PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31838904-6	2020	Pharmacological inhibition of Sphk1 improved endothelial function of arteries of hypertensive mice that could be mediated via decrease in eNOS (endothelial nitric oxide synthase) phosphorylation at T495.	Nitric Oxide	156-168	sphingosine kinase 1	Mus musculus	30-35	
20036321-0	2010	Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.	Nitric Oxide	79-91	sphingosine kinase 1	Mus musculus	0-20	
20036321-3	2010	In this study, we demonstrate that sphingosine kinase1 (SphK1), a key enzyme of the sphingolipid metabolic pathway, and its receptors are expressed in the mouse BV2 microglial cells and SphK1 alters the expression and production of proinflammatory cytokines and nitric oxide in microglia treated with lipopolysaccharide (LPS).	Nitric Oxide	262-274	sphingosine kinase 1	Mus musculus	35-54	
20036321-3	2010	In this study, we demonstrate that sphingosine kinase1 (SphK1), a key enzyme of the sphingolipid metabolic pathway, and its receptors are expressed in the mouse BV2 microglial cells and SphK1 alters the expression and production of proinflammatory cytokines and nitric oxide in microglia treated with lipopolysaccharide (LPS).	Nitric Oxide	262-274	sphingosine kinase 1	Mus musculus	56-61	
20036321-3	2010	In this study, we demonstrate that sphingosine kinase1 (SphK1), a key enzyme of the sphingolipid metabolic pathway, and its receptors are expressed in the mouse BV2 microglial cells and SphK1 alters the expression and production of proinflammatory cytokines and nitric oxide in microglia treated with lipopolysaccharide (LPS).	Nitric Oxide	262-274	sphingosine kinase 1	Mus musculus	186-191	
20036321-5	2010	Suppression of SphK1 by its inhibitor, N, N Dimethylsphingosine (DMS), or siRNA resulted in decreased mRNA expression of TNF-alpha, IL-1beta, and iNOS and release of TNF-alpha and nitric oxide (NO) in LPS-activated microglia.	Nitric Oxide	180-192	sphingosine kinase 1	Mus musculus	15-20