PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14617628-0 2004 JNK-dependent phosphorylation of c-Jun on serine 63 mediates nitric oxide-induced apoptosis of neuroblastoma cells. Nitric Oxide 61-73 mitogen-activated protein kinase 8 Homo sapiens 0-3 15970429-1 2006 Our previous studies demonstrated that high glucose-induced apoptosis in human umbilical vein endothelial cells (HUVECs) is mediated by sequential activation of c-Jun N-terminal kinase (JNK) and caspase, and prevented by exogenous nitric oxide (NO). Nitric Oxide 231-243 mitogen-activated protein kinase 8 Homo sapiens 186-189 16158421-0 2006 Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric oxide in human glioblastoma cells. Nitric Oxide 75-87 mitogen-activated protein kinase 8 Homo sapiens 33-36 16307444-7 2006 These results underscore the neuroprotective potential of JNK inhibitor and alpha-tocopherol, in the sense that both agents could rescue dopaminergic neurons under inflammatory conditions associated with robust increases in nitric oxide production. Nitric Oxide 224-236 mitogen-activated protein kinase 8 Homo sapiens 58-61 16413574-0 2006 Activation of JNK and xanthine oxidase by TNF-alpha impairs nitric oxide-mediated dilation of coronary arterioles. Nitric Oxide 60-72 mitogen-activated protein kinase 8 Homo sapiens 14-17 14661860-0 2003 JNK/SAPK is required in nitric oxide-induced apoptosis in osteoblasts. Nitric Oxide 24-36 mitogen-activated protein kinase 8 Homo sapiens 0-3 32201424-0 2020 Induction of PD-L1 by Nitric Oxide via JNK Activation in A172 Glioblastoma Cells. Nitric Oxide 22-34 mitogen-activated protein kinase 8 Homo sapiens 39-42 9354637-3 1997 Here, we demonstrate that nitric oxide induced the stimulation of c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase (SAPK) in intact cells. Nitric Oxide 26-38 mitogen-activated protein kinase 8 Homo sapiens 66-91 9354637-3 1997 Here, we demonstrate that nitric oxide induced the stimulation of c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase (SAPK) in intact cells. Nitric Oxide 26-38 mitogen-activated protein kinase 8 Homo sapiens 93-96 9354637-4 1997 Exposure of cultured HEK293 cells to sodium nitroprusside, a nitric oxide releasing agent, resulted in the stimulation of JNK1 activity. Nitric Oxide 61-73 mitogen-activated protein kinase 8 Homo sapiens 122-126 9354637-6 1997 Nitric oxide production from HEK293 cells ectopically expressing nitric oxide synthases resulted in the stimulation of JNK1 activity, while JNK1 stimulation in nitric oxide synthase-overexpressing cells was abrogated by a nitric oxide synthase inhibitor, NG-nitro-L-arginine. Nitric Oxide 0-12 mitogen-activated protein kinase 8 Homo sapiens 119-123 9354637-6 1997 Nitric oxide production from HEK293 cells ectopically expressing nitric oxide synthases resulted in the stimulation of JNK1 activity, while JNK1 stimulation in nitric oxide synthase-overexpressing cells was abrogated by a nitric oxide synthase inhibitor, NG-nitro-L-arginine. Nitric Oxide 0-12 mitogen-activated protein kinase 8 Homo sapiens 140-144 9354637-8 1997 Taken together, our data suggest that nitric oxide modulates the JNK activity through activating JNKK1/SEK1. Nitric Oxide 38-50 mitogen-activated protein kinase 8 Homo sapiens 65-68 26086160-0 2015 Reactive oxygen species mediate nitric oxide production through ERK/JNK MAPK signaling in HAPI microglia after PFOS exposure. Nitric Oxide 32-44 mitogen-activated protein kinase 8 Homo sapiens 68-71 30026697-6 2018 Cardioprotective and neuroprotective mechanisms of JNK inhibitors are discussed in detail including synthetic small molecule inhibitors (AS601245, SP600125, IQ-1S, and SR-3306), ion channel inhibitor GsMTx4, JNK-interacting proteins, inhibitors of mixed-lineage kinase (MLK) and MLK-interacting proteins, inhibitors of glutamate receptors, nitric oxide (NO) donors, and anesthetics. Nitric Oxide 340-352 mitogen-activated protein kinase 8 Homo sapiens 51-54 31927008-0 2020 FSTL1 promotes nitric oxide-induced chondrocyte apoptosis via activating the SAPK/JNK/ caspase3 signaling pathway. Nitric Oxide 15-27 mitogen-activated protein kinase 8 Homo sapiens 82-85 29716662-0 2018 Nitric oxide balances osteoblast and adipocyte lineage differentiation via the JNK/MAPK signaling pathway in periodontal ligament stem cells. Nitric Oxide 0-12 mitogen-activated protein kinase 8 Homo sapiens 79-82 26800561-7 2016 Inhibition of Wnt5a and JNK signaling restored insulin and A23187-mediated eNOS activation and improved nitric oxide production in endothelial cells from patients with diabetes mellitus. Nitric Oxide 104-116 mitogen-activated protein kinase 8 Homo sapiens 24-27 26800561-9 2016 In human aortic endothelial cells, Wnt5a-induced impairment of eNOS activation and nitric oxide production was reversed by Wnt5a and JNK inhibition. Nitric Oxide 83-95 mitogen-activated protein kinase 8 Homo sapiens 133-136 24863670-0 2015 Nitric oxide induces apoptosis in human gingival fibroblast through mitochondria-dependent pathway and JNK activation. Nitric Oxide 0-12 mitogen-activated protein kinase 8 Homo sapiens 103-106 26491301-8 2015 Following, by using specific MAPK inhibitors, we observed that lipopolysaccharide-induced production of monocyte chemotactic protein-1 and nitric oxide was significantly inhibited on the Ti/TiO2 surface via p38 and ERK1/2, but not via JNK. Nitric Oxide 139-151 mitogen-activated protein kinase 8 Homo sapiens 235-238 26491301-9 2015 However, the selective inhibitor for JNK signaling pathway (SP600125) was effective in reducing tumor necrosis factor alpha release as well as monocyte chemotactic protein-1 and nitric oxide production. Nitric Oxide 178-190 mitogen-activated protein kinase 8 Homo sapiens 37-40 24863670-11 2015 CONCLUSION: Nitric oxide induced apoptosis in human gingival fibroblast through the mitochondria-mediated pathway by regulation of Bcl-2 family and JNK activation. Nitric Oxide 12-24 mitogen-activated protein kinase 8 Homo sapiens 148-151 24501244-0 2014 Nitric oxide inhibits autophagy via suppression of JNK in meniscal cells. Nitric Oxide 0-12 mitogen-activated protein kinase 8 Homo sapiens 52-55 24359220-6 2014 Stimulation of nitric oxide formation causes S-nitrosylation of several kinases, including JNK1 and IkappaB kinase beta, which blocks autophagy and could promote apoptosis. Nitric Oxide 15-27 mitogen-activated protein kinase 8 Homo sapiens 91-95 23859017-4 2013 Cytotoxic concentrations of the nitric oxide donor sodium nitroprusside activated several proapoptotic mechanisms, including stimulation of the stress kinase pathways mediated by c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), inhibition of the translation initiation factor eIF2alpha, induction and phosphorylation of the p53 protein, and inhibited Akt-mediated antiapoptotic signaling, independent of Ras function. Nitric Oxide 32-44 mitogen-activated protein kinase 8 Homo sapiens 179-202 23859017-4 2013 Cytotoxic concentrations of the nitric oxide donor sodium nitroprusside activated several proapoptotic mechanisms, including stimulation of the stress kinase pathways mediated by c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), inhibition of the translation initiation factor eIF2alpha, induction and phosphorylation of the p53 protein, and inhibited Akt-mediated antiapoptotic signaling, independent of Ras function. Nitric Oxide 32-44 mitogen-activated protein kinase 8 Homo sapiens 204-207 22920281-0 2012 Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation. Nitric Oxide 0-12 mitogen-activated protein kinase 8 Homo sapiens 103-106 23595304-0 2013 [Role of JNK signaling pathway in chondrocyte apoptosis induced by nitric oxide]. Nitric Oxide 67-79 mitogen-activated protein kinase 8 Homo sapiens 9-12 23595304-1 2013 OBJECTIVE: To study the role of c-jun N-terminal kinase (JNK) signaling pathway in chondrocyte apoptosis induced by nitric oxide (NO) using NO donor sodium nitroprusside (SNP) and JNK inhibitor SP600125. Nitric Oxide 116-128 mitogen-activated protein kinase 8 Homo sapiens 32-55 23595304-1 2013 OBJECTIVE: To study the role of c-jun N-terminal kinase (JNK) signaling pathway in chondrocyte apoptosis induced by nitric oxide (NO) using NO donor sodium nitroprusside (SNP) and JNK inhibitor SP600125. Nitric Oxide 116-128 mitogen-activated protein kinase 8 Homo sapiens 57-60 22920281-0 2012 Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation. Nitric Oxide 0-12 mitogen-activated protein kinase 8 Homo sapiens 191-194 21709153-0 2011 Activated microglia are less vulnerable to hemin toxicity due to nitric oxide-dependent inhibition of JNK and p38 MAPK activation. Nitric Oxide 65-77 mitogen-activated protein kinase 8 Homo sapiens 102-105 21933914-7 2012 These events were associated with regulation of mitogen-activated protein kinases (MAPK; including p38 MAPK, JNK, and ERK) phosphorylation and promoted downstream nitric oxide (NO) production. Nitric Oxide 163-175 mitogen-activated protein kinase 8 Homo sapiens 109-112 21541041-3 2011 In the current study, pretreatment with nitric oxide (NO) scavengers inhibited PDT-induced mitochondrial membrane potential (MMP) changes, activation of caspase-9, caspase-3, p21-activated protein kinase 2 (PAK2) and c-Jun N-terminal kinase (JNK), and gene expression of p53 and p21 involved in apoptotic signaling. Nitric Oxide 40-52 mitogen-activated protein kinase 8 Homo sapiens 217-240 21541041-3 2011 In the current study, pretreatment with nitric oxide (NO) scavengers inhibited PDT-induced mitochondrial membrane potential (MMP) changes, activation of caspase-9, caspase-3, p21-activated protein kinase 2 (PAK2) and c-Jun N-terminal kinase (JNK), and gene expression of p53 and p21 involved in apoptotic signaling. Nitric Oxide 40-52 mitogen-activated protein kinase 8 Homo sapiens 242-245 18523870-0 2007 Effect of nitric oxide donor and gamma irradiation on modifications of ERK and JNK in murine peritoneal macrophages. Nitric Oxide 10-22 mitogen-activated protein kinase 8 Homo sapiens 79-82 27713248-5 2010 It was discovered that the stress-protective activity of adaptogens was associated with regulation of homeostasis via several mechanisms of action, which was linked with the hypothalamic-pituitary-adrenal axis and the regulation of key mediators of stress response, such as molecular chaperons (e.g., HSP70), stress-activated c-Jun N-terminal protein kinase 1 (JNK1), Forkhead box O (FOXO) transcription factor DAF-16, cortisol and nitric oxide. Nitric Oxide 432-444 mitogen-activated protein kinase 8 Homo sapiens 326-359 27713248-5 2010 It was discovered that the stress-protective activity of adaptogens was associated with regulation of homeostasis via several mechanisms of action, which was linked with the hypothalamic-pituitary-adrenal axis and the regulation of key mediators of stress response, such as molecular chaperons (e.g., HSP70), stress-activated c-Jun N-terminal protein kinase 1 (JNK1), Forkhead box O (FOXO) transcription factor DAF-16, cortisol and nitric oxide. Nitric Oxide 432-444 mitogen-activated protein kinase 8 Homo sapiens 361-365 19648647-0 2009 Repair of nitric oxide-damaged DNA in beta-cells requires JNK-dependent GADD45alpha expression. Nitric Oxide 10-22 mitogen-activated protein kinase 8 Homo sapiens 58-61 19648647-4 2009 JNK plays a central regulatory role because inhibition of this kinase attenuates the repair of nitric oxide-induced DNA damage. Nitric Oxide 95-107 mitogen-activated protein kinase 8 Homo sapiens 0-3 19648647-7 2009 In contrast, expression of growth arrest and DNA damage (GADD) 45alpha, a DNA repair gene that can be regulated by p53-dependent and p53-independent pathways, is stimulated by nitric oxide in a JNK-dependent manner, and knockdown of GADD45alpha expression attenuates the repair of nitric oxide-induced beta-cell DNA damage. Nitric Oxide 176-188 mitogen-activated protein kinase 8 Homo sapiens 194-197 19648647-7 2009 In contrast, expression of growth arrest and DNA damage (GADD) 45alpha, a DNA repair gene that can be regulated by p53-dependent and p53-independent pathways, is stimulated by nitric oxide in a JNK-dependent manner, and knockdown of GADD45alpha expression attenuates the repair of nitric oxide-induced beta-cell DNA damage. Nitric Oxide 281-293 mitogen-activated protein kinase 8 Homo sapiens 194-197 18855718-6 2008 Angiotensin II acting through the AT1 receptor can inhibit insulin-induced nitric oxide (NO) production by activating ERK 1/2 and JNK and enhances the activity of NADPH oxidase that leads to an increased reactive oxygen species generation. Nitric Oxide 75-87 mitogen-activated protein kinase 8 Homo sapiens 130-133 17262823-0 2007 Pretreatment with low nitric oxide protects osteoblasts from high nitric oxide-induced apoptotic insults through regulation of c-Jun N-terminal kinase/c-Jun-mediated Bcl-2 gene expression and protein translocation. Nitric Oxide 22-34 mitogen-activated protein kinase 8 Homo sapiens 127-150 17262823-0 2007 Pretreatment with low nitric oxide protects osteoblasts from high nitric oxide-induced apoptotic insults through regulation of c-Jun N-terminal kinase/c-Jun-mediated Bcl-2 gene expression and protein translocation. Nitric Oxide 66-78 mitogen-activated protein kinase 8 Homo sapiens 127-150 16887914-0 2006 Interleukin-1beta signals through a c-Jun N-terminal kinase-dependent inducible nitric oxide synthase and nitric oxide production pathway in Sertoli epithelial cells. Nitric Oxide 80-92 mitogen-activated protein kinase 8 Homo sapiens 36-59