PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34085601-0 2021 Resveratrol acts via melanoma-associated antigen A12 (MAGEA12)/protein kinase B (Akt) signaling to inhibit the proliferation of oral squamous cell carcinoma cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 81-84 34935193-9 2022 RES also inhibits the PI3K/Akt/mTOR pathway to induce apoptosis. Resveratrol 0-3 AKT serine/threonine kinase 1 Homo sapiens 27-30 34085601-1 2021 The present study examined how resveratrol affects cell growth and MAGEA12/Akt signaling pathway in OSCC cells. Resveratrol 31-42 AKT serine/threonine kinase 1 Homo sapiens 75-78 34085601-9 2021 Furthermore, resveratrol could inhibit the proliferation and colony in Cal-27 cells and decrease the expressions of MAGEA12 and p-Akt depending on the time and concentration. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 130-133 34085601-11 2021 In summary, resveratrol may suppress the growth of OSCC cells by inactivating MAGEA12/Akt signaling. Resveratrol 12-23 AKT serine/threonine kinase 1 Homo sapiens 86-89 34832850-3 2021 We found that both curcumin and resveratrol were efficient in reducing cancer cell survival and that they differently affected autophagy, ROS and activation of the PI3K/AKT/mTOR pathway. Resveratrol 32-43 AKT serine/threonine kinase 1 Homo sapiens 169-172 34791915-7 2021 CONCLUSION: The present study concludes that the combination of curcumin and resveratrol significantly sensitized the EOC cells to cisplatin treatment, thereby inhibiting chemoresistance in ovarian cancer cells by significant inhibition of the PI3K/AKT/mTOR pathway. Resveratrol 78-89 AKT serine/threonine kinase 1 Homo sapiens 250-253 34966970-4 2021 In triethylsilyl resveratrol treated HuH7 cells expression of activated PI3K and Akt proteins showed a prominent decrease compared to the control cells. Resveratrol 17-28 AKT serine/threonine kinase 1 Homo sapiens 81-84 34512368-3 2021 In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53. Resveratrol 113-124 AKT serine/threonine kinase 1 Homo sapiens 306-309 34077275-0 2021 Resveratrol upregulates miR-455-5p to antagonize cisplatin ototoxicity via modulating the PTEN-PI3K-AKT axis. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 100-103 34439500-5 2021 In addition, RES, OXYRES, and their acetylated derivatives suppressed UVB-induced matrix metalloproteinase (MMP)-1 expression via inhibition of mitogen-activated protein kinases (MAPKs) and Akt/mTOR signaling pathways. Resveratrol 13-16 AKT serine/threonine kinase 1 Homo sapiens 190-193 34165165-0 2021 (Retracted) Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways. Resveratrol 32-43 AKT serine/threonine kinase 1 Homo sapiens 98-101 34287272-8 2021 Downregulation of inflammatory cytokine production, and inhibition of AKT, c-Raf, Stat3, and NFkappaB phosphorylation were observed in ARPE-19 cells that were treated with resveratrol. Resveratrol 172-183 AKT serine/threonine kinase 1 Homo sapiens 70-73 34227646-0 2021 Resveratrol prevents inflammation and oxidative stress response in LPS-induced human gingival fibroblasts by targeting the PI3K/AKT and Wnt/beta-catenin signaling pathways. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 128-131 34227646-5 2021 Additionally, RSV-induced deactivation of the PI3K/AKT and Wnt/beta-catenin pathways in LPS-induced HGFs was observed by western blot analysis. Resveratrol 14-17 AKT serine/threonine kinase 1 Homo sapiens 51-54 34227646-6 2021 Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs. Resveratrol 216-219 AKT serine/threonine kinase 1 Homo sapiens 54-57 34227646-7 2021 These results suggested RSV attenuated the inflammation and OS injury of P. gingivalis LPS-treated HGFs by deactivating the PI3K/AKT and Wnt/beta-catenin signaling pathways. Resveratrol 24-27 AKT serine/threonine kinase 1 Homo sapiens 129-132 34073143-5 2021 In addition, resveratrol treatment suppressed the phosphorylation of phosphatidylinositol 3-kinase/AKT and extracellular signal-regulated kinase 1/2. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 99-102 34077275-2 2021 This study explores the effects from the regulation of miR-455-5p by resveratrol on cisplatin-induced ototoxicity via the PTEN-PI3K-AKT signaling pathway. Resveratrol 69-80 AKT serine/threonine kinase 1 Homo sapiens 132-135 35466048-0 2022 Erratum to "Resveratrol prevents TNF-alpha-induced muscle atrophy via regulation of Akt/mTOR/FoxO1 signaling in C2C12 myotubes" (Int. Resveratrol 12-23 AKT serine/threonine kinase 1 Homo sapiens 84-87 35367197-0 2022 Resveratrol sensitizes breast cancer to PARP inhibitor, talazoparib through dual inhibition of AKT and autophagy flux. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 95-98 35367197-8 2022 Intriguingly, our results showed potential of resveratrol in dual-inhibition of AKT-signalling and autophagy flux to impair HR-mediated DSB-repair in breast cancer cells. Resveratrol 46-57 AKT serine/threonine kinase 1 Homo sapiens 80-83 33912959-9 2021 Furthermore, resveratrol promoted autophagy via the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, thereby protecting IEC-6 cells against radiation-induced damage. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 85-88 35399833-7 2022 Resveratrol has obvious effects on regulating glucolipid metabolism, and its mechanism of action is associated with its ability to increase the antioxidant activity of the body, activate the Akt signaling pathway, and improve liver pathological damage. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 191-194 35178649-5 2022 Resveratrol-treated AML-12 hepatocytes showed reduced ratio of the following key metabolic factors: phosphorylated PP2A to total PP2A (pPP2A/PP2A), pAKT/AKT, pFOXO1/FOXO1 and pAMPK/AMPK, indicating inhibition of AKT and AMPK, but activation of PP2A and FOXO1. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 153-156 35178649-5 2022 Resveratrol-treated AML-12 hepatocytes showed reduced ratio of the following key metabolic factors: phosphorylated PP2A to total PP2A (pPP2A/PP2A), pAKT/AKT, pFOXO1/FOXO1 and pAMPK/AMPK, indicating inhibition of AKT and AMPK, but activation of PP2A and FOXO1. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 212-215 33103284-10 2021 Resveratrol could increase FoxO4 phosphorylation through the PI3K/AKT pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 66-69 33103284-13 2021 This study validates that resveratrol could reduce bile acid-induced GIM through the PI3K/AKT/p-FoxO4 signalling pathway and has a potential reversing effect on GIM, especially that caused by bile acid reflux. Resveratrol 26-37 AKT serine/threonine kinase 1 Homo sapiens 90-93 33103284-0 2021 Resveratrol inhibits bile acid-induced gastric intestinal metaplasia via the PI3K/AKT/p-FoxO4 signalling pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 82-85 33070070-9 2021 By inhibiting PKA, Akt/PKB and MAPK signaling pathways we observed that resveratrol presented an altered performance in the aging process, changing signaling pattern of MAPK pathway. Resveratrol 72-83 AKT serine/threonine kinase 1 Homo sapiens 19-22 33070070-9 2021 By inhibiting PKA, Akt/PKB and MAPK signaling pathways we observed that resveratrol presented an altered performance in the aging process, changing signaling pattern of MAPK pathway. Resveratrol 72-83 AKT serine/threonine kinase 1 Homo sapiens 23-26 33461468-0 2021 Resveratrol Promotes HIV-1 Tat Accumulation via AKT/FOXO1 Signaling Axis and Potentiates Vorinostat to antagonize HIV-1 latency. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 48-51 33461468-9 2021 RESULTS: Resveratrol promoted HIV-1 Tat protein levels, and resveratrol-induced Tat promotion was dependent on the AKT/FOXO1 signaling axis. Resveratrol 60-71 AKT serine/threonine kinase 1 Homo sapiens 115-118 32901891-0 2020 Resveratrol inhibits viability and induces apoptosis in the small-cell lung cancer H446 cell line via the PI3K/Akt/c-Myc pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 111-114 33339133-0 2020 Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 51-54 33339133-9 2020 Resveratrol activated Akt by regulating Mammalian Target of Rapamycin (mTOR) Complex 2 (mTORC2) via phosphatase and tensin homolog (PTEN) and ribosomal protein S6 kinase beta-1 (S6K1). Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 22-25 33339133-11 2020 Importantly, resveratrol increased the expression of c-Myb, a downstream transcription factor of Akt and mTORC2. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 97-100 33339133-13 2020 Our results demonstrate that resveratrol activates NK cells through Akt- and mTORC2-mediated c-Myb upregulation. Resveratrol 29-40 AKT serine/threonine kinase 1 Homo sapiens 68-71 32798507-6 2020 The results showed that the effect of resveratrol may be closely associated with targets such as AKT serine/threonine kinase 1 (AKT1), mitogen-activated protein kinase 3 (MAPK3), Sirtuin-1 (SIRT1) and proto-oncogene tyrosine-protein kinase Src (SRC), as well as biological processes such as cell proliferation, inflammatory response, and redox balance. Resveratrol 38-49 AKT serine/threonine kinase 1 Homo sapiens 97-126 32798507-6 2020 The results showed that the effect of resveratrol may be closely associated with targets such as AKT serine/threonine kinase 1 (AKT1), mitogen-activated protein kinase 3 (MAPK3), Sirtuin-1 (SIRT1) and proto-oncogene tyrosine-protein kinase Src (SRC), as well as biological processes such as cell proliferation, inflammatory response, and redox balance. Resveratrol 38-49 AKT serine/threonine kinase 1 Homo sapiens 128-132 32934736-0 2020 Resveratrol inhibits proliferation and promotes apoptosis via the androgen receptor splicing variant 7 and PI3K/AKT signaling pathway in LNCaP prostate cancer cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 112-115 33289908-6 2021 Pathway analysis demonstrated that the cellular oxidative stress caused by the activation of phosphoinositide-3-kinase/Akt1 (PI3K/Akt1) pathway that leads to the production of reactive oxygen species (ROS), chronic inflammatory response induced by the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathway and nutrient utilization pathways were favourably modulated by trans-resveratrol in the PgLPS challenged IMR-32 cells. Resveratrol 408-425 AKT serine/threonine kinase 1 Homo sapiens 119-123 33289908-6 2021 Pathway analysis demonstrated that the cellular oxidative stress caused by the activation of phosphoinositide-3-kinase/Akt1 (PI3K/Akt1) pathway that leads to the production of reactive oxygen species (ROS), chronic inflammatory response induced by the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathway and nutrient utilization pathways were favourably modulated by trans-resveratrol in the PgLPS challenged IMR-32 cells. Resveratrol 408-425 AKT serine/threonine kinase 1 Homo sapiens 130-134 33292283-0 2020 Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 73-76 32901891-10 2020 The results of the present study indicated that Res may inhibit the viability and promote the apoptosis of human SCLC H446 cells through the PI3K/Akt/c-Myc pathway and that oxidative stress and mitochondrial membrane potential depolarization may be involved in the aforementioned processes. Resveratrol 48-51 AKT serine/threonine kinase 1 Homo sapiens 146-149 32318334-0 2020 Resveratrol Sensitizes Colorectal Cancer Cells to Cetuximab by Connexin 43 Upregulation-Induced Akt Inhibition. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 96-99 32531316-0 2020 Resveratrol potentiates the anti-tumor effects of rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 94-97 32531316-3 2020 Resveratrol can also inhibit tumor growth by regulating the PI3K/AKT/mTOR signaling pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 65-68 32696949-1 2020 OBJECTIVE: The purpose of this study was to investigate the specific downstream signaling pathway mediated by PI3K/Akt in resveratrol (RES) anti-apoptosis of NPCs. Resveratrol 123-134 AKT serine/threonine kinase 1 Homo sapiens 116-119 32696949-1 2020 OBJECTIVE: The purpose of this study was to investigate the specific downstream signaling pathway mediated by PI3K/Akt in resveratrol (RES) anti-apoptosis of NPCs. Resveratrol 136-139 AKT serine/threonine kinase 1 Homo sapiens 116-119 32530437-0 2020 Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 113-116 32477148-9 2020 Western blot results confirmed that resveratrol inhibited glutamate-induced apoptosis of hippocampal neurons partly by regulating the PI3K/AKT/mTOR pathway. Resveratrol 36-47 AKT serine/threonine kinase 1 Homo sapiens 139-142 32945383-12 2020 RSV elevated the p53 levels and decreased the phosphorylated (p-)Mdm2 and p-Akt levels. Resveratrol 0-3 AKT serine/threonine kinase 1 Homo sapiens 76-79 32581510-0 2020 Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-kappaB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1beta-Stimulated SW1353 Cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 106-109 32581510-3 2020 The aim of the present study was to investigate whether resveratrol-mediated PI3K/Akt expression is linked to TLR4/NF-kappaB pathway and the role of TLR4/Akt/FoxO1 axis in the anti-osteoarthritic effect of resveratrol. Resveratrol 56-67 AKT serine/threonine kinase 1 Homo sapiens 82-85 32581510-3 2020 The aim of the present study was to investigate whether resveratrol-mediated PI3K/Akt expression is linked to TLR4/NF-kappaB pathway and the role of TLR4/Akt/FoxO1 axis in the anti-osteoarthritic effect of resveratrol. Resveratrol 56-67 AKT serine/threonine kinase 1 Homo sapiens 154-157 32581510-10 2020 Resveratrol treatment can upregulate PI3K/Akt phosphorylation and inactivate FoxO1, thereby reducing TLR4 and inflammation. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 42-45 32581510-13 2020 Resveratrol may exert anti-OA effect by enhancing the self-limiting mechanism of inflammation through TLR4/Akt/FoxO1 axis. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 107-110 32318334-4 2020 It has been reported that resveratrol and connexin 43 regulate Akt in different ways based on tissue type. Resveratrol 26-37 AKT serine/threonine kinase 1 Homo sapiens 63-66 32318334-6 2020 Our work confirmed that resveratrol increases the inhibition of growth by cetuximab in vitro and in vivo, upregulates connexin 43 expression and phosphorylation, increases gap junction function, and inhibits the activation of Akt and NFkappaB in parental or cetuximab-treated parental HCT116 and CT26 cells. Resveratrol 24-35 AKT serine/threonine kinase 1 Homo sapiens 226-229 28195449-1 2020 BACKGROUND: We observed the effects of resveratrol on the expression of molecules involved in the mTOR signaling pathway in pathological scar fibroblasts, including PI3K, Akt and mTOR. Resveratrol 39-50 AKT serine/threonine kinase 1 Homo sapiens 171-174 28195449-3 2020 After being treated with different concentrations of resveratrol, the expression of PI3K, Akt and mTOR mRNA and protein were detected by RT-PCR and Western Blot respectively. Resveratrol 53-64 AKT serine/threonine kinase 1 Homo sapiens 90-93 28195449-8 2020 CONCLUSIONS: The mechanism of resveratrol in the inhibition of the proliferation of pathological scar fibroblasts may be related to its down-regulation in the expression of Akt and mTOR, which are the key molecules of mTOR signaling pathway. Resveratrol 30-41 AKT serine/threonine kinase 1 Homo sapiens 173-176 31665911-0 2019 PRMT5 Promotes Human Lung Cancer Cell Apoptosis via Akt/Gsk3beta Signaling Induced by Resveratrol. Resveratrol 86-97 AKT serine/threonine kinase 1 Homo sapiens 52-55 32233996-8 2020 The molecular mechanism of the adjuvant action of resveratrol may depend upon the reduction of PI3K/AKT/NF-kappaB axis and downstream targets O-6-methylguanine-DNA methyltransferase (MGMT) and metalloproteinase-2 (MMP-2). Resveratrol 50-61 AKT serine/threonine kinase 1 Homo sapiens 100-103 31665911-6 2019 Further investigation showed that inhibition or down-regulation of PRMT5 further reduced Akt/GSK3beta phosphorylation and the downstream targets cyclin D1 and E1 expression upon resveratrol treatment. Resveratrol 178-189 AKT serine/threonine kinase 1 Homo sapiens 89-92 31406997-8 2019 Collectively, dietary resveratrol could have beneficial effects to regulate innate immunity and inflammatory response, via inhibiting the activation of NF-kappaB, MAPK, and PI3K/AKT signaling pathways induced by heat stress in the spleen. Resveratrol 22-33 AKT serine/threonine kinase 1 Homo sapiens 178-181 31412263-13 2019 Further results indicated that PI3K/AKT pathway-mediated inhibition of the mammalian target of rapamycin (mTOR) pathway played a role in the activation of autophagy by resveratrol after CIH stimulation. Resveratrol 168-179 AKT serine/threonine kinase 1 Homo sapiens 36-39 31412263-14 2019 SIGNIFICANCE: In conclusion, resveratrol supplementation during CIH upregulates autophagy by targeting the PI3K/AKT/mTOR pathway, which appears to be beneficial for resisting cardiac hypertrophy. Resveratrol 29-40 AKT serine/threonine kinase 1 Homo sapiens 112-115 31524255-0 2019 Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial- mesenchymal transition via the AKT/GSK-3beta/Snail signaling pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 128-131 31524255-5 2019 The results revealed that resveratrol treatment and AKT1 knockdown significantly inhibited cell migration and invasion in colon cancer, and markedly increased E-cadherin expression and decreased that of N-cadherin, phospho (p)-AKT1, p-GSK-3beta, and Snail in colon cancer both in vitro and in vivo. Resveratrol 26-37 AKT serine/threonine kinase 1 Homo sapiens 227-231 31524255-6 2019 Furthermore, the effects of resveratrol were significantly weaker in the AKT1-knockdown cells. Resveratrol 28-39 AKT serine/threonine kinase 1 Homo sapiens 73-77 31524255-7 2019 In conclusion, resveratrol may suppress the invasion and metastasis of colon cancer through reversal of EMT via the AKT/GSK-3beta/Snail signaling pathway. Resveratrol 15-26 AKT serine/threonine kinase 1 Homo sapiens 116-119 31173300-0 2019 Preliminary results indicate resveratrol affects proliferation and apoptosis of leukemia cells by regulating PTEN/PI3K/AKT pathway. Resveratrol 29-40 AKT serine/threonine kinase 1 Homo sapiens 119-122 30066962-5 2019 Further research revealed that both protein phosphatase 2A (PP2A) and phosphatase and tensin homolog (PTEN)-Akt were implicated in resveratrol-inactivated Erk1/2-dependent cell adhesion. Resveratrol 131-142 AKT serine/threonine kinase 1 Homo sapiens 108-111 30816513-7 2019 Western blot analysis demonstrated that resveratrol also upregulated phospho-phosphatase and tensin homolog (p-PTEN) and downregulated phospho-Akt (p-Akt). Resveratrol 40-51 AKT serine/threonine kinase 1 Homo sapiens 143-146 30816513-7 2019 Western blot analysis demonstrated that resveratrol also upregulated phospho-phosphatase and tensin homolog (p-PTEN) and downregulated phospho-Akt (p-Akt). Resveratrol 40-51 AKT serine/threonine kinase 1 Homo sapiens 150-153 30816513-8 2019 Overexpression of p-Akt by transfection with a constitutively active form (caAkt), and the p-PTEN inhibitor SF1670 prevented resveratrol-induced cell death. Resveratrol 125-136 AKT serine/threonine kinase 1 Homo sapiens 20-23 30816513-10 2019 Taken together, the results of the present study suggest that resveratrol induces caspase-dependent cell death through suppression of Notch1 and PTEN/Akt signaling and it is mediated by increased ROS generation in human ovarian cancer cells. Resveratrol 62-73 AKT serine/threonine kinase 1 Homo sapiens 150-153 30066962-7 2019 Overexpression of wild-type PTEN or dominant-negative Akt or inhibition of Akt with Akt inhibitor X strengthened resveratrol"s inhibition of the basal or IGF-1-stimulated Erk1/2 phosphorylation and cell adhesion. Resveratrol 113-124 AKT serine/threonine kinase 1 Homo sapiens 54-57 30066962-7 2019 Overexpression of wild-type PTEN or dominant-negative Akt or inhibition of Akt with Akt inhibitor X strengthened resveratrol"s inhibition of the basal or IGF-1-stimulated Erk1/2 phosphorylation and cell adhesion. Resveratrol 113-124 AKT serine/threonine kinase 1 Homo sapiens 75-78 30066962-7 2019 Overexpression of wild-type PTEN or dominant-negative Akt or inhibition of Akt with Akt inhibitor X strengthened resveratrol"s inhibition of the basal or IGF-1-stimulated Erk1/2 phosphorylation and cell adhesion. Resveratrol 113-124 AKT serine/threonine kinase 1 Homo sapiens 75-78 30066962-8 2019 Furthermore, inhibition of mechanistic/mammalian target of rapamycin (mTOR) with rapamycin or silencing mTOR enhanced resveratrol"s inhibitory effects on the basal and IGF-1-induced inhibition of PP2A-PTEN, activation of Akt-Erk1/2, and cell adhesion. Resveratrol 118-129 AKT serine/threonine kinase 1 Homo sapiens 221-224 30816513-0 2019 Resveratrol induces cell death through ROS-dependent downregulation of Notch1/PTEN/Akt signaling in ovarian cancer cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 83-86 30445019-0 2019 Resveratrol protects cardiomyocytes against anoxia/reoxygenation via dephosphorylation of VDAC1 by Akt-GSK3 beta pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 99-102 30445019-10 2019 In addition, Akt and its downstream glycogen synthase kinase 3 beta (GSK3beta) were phosphorylated by the action of resveratrol. Resveratrol 116-127 AKT serine/threonine kinase 1 Homo sapiens 13-16 30445019-11 2019 Akt inhibitor IV abrogated Akt-GSK3beta phosphorylation and thereby abolished the dephosphorylation activity of resveratrol on VDAC1. Resveratrol 112-123 AKT serine/threonine kinase 1 Homo sapiens 0-3 30445019-11 2019 Akt inhibitor IV abrogated Akt-GSK3beta phosphorylation and thereby abolished the dephosphorylation activity of resveratrol on VDAC1. Resveratrol 112-123 AKT serine/threonine kinase 1 Homo sapiens 27-30 30445019-12 2019 Moreover, all resveratrol-mediated protective effects on A/R injured cardiomyocytes were abolished by Akt inhibitor IV. Resveratrol 14-25 AKT serine/threonine kinase 1 Homo sapiens 102-105 30445019-13 2019 Taken together, our data indicated that A/R injury enhanced VDAC1 phosphorylation in cardiomyocytes, whereas pretreatment with resveratrol dephosphorylated VDAC1 through the Akt-GSK3beta pathway, thereby protecting cardiomyocytes against A/R injury. Resveratrol 127-138 AKT serine/threonine kinase 1 Homo sapiens 174-177 30387805-0 2019 Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 60-63 30387805-8 2019 Notably, the results obtained from in silico computational screening identified AKT serine/threonine kinase 1 (AKT1) and AKT2 as novel targets of resveratrol. Resveratrol 146-157 AKT serine/threonine kinase 1 Homo sapiens 80-109 30387805-8 2019 Notably, the results obtained from in silico computational screening identified AKT serine/threonine kinase 1 (AKT1) and AKT2 as novel targets of resveratrol. Resveratrol 146-157 AKT serine/threonine kinase 1 Homo sapiens 111-115 30387805-9 2019 Computational docking suggested that there are three or four possible hydrogen bonds in the active pocket of AKT1 and AKT2 that contribute to the mode of action of resveratrol. Resveratrol 164-175 AKT serine/threonine kinase 1 Homo sapiens 109-113 30387805-10 2019 The present study confirmed that resveratrol bound to AKT1 and AKT2 with a pull-down assay. Resveratrol 33-44 AKT serine/threonine kinase 1 Homo sapiens 54-58 30387805-12 2019 Taken together, the present results suggest that the targeting effects of resveratrol to AKT1 and AKT2 may be a potent strategy for chemoprevention or therapy for colon cancer. Resveratrol 74-85 AKT serine/threonine kinase 1 Homo sapiens 89-93 31032633-0 2019 Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells. Resveratrol 54-65 AKT serine/threonine kinase 1 Homo sapiens 24-27 31032633-2 2019 We hypothesized that the natural compound resveratrol (Res) may reverse AML drug resistance through the PI3K/Akt/Nrf2 pathway. Resveratrol 42-53 AKT serine/threonine kinase 1 Homo sapiens 109-112 31032633-2 2019 We hypothesized that the natural compound resveratrol (Res) may reverse AML drug resistance through the PI3K/Akt/Nrf2 pathway. Resveratrol 55-58 AKT serine/threonine kinase 1 Homo sapiens 109-112 30464525-0 2018 Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 110-113 30132535-7 2018 It was revealed that resveratrol upregulated the expression of p53 while decreasing the ratio of phosphorylated protein kinase B (p-Akt)/Akt in HCC cells. Resveratrol 21-32 AKT serine/threonine kinase 1 Homo sapiens 132-135 30132535-7 2018 It was revealed that resveratrol upregulated the expression of p53 while decreasing the ratio of phosphorylated protein kinase B (p-Akt)/Akt in HCC cells. Resveratrol 21-32 AKT serine/threonine kinase 1 Homo sapiens 137-140 30132535-8 2018 Treatment with p53 inhibitor pifithrin-alpha and Akt activator insulin-like growth factor-1 decreased the expression of Beclin1 while significantly promoting cell proliferation, invasion and migration compared with the resveratrol treatment group. Resveratrol 219-230 AKT serine/threonine kinase 1 Homo sapiens 49-52 30132535-9 2018 Taken together, the results of the present study revealed that resveratrol inhibited the proliferation and mobility of HCC cells through inducing autophagy via activating p53 and inhibiting phosphoinositide 3-kinase/Akt. Resveratrol 63-74 AKT serine/threonine kinase 1 Homo sapiens 216-219 30464525-14 2018 Besides that, resveratrol treatment inhibited Akt/mTOR while p38-MAPK was activated in NSCLC cells in a dose-dependent manner. Resveratrol 14-25 AKT serine/threonine kinase 1 Homo sapiens 46-49 30464525-16 2018 Conclusion: Taken together, our findings suggest that resveratrol inhibited proliferation but induced apoptosis and autophagy via inhibiting Akt/mTOR and activating p38-MAPK pathway. Resveratrol 54-65 AKT serine/threonine kinase 1 Homo sapiens 141-144 29788929-11 2018 CONCLUSIONS: These results suggest that resveratrol induced apoptotic cell death of HL-60 cells depends on the autophagy activated through both the LKB1-AMPK and PI3K/AKT-regulated mTOR signaling pathways. Resveratrol 40-51 AKT serine/threonine kinase 1 Homo sapiens 167-170 30107164-0 2018 Suppression of TLR4 activation by resveratrol is associated with STAT3 and Akt inhibition in oxidized low-density lipoprotein-activated platelets. Resveratrol 34-45 AKT serine/threonine kinase 1 Homo sapiens 75-78 30107164-8 2018 A mechanistic analysis indicated that the inhibitory effect of resveratrol on TLR4 expression was associated with the suppression of Akt phosphorylation. Resveratrol 63-74 AKT serine/threonine kinase 1 Homo sapiens 133-136 30107164-9 2018 The combination of resveratrol and the PI3K inhibitor LY294002 had a synergistic effect on the inhibition of Akt phosphorylation and TLR4 expression. Resveratrol 19-30 AKT serine/threonine kinase 1 Homo sapiens 109-112 30031063-0 2018 Resveratrol sensitizes lung cancer cell to TRAIL by p53 independent and suppression of Akt/NF-kappaB signaling. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 87-90 30250641-0 2018 Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells. Resveratrol 15-26 AKT serine/threonine kinase 1 Homo sapiens 117-120 30250641-8 2018 We herein showed that resveratrol and 5-FU combination treatments caused the anti-cancer activities by simultaneously inhibiting STAT3 and Akt signaling pathways. Resveratrol 22-33 AKT serine/threonine kinase 1 Homo sapiens 139-142 29704506-13 2018 In the mechanism study, RSV-miR-17 axis was found to activate PTEN/PI3K/AKT and mTOR pathways in LPS-treated cells. Resveratrol 24-27 AKT serine/threonine kinase 1 Homo sapiens 72-75 29704506-14 2018 CONCLUSION: RSV alleviated LPS-induced injury in human keratinocyte cell line HaCaT through activations of PTEN/PI3K/AKT and mTOR pathways, which were modulated by miR-17. Resveratrol 12-15 AKT serine/threonine kinase 1 Homo sapiens 117-120 29074559-0 2017 Resveratrol increases nucleus pulposus matrix synthesis through activating the PI3K/Akt signaling pathway under mechanical compression in a disc organ culture. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 84-87 29849922-7 2018 Overexpression of Synd4 or pretreatment of resveratrol reversed AGE-impaired tube formation of EPCs and regulated the Akt/eNOS pathway. Resveratrol 43-54 AKT serine/threonine kinase 1 Homo sapiens 118-121 29849922-8 2018 Furthermore, resveratrol suppressed Synd4 shedding via the inhibition of oxidative stress and improved tube formation of late EPCs via the regulation of the Synd4/Akt/eNOS pathway. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 163-166 29241073-0 2018 Resveratrol inhibits proliferation, migration and invasion via Akt and ERK1/2 signaling pathways in renal cell carcinoma cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 63-66 28385009-7 2017 Western blot analysis of the effects of resveratrol on upstream cyclin D1 transcriptional signaling, extracellular signal-related kinase (ERK), p90RSK, Akt, and p70S6K revealed inhibition of Akt but not the ERK signaling pathway. Resveratrol 40-51 AKT serine/threonine kinase 1 Homo sapiens 191-194 28385009-8 2017 Collectively, the results indicate that resveratrol inhibits Huh7-HBx proliferation by decreasing cyclin D1 expression through blockade of Akt signaling. Resveratrol 40-51 AKT serine/threonine kinase 1 Homo sapiens 139-142 29211809-5 2017 Moreover, in HEK293 cells, we observed RSV enhanced klf5 phosphorylation and separated the interaction of klf5 with c-Myc through inhibiting the activation of PI3K/PKD1/Akt pathway, which maybe promoted c-Myc binding to the promoter to inhibit Cav-1 expression. Resveratrol 39-42 AKT serine/threonine kinase 1 Homo sapiens 169-172 29477771-9 2018 In addition, resveratrol inhibited Sox2 expression as well as activation of Akt and STAT3 induced by CAF-CM in breast cancer cells. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 76-79 28211035-0 2017 Resveratrol decreases FoXO protein expression through PI3K-Akt-dependent pathway inhibition in H2O2-treated synoviocytes. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 59-62 28983625-0 2017 Resveratrol inhibits proliferation and migration through SIRT1 mediated post-translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 112-115 29074559-9 2017 Further analysis indicated that resveratrol partly stimulated NP matrix synthesis and increased activity of the PI3K/Akt pathway in a dose-dependent manner under mechanical compression. Resveratrol 32-43 AKT serine/threonine kinase 1 Homo sapiens 117-120 28656233-4 2017 In cancer, resveratrol has been reported to abrogate the phosphoinositide 3-kinase/protein kinase B (AKT) signaling pathway, thereby inhibiting tumor development. Resveratrol 11-22 AKT serine/threonine kinase 1 Homo sapiens 101-104 28983625-5 2017 As a sirtuin (SIRT) 1 activator, resveratrol elevated SIRT1 protein expression and its enzyme activity and decreased expression levels of phosphorylated (p)-phosphoinositide-3-kinase (PI3K), p-AKT Serine/Threonine Kinase 1 (AKT), and its downstream target p-Forkhead Box O3a in HepG2 cells. Resveratrol 33-44 AKT serine/threonine kinase 1 Homo sapiens 193-196 28983625-5 2017 As a sirtuin (SIRT) 1 activator, resveratrol elevated SIRT1 protein expression and its enzyme activity and decreased expression levels of phosphorylated (p)-phosphoinositide-3-kinase (PI3K), p-AKT Serine/Threonine Kinase 1 (AKT), and its downstream target p-Forkhead Box O3a in HepG2 cells. Resveratrol 33-44 AKT serine/threonine kinase 1 Homo sapiens 224-227 28983625-7 2017 This demonstrated that resveratrol inhibited the PI3K/AKT pathway by SIRT1 activation. Resveratrol 23-34 AKT serine/threonine kinase 1 Homo sapiens 54-57 28983625-8 2017 In addition to inhibition of cancer cell migration, tumor suppressor gene DLC1 Rho GTPase activating protein level was upregulated and its phosphorylation was enhanced by AKT with resveratrol treatment. Resveratrol 180-191 AKT serine/threonine kinase 1 Homo sapiens 171-174 28983625-9 2017 These findings suggested that resveratrol inhibits proliferation and migration through SIRT1 mediated post-translational modification of PI3K/AKT pathway in HCC cells. Resveratrol 30-41 AKT serine/threonine kinase 1 Homo sapiens 142-145 28656233-6 2017 Resveratrol was demonstrated to be inhibitory in a dose-dependent manner on hypoxia-induced cell proliferation and migration, and protein expression levels of phosphorylated AKT and AKT. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 174-177 28656233-6 2017 Resveratrol was demonstrated to be inhibitory in a dose-dependent manner on hypoxia-induced cell proliferation and migration, and protein expression levels of phosphorylated AKT and AKT. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 182-185 28656233-7 2017 Additionally, resveratrol was identified to act synergistically with LY-294002, a phosphorylation inhibitor of AKT, but antagonistically with insulin-like growth factor-1, an agonist of AKT phosphorylation. Resveratrol 14-25 AKT serine/threonine kinase 1 Homo sapiens 111-114 28656233-7 2017 Additionally, resveratrol was identified to act synergistically with LY-294002, a phosphorylation inhibitor of AKT, but antagonistically with insulin-like growth factor-1, an agonist of AKT phosphorylation. Resveratrol 14-25 AKT serine/threonine kinase 1 Homo sapiens 186-189 28656233-8 2017 This suggested that resveratrol may reduce proliferation and migration by diminishing expression and phosphorylation of AKT, thereby preventing development of HPH. Resveratrol 20-31 AKT serine/threonine kinase 1 Homo sapiens 120-123 29082697-9 2017 The protein expressions of Caspase-3, PTEN and p53 were all increased after being treated with resveratrol, while the expression of p-AKT was decreased after the treatment. Resveratrol 95-106 AKT serine/threonine kinase 1 Homo sapiens 134-137 28534975-0 2017 Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 29-32 28534975-9 2017 Res does not activate the BMPs/Smads signaling, but decreases the phosphorylation of Akt1/2/3 substantially in HCT116 cells. Resveratrol 0-3 AKT serine/threonine kinase 1 Homo sapiens 85-93 28495310-7 2017 In addition, PM induced Akt, ERK1/2, or p38 MAPK activation, which was inhibited by resveratrol. Resveratrol 84-95 AKT serine/threonine kinase 1 Homo sapiens 24-27 28429008-6 2017 We found that the resveratrol analogues also significantly inhibited Akt and MAPK signalling and reduced the migration of IL-6 and EGF-treated cells. Resveratrol 18-29 AKT serine/threonine kinase 1 Homo sapiens 69-72 28617535-9 2017 Targeting thyroid hormone restoration, inhibition of ACE and GSK3beta via PI3K/AKT signaling pathway using LA, Resveratrol and Quercetin are potential novel therapeutic approaches for developing pharmaceuticals that could make significance in MS treatment. Resveratrol 111-122 AKT serine/threonine kinase 1 Homo sapiens 79-82 27419830-0 2017 Resveratrol targeting of AKT and p53 in glioblastoma and glioblastoma stem-like cells to suppress growth and infiltration. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 25-28 27419830-4 2017 METHODS Resveratrol"s effects on cell proliferation, sphere-forming ability, and invasion were tested using multiple patient-derived GBM stem-like cell (GSC) lines and established U87 glioma cells, and changes in oncogenic AKT and tumor suppressive p53 were analyzed. Resveratrol 8-19 AKT serine/threonine kinase 1 Homo sapiens 223-226 27419830-10 2017 In U87 glioma cells and GSCs, resveratrol reduced AKT phosphorylation and induced p53 expression and activation that led to transcription of downstream p53 target genes. Resveratrol 30-41 AKT serine/threonine kinase 1 Homo sapiens 50-53 27419830-13 2017 CONCLUSIONS Resveratrol potently inhibited GBM and GSC growth and infiltration, acting partially via AKT deactivation and p53 induction, and suppressed glioblastoma growth in vivo. Resveratrol 12-23 AKT serine/threonine kinase 1 Homo sapiens 101-104 27419830-14 2017 The ability of resveratrol to modulate AKT and p53, as well as reportedly many other antitumorigenic pathways, is attractive for therapy against a genetically heterogeneous tumor such as GBM. Resveratrol 15-26 AKT serine/threonine kinase 1 Homo sapiens 39-42 28216158-7 2017 RSV treatment increased AMPK activity and decreased Akt activity. Resveratrol 0-3 AKT serine/threonine kinase 1 Homo sapiens 52-55 28126034-0 2017 Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 122-125 28197625-6 2017 Instead, resveratrol significantly reduced Akt activation with the downregulation of H-Ras, resulting in facilitation of Bax translocation to mitochondria in leukemic cells. Resveratrol 9-20 AKT serine/threonine kinase 1 Homo sapiens 43-46 28197625-7 2017 This study suggests that resveratrol can induce apoptotic cell death in human leukemic cells to a greater extent than in human solid tumor cells via reducing Akt activation due to Ras downregulation. Resveratrol 25-36 AKT serine/threonine kinase 1 Homo sapiens 158-161 28197628-0 2017 Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 119-122 27225870-5 2017 In combination with rapamycin, resveratrol was able to block rapamycin-induced Akt activation, while maintaining mTOR pathway inhibition. Resveratrol 31-42 AKT serine/threonine kinase 1 Homo sapiens 79-82 27798117-9 2017 The major molecular targets of the action of resveratrol are growth factors and their signaling pathways, phosphoinositol-3-kinase/Akt and mitogen-activated protein kinase pathways, transcription factors, and SIRT-1. Resveratrol 45-56 AKT serine/threonine kinase 1 Homo sapiens 131-134 27373419-8 2016 Resveratrol also protected astrocytes via phosphatidylinositide 3-kinase (PI3K)/Akt. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 80-83 27840966-0 2017 Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 108-111 27829129-0 2016 Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 100-103 27829129-4 2016 Exposure to resveratrol decreased EGFR and downstream kinases Akt and ERK1/2 activation. Resveratrol 12-23 AKT serine/threonine kinase 1 Homo sapiens 62-65 27829129-5 2016 Moreover, we revealed that resveratrol impaired glucose metabolism by mainly inhibiting expression of HK2 mediated by the Akt signaling pathway, and exogenous overexpression of constitutively activated Akt1 in NSCLC cells substantially rescued resveratrol-induced glycolysis suppression. Resveratrol 27-38 AKT serine/threonine kinase 1 Homo sapiens 122-125 27829129-5 2016 Moreover, we revealed that resveratrol impaired glucose metabolism by mainly inhibiting expression of HK2 mediated by the Akt signaling pathway, and exogenous overexpression of constitutively activated Akt1 in NSCLC cells substantially rescued resveratrol-induced glycolysis suppression. Resveratrol 244-255 AKT serine/threonine kinase 1 Homo sapiens 202-206 28968596-0 2017 Resveratrol Inhibits the Epidermal Growth Factor-Induced Migration of Osteoblasts: the Suppression of SAPK/JNK and Akt. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 115-118 28968596-8 2017 In addition, resveratrol markedly attenuated the EGF-induced phosphorylation of SAPK/JNK and Akt without affecting the phosphorylation of p44/p42 MAP kinase or p38 MAP kinase. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 93-96 28968596-10 2017 CONCLUSION: Our results strongly suggest that resveratrol reduces the EGF-stimulated migration of osteoblasts via suppression of SAPK and Akt, and that the inhibitory effect of resveratrol is mediated in part via SIRT1. Resveratrol 46-57 AKT serine/threonine kinase 1 Homo sapiens 138-141 27354627-0 2016 Resveratrol Overcomes Cellular Resistance to Vemurafenib Through Dephosphorylation of AKT in BRAF-mutated Melanoma Cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 86-89 27354627-6 2016 Notably, resveratrol both alone and in combination with vemurafenib effectively suppressed cell proliferation and AKT phosphorylation in both parental and vemurafenib-resistant melanoma cells. Resveratrol 9-20 AKT serine/threonine kinase 1 Homo sapiens 114-117 26759241-7 2016 Taken together, our findings demonstrate that resveratrol counteracts the unexpected metastatic potential induced by anti-AKT therapy and therefore suggest that the addition of resveratrol to an anti-AKT therapeutic regimen may provide extra support for limiting EMT. Resveratrol 46-57 AKT serine/threonine kinase 1 Homo sapiens 122-125 26460589-0 2016 Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 131-134 26460589-6 2016 Resveratrol decreased the phosphorylation of Akt and mTOR but did not affect the phosphorylations of JNK or ERK1/2. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 45-48 26460589-7 2016 These results demonstrated that resveratrol could increase the anti-proliferative activity of bestatin through downregulating P-gp expression via suppressing the PI3K/Akt/mTOR signaling pathway. Resveratrol 32-43 AKT serine/threonine kinase 1 Homo sapiens 167-170 25917875-5 2016 Furthermore, RSV treatment also decreases ER calcium storage and store operated calcium entry (SOCE), which induces endoplasmic reticulum (ER) stress, thereby, activating AMPK and inhibiting the AKT/mTOR pathway. Resveratrol 13-16 AKT serine/threonine kinase 1 Homo sapiens 195-198 27047993-2 2016 We hypothesized that chloroquine and resveratrol, both known ATM activators, would also activate AMPK and Akt. Resveratrol 37-48 AKT serine/threonine kinase 1 Homo sapiens 106-109 27047993-3 2016 MAIN METHODS: Phosphorylation of AMPK and Akt was assessed after C2C12 myotubes were exposed to chloroquine or resveratrol. Resveratrol 111-122 AKT serine/threonine kinase 1 Homo sapiens 42-45 26891914-0 2016 Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 117-120 26704305-5 2016 Additionally, an ER UDPase, ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), modulated protein glycosylation by Akt attenuation in response to resveratrol. Resveratrol 153-164 AKT serine/threonine kinase 1 Homo sapiens 122-125 26709007-0 2016 Resveratrol induces apoptosis through modulation of the Akt/FoxO3a/Bim pathway in HepG2 cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 56-59 26891914-6 2016 Combined treatment with both RSV and 2-DG reduced GRP78, GRP94 and Akt phosphorylation but increased CHOP and NB cell death when compared with the administration of 2-DG alone. Resveratrol 29-32 AKT serine/threonine kinase 1 Homo sapiens 67-70 26891914-9 2016 Pretreatment of cells with tautomycin, a selective PP1alpha inhibitor, prevented the RSV-mediated decrease in Akt phosphorylation, suggesting that RSV enhances 2-DG-induced cell death by activating PP1 and downregulating Akt. Resveratrol 85-88 AKT serine/threonine kinase 1 Homo sapiens 110-113 26891914-9 2016 Pretreatment of cells with tautomycin, a selective PP1alpha inhibitor, prevented the RSV-mediated decrease in Akt phosphorylation, suggesting that RSV enhances 2-DG-induced cell death by activating PP1 and downregulating Akt. Resveratrol 85-88 AKT serine/threonine kinase 1 Homo sapiens 221-224 26891914-9 2016 Pretreatment of cells with tautomycin, a selective PP1alpha inhibitor, prevented the RSV-mediated decrease in Akt phosphorylation, suggesting that RSV enhances 2-DG-induced cell death by activating PP1 and downregulating Akt. Resveratrol 147-150 AKT serine/threonine kinase 1 Homo sapiens 110-113 26891914-9 2016 Pretreatment of cells with tautomycin, a selective PP1alpha inhibitor, prevented the RSV-mediated decrease in Akt phosphorylation, suggesting that RSV enhances 2-DG-induced cell death by activating PP1 and downregulating Akt. Resveratrol 147-150 AKT serine/threonine kinase 1 Homo sapiens 221-224 26891914-10 2016 The RSV-mediated inhibition of Akt in the presence of 2-DG was not prevented by the selective inhibition of SIRT1, a known target of RSV, indicating that the effects of RSV on this pathway are independent of SIRT1. Resveratrol 4-7 AKT serine/threonine kinase 1 Homo sapiens 31-34 26891914-11 2016 We propose that RSV inhibits Akt activity by increasing PP1alpha activity, thereby potentiating 2-DG-induced ER stress and NB cell death. Resveratrol 16-19 AKT serine/threonine kinase 1 Homo sapiens 29-32 26709007-5 2016 Following resveratrol treatment, Akt-mediated phosphorylation of FoxO3a was observed to be diminished in HepG2 cells. Resveratrol 10-21 AKT serine/threonine kinase 1 Homo sapiens 33-36 27551486-0 2015 Resveratrol chemosensitizes HER-2-overexpressing breast cancer cells to docetaxel chemoresistance by inhibiting docetaxel-mediated activation of HER-2-Akt axis. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 151-154 26530037-0 2016 Resveratrol attenuates the progress of liver fibrosis via the Akt/nuclear factor-kappaB pathways. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 62-65 26530037-14 2016 Finally, resveratrol prevented the activation of NF-kappaB and Akt. Resveratrol 9-20 AKT serine/threonine kinase 1 Homo sapiens 63-66 26530037-15 2016 The results of the present study therefore indicated that resveratrol attenuates liver fibrosis via the Akt/NF-kappaB pathways. Resveratrol 58-69 AKT serine/threonine kinase 1 Homo sapiens 104-107 26530632-0 2016 Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN-regulated PI3K/Akt signaling pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 103-106 26530632-5 2016 Furthermore, western blotting demonstrated that resveratrol decreased the protein expression of phospho-glycogen synthase kinase 3beta (p-GSK3beta), cyclin D1, phospho-phosphatase and tensin homologue (p-PTEN), phospho-phosphatidylinositol 3"-OH kinase (p-PI3K), and phospho-protein kinase B (p-PKB/Akt). Resveratrol 48-59 AKT serine/threonine kinase 1 Homo sapiens 299-302 26530632-6 2016 We also found that resveratrol inhibited the progression of the cell cycle in MGC803 cells by repressing p-PI3K and p-Akt expression. Resveratrol 19-30 AKT serine/threonine kinase 1 Homo sapiens 118-121 26530632-8 2016 Taken together, these results suggest that resveratrol induced cell cycle arrest in human gastric cancer MGC803 cells by regulating the PTEN/PI3K/Akt signaling pathway. Resveratrol 43-54 AKT serine/threonine kinase 1 Homo sapiens 146-149 26499368-5 2016 We additionally studied the mechanism of resveratrol on Sirt1, a class III histone deacetylase, and Akt phosphorylation. Resveratrol 41-52 AKT serine/threonine kinase 1 Homo sapiens 100-103 26499368-8 2016 Furthermore, we showed that resveratrol-induced Sirt1 blocked Akt phosphorylation. Resveratrol 28-39 AKT serine/threonine kinase 1 Homo sapiens 62-65 26499368-9 2016 The present results indicated that resveratrol inhibited the Akt pathways by inducing Sirt1, thus leading to cell death. Resveratrol 35-46 AKT serine/threonine kinase 1 Homo sapiens 61-64 27551486-3 2015 We observed that introducing resveratrol as a chemosensitizer in docetaxel chemotherapy blocks upregulation and activation of HER-2 in addition to blocking downstream signaling pathways such as Akt. Resveratrol 29-40 AKT serine/threonine kinase 1 Homo sapiens 194-197 26046675-0 2015 Resveratrol Enhances Etoposide-Induced Cytotoxicity through Down-Regulating ERK1/2 and AKT-Mediated X-ray Repair Cross-Complement Group 1 (XRCC1) Protein Expression in Human Non-Small-Cell Lung Cancer Cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 87-90 26046675-8 2015 Furthermore, transfection with constitutive active MKK1 or AKT vectors could rescue the XRCC1 protein level and also the cell survival suppressed by co-treatment with etoposide and resveratrol. Resveratrol 181-192 AKT serine/threonine kinase 1 Homo sapiens 59-62 25307508-0 2015 Cancer-specific interruption of glucose metabolism by resveratrol is mediated through inhibition of Akt/GLUT1 axis in ovarian cancer cells. Resveratrol 54-65 AKT serine/threonine kinase 1 Homo sapiens 100-103 25307508-6 2015 Suppressed plasma membrane GLUT1 localization in ovarian cancer was found to be associated with the inhibition of Akt activity by RSV, as confirmed by the action of the Akt inhibitors (LY294002 and Akt inhibitor IV), as well as overexpression of a constitutive active form of Akt. Resveratrol 130-133 AKT serine/threonine kinase 1 Homo sapiens 114-117 25307508-7 2015 Taken together, these findings suggested that RSV induced apoptosis in ovarian cancer cells by impairing glucose uptake, a process involving Akt-regulated plasma membrane GLUT1 trafficking. Resveratrol 46-49 AKT serine/threonine kinase 1 Homo sapiens 141-144 26314862-4 2015 This resveratrol analog activated the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway through stimulating phosphorylation of Akt and inducing keap1 modification, thereby resulting in its nuclear translocation and subsequent transcriptional induction of phase II detoxifying enzymes. Resveratrol 5-16 AKT serine/threonine kinase 1 Homo sapiens 136-139 26043036-0 2015 Resveratrol Inhibits the Invasion of Glioblastoma-Initiating Cells via Down-Regulation of the PI3K/Akt/NF-kappaB Signaling Pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 99-102 25936406-0 2015 Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways. Resveratrol 20-31 AKT serine/threonine kinase 1 Homo sapiens 86-89 27551486-11 2015 Resveratrol also downregulated docetaxel-induced activation of MAPK and Akt, survival signaling pathways downstream of HER-2. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 72-75 27551486-12 2015 In short, this study, for the first time, establishes the role of HER-2-Akt signaling axis in regulating the synergistic effect of docetaxel and resveratrol in breast cancer cells overexpressing HER-2. Resveratrol 145-156 AKT serine/threonine kinase 1 Homo sapiens 72-75 26446654-6 2015 RESULTS: In ARPE-19 cells, resveratrol significantly inhibited HIF-1alpha and VEGF in a dose-dependent manner, by blocking the PI3K/Akt/mTOR signaling pathway and by promoting proteasomal HIF-1alpha degradation. Resveratrol 27-38 AKT serine/threonine kinase 1 Homo sapiens 132-135 25929783-6 2015 In addition, resveratrol inhibited the over-expression of p-AKT and p-ERK1/2. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 60-63 24951775-0 2014 Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 128-131 25447541-0 2015 Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 27-30 25447541-4 2015 Further, we show that resveratrol promotes acetylation and reactivation of PTEN via inhibition of the MTA1/HDAC complex, resulting in inhibition of the Akt pathway. Resveratrol 22-33 AKT serine/threonine kinase 1 Homo sapiens 152-155 25447541-8 2015 Finally, using orthotopic prostate cancer xenografts, we demonstrate that both resveratrol treatment and MTA1 knockdown enhance PTEN levels leading to a decreased p-Akt expression and proliferation index. Resveratrol 79-90 AKT serine/threonine kinase 1 Homo sapiens 165-168 26040106-11 2015 In conclusion, resveratrol induced apoptosis in HeLa cells in an Akt/GSK3beta-independent manner and down-regulated beta-catenin levels during apoptosis through action of caspase-3 and proteasomal degradation, independent of GSK3beta-mediated phosphorylation. Resveratrol 15-26 AKT serine/threonine kinase 1 Homo sapiens 65-68 25311616-0 2014 Phosphoproteomics reveals resveratrol-dependent inhibition of Akt/mTORC1/S6K1 signaling. Resveratrol 26-37 AKT serine/threonine kinase 1 Homo sapiens 62-65 25448084-9 2014 Resveratrol also alleviated the PI3K/Akt/mTOR signaling by down-regulation of Akt phosphorylation and up-regulation of PTEN expression. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 37-40 25448084-9 2014 Resveratrol also alleviated the PI3K/Akt/mTOR signaling by down-regulation of Akt phosphorylation and up-regulation of PTEN expression. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 78-81 25290095-0 2014 Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts. Resveratrol 19-30 AKT serine/threonine kinase 1 Homo sapiens 125-128 25290095-9 2014 The phosphorylation of Akt induced by FGF-2 was significantly suppressed by resveratrol or SRT1720. Resveratrol 76-87 AKT serine/threonine kinase 1 Homo sapiens 23-26 25290095-10 2014 These findings strongly suggest that resveratrol down-regulates FGF-2-stimulated OPG synthesis through the suppression of the Akt pathway in osteoblasts and that the inhibitory effect of resveratrol is mediated at least in part by SIRT1 activation. Resveratrol 37-48 AKT serine/threonine kinase 1 Homo sapiens 126-129 25672876-0 2015 Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 107-110 25672876-9 2015 Moreover, we found that the growth inhibitory effects of resveratrol were enhanced by treatment with LY294002 [a phosphatidylinositol 3-kinase (PI3-K) inhibitor] more so than by treatment with PD98059 (a MEK inhibitor), which indicates that resveratrol exerts its inhibitory effects on sebocyte proliferation through the inhibition of Akt. Resveratrol 57-68 AKT serine/threonine kinase 1 Homo sapiens 335-338 25672876-12 2015 Our results indicate that resveratrol plays a critical role in the inhibition of sebocyte growth through the inactivation of the Akt pathway. Resveratrol 26-37 AKT serine/threonine kinase 1 Homo sapiens 129-132 24951775-9 2014 Furthermore, we found that the inhibitory effect of resveratrol on arginase II in hPASMC was mediated through the PI3K-Akt signaling pathway. Resveratrol 52-63 AKT serine/threonine kinase 1 Homo sapiens 119-122 24968355-0 2014 Biochemical and cellular evidence demonstrating AKT-1 as a binding partner for resveratrol targeting protein NQO2. Resveratrol 79-90 AKT serine/threonine kinase 1 Homo sapiens 48-53 24756222-0 2014 The PTEN/PI3K/Akt and Wnt/beta-catenin signaling pathways are involved in the inhibitory effect of resveratrol on human colon cancer cell proliferation. Resveratrol 99-110 AKT serine/threonine kinase 1 Homo sapiens 14-17 24968355-8 2014 Modeling analysis further revealed that kinase domain of AKT binds NQO2 in the vicinity of asparagine 161 located in the resveratrol-binding domain of NQO2. Resveratrol 121-132 AKT serine/threonine kinase 1 Homo sapiens 57-60 24968355-11 2014 AKT binds with high affinity to the column suggesting that it is a target of resveratrol. Resveratrol 77-88 AKT serine/threonine kinase 1 Homo sapiens 0-3 24968355-13 2014 The inhibition of AKT by resveratrol was attenuated in NQO2-expressing relative to NQO2-knockdown cells. Resveratrol 25-36 AKT serine/threonine kinase 1 Homo sapiens 18-21 24968355-14 2014 CONCLUSION/SIGNIFICANCE: Both NQO2 and AKT are targets of resveratrol; NQO2:AKT interaction is a novel physiological regulator of AKT activation/function. Resveratrol 58-69 AKT serine/threonine kinase 1 Homo sapiens 39-42 24968355-14 2014 CONCLUSION/SIGNIFICANCE: Both NQO2 and AKT are targets of resveratrol; NQO2:AKT interaction is a novel physiological regulator of AKT activation/function. Resveratrol 58-69 AKT serine/threonine kinase 1 Homo sapiens 76-79 24968355-14 2014 CONCLUSION/SIGNIFICANCE: Both NQO2 and AKT are targets of resveratrol; NQO2:AKT interaction is a novel physiological regulator of AKT activation/function. Resveratrol 58-69 AKT serine/threonine kinase 1 Homo sapiens 76-79 24535223-0 2014 Resveratrol induces apoptosis of bladder cancer cells via miR-21 regulation of the Akt/Bcl-2 signaling pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 83-86 24932295-2 2014 The present study was conducted to investigate the effect of resveratrol on the activation of the phosphatidylinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling cascade in K562 cells. Resveratrol 61-72 AKT serine/threonine kinase 1 Homo sapiens 154-157 24534773-0 2014 Resveratrol prevents TNF-alpha-induced muscle atrophy via regulation of Akt/mTOR/FoxO1 signaling in C2C12 myotubes. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 72-75 24534773-7 2014 Resveratrol supplementation effectively counteracts TNF-alpha induced muscle protein loss and reverses declining expression of Akt, mTOR, p70S6K, 4E-BP1and FoxO1, but exerts no influence of FoxO3a expression. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 127-130 24534773-8 2014 Our study demonstrates that resveratrol can reverse the muscle cell atrophy caused by TNF-alpha through regulation of the Akt/mTOR/FoxO1 signaling pathways, followed by inhibition of the atrophy-related ubiquitin ligase. Resveratrol 28-39 AKT serine/threonine kinase 1 Homo sapiens 122-125 24932295-4 2014 In addition, resveratrol attenuated the phosphorylation of PI3K, Akt and mTOR in the K562 cells. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 65-68 24932295-5 2014 Furthermore, the selected inhibitors of PI3K (LY294002), Akt (SH-6) and mTOR (rapamycin) enhanced the effects of resveratrol in K562 cells. Resveratrol 113-124 AKT serine/threonine kinase 1 Homo sapiens 57-60 24932295-8 2014 These results suggested that the downregulation of the PI3K/Akt/mTOR signaling cascades may be a crucial mediator in the inhibition of proliferation and induction of apoptosis by resveratrol in K562 cells. Resveratrol 179-190 AKT serine/threonine kinase 1 Homo sapiens 60-63 24535223-5 2014 The expression of phospho-Akt and Bcl-2 following treatment with resveratrol or the downregulation of miR-21 expression were also measured. Resveratrol 65-76 AKT serine/threonine kinase 1 Homo sapiens 26-29 24535223-7 2014 Resveratrol decreased the expression of miR-21, the level of phospho-Akt and Bcl-2 protein expression. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 69-72 24535223-11 2014 Collectively, data revealed that the effect of resveratrol on bladder cancer cell apoptosis was due to miR-21 regulation of the Akt/Bcl-2 signaling pathway. Resveratrol 47-58 AKT serine/threonine kinase 1 Homo sapiens 128-131 24416418-7 2014 We found that low dose resveratrol stimulated differentiation through SirT1-mediated activation of AKT, whereas high dose resveratrol stimulated differentiation through AMPK-mediated inhibition of the mTORC1 pathway, allowing activation of AKT. Resveratrol 122-133 AKT serine/threonine kinase 1 Homo sapiens 240-243 24812624-8 2014 CONCLUSION: Resveratrol acts as an antioxidant at nutritionally relevant concentrations by inducing the expression of antioxidant enzymes, through a mechanism involving PTEN/Akt signaling pathway. Resveratrol 12-23 AKT serine/threonine kinase 1 Homo sapiens 174-177 24579778-0 2014 Resveratrol triggers protective autophagy through the ceramide/Akt/mTOR pathway in melanoma B16 cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 63-66 24107596-0 2014 Resveratrol inhibits hydrogen peroxide-induced apoptosis in endothelial cells via the activation of PI3K/Akt by miR-126. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 105-108 23673314-8 2013 Resveratrol, an SIRT1 activator, prevented the UVB-induced damage by inhibiting AKT and ERK phosphorylation. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 80-83 24221993-15 2013 Resveratrol also inhibited Akt activation; in addition, inhibitors and small interfering RNAs against phosphoinositide 3-kinase decreased (18)F-FDG uptake. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 27-30 24331535-0 2013 Resveratrol induces apoptosis and autophagy in T-cell acute lymphoblastic leukemia cells by inhibiting Akt/mTOR and activating p38-MAPK. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 103-106 23272906-3 2013 It has been found that resveratrol targets multiple components of the phosphatidylinositol 3- kinase(PI3K)/Akt and mTOR signaling pathways, including PI3K, Akt, PTEN, and DEPTOR, suggesting that this natural compound and its derivatives may offer a promising new cancer treatment. Resveratrol 23-34 AKT serine/threonine kinase 1 Homo sapiens 107-110 23272906-3 2013 It has been found that resveratrol targets multiple components of the phosphatidylinositol 3- kinase(PI3K)/Akt and mTOR signaling pathways, including PI3K, Akt, PTEN, and DEPTOR, suggesting that this natural compound and its derivatives may offer a promising new cancer treatment. Resveratrol 23-34 AKT serine/threonine kinase 1 Homo sapiens 156-159 24331535-8 2013 Furthermore, resveratrol induced significant dephosphorylation of Akt, mTOR, p70S6K, and 4E-BP1, but enhanced specific phosphorylation of p38-MAPK which could be blocked by SB203580. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 66-69 24331535-10 2013 CONCLUSION: Our findings have suggested that resveratrol induces cell cycle arrest, apoptosis, and autophagy in T-ALL cells through inhibiting Akt/mTOR/p70S6K/4E-BP1 and activating p38-MAPK signaling pathways. Resveratrol 45-56 AKT serine/threonine kinase 1 Homo sapiens 143-146 23525482-2 2013 An early resveratrol effect was the inhibition of AKT and mitogen-activated protein kinase signaling, accompanied by down regulation of cyclin D1 expression, abrogation of retinoblastoma protein hyperphosphorylation, and subsequent inhibition of cell cycle reentry and clonal expansion, as indicated by cyclin A2 repression. Resveratrol 9-20 AKT serine/threonine kinase 1 Homo sapiens 50-53 23921149-0 2013 3,5,4"-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/beta-catenin signaling cascades and reversal of epithelial-mesenchymal transition. Resveratrol 60-71 AKT serine/threonine kinase 1 Homo sapiens 140-143 22990594-8 2013 After SIRT1 siRNA was transfected, NP cells decreased phosphorylation of Akt, while resveratrol phosphorylated Akt. Resveratrol 84-95 AKT serine/threonine kinase 1 Homo sapiens 111-114 23922164-0 2013 Resveratrol mitigates isoflurane-induced neuroapoptosis by inhibiting the activation of the Akt-regulated mitochondrial apoptotic signaling pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 92-95 22925919-8 2013 Moreover, Akt was identified previously as a direct target of TRAF6, and we found that, similarly to MAPKs, phosphorylation pattern of Akt followed the activation of TRAF6, and it was inhibited by resveratrol at all time points. Resveratrol 197-208 AKT serine/threonine kinase 1 Homo sapiens 10-13 23829535-5 2013 A chromatin immunoprecipitation assay for Nrf2 after AMPKalpha knockdown with siRNA revealed that Nrf2 nuclear accumulation and subsequent binding to the ferritin H ARE induced by resveratrol were dependent on activation of AMPKalpha, but not PI3K/AKT. Resveratrol 180-191 AKT serine/threonine kinase 1 Homo sapiens 248-251 23328930-0 2013 Resveratrol inhibits TNF-alpha-induced IL-1beta, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 153-156 23328930-7 2013 Resveratrol also decreased significantly the expression of phosphorylated Akt dose dependently. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 74-77 23328930-9 2013 Immunofluorescence staining showed that TNF-alpha alone increased the production of P-Akt, whereas LY294002 and 50 muM resveratrol suppressed the TNF-alpha-stimulated expression of P-Akt. Resveratrol 119-130 AKT serine/threonine kinase 1 Homo sapiens 183-186 23328930-10 2013 Resveratrol attenuates TNF-alpha-induced production of IL-1beta and MMP-3 via inhibition of PI3K-Akt signaling pathway in RA FLS, suggesting that resveratrol plays an anti-inflammatory role and might have beneficial effects in preventing and treating RA. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 97-100 23328930-10 2013 Resveratrol attenuates TNF-alpha-induced production of IL-1beta and MMP-3 via inhibition of PI3K-Akt signaling pathway in RA FLS, suggesting that resveratrol plays an anti-inflammatory role and might have beneficial effects in preventing and treating RA. Resveratrol 146-157 AKT serine/threonine kinase 1 Homo sapiens 97-100 22925919-8 2013 Moreover, Akt was identified previously as a direct target of TRAF6, and we found that, similarly to MAPKs, phosphorylation pattern of Akt followed the activation of TRAF6, and it was inhibited by resveratrol at all time points. Resveratrol 197-208 AKT serine/threonine kinase 1 Homo sapiens 135-138 22925919-9 2013 Here, we provide the first evidence that resveratrol, by suppressing LPS-induced TRAF6 expression and ubiquitination, attenuates the LPS-induced TLR4-TRAF6, MAP kinase and Akt pathways that can be significant in its anti-inflammatory effects. Resveratrol 41-52 AKT serine/threonine kinase 1 Homo sapiens 172-175 23229870-8 2013 Moreover, the Akt kinase was inhibited by resveratrol in the HT1080 cells. Resveratrol 42-53 AKT serine/threonine kinase 1 Homo sapiens 14-17 23314035-8 2013 In addition, resveratrol treatment also significantly decreased the phosphorylation levels of Akt1, p70S6K and p-4E-BP-1 and the protein expression of several cyclins involved in cell cycle regulation. Resveratrol 25-36 AKT serine/threonine kinase 1 Homo sapiens 118-122 26064836-7 2013 Insulin-stimulated Akt phosphorylation is also dose-dependently reduced with resveratrol treatment. Resveratrol 77-88 AKT serine/threonine kinase 1 Homo sapiens 19-22 26064836-8 2013 Interestingly, Akt phosphorylation is upregulated when cells are treated with long-term low doses of resveratrol, suggesting that only low doses of resveratrol improve metabolic conditions. Resveratrol 101-112 AKT serine/threonine kinase 1 Homo sapiens 15-18 26064836-8 2013 Interestingly, Akt phosphorylation is upregulated when cells are treated with long-term low doses of resveratrol, suggesting that only low doses of resveratrol improve metabolic conditions. Resveratrol 148-159 AKT serine/threonine kinase 1 Homo sapiens 15-18 23146690-7 2013 Taken together, the data provide evidence that the synergistic antiproliferative effect of resveratrol and clofarabine is linked to the inhibition of Akt and Sp1 activities, and suggest that this combination may have therapeutic value in treatment of malignant mesothelioma. Resveratrol 91-102 AKT serine/threonine kinase 1 Homo sapiens 150-153 23229870-9 2013 The inhibition of p38 and Akt kinases with SB203580 and LY294002 further increased resveratrol-induced MMP-9 as well as cell migration in the HT1080 cells. Resveratrol 95-106 AKT serine/threonine kinase 1 Homo sapiens 26-29 23457620-0 2013 Inhibitory effects of resveratrol on PDGF-BB-induced retinal pigment epithelial cell migration via PDGFRbeta, PI3K/Akt and MAPK pathways. Resveratrol 22-33 AKT serine/threonine kinase 1 Homo sapiens 115-118 23992306-0 2013 Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-kappaB pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 115-118 23992306-5 2013 In addition, the levels of phospho-Akt and phospho- NF-kappaB in BxPC-3 and Panc-1 cells were reduced by both resveratrol and LY294002 (a PI3-K inhibitor). Resveratrol 110-121 AKT serine/threonine kinase 1 Homo sapiens 35-38 23992306-7 2013 Taken together, these data indicate that resveratrol suppresses pancreatic cancer migration and invasion through the inhibition of the PI-3K/Akt/NF-kappaB signaling pathway. Resveratrol 41-52 AKT serine/threonine kinase 1 Homo sapiens 141-144 22878646-2 2012 It has been known that resveratrol is a sirtuin 1 (SIRT1) activator and protective effects of resveratrol are mediated by Akt and mitogen-activated protein kinases. Resveratrol 23-34 AKT serine/threonine kinase 1 Homo sapiens 122-125 22878646-2 2012 It has been known that resveratrol is a sirtuin 1 (SIRT1) activator and protective effects of resveratrol are mediated by Akt and mitogen-activated protein kinases. Resveratrol 94-105 AKT serine/threonine kinase 1 Homo sapiens 122-125 22878646-5 2012 In the present study, we defined the signaling pathways modulated by resveratrol in ischemia by examining SIRT1 expression and phosphorylation of Akt, ERK1/2 and p38 in the ischemic cortex. Resveratrol 69-80 AKT serine/threonine kinase 1 Homo sapiens 146-149 22878646-6 2012 Resveratrol increased expression of SIRT1 and phosphorylation of Akt and p38 but inhibited the increase in phosphorylation of ERK1/2. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 65-68 22936809-6 2012 IL-1beta-induced NF-kappaB and PI3K activation was inhibited by resveratrol or the inhibitors of PI3K (wortmannin), c-Src (PP1), and Akt (SH-5) through inhibition of IkappaB kinase, IkappaBalpha phosphorylation, and inhibition of nuclear translocation of NF-kappaB, suggesting that PI3K signaling pathway may be one of the signaling pathways inhibited by resveratrol to abrogate NF-kappaB activation. Resveratrol 64-75 AKT serine/threonine kinase 1 Homo sapiens 133-136 22936809-6 2012 IL-1beta-induced NF-kappaB and PI3K activation was inhibited by resveratrol or the inhibitors of PI3K (wortmannin), c-Src (PP1), and Akt (SH-5) through inhibition of IkappaB kinase, IkappaBalpha phosphorylation, and inhibition of nuclear translocation of NF-kappaB, suggesting that PI3K signaling pathway may be one of the signaling pathways inhibited by resveratrol to abrogate NF-kappaB activation. Resveratrol 355-366 AKT serine/threonine kinase 1 Homo sapiens 133-136 23457620-14 2013 CONCLUSIONS: These results indicate that resveratrol is an effective inhibitor of PDGF-BB-induced RPE cell migration via PDGFRbeta, PI3K/Akt and MAPK pathways, but has no effects on the RPE cell adhesion to fibronectin. Resveratrol 41-52 AKT serine/threonine kinase 1 Homo sapiens 137-140 22571807-8 2012 Resveratrol suppressed ROS production and phosphorylation of Akt and ERK induced by 4-OHE2 treatment. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 61-64 22765290-3 2012 In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53. Resveratrol 106-117 AKT serine/threonine kinase 1 Homo sapiens 326-329 22234583-5 2012 Our findings demonstrate that resveratrol down-regulates the protein cyclin D1 and, in a concentration dependent manner, the phosphorylation levels of protein kinase B (Akt) and glycogen synthase kinase-3beta (GSK-3beta). Resveratrol 30-41 AKT serine/threonine kinase 1 Homo sapiens 169-172 22314268-7 2012 These effects of resveratrol were accompanied by activation of phosphoinositide 3 kinase (PI3-K)/Akt and Mitogen-Activated Protein Kinase (MAPK)/ERK signaling pathways that led to endothelial nitric oxide synthase upregulation and increased nitric oxide (NO) levels. Resveratrol 17-28 AKT serine/threonine kinase 1 Homo sapiens 97-100 22437738-9 2012 Resveratrol triggers some of the similar intracellular insulin signalling components in myocardium such as eNOS, AKT through the AMPK pathway, and plays an essential role in Glut-4 translocation and glucose uptake in STZ-induced diabetic myocardium. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 113-116 22234583-0 2012 Resveratrol downregulates Akt/GSK and ERK signalling pathways in OVCAR-3 ovarian cancer cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 26-29 22266466-9 2012 Our results indicate a hitherto unreported role of NQO2 in the control of AKT/GSK-3beta/cyclin D1 and highlight the involvement of NQO2 in degradation of cyclin D1, as part of mechanism of chemoprevention by resveratrol. Resveratrol 208-219 AKT serine/threonine kinase 1 Homo sapiens 74-77 22334499-0 2012 Notice of data fabrication in "Resveratrol-mediated activation of cAMP response element-binding protein through adenosine A3 receptor by Akt-dependent and -independent pathways". Resveratrol 31-42 AKT serine/threonine kinase 1 Homo sapiens 137-140 22234583-9 2012 Moreover, resveratrol had an inhibitory effect on the AKT phosphorylation in cultured cells derived from the ascites of ovarian cancer patients and in a panel of human cancer cell lines. Resveratrol 10-21 AKT serine/threonine kinase 1 Homo sapiens 54-57 23272133-0 2012 Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 76-79 23272133-9 2012 PC-3M-MM2 cells also exhibited high levels of phospho-Akt (pAkt), which were reduced by both resveratrol and LY294002 (a PI3-kinase inhibitor). Resveratrol 93-104 AKT serine/threonine kinase 1 Homo sapiens 54-57 23272133-14 2012 Similar anti-tumor effects of resveratrol were observed in DU145 and LNCaP prostate cancer cells which were associated with suppression of Akt and PDCD4, but independent of miR-21.These data suggest that resveratrol"s anti-tumor actions in prostate cancer could be explained, in part, through inhibition of Akt/miR-21 signaling pathway. Resveratrol 30-41 AKT serine/threonine kinase 1 Homo sapiens 139-142 23272133-14 2012 Similar anti-tumor effects of resveratrol were observed in DU145 and LNCaP prostate cancer cells which were associated with suppression of Akt and PDCD4, but independent of miR-21.These data suggest that resveratrol"s anti-tumor actions in prostate cancer could be explained, in part, through inhibition of Akt/miR-21 signaling pathway. Resveratrol 204-215 AKT serine/threonine kinase 1 Homo sapiens 307-310 21743969-7 2011 Significant de-phosphorylation of Akt, increased Bax expression, decreased Bcl-2 expression and cleavage of caspase-3 were also observed in resveratrol-induced apoptosis in glioblastoma cells. Resveratrol 140-151 AKT serine/threonine kinase 1 Homo sapiens 34-37 22340406-12 2011 The expression of hTERT is regulated by the PI3-K/Akt pathway; therefore, we examined the effect of resveratrol on Akt activity in EPCs. Resveratrol 100-111 AKT serine/threonine kinase 1 Homo sapiens 115-118 22340406-13 2011 Immunoblotting analysis revealed that resveratrol led to dose-dependent phosphorylation and activation of Akt in EPCs. Resveratrol 38-49 AKT serine/threonine kinase 1 Homo sapiens 106-109 21745208-9 2011 Further mechanistic studies revealed that resveratrol treatment increased the phosphorylation of Akt, adenosine monophosphate kinase (AMPK), Smad 1/5/8 and c-Jun N-terminal kinase, but reduced OM-induced activation of nuclear factor-kappaB. Resveratrol 42-53 AKT serine/threonine kinase 1 Homo sapiens 97-100 21749920-6 2011 We also review the data that suggest that the effects of calorie restriction and resveratrol on the cardiovascular system may involve signaling through the silent information regulator of transcription (SIRT), Akt and the AMP-activated protein kinase (AMPK) pathways. Resveratrol 81-92 AKT serine/threonine kinase 1 Homo sapiens 210-213 22029423-11 2011 RSV enhanced IR-activation of ATM and AMPK but inhibited basal and IR-induced phosphorylation of Akt. Resveratrol 0-3 AKT serine/threonine kinase 1 Homo sapiens 97-100 22029423-12 2011 CONCLUSIONS: Our results suggest that RSV arrests cell cycle, promotes apoptosis and sensitizes PrCa cells to IR likely through a desirable dual action to activate the ATM-AMPK-p53-p21(cip1)/p27(kip1) and inhibit the Akt signalling pathways. Resveratrol 38-41 AKT serine/threonine kinase 1 Homo sapiens 217-220 21467134-6 2011 Interestingly, extracellular signal-regulated kinases (ERK), c-Jun NH(2)-terminal kinases (JNK), and Akt also accumulate in lipid rafts on resveratrol exposure (IC(50) at 48 h 30 mumol/L in SW480 and U937 cells). Resveratrol 139-150 AKT serine/threonine kinase 1 Homo sapiens 101-104 21385509-0 2011 Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 85-88 21385509-5 2011 After the fourth week, resveratrol significantly decreased insulin resistance (homeostasis model of assessment for insulin resistance) and urinary ortho-tyrosine excretion, while it increased the pAkt:Akt ratio in platelets. Resveratrol 23-34 AKT serine/threonine kinase 1 Homo sapiens 197-200 21385509-7 2011 The present study shows for the first time that resveratrol improves insulin sensitivity in humans, which might be due to a resveratrol-induced decrease in oxidative stress that leads to a more efficient insulin signalling via the Akt pathway. Resveratrol 48-59 AKT serine/threonine kinase 1 Homo sapiens 231-234 21385509-7 2011 The present study shows for the first time that resveratrol improves insulin sensitivity in humans, which might be due to a resveratrol-induced decrease in oxidative stress that leads to a more efficient insulin signalling via the Akt pathway. Resveratrol 124-135 AKT serine/threonine kinase 1 Homo sapiens 231-234 21168265-0 2011 Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 154-157 21269063-0 2011 Resveratrol inhibits transforming growth factor-beta-induced proliferation and differentiation of ex vivo human lung fibroblasts into myofibroblasts through ERK/Akt inhibition and PTEN restoration. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 161-164 21168265-3 2011 We found that resveratrol, a natural phytoalexin, suppressed the phosphorylation and activation of the PI3K/AKT pathway in all the three breast cancer cell lines that we tested. Resveratrol 14-25 AKT serine/threonine kinase 1 Homo sapiens 108-111 21168265-5 2011 The combined use of resveratrol and rapamycin resulted in modest additive inhibitory effects on the growth of breast cancer cells, mainly through suppressing rapamycin-induced AKT activation. Resveratrol 20-31 AKT serine/threonine kinase 1 Homo sapiens 176-179 21168265-6 2011 We, therefore, reveal a novel combination whereby resveratrol potentiates the growth inhibitory effect of rapamycin, with the added benefit of preventing eventual resistance to rapamycin, likely by suppressing AKT signaling. Resveratrol 50-61 AKT serine/threonine kinase 1 Homo sapiens 210-213 21168265-7 2011 We also present data herein that PTEN is an important contributor to resveratrol"s growth suppressive effects and its potentiation of rapamycin in this therapeutic scenario, as resveratrol"s suppression of rapamycin-mediated induction of P-AKT is both PTEN-dependent and -independent. Resveratrol 177-188 AKT serine/threonine kinase 1 Homo sapiens 240-243 21208159-12 2011 Resveratrol (10-50 microM) inhibited phosphorylation of the serine/threonine kinase Akt, by Western blot (15 min, 1h) with a prolonged inhibition (24h) for 25 microM. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 84-87 20972827-7 2011 Treatment of B65 neuroblastoma cells with resveratrol also reduced the content of the phosphorylated form of AKT. Resveratrol 42-53 AKT serine/threonine kinase 1 Homo sapiens 109-112 20980258-8 2011 In addition, we show that the stimulatory effect of RSV is regulated by both the Akt/FOXO1 and the AMPK signaling pathways. Resveratrol 52-55 AKT serine/threonine kinase 1 Homo sapiens 81-84 21737923-6 2011 The phosphatidylinositol 3-kinase-Akt pathway was implicated in resveratrol-dependent nuclear Nrf2 accumulation, whereas extracellular signal-regulated kinase and p38 were involved in epsilon-viniferin-induced Nrf2 accumulation. Resveratrol 64-75 AKT serine/threonine kinase 1 Homo sapiens 34-37 21931821-5 2011 CONCLUSION/SIGNIFICANCE: Altogether, these data suggest that Resveratrol acts as a suppressor of AKT/PKB pathway leading to apoptosis via generation of ROS and at the same time primes DLBCL cells via up-regulation of DR5 to TRAIL-mediated apoptosis. Resveratrol 61-72 AKT serine/threonine kinase 1 Homo sapiens 97-104 21865729-5 2011 Combined treatment with resveratrol sensitized colon cancer cells to 5-fluorouracil, inducing a further increase in oxidative stress, which was linked to the inhibition of AKT and STAT3 proteins, which are known to have oncogenic potential in colorectal carcinomas. Resveratrol 24-35 AKT serine/threonine kinase 1 Homo sapiens 172-175 20133117-7 2011 Also, resveratrol treatment downregulated cyclin D1 as well as p38 MAP kinase, Akt and Pak1 expression and activity in HepG2 cells, suggesting that growth inhibitory activity of resveratrol is associated with the downregulation of cell proliferation and survival pathways. Resveratrol 6-17 AKT serine/threonine kinase 1 Homo sapiens 79-82 20133117-7 2011 Also, resveratrol treatment downregulated cyclin D1 as well as p38 MAP kinase, Akt and Pak1 expression and activity in HepG2 cells, suggesting that growth inhibitory activity of resveratrol is associated with the downregulation of cell proliferation and survival pathways. Resveratrol 178-189 AKT serine/threonine kinase 1 Homo sapiens 79-82 21980390-15 2011 CONCLUSIONS: These data suggest that inhibition of ERK and AKT pathways act together to activate FOXO transcription factors which are involved in resveratrol-mediated pancreatic tumor growth suppression. Resveratrol 146-157 AKT serine/threonine kinase 1 Homo sapiens 59-62 21931821-0 2011 Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 50-53 21931821-3 2011 METHODOLOGY/PRINCIPAL FINDINGS: We investigated the action of Resveratrol on DLBCL cells and found that Resveratrol inhibited cell viability and induced apoptosis by inhibition of constitutively activated AKT and its downstream targets via generation of reactive oxygen species (ROS). Resveratrol 104-115 AKT serine/threonine kinase 1 Homo sapiens 205-208 21078299-5 2010 We found that the resveratrol treatment resulted in a decrease in the phosphorylation of Akt and FOXO1, which are independent of SIRT1 action. Resveratrol 18-29 AKT serine/threonine kinase 1 Homo sapiens 89-92 21179458-3 2010 The present study was carried out to examine whether PI3K/AKT/FOXO pathway mediates the biological effects of resveratrol. Resveratrol 110-121 AKT serine/threonine kinase 1 Homo sapiens 58-61 21179458-4 2010 METHODOLOGY/PRINCIPAL FINDINGS: Resveratrol inhibited the phosphorylation of PI3K, AKT and mTOR. Resveratrol 32-43 AKT serine/threonine kinase 1 Homo sapiens 83-86 21179458-9 2010 Furthermore, apoptosis-inducing potential of resveratrol was enhanced by dominant negative AKT, and inhibited by wild-type AKT and constitutively active AKT. Resveratrol 45-56 AKT serine/threonine kinase 1 Homo sapiens 91-94 21179458-9 2010 Furthermore, apoptosis-inducing potential of resveratrol was enhanced by dominant negative AKT, and inhibited by wild-type AKT and constitutively active AKT. Resveratrol 45-56 AKT serine/threonine kinase 1 Homo sapiens 123-126 21179458-9 2010 Furthermore, apoptosis-inducing potential of resveratrol was enhanced by dominant negative AKT, and inhibited by wild-type AKT and constitutively active AKT. Resveratrol 45-56 AKT serine/threonine kinase 1 Homo sapiens 123-126 21179458-13 2010 Similarly, resveratrol-induced FOXO transcriptional activity was further enhanced when activation of PI3K/AKT pathway was blocked. Resveratrol 11-22 AKT serine/threonine kinase 1 Homo sapiens 106-109 20626463-8 2010 In HaCaT cells, resveratrol induces dose- and time-dependent growth arrest, p66Shc-Ser36 phosphorylation, ERK1/2 phosphorylation and AKT dephosphorylation. Resveratrol 16-27 AKT serine/threonine kinase 1 Homo sapiens 133-136 20696143-9 2010 We demonstrated that both Akt and ERK signaling pathways, which are known to be critical for angiogenesis, became activated in response to 5muM of resveratrol and functioned to inactivate GSK3beta. Resveratrol 147-158 AKT serine/threonine kinase 1 Homo sapiens 26-29 21931821-6 2011 These data raise the possibility that Resveratrol may have a future therapeutic role in DLBCL and possibly other malignancies with constitutive activation of the AKT/PKB pathway. Resveratrol 38-49 AKT serine/threonine kinase 1 Homo sapiens 162-165 21931821-6 2011 These data raise the possibility that Resveratrol may have a future therapeutic role in DLBCL and possibly other malignancies with constitutive activation of the AKT/PKB pathway. Resveratrol 38-49 AKT serine/threonine kinase 1 Homo sapiens 166-169 20457218-10 2010 Additionally ss-arrestin 2 exerted an additive effect on resveratrol-reduced levels of p-Akt and p-GSK3ss. Resveratrol 57-68 AKT serine/threonine kinase 1 Homo sapiens 89-92 20457218-11 2010 Overexpression of ss-arrestin 2 decreased the percentage of apoptosis and caspase-3 activation and attenuated resveratrol-reduced levels of p-Akt and p-GSK3ss. Resveratrol 110-121 AKT serine/threonine kinase 1 Homo sapiens 142-145 20457218-13 2010 MAJOR CONCLUSIONS: Resveratrol primes EC cells to undergo apoptosis by modulating beta-arrestin 2 mediated Akt/GSK3ss signaling pathways. Resveratrol 19-30 AKT serine/threonine kinase 1 Homo sapiens 107-110 20097879-6 2010 Mechanistic studies reveal that resveratrol inhibits PI3K-driven phosphorylation of Akt, leading to increased Bax activation, loss of mitochondrial membrane potential, cytochrome c release, and caspase-dependent apoptosis. Resveratrol 32-43 AKT serine/threonine kinase 1 Homo sapiens 84-87 20519497-9 2010 In contrast, the effect of resveratrol was independent of FoxO1 acetylation and its phosphorylation on Ser-253 and Thr-24, suggesting that resveratrol acts on FoxO1 in a Sirt1- and Akt-independent manner. Resveratrol 139-150 AKT serine/threonine kinase 1 Homo sapiens 181-184 20572158-4 2010 Analysis of cell signaling molecules showed that resveratrol induced the activation of JNK, p38, Akt, and NF-kappaB signaling pathways in these cells. Resveratrol 49-60 AKT serine/threonine kinase 1 Homo sapiens 97-100 20012470-7 2010 Antiangiogenic effects of resveratrol were enhanced by inhibitors of AKT and MEK. Resveratrol 26-37 AKT serine/threonine kinase 1 Homo sapiens 69-72 20504360-6 2010 Treatment with resveratrol suppressed IGF-1R protein levels and concurrently attenuated the downstream Akt/Wnt signaling pathways that play a critical role in cell proliferation. Resveratrol 15-26 AKT serine/threonine kinase 1 Homo sapiens 103-106 20504360-10 2010 CONCLUSIONS: For the first time, we report that resveratrol suppresses colon cancer cell proliferation and elevates apoptosis even in the presence of IGF-1 via suppression of IGF-1R/Akt/Wnt signaling pathways and activation of p53, suggesting its potential role as a chemotherapeutic agent. Resveratrol 48-59 AKT serine/threonine kinase 1 Homo sapiens 182-185 20026400-9 2010 Phosphorylation of Akt/PKB and Foxo1 phosphorylation/acetylation decreased exclusively in resveratrol-treated wild-type cells, leading to nuclear localization of Foxo1 and up-regulation of Bim. Resveratrol 90-101 AKT serine/threonine kinase 1 Homo sapiens 19-26 20090934-0 2010 Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70. Resveratrol 41-52 AKT serine/threonine kinase 1 Homo sapiens 14-17 20028382-6 2010 Resveratrol also inhibited the phosphorylation of Akt, whereas the phosphorylation of p38 MAPK was enhanced. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 50-53 20090934-3 2010 METHODOLOGY/PRINCIPAL FINDINGS: Cells exposed to 40microM Resveratrol rapidly abolished serine473 phosphorylation of Akt and significantly reduced its kinase activity. Resveratrol 58-69 AKT serine/threonine kinase 1 Homo sapiens 117-120 20090934-4 2010 Inactivation of Akt pathway by Resveratrol subsequently blocked serine9 phosphorylation of Gsk3beta. Resveratrol 31-42 AKT serine/threonine kinase 1 Homo sapiens 16-19 20090934-15 2010 CONCLUSION/SIGNIFICANCE: Thus our study comprehensively illustrates that Resveratrol acts downstream of Bcr-Abl and inhibits Akt activity but stimulates ERK1/2 activity. Resveratrol 73-84 AKT serine/threonine kinase 1 Homo sapiens 125-128 19108833-7 2009 Resveratrol blocked the oxLDL-induced phosphorylation and activation of the PI3K/Akt/mTOR/p70S6K pathway and strongly inhibited both the DNA synthesis and proliferation of SMC. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 81-84 27713233-6 2009 By activating sirtuin 1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1 alpha), the FOXO family, Akt (protein kinase B) and NFkappabeta. Resveratrol 25-36 AKT serine/threonine kinase 1 Homo sapiens 186-189 20198347-0 2010 Differential effects of resveratrol and novel resveratrol derivative, HS-1793, on endoplasmic reticulum stress-mediated apoptosis and Akt inactivation. Resveratrol 46-57 AKT serine/threonine kinase 1 Homo sapiens 134-137 20198347-9 2010 We also demonstrated that HS-1793, compared to resveratrol, exerted more effective apoptosis inducing activity in Akt-activated cells. Resveratrol 47-58 AKT serine/threonine kinase 1 Homo sapiens 114-117 18077353-10 2007 Resveratrol, an activator of Sirt1, increases the transcriptional activity of FoxO1 and triggers Akt phosphorylation in heart. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 97-100 19827268-0 2009 Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 31-34 19827268-3 2009 In the current studies, the effect of resveratrol on phosphoinositide kinase-3 (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway was examined in human U251 glioma cells. Resveratrol 38-49 AKT serine/threonine kinase 1 Homo sapiens 104-107 19827268-4 2009 Resveratrol decreased both the expression and phosphorylation of Akt. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 65-68 19827268-5 2009 Inhibitors of PI3K (LY294002) and Akt (SH-6) enhanced resveratrol-induced LDH release and caspase-3 activation. Resveratrol 54-65 AKT serine/threonine kinase 1 Homo sapiens 34-37 19827268-7 2009 These results suggest that the downregulation of PI3K/Akt/mTOR signaling pathways may be an important mediator in resveratrol-induced apoptosis in glioma cells. Resveratrol 114-125 AKT serine/threonine kinase 1 Homo sapiens 54-57 18587418-0 2008 Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 107-110 18587418-11 2008 Resveratrol significantly increased telomerase activity and Akt phosphorylation. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 60-63 18587418-13 2008 CONCLUSIONS AND IMPLICATIONS: Resveratrol delayed the onset of EPC senescence and this effect was accompanied by activation of telomerase through the PI3K-Akt signalling pathway. Resveratrol 30-41 AKT serine/threonine kinase 1 Homo sapiens 155-158 18567737-4 2008 Resveratrol significantly blocked PDGF-stimulated c-Src and Akt kinase activation, resulting in reduced cyclin D1 expression and attenuated pRb phosphorylation and cyclin-dependent kinase-2 (CDK2) activity. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 60-63 18567737-7 2008 Interestingly, resveratrol increased the activity of protein tyrosine phosphatase PTP1B, which dephosphorylates PDGF-stimulated phosphorylation at tyrosine-751 and tyrosine-716 on PDGFR with concomitant reduction in Akt and Erk1/2 kinase activity. Resveratrol 15-26 AKT serine/threonine kinase 1 Homo sapiens 216-219 19477653-0 2009 Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3beta pathway. Resveratrol 10-21 AKT serine/threonine kinase 1 Homo sapiens 92-95 19477653-7 2009 Our study thus demonstrates that the resveratrol aliphatic acid inhibits cell apoptosis through TLR2 by the involvement of Akt/GSK3beta pathway. Resveratrol 37-48 AKT serine/threonine kinase 1 Homo sapiens 123-126 18812223-8 2008 Treatment of the repetitively stressed cells concurrently with Resveratrol or SB203580, a p38MAPK inhibitor, robustly blocked activation of p38MAPK, NFkappaB transcriptional activity, phosphorylation and nuclear localization of p65, and Akt phosphorylation. Resveratrol 63-74 AKT serine/threonine kinase 1 Homo sapiens 237-240 18812223-12 2008 We conclude that Resveratrol acts as an antioxidant and completely reverses the anti-apoptotic effects of repetitive stress by blocking oxidative stress-induced p38MAPK activation which is the key regulatory step for the activation of down-stream survival elements Akt and NFkappaB. Resveratrol 17-28 AKT serine/threonine kinase 1 Homo sapiens 265-268 18398872-11 2008 The inhibitory effect of resveratrol was mediated in part through the suppression of the activation of PI-3K/Akt signaling pathway. Resveratrol 25-36 AKT serine/threonine kinase 1 Homo sapiens 109-112 17513867-6 2007 The tumor-suppressive effects of resveratrol were the consequence of Akt inactivation-mediated FOXO3a nuclear accumulation and activation. Resveratrol 33-44 AKT serine/threonine kinase 1 Homo sapiens 69-72 17825886-10 2007 Moreover, resveratrol reduces the levels of phosphorylated Akt and mTOR, two signals that increase glucose uptake and the rate limiting steps in glycolysis. Resveratrol 10-21 AKT serine/threonine kinase 1 Homo sapiens 59-62 18356579-6 2007 In line with this, PKB Ser473-phosphorylation is inhibited best by delta-tocopherol and resveratrol combinatory treatment. Resveratrol 88-99 AKT serine/threonine kinase 1 Homo sapiens 19-22 17356711-0 2007 Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 34-37 17356711-6 2007 Our results demonstrate that 50 microM resveratrol decreases Rac and Cdc42 activity, whereas estrogen and 5 microM resveratrol increase Rac activity in breast cancer cells. Resveratrol 39-50 AKT serine/threonine kinase 1 Homo sapiens 61-64 17356711-6 2007 Our results demonstrate that 50 microM resveratrol decreases Rac and Cdc42 activity, whereas estrogen and 5 microM resveratrol increase Rac activity in breast cancer cells. Resveratrol 115-126 AKT serine/threonine kinase 1 Homo sapiens 136-139 17356711-7 2007 MDA-MB-231 cells expressing dominant-negative Cdc42 or dominant-negative Rac retain filopodia response to 50 microM resveratrol. Resveratrol 116-127 AKT serine/threonine kinase 1 Homo sapiens 73-76 17356711-8 2007 Lamellipodia response to 5 microM resveratrol, estrogen, or epidermal growth factor is inhibited in cells expressing dominant-negative Rac, indicating that Rac regulates estrogen and resveratrol (5 microM) signaling to the actin cytoskeleton. Resveratrol 34-45 AKT serine/threonine kinase 1 Homo sapiens 135-138 17356711-8 2007 Lamellipodia response to 5 microM resveratrol, estrogen, or epidermal growth factor is inhibited in cells expressing dominant-negative Rac, indicating that Rac regulates estrogen and resveratrol (5 microM) signaling to the actin cytoskeleton. Resveratrol 34-45 AKT serine/threonine kinase 1 Homo sapiens 156-159 17356711-8 2007 Lamellipodia response to 5 microM resveratrol, estrogen, or epidermal growth factor is inhibited in cells expressing dominant-negative Rac, indicating that Rac regulates estrogen and resveratrol (5 microM) signaling to the actin cytoskeleton. Resveratrol 183-194 AKT serine/threonine kinase 1 Homo sapiens 135-138 17356711-8 2007 Lamellipodia response to 5 microM resveratrol, estrogen, or epidermal growth factor is inhibited in cells expressing dominant-negative Rac, indicating that Rac regulates estrogen and resveratrol (5 microM) signaling to the actin cytoskeleton. Resveratrol 183-194 AKT serine/threonine kinase 1 Homo sapiens 156-159 17356711-9 2007 These results indicate that signaling to the actin cytoskeleton by low and high concentrations of resveratrol may be differentially regulated by Rac and Cdc42. Resveratrol 98-109 AKT serine/threonine kinase 1 Homo sapiens 145-148 17115889-4 2007 In addition, resveratrol improved postischemic recovery of left ventricular contractile function, attenuated myocardial injury, and increased myocardial activation of the survival kinase Akt in the intact heart. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 187-190 17164350-6 2007 In addition, resveratrol down-regulated the constitutive activation of AKT. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 71-74 17299206-0 2006 Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 143-146 17299206-4 2006 Phosphorylation of the oncogene product Akt was significantly reduced followed by decreased phosphorylation and increased processing of pro-caspase-9 on resveratrol treatment. Resveratrol 153-164 AKT serine/threonine kinase 1 Homo sapiens 40-43 17299206-5 2006 These results indicate that resveratrol seems to exert its growth-inhibitory/apoptotic effect on the breast cancer cell line MCF7 via the Akt-caspase-9 pathway. Resveratrol 28-39 AKT serine/threonine kinase 1 Homo sapiens 138-141 18356579-7 2007 Resveratrol acts more efficiently as an inhibitor of PKB phosphorylation than alpha-, beta-, gamma-tocopherols, whereas delta-tocopherol shows a stronger inhibition possibly as a result of its apoptotic secondary effects. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 53-56 18356579-8 2007 Our data suggest that delta-tocopherol and resveratrol can act additively in reducing cell proliferation and PKB phosphorylation. Resveratrol 43-54 AKT serine/threonine kinase 1 Homo sapiens 109-112 17044934-0 2006 Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 28-31 17044934-8 2006 Resveratrol also reduced cellular levels of the phosphorylated/active form of anti-apoptotic kinase AKT. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 100-103 16227395-6 2005 In addition, resveratrol remarkably inhibited hypoxia-mediated activation of extracellular signal-regulated kinase 1/2 and Akt, leading to a marked decrease in hypoxia-induced HIF-1alpha protein accumulation and VEGF transcriptional activation. Resveratrol 13-24 AKT serine/threonine kinase 1 Homo sapiens 77-126 16343977-5 2006 Resveratrol did not, however, decrease epidermal growth factor receptor autophosphorylation or activation of extracellular regulated kinases, but strongly inhibited the phosphorylation of Akt and of its substrate forkhead related transcription factor. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 188-191 16343977-6 2006 This suggested that resveratrol inhibited epidermal growth factor-induced mitogenic signaling through inhibition of the phosphatidylinositol 3-kinase /Akt pathway. Resveratrol 20-31 AKT serine/threonine kinase 1 Homo sapiens 151-154 16343977-9 2006 Resveratrol did not directly inhibit phosphatidylinositol 3-kinase activity measured on immunoprecipitates from epidermal growth factor-stimulated myofibroblasts, but it strongly reduced the autophosphorylation of the phosphatidylinositol 3-kinase downstream target phospho-inositide-dependent kinase-1 that phosphorylates Akt. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 323-326 16343977-10 2006 We, thus, show that resveratrol has growth factor-specific effects: it inhibits platelet-derived growth factor signaling via reduced receptor activation, whereas it reduces epidermal growth factor-dependent DNA synthesis via inhibition of the phosphatidylinositol 3-kinase/Akt pathway, possibly through inhibition of phospho-inositide-dependent kinase-1 activity. Resveratrol 20-31 AKT serine/threonine kinase 1 Homo sapiens 273-276 16860989-7 2006 Immunoblotting revealed that resveratrol 50 microM induced the phosphorylation/activation of Akt and extracellular signal-regulated kinase-1 and -2 (ERK1/2) and the phosphorylation/inactivation of glycogen synthase kinase-3beta (GSK-3beta). Resveratrol 29-40 AKT serine/threonine kinase 1 Homo sapiens 93-96 16860989-8 2006 Our results suggest that PI3-k/Akt pathway are involved in the neuroprotective effect of resveratrol. Resveratrol 89-100 AKT serine/threonine kinase 1 Homo sapiens 31-34 16731767-0 2006 Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3"-kinase/Akt pathway and Bcl-2 family proteins. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 130-133 16731767-6 2006 Furthermore, our data showed that resveratrol-treatment resulted in significant dose-dependent inhibition in the constitutive expression of phosphatidylinositol 3"-kinase and phosphorylated (active) Akt in LNCaP cells. Resveratrol 34-45 AKT serine/threonine kinase 1 Homo sapiens 199-202 16731767-8 2006 Taken together, our data suggested that resveratrol causes an inhibition of phosphatidylinositol 3"-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of LNCaP cells is promoted. Resveratrol 40-51 AKT serine/threonine kinase 1 Homo sapiens 107-110 15517885-4 2004 Resveratrol has been shown to suppress the activation of several transcription factors, including NF-kappaB, AP-1 and Egr-1; to inhibit protein kinases including IkappaBalpha kinase, JNK, MAPK, Akt, PKC, PKD and casein kinase II; and to down-regulate products of genes such as COX-2, 5-LOX, VEGF, IL-1, IL-6, IL-8, AR and PSA. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 194-197 15297429-7 2004 First, resveratrol inhibited AKT and mitogen-activated protein kinase activation, which played a partial role in the down-regulation of HIF-1alpha expression. Resveratrol 7-18 AKT serine/threonine kinase 1 Homo sapiens 29-32 12421874-9 2002 E2, genistein and daidzein increased whereas resveratrol decreased both Akt and FAK phosphorylation in nonmetastatic ER-positive T47D cells. Resveratrol 45-56 AKT serine/threonine kinase 1 Homo sapiens 72-75