shock protein 90 alpha family class A member 1 Homo sapiens 50-55 9580552-2 1998 Here we show that Hsp90 associates with endothelial nitric oxide synthase (eNOS) and is rapidly recruited to the eNOS complex by agonists that stimulate production of nitric oxide, namely vascular endothelial growth factor, histamine and fluid shear stress. Nitric Oxide 52-64 heat shock protein 90 alpha family class A member 1 Homo sapiens 18-23 9580552-4 1998 Inhibition of signalling through Hsp90 attenuates both agonist-stimulated production of nitric oxide and endothelium-dependent relaxation of isolated blood vessels. Nitric Oxide 88-100 heat shock protein 90 alpha family class A member 1 Homo sapiens 33-38 31963524-7 2020 We focused on the implication of Hsp90 and Hsp70 in control under expression of neuronal nitric oxide synthase, localization of the enzyme, and further generation of nitro-oxidative stress. Nitric Oxide 89-101 heat shock protein 90 alpha family class A member 1 Homo sapiens 33-38 11701613-0 2001 Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. Nitric Oxide 57-69 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-5 33603951-9 2021 HSPs are multifunctional proteins because they closely interact with the antioxidant and the nitric oxide generation systems, such as HSP70/HSP90/NOS. Nitric Oxide 93-105 heat shock protein 90 alpha family class A member 1 Homo sapiens 140-145 32573772-0 2020 Heat shock protein 90 enhances the electron transfer between the FMN and heme cofactors in neuronal nitric oxide synthase. Nitric Oxide 100-112 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-21 31963524-9 2020 Herein, we evidenced that inhibition of Hsp90 controls the protein expression of 2-methoxyestradiol-induced neuronal nitric oxide synthase and inhibits enzyme nuclear translocation. Nitric Oxide 117-129 heat shock protein 90 alpha family class A member 1 Homo sapiens 40-45 31963524-10 2020 We propose that decreased level of neuronal nitric oxide synthase protein after a combined treatment with 2-methoxyestradiol and geldanamycin is directly associated with the accompanying upregulation of Hsp70 and downregulation of Hsp90. Nitric Oxide 44-56 heat shock protein 90 alpha family class A member 1 Homo sapiens 231-236 35563784-0 2022 HSP90 Modulates T2R Bitter Taste Receptor Nitric Oxide Production and Innate Immune Responses in Human Airway Epithelial Cells and Macrophages. Nitric Oxide 42-54 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-5 33150887-1 2020 An intelligent nitric oxide gas-releasing nanoplatform based on CuS-nanoplates has been designed to overcome the heat endurance of tumor cells by the inhibition of HSP90 expression with the released NO gas in mitochondria and thereby realize enhanced PTT under mild temperature conditions. Nitric Oxide 15-27 heat shock protein 90 alpha family class A member 1 Homo sapiens 164-169