PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29351386-0	2018	Protective effect of C-peptide on experimentally induced diabetic nephropathy and the possible link between C-peptide and nitric oxide.	Nitric Oxide	122-134	insulin 2	Rattus norvegicus	108-117	
29351386-3	2018	We described the role of C-peptide replacement therapy on experimentally induced diabetic nephropathy, and its potential mechanisms of action by studying the role of nitric oxide (NO) as a mediator of C-peptide effects by in vivo modulating its production by NG-nitro-l-arginine methyl ester (L-NAME).	Nitric Oxide	166-178	insulin 2	Rattus norvegicus	201-210	
12829651-2	2003	This could be due to a direct action on nerve fibers or via vascular mechanisms as C-peptide stimulates the nitric oxide (NO) system and NO-mediated vasodilation could potentially account for any beneficial C-peptide effects.	Nitric Oxide	108-120	insulin 2	Rattus norvegicus	83-92	
11053258-1	2000	C-peptide is a cleavage product that comes from processing proinsulin to insulin that induces nitric oxide (NO) -mediated vasodilation.	Nitric Oxide	94-106	insulin 2	Rattus norvegicus	0-9	
10199846-7	1999	These results indicate that C-peptide has the capacity to evoke arteriolar dilation in skeletal muscle via a nitric oxide-mediated mechanism that appears to be enhanced by an interaction with insulin.	Nitric Oxide	109-121	insulin 2	Rattus norvegicus	28-37